NO794249L - Fremgangsmaate for kontroll av hypertensjon og intestinale mangler, samt preparater derfor - Google Patents

Fremgangsmaate for kontroll av hypertensjon og intestinale mangler, samt preparater derfor

Info

Publication number: NO794249L
Authority: NO; Norway
Prior art keywords: urea; compound; imidazolidinylidene; formula; pharmaceutically acceptable
Prior art date: 1978-12-22

Application number

NO794249A

Other languages

English (en)

Norwegian (no)

Inventor

Chris Royce Rasmussen

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-12-22

Filing date

1979-12-21

Publication date

1980-06-24

1978-12-22 Priority claimed from US05/972,579 external-priority patent/US4229462A/en

1978-12-22 Priority claimed from US05/972,580 external-priority patent/US4239768A/en

1979-12-21 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1980-06-24 Publication of NO794249L publication Critical patent/NO794249L/no

Links

238000000034 method Methods 0.000 title claims description 44
206010020772 Hypertension Diseases 0.000 title claims description 24
238000002360 preparation method Methods 0.000 title claims description 21
230000000968 intestinal effect Effects 0.000 title claims description 18
-1 urea compound Chemical class 0.000 claims description 58
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 53
239000004202 carbamide Substances 0.000 claims description 51
150000001875 compounds Chemical class 0.000 claims description 48
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201000010099 disease Diseases 0.000 claims description 14
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
DISXFZWKRTZTRI-UHFFFAOYSA-N 4,5-dihydro-1h-imidazol-2-amine Chemical compound NC1=NCCN1 DISXFZWKRTZTRI-UHFFFAOYSA-N 0.000 claims description 12
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239000000825 pharmaceutical preparation Substances 0.000 claims description 10
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WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 8
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HWCCNFKEGFHVAL-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(2-fluoro-6-methylphenyl)urea Chemical compound CC1=CC=CC(F)=C1NC(=O)N=C1NCCN1 HWCCNFKEGFHVAL-UHFFFAOYSA-N 0.000 description 1
XTIOEXHNTCIDTA-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(2-methoxy-6-methylphenyl)urea Chemical compound COC1=CC=CC(C)=C1NC(=O)N=C1NCCN1 XTIOEXHNTCIDTA-UHFFFAOYSA-N 0.000 description 1
PWFHBCCOJISUPB-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(2-methoxyphenyl)urea;hydrochloride Chemical compound Cl.COC1=CC=CC=C1NC(=O)N=C1NCCN1 PWFHBCCOJISUPB-UHFFFAOYSA-N 0.000 description 1
YAAVQOVNXYQRIO-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(2-methyl-6-methylsulfonylphenyl)urea Chemical compound CC1=CC=CC(S(C)(=O)=O)=C1NC(=O)N=C1NCCN1 YAAVQOVNXYQRIO-UHFFFAOYSA-N 0.000 description 1
NLMVEPFRNHSWCP-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(4-fluoro-2,6-dimethylphenyl)urea Chemical compound CC1=CC(F)=CC(C)=C1NC(=O)N=C1NCCN1 NLMVEPFRNHSWCP-UHFFFAOYSA-N 0.000 description 1
GQBQEKLCSXSNHI-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(4-methoxyphenyl)urea Chemical compound C1=CC(OC)=CC=C1NC(=O)NC1=NCCN1 GQBQEKLCSXSNHI-UHFFFAOYSA-N 0.000 description 1
HTBQGABOJXXYMH-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-(4-methylphenyl)urea Chemical compound C1=CC(C)=CC=C1NC(=O)N=C1NCCN1 HTBQGABOJXXYMH-UHFFFAOYSA-N 0.000 description 1
MFEKUUGKPZWINT-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-[2-methyl-6-(trifluoromethyl)phenyl]urea Chemical compound CC1=CC=CC(C(F)(F)F)=C1NC(=O)N=C1NCCN1 MFEKUUGKPZWINT-UHFFFAOYSA-N 0.000 description 1
WTABVQIXVUVUPO-UHFFFAOYSA-N 1-(4,5-dihydro-1h-imidazol-2-yl)-3-phenylurea Chemical compound N1CCNC1=NC(=O)NC1=CC=CC=C1 WTABVQIXVUVUPO-UHFFFAOYSA-N 0.000 description 1
VTLPPKOCITWBTF-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-3-(4,5-dihydro-1h-imidazol-2-yl)urea Chemical compound FC(F)(F)C1=CC=C(Cl)C(NC(=O)N=C2NCCN2)=C1 VTLPPKOCITWBTF-UHFFFAOYSA-N 0.000 description 1
FBTQQNYGMICJQZ-UHFFFAOYSA-N 1-chloro-2-isocyanato-3-methylbenzene Chemical compound CC1=CC=CC(Cl)=C1N=C=O FBTQQNYGMICJQZ-UHFFFAOYSA-N 0.000 description 1
NOHQUGRVHSJYMR-UHFFFAOYSA-N 1-chloro-2-isocyanatobenzene Chemical compound ClC1=CC=CC=C1N=C=O NOHQUGRVHSJYMR-UHFFFAOYSA-N 0.000 description 1
HHIRBXHEYVDUAM-UHFFFAOYSA-N 1-chloro-3-isocyanatobenzene Chemical compound ClC1=CC=CC(N=C=O)=C1 HHIRBXHEYVDUAM-UHFFFAOYSA-N 0.000 description 1
YMAVXDRFOILNKI-UHFFFAOYSA-N 1-ethyl-2-isocyanato-3-methylbenzene Chemical compound CCC1=CC=CC(C)=C1N=C=O YMAVXDRFOILNKI-UHFFFAOYSA-N 0.000 description 1
SUVCZZADQDCIEQ-UHFFFAOYSA-N 1-isocyanato-2-methoxybenzene Chemical compound COC1=CC=CC=C1N=C=O SUVCZZADQDCIEQ-UHFFFAOYSA-N 0.000 description 1
