NO792968L - Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer - Google Patents

Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer

Info

Publication number: NO792968L
Authority: NO; Norway
Prior art keywords: allergen; product; pollen; formaldehyde; aldehyde
Prior art date: 1978-10-04

Application number

NO792968A

Other languages

English (en)

Norwegian (no)

Inventor

David George Marsh

Original Assignee

Univ Johns Hopkins

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-04

Filing date

1979-09-13

Publication date

1980-04-09

1979-09-13 Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins

1980-04-09 Publication of NO792968L publication Critical patent/NO792968L/no

Links

238000000034 method Methods 0.000 title claims description 80
230000002009 allergenic effect Effects 0.000 title claims description 28
239000000126 substance Substances 0.000 title claims description 16
238000002360 preparation method Methods 0.000 title claims description 7
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 155
239000013566 allergen Substances 0.000 claims description 155
150000001299 aldehydes Chemical class 0.000 claims description 53
239000000463 material Substances 0.000 claims description 46
238000006243 chemical reaction Methods 0.000 claims description 44
229960004784 allergens Drugs 0.000 claims description 37
208000010668 atopic eczema Diseases 0.000 claims description 24
230000000172 allergic effect Effects 0.000 claims description 23
101001094887 Ambrosia artemisiifolia Pectate lyase 1 Proteins 0.000 claims description 19
101001123576 Ambrosia artemisiifolia Pectate lyase 2 Proteins 0.000 claims description 19
101001123572 Ambrosia artemisiifolia Pectate lyase 3 Proteins 0.000 claims description 19
101000573177 Ambrosia artemisiifolia Pectate lyase 5 Proteins 0.000 claims description 19
ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 17
230000003053 immunization Effects 0.000 claims description 17
208000024891 symptom Diseases 0.000 claims description 17
230000008569 process Effects 0.000 claims description 16
239000000203 mixture Substances 0.000 claims description 14
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 12
239000000654 additive Substances 0.000 claims description 11
230000000903 blocking effect Effects 0.000 claims description 11
239000006286 aqueous extract Substances 0.000 claims description 10
239000008098 formaldehyde solution Substances 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 10
230000000996 additive effect Effects 0.000 claims description 8
125000001931 aliphatic group Chemical group 0.000 claims description 6
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 6
241000196324 Embryophyta Species 0.000 claims description 5
241000124008 Mammalia Species 0.000 claims description 5
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 5
241000233866 Fungi Species 0.000 claims description 4
241000238631 Hexapoda Species 0.000 claims description 4
230000006872 improvement Effects 0.000 claims description 4
KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims description 4
239000009342 ragweed pollen Substances 0.000 claims description 4
230000015572 biosynthetic process Effects 0.000 claims description 3
238000007710 freezing Methods 0.000 claims description 3
230000008014 freezing Effects 0.000 claims description 3
230000009257 reactivity Effects 0.000 claims description 3
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
GVNWZKBFMFUVNX-UHFFFAOYSA-N Adipamide Chemical compound NC(=O)CCCCC(N)=O GVNWZKBFMFUVNX-UHFFFAOYSA-N 0.000 claims description 2
239000004475 Arginine Substances 0.000 claims description 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
239000004472 Lysine Substances 0.000 claims description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
241001465754 Metazoa Species 0.000 claims description 2
239000005700 Putrescine Substances 0.000 claims description 2
241000238711 Pyroglyphidae Species 0.000 claims description 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
235000004279 alanine Nutrition 0.000 claims description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
235000003704 aspartic acid Nutrition 0.000 claims description 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
239000013568 food allergen Substances 0.000 claims description 2
229940046528 grass pollen Drugs 0.000 claims description 2
239000013574 grass pollen allergen Substances 0.000 claims description 2
229940046533 house dust mites Drugs 0.000 claims description 2
235000004400 serine Nutrition 0.000 claims description 2
229940046536 tree pollen allergenic extract Drugs 0.000 claims description 2
229920006395 saturated elastomer Polymers 0.000 claims 2
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
238000006703 hydration reaction Methods 0.000 claims 1
229960003104 ornithine Drugs 0.000 claims 1
239000002904 solvent Substances 0.000 claims 1
238000011282 treatment Methods 0.000 description 43
239000000243 solution Substances 0.000 description 36
