NO823619L - Fremgangsmaate ved kvantitativ bestemmelse av blodkoaguleringsfaktor xii i menneskeplasma - Google Patents

Fremgangsmaate ved kvantitativ bestemmelse av blodkoaguleringsfaktor xii i menneskeplasma

Info

Publication number: NO823619L
Authority: NO; Norway
Prior art keywords: factor; plasma; ylamino; nitro; factor xii
Prior art date: 1981-11-02

Application number

NO823619A

Other languages

English (en)

Norwegian (no)

Inventor

Lars Gundro Svendsen

Original Assignee

Pentapharm Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-11-02

Filing date

1982-11-01

Publication date

1983-05-03

1982-11-01 Application filed by Pentapharm Ag filed Critical Pentapharm Ag

1983-05-03 Publication of NO823619L publication Critical patent/NO823619L/no

Links

238000000034 method Methods 0.000 title claims abstract description 20
239000008280 blood Substances 0.000 title 1
210000004369 blood Anatomy 0.000 title 1
210000002381 plasma Anatomy 0.000 claims abstract description 23
102000000429 Factor XII Human genes 0.000 claims abstract description 20
108010080865 Factor XII Proteins 0.000 claims abstract description 18
239000012190 activator Substances 0.000 claims abstract description 6
239000002253 acid Substances 0.000 claims description 8
229910052739 hydrogen Inorganic materials 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 8
-1 4-hydroxybenzylmethyl residue Chemical group 0.000 claims description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
235000010469 Glycine max Nutrition 0.000 claims description 5
244000068988 Glycine max Species 0.000 claims description 5
229940122618 Trypsin inhibitor Drugs 0.000 claims description 5
101710162629 Trypsin inhibitor Proteins 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 5
238000003776 cleavage reaction Methods 0.000 claims description 5
230000007017 scission Effects 0.000 claims description 5
239000002753 trypsin inhibitor Substances 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 4
239000005995 Aluminium silicate Substances 0.000 claims description 3
125000002947 alkylene group Chemical group 0.000 claims description 3
235000012211 aluminium silicate Nutrition 0.000 claims description 3
125000003277 amino group Chemical group 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
238000006243 chemical reaction Methods 0.000 claims description 3
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 2
ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 2
229920002079 Ellagic acid Polymers 0.000 claims description 2
239000007853 buffer solution Substances 0.000 claims description 2
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
229960002852 ellagic acid Drugs 0.000 claims description 2
235000004132 ellagic acid Nutrition 0.000 claims description 2
150000002431 hydrogen Chemical class 0.000 claims description 2
FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 2
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 1
125000004429 atom Chemical group 0.000 claims 1
229910052804 chromium Inorganic materials 0.000 claims 1
239000011651 chromium Substances 0.000 claims 1
125000001153 fluoro group Chemical group F* 0.000 claims 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
230000002255 enzymatic effect Effects 0.000 abstract description 5
108010071241 Factor XIIa Proteins 0.000 abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 8
230000004913 activation Effects 0.000 description 8
239000000203 mixture Substances 0.000 description 7
230000015271 coagulation Effects 0.000 description 6
238000005345 coagulation Methods 0.000 description 6
102000004190 Enzymes Human genes 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 5
238000005259 measurement Methods 0.000 description 4
238000000691 measurement method Methods 0.000 description 4
239000000758 substrate Substances 0.000 description 4
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
239000000872 buffer Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 description 2
TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical group NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 2
102000007469 Actins Human genes 0.000 description 2
108010085238 Actins Proteins 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
108010074506 Transfer Factor Proteins 0.000 description 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
235000011054 acetic acid Nutrition 0.000 description 2
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
238000011088 calibration curve Methods 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
230000000694 effects Effects 0.000 description 2
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
102000010911 Enzyme Precursors Human genes 0.000 description 1
108010062466 Enzyme Precursors Proteins 0.000 description 1
SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 1
108090000113 Plasma Kallikrein Proteins 0.000 description 1
102000003827 Plasma Kallikrein Human genes 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000023555 blood coagulation Effects 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
DEKPYXUDJRABNK-UHFFFAOYSA-N dimethyl 5-aminobenzene-1,3-dicarboxylate Chemical compound COC(=O)C1=CC(N)=CC(C(=O)OC)=C1 DEKPYXUDJRABNK-UHFFFAOYSA-N 0.000 description 1
239000003527 fibrinolytic agent Substances 0.000 description 1
230000003480 fibrinolytic effect Effects 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
208000031169 hemorrhagic disease Diseases 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
229950003188 isovaleryl diethylamide Drugs 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
125000000405 phenylalanyl group Chemical group 0.000 description 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
125000002233 tyrosyl group Chemical group 0.000 description 1
125000002114 valyl group Chemical group 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96458—Factor XII (3.4.21.38)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)