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 1
RSWXSBGLJUAXKD-UHFFFAOYSA-N 4,5-dihydro-1h-imidazol-2-ylurea Chemical class NC(=O)NC1=NCCN1 RSWXSBGLJUAXKD-UHFFFAOYSA-N 0.000 description 1
208000004998 Abdominal Pain Diseases 0.000 description 1
102000015427 Angiotensins Human genes 0.000 description 1
108010064733 Angiotensins Proteins 0.000 description 1
206010048964 Carotid artery occlusion Diseases 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
CHHIJDJBFMPYRK-UHFFFAOYSA-N Cl.ClC1=C(C=CC=C1)NC(=O)N=C1NCCN1 Chemical compound Cl.ClC1=C(C=CC=C1)NC(=O)N=C1NCCN1 CHHIJDJBFMPYRK-UHFFFAOYSA-N 0.000 description 1
VPGRYOFKCNULNK-ACXQXYJUSA-N Deoxycorticosterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 VPGRYOFKCNULNK-ACXQXYJUSA-N 0.000 description 1
PDQAZBWRQCGBEV-UHFFFAOYSA-N Ethylenethiourea Chemical compound S=C1NCCN1 PDQAZBWRQCGBEV-UHFFFAOYSA-N 0.000 description 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
SQSPRWMERUQXNE-UHFFFAOYSA-N Guanylurea Chemical compound NC(=N)NC(N)=O SQSPRWMERUQXNE-UHFFFAOYSA-N 0.000 description 1
208000010496 Heart Arrest Diseases 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
206010022998 Irritability Diseases 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
229960004373 acetylcholine Drugs 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
239000000538 analytical sample Substances 0.000 description 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
230000001262 anti-secretory effect Effects 0.000 description 1
229940030600 antihypertensive agent Drugs 0.000 description 1
239000002220 antihypertensive agent Substances 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
125000001769 aryl amino group Chemical group 0.000 description 1
210000003403 autonomic nervous system Anatomy 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
229940077388 benzenesulfonate Drugs 0.000 description 1
230000002146 bilateral effect Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000012455 biphasic mixture Substances 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
UMGDCJDMYOKAJW-UHFFFAOYSA-M carbamimidothioate Chemical compound NC([S-])=N UMGDCJDMYOKAJW-UHFFFAOYSA-M 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
230000008859 change Effects 0.000 description 1
125000000068 chlorophenyl group Chemical group 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
125000004093 cyano group Chemical group *C#N 0.000 description 1
229960004486 desoxycorticosterone acetate Drugs 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
239000003651 drinking water Substances 0.000 description 1
235000020188 drinking water Nutrition 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
229960005139 epinephrine Drugs 0.000 description 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000004744 fabric Substances 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
210000001105 femoral artery Anatomy 0.000 description 1
210000003191 femoral vein Anatomy 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
210000005224 forefinger Anatomy 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000003979 granulating agent Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
KRZGKJJPEOUIBI-UHFFFAOYSA-N hydron;thiourea;iodide Chemical compound I.NC(S)=N KRZGKJJPEOUIBI-UHFFFAOYSA-N 0.000 description 1
238000007654 immersion Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
150000002513 isocyanates Chemical class 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
DGEYTDCFMQMLTH-UHFFFAOYSA-N methanol;propan-2-ol Chemical compound OC.CC(C)O DGEYTDCFMQMLTH-UHFFFAOYSA-N 0.000 description 1
230000001035 methylating effect Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000004321 preservation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000000523 sample Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
210000001991 scapula Anatomy 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
AWLILQARPMWUHA-UHFFFAOYSA-M thiopental sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC([S-])=NC1=O AWLILQARPMWUHA-UHFFFAOYSA-M 0.000 description 1
210000003813 thumb Anatomy 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000000844 transformation Methods 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
230000001515 vagal effect Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000009423 ventilation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO794249A 1978-12-22 1979-12-21 Fremgangsmaate for kontroll av hypertensjon og intestinale mangler, samt preparater derfor NO794249L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/972,579 US4229462A (en)	1978-12-22	1978-12-22	Method for controlling hypertension and compositions
US05/972,580 US4239768A (en)	1978-12-22	1978-12-22	Method for relieving irritable bowel syndrome symptoms