239000010267 Allergoid Substances 0.000 description 33
238000002347 injection Methods 0.000 description 30
239000007924 injection Substances 0.000 description 30
239000000284 extract Substances 0.000 description 29
210000002966 serum Anatomy 0.000 description 28
239000000872 buffer Substances 0.000 description 23
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 22
235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 19
238000000502 dialysis Methods 0.000 description 18
238000012360 testing method Methods 0.000 description 16
244000036975 Ambrosia artemisiifolia Species 0.000 description 15
235000003484 annual ragweed Nutrition 0.000 description 14
239000000427 antigen Substances 0.000 description 14
235000006263 bur ragweed Nutrition 0.000 description 14
235000003488 common ragweed Nutrition 0.000 description 14
238000011534 incubation Methods 0.000 description 14
235000009736 ragweed Nutrition 0.000 description 14
102000036639 antigens Human genes 0.000 description 13
108091007433 antigens Proteins 0.000 description 13
229940074608 allergen extract Drugs 0.000 description 11
239000007787 solid Substances 0.000 description 11
230000009885 systemic effect Effects 0.000 description 11
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 10
238000002474 experimental method Methods 0.000 description 10
238000009169 immunotherapy Methods 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
239000012153 distilled water Substances 0.000 description 8
244000281762 Chenopodium ambrosioides Species 0.000 description 7
235000000509 Chenopodium ambrosioides Nutrition 0.000 description 7
235000005490 Chenopodium botrys Nutrition 0.000 description 7
206010020751 Hypersensitivity Diseases 0.000 description 7
230000005875 antibody response Effects 0.000 description 7
210000004369 blood Anatomy 0.000 description 7
239000008280 blood Substances 0.000 description 7
239000007975 buffered saline Substances 0.000 description 7
239000011541 reaction mixture Substances 0.000 description 7
244000025254 Cannabis sativa Species 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
238000004132 cross linking Methods 0.000 description 6
238000010790 dilution Methods 0.000 description 6
239000012895 dilution Substances 0.000 description 6
238000000605 extraction Methods 0.000 description 6
238000002649 immunization Methods 0.000 description 6
239000008363 phosphate buffer Substances 0.000 description 6
230000035945 sensitivity Effects 0.000 description 6
238000002560 therapeutic procedure Methods 0.000 description 6
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 5
241000700198 Cavia Species 0.000 description 5
230000007815 allergy Effects 0.000 description 5
229960001340 histamine Drugs 0.000 description 5
210000004379 membrane Anatomy 0.000 description 5
239000012528 membrane Substances 0.000 description 5
210000003491 skin Anatomy 0.000 description 5
241000894007 species Species 0.000 description 5
238000000108 ultra-filtration Methods 0.000 description 5
244000037005 Ambrosia artemisiifolia var. elatior Species 0.000 description 4
241000234645 Festuca pratensis Species 0.000 description 4
206010024769 Local reaction Diseases 0.000 description 4
241000283973 Oryctolagus cuniculus Species 0.000 description 4
238000007792 addition Methods 0.000 description 4
-1 aliphatic diamines Chemical class 0.000 description 4
208000026935 allergic disease Diseases 0.000 description 4
238000004458 analytical method Methods 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
230000001186 cumulative effect Effects 0.000 description 4
230000036512 infertility Effects 0.000 description 4
210000000265 leukocyte Anatomy 0.000 description 4
238000005259 measurement Methods 0.000 description 4
239000003208 petroleum Substances 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
230000004044 response Effects 0.000 description 4
239000012064 sodium phosphate buffer Substances 0.000 description 4
230000008961 swelling Effects 0.000 description 4
231100000331 toxic Toxicity 0.000 description 4
230000002588 toxic effect Effects 0.000 description 4
UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
229930182837 (R)-adrenaline Natural products 0.000 description 3
RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 description 3
241000282472 Canis lupus familiaris Species 0.000 description 3
241000283707 Capra Species 0.000 description 3
241000209049 Poa pratensis Species 0.000 description 3
239000002253 acid Substances 0.000 description 3
235000001014 amino acid Nutrition 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
239000011324 bead Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000027455 binding Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
229960005139 epinephrine Drugs 0.000 description 3
238000002523 gelfiltration Methods 0.000 description 3
239000011521 glass Substances 0.000 description 3
239000012510 hollow fiber Substances 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