NO823619A 1981-11-02 1982-11-01 Fremgangsmaate ved kvantitativ bestemmelse av blodkoaguleringsfaktor xii i menneskeplasma NO823619L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH697281		1981-11-02

Publications (1)

Publication Number	Publication Date
NO823619L true NO823619L (no)	1983-05-03

Family

ID=4317925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO823619A NO823619L (no)	1981-11-02	1982-11-01	Fremgangsmaate ved kvantitativ bestemmelse av blodkoaguleringsfaktor xii i menneskeplasma

Country Status (9)

Country	Link
US (1)	US4598043A (fr)
EP (1)	EP0078764B1 (fr)
JP (1)	JPS5886100A (fr)
AT (1)	ATE17262T1 (fr)
CA (1)	CA1184837A (fr)
DE (1)	DE3268329D1 (fr)
DK (1)	DK156668C (fr)
ES (1)	ES8400603A1 (fr)
NO (1)	NO823619L (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4882272A (en) *	1986-10-01	1989-11-21	Temple University - Of The Commonwealth System Of Higher Education	High molecular weight kininogen assay
JP3213831B2 (ja) *	1993-08-06	2001-10-02	日本臓器製薬株式会社	被検物質の活性測定方法
JP3213832B2 (ja) *	1993-08-06	2001-10-02	日本臓器製薬株式会社	被検物質の活性測定法
US6913900B2 (en) *	2001-08-29	2005-07-05	Nippon Zoki Pharmaceutical Co., Ltd.	Plasma prekallikrein activation and kallikrein production assay
GB0208989D0 (en) *	2002-04-19	2002-05-29	Amersham Biosciences Uk Ltd	Methods for measuring enzyme activity
EP1573339A2 (fr) *	2002-12-20	2005-09-14	Axis-Shield Diagnostics Limited	Detection ou determination des variants du facteur xiia
DE102005003145B4 (de) *	2005-01-21	2006-10-19	Dade Behring Marburg Gmbh	Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
US20070166344A1 (en) *	2006-01-18	2007-07-19	Xin Qu	Non-leaching surface-active film compositions for microbial adhesion prevention
GB0607515D0 (en) *	2006-04-13	2006-05-24	Axis Shield Diagnostics Ltd	Anti-factor xlla therapy
EP2333555A1 (fr) *	2009-12-09	2011-06-15	Siemens Healthcare Diagnostics Products GmbH	Test de coagulation hétérogène
EP2465941A1 (fr)	2010-12-20	2012-06-20	Siemens Healthcare Diagnostics Products GmbH	Procédé de détermination simultanée de plusieurs protéases de coagulation
EP3198272B1 (fr)	2014-09-26	2022-04-06	Abbott Point Of Care, Inc.	Identification de dispositif de cartouche pour analyses de coagulation dans des échantillons de fluide
US10048282B2 (en)	2014-09-26	2018-08-14	Abbott Point Of Care Inc.	Cartridge device with fluidic junctions for coagulation assays in fluid samples
CN107110874B (zh)	2014-09-26	2019-06-04	雅培医护站股份有限公司	用于测定流体样品中的凝固的传感器
EP3954457A3 (fr)	2014-09-26	2022-05-18	Abbott Point Of Care Inc	Dispositif microfabriqué avec des capteurs de microenvironnement pour analyser la coagulation dans des échantillons fluides
CN106999930B (zh)	2014-09-26	2020-09-08	雅培医护站股份有限公司	用于测定流体样本中的凝结的具有分段射流的盒设备
WO2016049557A1 (fr)	2014-09-26	2016-03-31	Abbott Point Of Care Inc.	Formulations d'acide ellagique pour une utilisation dans des tests de coagulation
US10114031B2 (en)	2014-09-26	2018-10-30	Abbott Point Of Care Inc.	Single channel cartridge device for coagulation assays in fluid samples

