NO782001L - Nye cefalosporinderivater, fremgangsmaate for fremstilling derav og sammensetninger inneholdende de samme - Google Patents

Nye cefalosporinderivater, fremgangsmaate for fremstilling derav og sammensetninger inneholdende de samme

Info

Publication number: NO782001L
Authority: NO; Norway
Prior art keywords: group; acid; formula; denotes; dithiin
Prior art date: 1977-06-09

Application number

NO782001A

Other languages

English (en)

Norwegian (no)

Inventor

Christian Berger

Dominique Deprez

Daniel Farge

Claude Moutonnier

Gerard Wolff

Original Assignee

Rhone Poulenc Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-09

Filing date

1978-06-08

Publication date

1978-12-12

1978-06-08 Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind

1978-12-12 Publication of NO782001L publication Critical patent/NO782001L/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 41
238000000034 method Methods 0.000 title claims abstract description 21
238000004519 manufacturing process Methods 0.000 title description 3
HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
238000002360 preparation method Methods 0.000 claims abstract description 18
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150000001780 cephalosporins Chemical class 0.000 claims abstract description 10
239000002253 acid Substances 0.000 claims description 48
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125000006239 protecting group Chemical group 0.000 claims description 26
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230000002475 laxative effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000155 melt Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
150000002895 organic esters Chemical class 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
238000011197 physicochemical method Methods 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
UJJDEOLXODWCGK-UHFFFAOYSA-N tert-butyl carbonochloridate Chemical compound CC(C)(C)OC(Cl)=O UJJDEOLXODWCGK-UHFFFAOYSA-N 0.000 description 1
RUPAXCPQAAOIPB-UHFFFAOYSA-N tert-butyl formate Chemical group CC(C)(C)OC=O RUPAXCPQAAOIPB-UHFFFAOYSA-N 0.000 description 1
ISHLCKAQWKBMAU-UHFFFAOYSA-N tert-butyl n-diazocarbamate Chemical compound CC(C)(C)OC(=O)N=[N+]=[N-] ISHLCKAQWKBMAU-UHFFFAOYSA-N 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO782001A 1977-06-09 1978-06-08 Nye cefalosporinderivater, fremgangsmaate for fremstilling derav og sammensetninger inneholdende de samme NO782001L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR777717663A FR2393806A1 (fr)	1977-06-09	1977-06-09	Nouveaux derives de la cephalosporine, leur preparation et les compositions qui les contiennent

Publications (1)

Publication Number	Publication Date
NO782001L true NO782001L (no)	1978-12-12

Family

ID=9191876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO782001A NO782001L (no)	1977-06-09	1978-06-08	Nye cefalosporinderivater, fremgangsmaate for fremstilling derav og sammensetninger inneholdende de samme

Country Status (22)

Country	Link
JP (1)	JPS545993A (de)
AT (1)	AT357678B (de)
AU (1)	AU3695778A (de)
BE (1)	BE867957A (de)
CA (1)	CA1097340A (de)
DE (1)	DE2825427A1 (de)
DK (1)	DK254478A (de)
ES (1)	ES470670A1 (de)
FI (1)	FI781850A7 (de)
FR (1)	FR2393806A1 (de)
GB (1)	GB1600728A (de)
GR (1)	GR64145B (de)
HU (1)	HU178715B (de)
IL (1)	IL54877A0 (de)
IT (1)	IT1098320B (de)
LU (1)	LU79788A1 (de)
NL (1)	NL7806004A (de)
NO (1)	NO782001L (de)
PL (1)	PL207238A1 (de)
PT (1)	PT68151A (de)
SE (1)	SE7806689L (de)
ZA (1)	ZA783271B (de)

1977
- 1977-06-09 FR FR777717663A patent/FR2393806A1/fr active Granted
1978
- 1978-01-27 GB GB44606/76A patent/GB1600728A/en not_active Expired
- 1978-05-31 PL PL20723878A patent/PL207238A1/xx unknown
- 1978-06-01 NL NL7806004A patent/NL7806004A/xx not_active Application Discontinuation
- 1978-06-07 HU HU78RO985A patent/HU178715B/hu unknown
- 1978-06-07 ZA ZA00783271A patent/ZA783271B/xx unknown
- 1978-06-07 JP JP6787278A patent/JPS545993A/ja active Pending
- 1978-06-08 AU AU36957/78A patent/AU3695778A/en active Pending
- 1978-06-08 LU LU79788A patent/LU79788A1/xx unknown
- 1978-06-08 CA CA305,063A patent/CA1097340A/fr not_active Expired
- 1978-06-08 GR GR56463A patent/GR64145B/el unknown
- 1978-06-08 DK DK254478A patent/DK254478A/da unknown
- 1978-06-08 NO NO782001A patent/NO782001L/no unknown
- 1978-06-08 PT PT68151A patent/PT68151A/pt unknown
- 1978-06-08 IL IL7854877A patent/IL54877A0/xx unknown
- 1978-06-08 SE SE7806689A patent/SE7806689L/xx unknown
- 1978-06-08 BE BE188442A patent/BE867957A/xx unknown
- 1978-06-09 AT AT420178A patent/AT357678B/de active
- 1978-06-09 DE DE19782825427 patent/DE2825427A1/de not_active Withdrawn
- 1978-06-09 FI FI781850A patent/FI781850A7/fi not_active Application Discontinuation
- 1978-06-09 IT IT24385/78A patent/IT1098320B/it active
- 1978-06-09 ES ES470670A patent/ES470670A1/es not_active Expired