238000003756 stirring Methods 0.000 description 3
239000011550 stock solution Substances 0.000 description 3
238000002562 urinalysis Methods 0.000 description 3
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
241000208841 Ambrosia trifida Species 0.000 description 2
ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
206010002198 Anaphylactic reaction Diseases 0.000 description 2
240000006891 Artemisia vulgaris Species 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
101100453921 Caenorhabditis elegans kin-29 gene Proteins 0.000 description 2
206010015150 Erythema Diseases 0.000 description 2
241000234642 Festuca Species 0.000 description 2
208000032912 Local swelling Diseases 0.000 description 2
240000004296 Lolium perenne Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
241000746983 Phleum pratense Species 0.000 description 2
241000209504 Poaceae Species 0.000 description 2
244000124765 Salsola kali Species 0.000 description 2
235000007658 Salsola kali Nutrition 0.000 description 2
244000082988 Secale cereale Species 0.000 description 2
235000007238 Secale cereale Nutrition 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
241001106462 Ulmus Species 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
229940072056 alginate Drugs 0.000 description 2
235000010443 alginic acid Nutrition 0.000 description 2
229920000615 alginic acid Polymers 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
235000012538 ammonium bicarbonate Nutrition 0.000 description 2
239000001099 ammonium carbonate Substances 0.000 description 2
230000002052 anaphylactic effect Effects 0.000 description 2
208000003455 anaphylaxis Diseases 0.000 description 2
208000006673 asthma Diseases 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
230000036772 blood pressure Effects 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
239000000287 crude extract Substances 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
239000000428 dust Substances 0.000 description 2
231100000321 erythema Toxicity 0.000 description 2
238000001914 filtration Methods 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
230000000984 immunochemical effect Effects 0.000 description 2
238000000760 immunoelectrophoresis Methods 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000013642 negative control Substances 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
229940068196 placebo Drugs 0.000 description 2
239000000902 placebo Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
230000009467 reduction Effects 0.000 description 2
230000028327 secretion Effects 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
238000003860 storage Methods 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
238000004448 titration Methods 0.000 description 2
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
WFIYPADYPQQLNN-UHFFFAOYSA-N 2-[2-(4-bromopyrazol-1-yl)ethyl]isoindole-1,3-dione Chemical compound C1=C(Br)C=NN1CCN1C(=O)C2=CC=CC=C2C1=O WFIYPADYPQQLNN-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
240000007241 Agrostis stolonifera Species 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
241000223600 Alternaria Species 0.000 description 1
108700032051 Ambrosia artemisiifolia Amb a I Proteins 0.000 description 1
240000004178 Anthoxanthum odoratum Species 0.000 description 1
235000014251 Anthoxanthum odoratum Nutrition 0.000 description 1
235000003826 Artemisia Nutrition 0.000 description 1
235000003097 Artemisia absinthium Nutrition 0.000 description 1
235000003261 Artemisia vulgaris Nutrition 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
206010003645 Atopy Diseases 0.000 description 1
235000018185 Betula X alpestris Nutrition 0.000 description 1
235000018212 Betula X uliginosa Nutrition 0.000 description 1
235000002992 Betula pubescens Nutrition 0.000 description 1
241001520764 Betula pubescens Species 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
206010011224 Cough Diseases 0.000 description 1
235000013175 Crataegus laevigata Nutrition 0.000 description 1
241000371644 Curvularia ravenelii Species 0.000 description 1
241000209210 Dactylis Species 0.000 description 1
240000004585 Dactylis glomerata Species 0.000 description 1
208000001840 Dandruff Diseases 0.000 description 1
241000238710 Dermatophagoides Species 0.000 description 1
102000016607 Diphtheria Toxin Human genes 0.000 description 1
108010053187 Diphtheria Toxin Proteins 0.000 description 1
241000255925 Diptera Species 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
241000295146 Gallionellaceae Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
241000257303 Hymenoptera Species 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
241000758789 Juglans Species 0.000 description 1
244000026839 Juglans californica Species 0.000 description 1
235000014053 Juglans californica Nutrition 0.000 description 1
235000009496 Juglans regia Nutrition 0.000 description 1
241001490312 Lithops pseudotruncatella Species 0.000 description 1
241000209082 Lolium Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