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE380257B (sv) *	1972-05-02	1975-11-03	Bofors Ab	Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) *	1972-05-02	1975-11-03	Bofors Ab	Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE407058B (sv) *	1974-12-05	1979-03-12	Kabi Ab	Nya kromogena enzymsubstrat for serinproteaser
US4137225A (en) *	1975-07-11	1979-01-30	Ab Kabi	Novel chromogenic enzyme substrates
SE407571B (sv) *	1975-07-11	1979-04-02	Kabi Ab	Nya kromogena enzymsubstrat for serinproteaser
US4169015A (en) *	1975-07-11	1979-09-25	Ab Kabi	Novel chromogenic thrombin substrates
CH634662A5 (de) *	1976-05-28	1983-02-15	Pentapharm Ag	Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
US4302538A (en) *	1978-03-27	1981-11-24	Ortho Diagnostics Inc.	Buffer system in an anti-thrombin III test
US4275153A (en) *	1978-08-03	1981-06-23	American Hospital Supply Corporation	Analytical fluorogenic substrates for proteolytic enzymes
EP0018002B1 (fr) *	1979-04-24	1983-02-09	Marcel Jozefonvicz	Procédé pour la détermination de protéases et d'anti-protéases

1982
- 1982-10-13 EP EP82810427A patent/EP0078764B1/fr not_active Expired
- 1982-10-13 AT AT82810427T patent/ATE17262T1/de not_active IP Right Cessation
- 1982-10-13 DE DE8282810427T patent/DE3268329D1/de not_active Expired
- 1982-10-28 US US06/437,207 patent/US4598043A/en not_active Expired - Lifetime
- 1982-10-29 CA CA000414506A patent/CA1184837A/fr not_active Expired
- 1982-10-29 ES ES516987A patent/ES8400603A1/es not_active Expired
- 1982-11-01 JP JP57190895A patent/JPS5886100A/ja active Granted
- 1982-11-01 DK DK484682A patent/DK156668C/da not_active IP Right Cessation
- 1982-11-01 NO NO823619A patent/NO823619L/no unknown

Also Published As

Publication number	Publication date
JPS5886100A (ja)	1983-05-23
DK484682A (da)	1983-05-03
CA1184837A (fr)	1985-04-02
DE3268329D1 (en)	1986-02-13
ATE17262T1 (de)	1986-01-15
ES516987A0 (es)	1983-10-16
JPH0346119B2 (fr)	1991-07-15
DK156668B (da)	1989-09-18
DK156668C (da)	1990-02-12
ES8400603A1 (es)	1983-10-16
EP0078764A1 (fr)	1983-05-11
EP0078764B1 (fr)	1986-01-02
US4598043A (en)	1986-07-01

Publication	Publication Date	Title
Rick	1974	Trypsin
US4598043A (en)	1986-07-01	Method for quantitatively assaying blood coagulation factor XII in human plasma
US4234682A (en)	1980-11-18	Method and reagent for determining biologically active heparin in plasma
DK163671B (da)	1992-03-23	Reagens og fremgangsmaade til fotometrisk bestemmelse af thromboplastintiden, reagensets fremstilling og anvendelse
NO151787B (no)	1985-02-25	Tripeptidderivater og anvendelse av disse ved bestemmelser av enzymer
NO135245B (fr)	1976-11-29
DK149333B (da)	1986-05-05	Tripeptidderivater samt salte deraf med mineralsyrer eller organiske syrer til anvendelse som substrater til kvantitativ bestemmelse af thrombin og thrombinlignende enzymer, ecarinthrombin, plasmin og plasminlignende enzymer samt proenzymer, proenzymaktivatorer og enzyminhibitorer herfor i legemsvaeskerfra mennesker og pattedyr samt i dyriske celleekstrakter
CA1086614A (fr)	1980-09-30	Substrat employe pour le dosage des activateurs de plasminogene
JPH0417640B2 (fr)	1992-03-26
Wirnt	1965	Chymotrypsin
JPS5856695A (ja)	1983-04-04	新規なトロンビン測定用基質
DK162179B (da)	1991-09-23	Reagens til ettrinsbestemmelse af den aktiverede partielle thromboplastintid samt reagensets anvendelse
JPH01309700A (ja)	1989-12-14	第１０３因子の動態測定のための方法および該測定のための手段を含むキツト
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