Publications (1)

Publication Number	Publication Date
NO794249L true NO794249L (no)	1980-06-24

Family

ID=27130555

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO794249A NO794249L (no)	1978-12-22	1979-12-21	Fremgangsmaate for kontroll av hypertensjon og intestinale mangler, samt preparater derfor

Country Status (23)

Country	Link
AT (1)	AT373878B (de)
AU (2)	AU532332B2 (de)
CA (1)	CA1127651A (de)
CH (1)	CH647236A5 (de)
DE (1)	DE2951213A1 (de)
DK (1)	DK548179A (de)
ES (1)	ES487159A0 (de)
FI (1)	FI66354C (de)
FR (2)	FR2444462B1 (de)
GB (2)	GB2040681B (de)
GR (1)	GR68018B (de)
HU (1)	HU183013B (de)
IL (1)	IL59019A (de)
IT (1)	IT1126839B (de)
NL (1)	NL7909265A (de)
NO (1)	NO794249L (de)
NZ (1)	NZ192453A (de)
PH (1)	PH16571A (de)
PT (1)	PT70624A (de)
SE (1)	SE7910612L (de)
SU (1)	SU971098A3 (de)
YU (1)	YU314979A (de)
ZW (1)	ZW25379A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US11516649B2 (en)	2018-10-29	2022-11-29	Apple Inc.	Mechanism to activate and manage a standalone device for cellular service

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1296962A (fr) *	1960-08-05	1962-06-22	Geigy Ag J R	Nouveaux composés 2-imino-1.3-di-aza et leur préparation
NL267923A (de) *	1960-08-05