229920002274 Nalgene Polymers 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
206010033799 Paralysis Diseases 0.000 description 1
241000219098 Parthenocissus Species 0.000 description 1
241001494479 Pecora Species 0.000 description 1
241000228143 Penicillium Species 0.000 description 1
241000746981 Phleum Species 0.000 description 1
241001127637 Plantago Species 0.000 description 1
241000219492 Quercus Species 0.000 description 1
244000274906 Quercus alba Species 0.000 description 1
235000009137 Quercus alba Nutrition 0.000 description 1
241000245165 Rhododendron ponticum Species 0.000 description 1
235000004443 Ricinus communis Nutrition 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
244000197975 Solidago virgaurea Species 0.000 description 1
235000000914 Solidago virgaurea Nutrition 0.000 description 1
238000000944 Soxhlet extraction Methods 0.000 description 1
208000024780 Urticaria Diseases 0.000 description 1
241000256856 Vespidae Species 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
150000007824 aliphatic compounds Chemical class 0.000 description 1
229940037003 alum Drugs 0.000 description 1
125000003368 amide group Chemical group 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
239000003708 ampul Substances 0.000 description 1
230000036783 anaphylactic response Effects 0.000 description 1
210000000628 antibody-producing cell Anatomy 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
235000009052 artemisia Nutrition 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
239000003659 bee venom Substances 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
239000000337 buffer salt Substances 0.000 description 1
239000008366 buffered solution Substances 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
235000013339 cereals Nutrition 0.000 description 1
238000003508 chemical denaturation Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000005238 degreasing Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
238000007865 diluting Methods 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
239000003480 eluent Substances 0.000 description 1
230000002996 emotional effect Effects 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
239000000499 gel Substances 0.000 description 1
150000002357 guanidines Chemical class 0.000 description 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
210000003630 histaminocyte Anatomy 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000028993 immune response Effects 0.000 description 1
230000000951 immunodiffusion Effects 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940027941 immunoglobulin g Drugs 0.000 description 1
239000002955 immunomodulating agent Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
238000012417 linear regression Methods 0.000 description 1
230000007774 longterm Effects 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000011034 membrane dialysis Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
238000003541 multi-stage reaction Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
235000014571 nuts Nutrition 0.000 description 1
238000011369 optimal treatment Methods 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
239000004033 plastic Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
239000002574 poison Substances 0.000 description 1
239000013573 pollen allergen Substances 0.000 description 1
230000010152 pollination Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000013641 positive control Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000013014 purified material Substances 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000007115 recruitment Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
231100000161 signs of toxicity Toxicity 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
MKWYFZFMAMBPQK-UHFFFAOYSA-J sodium feredetate Chemical compound [Na+].[Fe+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O MKWYFZFMAMBPQK-UHFFFAOYSA-J 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
238000011272 standard treatment Methods 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
230000001629 suppression Effects 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
229960001479 tosylchloramide sodium Drugs 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000006150 trypticase soy agar Substances 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000002435 venom Substances 0.000 description 1
231100000611 venom Toxicity 0.000 description 1
210000001048 venom Anatomy 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
230000002747 voluntary effect Effects 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
235000020234 walnut Nutrition 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO792968A 1978-10-04 1979-09-13 Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer NO792968L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/948,409 US4234569A (en)	1978-10-04	1978-10-04	Production of aldehyde-treated allergen-containing substances