Also Published As

Publication number	Publication date
IL54877A0 (en)	1978-08-31
IT1098320B (it)	1985-09-07
ZA783271B (en)	1979-06-27
GR64145B (en)	1980-01-31
FR2393806B1 (de)	1980-02-01
ES470670A1 (es)	1979-02-01
BE867957A (fr)	1978-12-08
AT357678B (de)	1980-07-25
ATA420178A (de)	1979-12-15
DK254478A (da)	1978-12-10
FR2393806A1 (fr)	1979-01-05
IT7824385A0 (it)	1978-06-09
PT68151A (fr)	1978-07-01
DE2825427A1 (de)	1978-12-21
PL207238A1 (pl)	1979-05-21
HU178715B (en)	1982-06-28
AU3695778A (en)	1979-12-13
CA1097340A (fr)	1981-03-10
FI781850A7 (fi)	1978-12-10
JPS545993A (en)	1979-01-17
GB1600728A (en)	1981-10-21
NL7806004A (nl)	1978-12-12
SE7806689L (sv)	1978-12-10
LU79788A1 (fr)	1979-02-02

Publication	Publication Date	Title
SU1480763A3 (ru)	1989-05-15	Способ получени производных 1-сульфо-2-оксоазетидинона или их солей, или сложных эфиров
DK166280B (da)	1993-03-29	Analogifremgangsmaade til fremstilling af terapeutisk aktive 2-azetidinoner
NO165027B (no)	1990-09-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive propenyl-cefalosporinforbindelser.
US4785090A (en)	1988-11-15	Cephalosporin derivatives
JPH0733389B2 (ja)	1995-04-12	新規３―置換セフェム化合物及びその製造方法
US4406898A (en)	1983-09-27	Oxazole and oxadiazole cephalosporins
SU1556541A3 (ru)	1990-04-07	Способ получени фармацевтически приемлемых эфиров 7- @ -[2-(2-амино-4-тиазолил)-алкеноиламино]-3-цефем-4-карбоновой кислоты
US4260607A (en)	1981-04-07	Cephalosporin esters
US4708956A (en)	1987-11-24	3-position halogenated cephalosporin analogs and pharmaceutical compositions
US4496560A (en)	1985-01-29	Cephalosporin derivatives, and pharmaceutical compositions containing them
JPH09506100A (ja)	1997-06-17	抗炎症剤および抗変性剤としての２−スピロ（２’−スピロシクロアルキル）シクロプロピルセファロスポリンスルホン類
US4880798A (en)	1989-11-14	Cephalosporin derivatives
US4572801A (en)	1986-02-25	4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
KR870002181B1 (ko)	1987-12-28	세팔로스포린의 제조방법
US4508717A (en)	1985-04-02	Cephalosporin derivatives, their preparation and compositions containing them
US4029781A (en)	1977-06-14	1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and compositions containing them
US4132789A (en)	1979-01-02	7-[2-(2-Imino-4-thiazolin-4-yl)-2-sulfoacetamido]cephalosporins and antibacterial compositions containing them
US4071531A (en)	1978-01-31	Oxathiino- and dithiino-aminoacetic acids
EP0287734A1 (de)	1988-10-26	2-Beta-substituiertes-methyl-penamderivate
JPH09506854A (ja)	1997-07-08	新規な２−スピロシクロプロピルセファロスポリンスルホン誘導体及びその製造方法
NO782001L (no)	1978-12-12	Nye cefalosporinderivater, fremgangsmaate for fremstilling derav og sammensetninger inneholdende de samme
CS202056B2 (en)	1980-12-31	Process for preparing derivatives for preparing 7-aminocephalosporanic acid and ester thereof
US4673739A (en)	1987-06-16	4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
EP0186586B1 (de)	1990-09-26	Cephemderivate und ihre Herstellung
US4179502A (en)	1979-12-18	7[2-Hydroxyiminoacetamido]cephalosporins