1979
- 1979-12-06 GR GR60697A patent/GR68018B/el unknown
- 1979-12-06 CA CA341,351A patent/CA1127651A/en not_active Expired
- 1979-12-13 PH PH23413A patent/PH16571A/en unknown
- 1979-12-13 AU AU53780/79A patent/AU532332B2/en not_active Ceased
- 1979-12-18 NZ NZ192453A patent/NZ192453A/xx unknown
- 1979-12-19 DE DE19792951213 patent/DE2951213A1/de not_active Ceased
- 1979-12-20 DK DK548179A patent/DK548179A/da not_active Application Discontinuation
- 1979-12-20 ES ES487159A patent/ES487159A0/es active Granted
- 1979-12-21 SU SU792860905A patent/SU971098A3/ru active
- 1979-12-21 YU YU03149/79A patent/YU314979A/xx unknown
- 1979-12-21 ZW ZW253/79A patent/ZW25379A1/xx unknown
- 1979-12-21 CH CH11419/79A patent/CH647236A5/de not_active IP Right Cessation
- 1979-12-21 HU HU79MA3254A patent/HU183013B/hu unknown
- 1979-12-21 FR FR7931473A patent/FR2444462B1/fr not_active Expired
- 1979-12-21 AT AT0808979A patent/AT373878B/de active
- 1979-12-21 PT PT70624A patent/PT70624A/pt unknown
- 1979-12-21 NO NO794249A patent/NO794249L/no unknown
- 1979-12-21 IT IT51164/79A patent/IT1126839B/it active
- 1979-12-21 IL IL59019A patent/IL59019A/xx unknown
- 1979-12-21 FI FI794036A patent/FI66354C/fi not_active IP Right Cessation
- 1979-12-21 GB GB7944114A patent/GB2040681B/en not_active Expired
- 1979-12-21 NL NL7909265A patent/NL7909265A/nl not_active Application Discontinuation
- 1979-12-21 SE SE7910612A patent/SE7910612L/xx not_active Application Discontinuation
1980
- 1980-04-04 FR FR8007757A patent/FR2445321B1/fr not_active Expired
1982
- 1982-07-26 GB GB08221517A patent/GB2113204B/en not_active Expired
1983
- 1983-06-29 AU AU16400/83A patent/AU566013B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ZW25379A1 (en)	1981-07-22
NZ192453A (en)	1982-09-07
NL7909265A (nl)	1980-06-24
GR68018B (de)	1981-10-27
GB2040681B (en)	1983-04-13
ES8101558A1 (es)	1980-12-16
CH647236A5 (de)	1985-01-15
FR2445321B1 (de)	1983-08-26
FR2444462A1 (fr)	1980-07-18
AU1640083A (en)	1983-11-17
AU5378079A (en)	1980-06-26
FI66354B (fi)	1984-06-29
DE2951213A1 (de)	1980-07-10
IL59019A0 (en)	1980-03-31
AT373878B (de)	1984-02-27
ES487159A0 (es)	1980-12-16
DK548179A (da)	1980-06-23
SU971098A3 (ru)	1982-10-30
PT70624A (en)	1980-01-01
GB2113204A (en)	1983-08-03
YU314979A (en)	1983-02-28
GB2113204B (en)	1984-02-01
FR2445321A1 (de)	1980-07-25
HU183013B (en)	1984-04-28
AU532332B2 (en)	1983-09-29
PH16571A (en)	1983-11-18
AU566013B2 (en)	1987-10-08
FR2444462B1 (fr)	1986-08-29
GB2040681A (en)	1980-09-03
ATA808979A (de)	1983-07-15
SE7910612L (sv)	1980-06-23
FI794036A7 (fi)	1980-06-23
FI66354C (fi)	1984-10-10
CA1127651A (en)	1982-07-13
IT7951164A0 (it)	1979-12-21
IT1126839B (it)	1986-05-21
IL59019A (en)	1984-05-31

Publication	Publication Date	Title
US4788196A (en)	1988-11-29	Phenyl piperazine anti-arrhythmia agents
CA2206201A1 (en)	1997-11-29	Pyrazole derivatives and their pharmaceutical use
BG62023B2 (bg)	1998-12-30	Тетрахидробензтиазоли,метод за получаването и приложението им като междинни продукти или като лекарствени средства
NO151463B (no)	1985-01-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinazolinderivater
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