Publications (1)

Publication Number	Publication Date
NO792968L true NO792968L (no)	1980-04-09

Family

ID=25487805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO792968A NO792968L (no)	1978-10-04	1979-09-13	Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer

Country Status (23)

Country	Link
US (1)	US4234569A (de)
JP (1)	JPS55115826A (de)
AR (1)	AR225616A1 (de)
AT (1)	AT368006B (de)
AU (1)	AU523526B2 (de)
BE (1)	BE879173A (de)
CA (1)	CA1122525A (de)
CH (1)	CH648757A5 (de)
DE (1)	DE2939557C2 (de)
DK (1)	DK415279A (de)
ES (1)	ES484702A1 (de)
FI (1)	FI793017A7 (de)
FR (1)	FR2437837A1 (de)
GB (1)	GB2034585B (de)
GR (1)	GR69120B (de)
IL (1)	IL58238A (de)
IT (1)	IT1193763B (de)
NL (1)	NL7907365A (de)
NO (1)	NO792968L (de)
PH (1)	PH15825A (de)
PT (1)	PT70244A (de)
SE (1)	SE7908199L (de)
ZA (1)	ZA794485B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58110240A (ja) *	1981-12-24	1983-06-30	いすゞ自動車株式会社	アスフアルトシ−ト及びその使用方法
EP0083497A3 (de) *	1982-01-06	1985-11-06	Beecham Group Plc	Verfahren zur Herstellung von modifizierten Allergenen und ihre Verwendung in der Behandlung von allergischen Zustanden
US4880635B1 (en) *	1984-08-08	1996-07-02	Liposome Company	Dehydrated liposomes
US4740371A (en) *	1984-09-17	1988-04-26	International Institute Of Cellular And Molecular Pathology	Treatment of allergy
US5026545A (en) *	1984-09-17	1991-06-25	Baxter International, Inc.	Treatment of allergy and composition therefor
US5543145A (en) *	1984-09-17	1996-08-06	Baxter International, Inc.	Pharmaceutical composition and method for the suppression of factor VIII inhibitor production
US4990336A (en) *	1989-02-08	1991-02-05	Biosearch, Inc.	Sustained release dosage form
NL8900652A (nl) *	1989-03-16	1990-10-16	Leti Lab	Primair-toxische stoffen of allergenen, isoleerbaar uit plantaardig materiaal, alsmede werkwijzen ter bereiding ervan en de toepassing ervan.
IT1237475B (it) *	1989-10-06	1993-06-07		Allergeni modificati chimicamente e procedimento per la loro preparazione
CA2015515C (en)	1990-01-03	1999-12-07	Jean-Marie Saint-Remy	Pharmaceutical compositions containing antigen-antibody complexes and uses therefor
US5126147A (en) *	1990-02-08	1992-06-30	Biosearch, Inc.	Sustained release dosage form
JPH07502890A (ja) *	1991-10-16	1995-03-30	イミユロジク・フアーマシユーチカル・コーポレーシヨン	ダーマトファゴイデス（Ｄｅｒｍａｔｏｐｈａｇｏｉｄｅｓ）（家ほこりダニ）からの主要なアレルゲンのＴ細胞エピトープ
US20020090381A1 (en) *	1999-04-09	2002-07-11	H. Kim Bottomly	System for controlling immune system response to antigen
GB0326439D0 (en) *	2003-11-13	2003-12-17	Imp College Innovations Ltd	Methods
EP1637147B1 (de) *	2004-09-18	2008-12-10	Protectimmun GmbH	Stallstaub-Extrakt zum Schutz vor Allergien
EP2258391A1 (de) *	2009-06-05	2010-12-08	Stallergenes S.A.	Reduktion der In-vitro-Genotoxizität von Pollenextrakten durch Entfernen von Flavonoiden
PT2853271T (pt)	2010-02-12	2018-07-09	Laboratorios Leti S L	Extratos alergénicos
GB201106802D0 (en) *	2011-04-21	2011-06-01	Allergy Therapeutics Ltd	Process for preparing vaccine composition
ES2439617B1 (es) *	2012-07-20	2015-03-13	Diater Lab De Diagnostico Y Aplicaciones Terapeuticas S A	Composicion para la administracion intradermica de alergoides
US20140170727A1 (en) *	2012-12-19	2014-06-19	Nanomr, Inc.	Affinity medium using fixed whole cells
US11617789B2 (en)	2018-11-09	2023-04-04	Jubilant HollisterStier LLC	Process for the preparation of allergenic extracts

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2019808A (en) *	1932-10-08	1935-11-05	Abbott Lab	Detoxified pollen extract
US3057775A (en) *	1959-02-04	1962-10-09	Champion Co	Embalming composition
US3135662A (en) *	1961-01-05	1964-06-02	Burroughs Wellcome Co	Diphtheria toxoid preparation and its production
CH453269A4 (de) *	1968-03-29	1973-01-31
FR1604982A (en) *	1968-03-29	1972-06-26		Active protein product - with polymeric carrier
FR2035774A2 (en) *	1969-03-19	1970-12-24	Anvar	Active protein product - with polymeric carrier
NO132132C (de) *	1968-10-10	1975-09-24	David George Marsh
GB1282163A (en) *	1969-08-06	1972-07-19	Beecham Group Ltd	Modified allergens and a process for their preparation
BE754523A (fr) *	1969-08-06	1971-02-08	Beecham Group Ltd	Vaccins
JPS4935413A (de) *	1972-08-09	1974-04-02
DE2310964A1 (de) *	1973-03-02	1974-09-05	Schering Ag	Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation
FR2227861B1 (de) *	1973-05-04	1976-07-02	Anvar
DE2422097A1 (de) *	1973-05-08	1974-11-28	Abbott Lab	Polymerisiertes ambrosiagewaechsantigen e und verfahren zur gewinnung und verwendung des stoffes
US4070455A (en) *	1974-02-16	1978-01-24	Beecham Group Limited	Process for preparing injectable desensitizing compositions and products thereof in microparticle form
GB1492973A (en) *	1974-02-16	1977-11-23	Beecham Group Ltd	Process for preparing injectable compositions

1978
- 1978-10-04 US US05/948,409 patent/US4234569A/en not_active Expired - Lifetime
1979
- 1979-08-24 ZA ZA00794485A patent/ZA794485B/xx unknown
- 1979-09-01 GR GR59946A patent/GR69120B/el unknown
- 1979-09-12 IL IL58238A patent/IL58238A/xx unknown
- 1979-09-13 NO NO792968A patent/NO792968L/no unknown
- 1979-09-24 PH PH23056A patent/PH15825A/en unknown
- 1979-09-24 AU AU51119/79A patent/AU523526B2/en not_active Ceased
- 1979-09-27 FI FI793017A patent/FI793017A7/fi not_active Application Discontinuation
- 1979-09-27 GB GB7933549A patent/GB2034585B/en not_active Expired
- 1979-09-28 AR AR278268A patent/AR225616A1/es active
- 1979-09-28 PT PT70244A patent/PT70244A/pt unknown
- 1979-09-28 DE DE2939557A patent/DE2939557C2/de not_active Expired
- 1979-10-03 CH CH8922/79A patent/CH648757A5/fr not_active IP Right Cessation
- 1979-10-03 AT AT0646179A patent/AT368006B/de not_active IP Right Cessation
- 1979-10-03 NL NL7907365A patent/NL7907365A/nl not_active Application Discontinuation
- 1979-10-03 SE SE7908199A patent/SE7908199L/xx not_active Application Discontinuation
- 1979-10-03 ES ES484702A patent/ES484702A1/es not_active Expired
- 1979-10-03 DK DK415279A patent/DK415279A/da not_active Application Discontinuation
- 1979-10-03 BE BE0/197457A patent/BE879173A/fr not_active IP Right Cessation
- 1979-10-04 IT IT50450/79A patent/IT1193763B/it active
- 1979-10-04 FR FR7924725A patent/FR2437837A1/fr active Granted
- 1979-10-04 CA CA336,952A patent/CA1122525A/en not_active Expired
- 1979-10-04 JP JP12742979A patent/JPS55115826A/ja active Pending

Also Published As

Publication number	Publication date
NL7907365A (nl)	1980-04-09
PT70244A (en)	1979-10-01
DK415279A (da)	1980-04-05
FR2437837A1 (fr)	1980-04-30
US4234569A (en)	1980-11-18
AT368006B (de)	1982-08-25
IL58238A0 (en)	1979-12-30
BE879173A (fr)	1980-02-01
GB2034585B (en)	1983-05-11
DE2939557A1 (de)	1980-04-24
GR69120B (de)	1982-05-03
ZA794485B (en)	1980-08-27
IT1193763B (it)	1988-08-24
GB2034585A (en)	1980-06-11
AR225616A1 (es)	1982-04-15
FR2437837B1 (de)	1983-10-21
CA1122525A (en)	1982-04-27
ATA646179A (de)	1982-01-15
IT7950450A0 (it)	1979-10-04
CH648757A5 (fr)	1985-04-15
AU523526B2 (en)	1982-07-29
ES484702A1 (es)	1980-06-16
JPS55115826A (en)	1980-09-06
PH15825A (en)	1983-04-08
AU5111979A (en)	1980-04-17
FI793017A7 (fi)	1981-01-01
IL58238A (en)	1982-07-30
SE7908199L (sv)	1980-04-05
DE2939557C2 (de)	1986-10-09

Publication	Publication Date	Title
US4234569A (en)	1980-11-18	Production of aldehyde-treated allergen-containing substances
Solley et al.	1976	The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.
Binder et al.	2002	Individual hymenoptera venom compounds induce upregulation of the basophil activation marker ectonucleotide pyrophosphatase/phosphodiesterase 3 (CD203c) in sensitized patients
Dessaint et al.	1975	Quantitative determination of specific IgE antibodies to Echinococcus granulosus and IgE levels in sera from patients with hydatid disease
US4338297A (en)	1982-07-06	Polypeptide active pollen immunosuppressant fraction
Arroyave et al.	1977	Plasma complement changes during bronchospasm provoked in asthmatic patients
DE2804457A1 (de)	1978-08-10	Immunsuppressive mittel
US4226853A (en)	1980-10-07	Formalinized allergen-containing substances and production thereof
Bruynzeel et al.	1979	IgE and IgG4 antibodies in specific human allergies
Paley et al.	1952	Dermal reactions to insulin therapy
JPS63277634A (ja)	1988-11-15	アレルギーの治療およびそのための組成物
WO2022028069A1 (zh)	2022-02-10	一种过敏原制剂
Franklin et al.	1975	Comparison of honeybee venoms and their components from various sources
DE2704766A1 (de)	1977-08-11	Toxoid-impfstoff gegen pseudomonas aeruginosa-infektionen
DE69416983T2 (de)	1999-11-04	Zederpollen-Proteine und ihre Verwendung
REISMAN et al.	1979	Clinical and immunological studies of venom immunotherapy
Weiss et al.	1965	Hemorrhagic disease in rodents caused by chikungunya virus. 1. Studies of hemostasis
Burrell et al.	1977	Mediators of experimental hypersensitivity pneumonitis
Friedlaender et al.	1964	Observations on basophil degranulation as an indicator of antigen-antibody reaction
Pegelow et al.	1984	Immunotherapy with alginate-conjugated and alum-precipitated grass pollen extracts in patients with allergic rhinoconjunctivitis.
Walzer et al.	1950	Passive transfer of atopic hypersensitiveness in man by means of leucocytes.
MILLER et al.	1941	Undenatured trichophytin: Preparation and clinical application
CN103087194A (zh)	2013-05-08	一种抗血循型蛇毒鸡卵黄抗体及其应用
White et al.	1985	284 Neutrophil induced mast cell degranulation
US20220079999A1 (en)	2022-03-17	Antivenom compositions and uses thereof