NO844489L - Fremgangsmaate ved fremstilling av nye atriale peptider - Google Patents

Fremgangsmaate ved fremstilling av nye atriale peptider

Info

Publication number: NO844489L
Authority: NO; Norway
Prior art keywords: ser; peptide; arg; production; phe
Prior art date: 1983-11-10

Application number

NO844489A

Other languages

English (en)

Norwegian (no)

Inventor

Philip Needleman

Original Assignee

Univ Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-10

Filing date

1984-11-09

Publication date

1985-05-13

1984-11-09 Application filed by Univ Washington filed Critical Univ Washington

1985-05-13 Publication of NO844489L publication Critical patent/NO844489L/no

Links

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YQAXFVHNHSPUPO-RNJOBUHISA-N 2-[[(2s)-2-[[2-[[(2s,4r)-1-[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H]1N(C(=O)CN)CCC1 YQAXFVHNHSPUPO-RNJOBUHISA-N 0.000 claims description 12
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WBIIPXYJAMICNU-AWEZNQCLSA-N (2s)-5-[amino-[(4-methylphenyl)sulfonylamino]methylidene]azaniumyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate Chemical compound CC1=CC=C(S(=O)(=O)NC(N)=NCCC[C@H](NC(=O)OC(C)(C)C)C(O)=O)C=C1 WBIIPXYJAMICNU-AWEZNQCLSA-N 0.000 description 1
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VRPJIFMKZZEXLR-UHFFFAOYSA-N 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid Chemical group CC(C)(C)OC(=O)NCC(O)=O VRPJIFMKZZEXLR-UHFFFAOYSA-N 0.000 description 1
102000004400 Aminopeptidases Human genes 0.000 description 1
108090000915 Aminopeptidases Proteins 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
101000957724 Catostomus commersonii Corticoliberin-1 Proteins 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
101000757797 Geobacillus stearothermophilus Aminopeptidase 2 Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
FYYSQDHBALBGHX-YFKPBYRVSA-N N(alpha)-t-butoxycarbonyl-L-asparagine Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC(N)=O FYYSQDHBALBGHX-YFKPBYRVSA-N 0.000 description 1
MDXGYYOJGPFFJL-QMMMGPOBSA-N N(alpha)-t-butoxycarbonyl-L-leucine Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)OC(C)(C)C MDXGYYOJGPFFJL-QMMMGPOBSA-N 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
101000733766 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Aminopeptidase 2, mitochondrial Proteins 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000003862 amino acid derivatives Chemical class 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
210000002376 aorta thoracic Anatomy 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000008512 biological response Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000012539 chromatography resin Substances 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000007822 coupling agent Substances 0.000 description 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
125000002228 disulfide group Chemical group 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
230000000674 effect on sodium Effects 0.000 description 1
210000000750 endocrine system Anatomy 0.000 description 1
230000000763 evoking effect Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000003907 kidney function Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
239000000472 muscarinic agonist Substances 0.000 description 1
239000002833 natriuretic agent Substances 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
230000006337 proteolytic cleavage Effects 0.000 description 1
239000002994 raw material Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000033904 relaxation of vascular smooth muscle Effects 0.000 description 1
210000004739 secretory vesicle Anatomy 0.000 description 1
150000003355 serines Chemical class 0.000 description 1
238000004904 shortening Methods 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO844489A 1983-11-10 1984-11-09 Fremgangsmaate ved fremstilling av nye atriale peptider NO844489L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55137283A	1983-11-10	1983-11-10
US06/569,684 US4496544A (en)	1983-11-10	1984-01-10	Atrial Peptides

Publications (1)

Publication Number	Publication Date
NO844489L true NO844489L (no)	1985-05-13

Family

ID=27069747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO844489A NO844489L (no)	1983-11-10	1984-11-09	Fremgangsmaate ved fremstilling av nye atriale peptider

Country Status (12)

Country	Link
US (1)	US4496544A (fr)
EP (1)	EP0142487B1 (fr)
JP (1)	JPH0672156B2 (fr)
AU (1)	AU566235B2 (fr)
DE (1)	DE3480930D1 (fr)
DK (1)	DK533484A (fr)
ES (1)	ES8606390A1 (fr)
FI (1)	FI83661C (fr)
GR (1)	GR80905B (fr)
IE (1)	IE58819B1 (fr)
IL (1)	IL73466A (fr)
NO (1)	NO844489L (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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EP0116784B1 (fr) *	1982-02-22	1992-06-10	Queen's University At Kingston	Facteur atrial natriurétique
AU572173B2 (en) *	1983-08-29	1988-05-05	Institut De Recherches Cliniques De Montreal	Natriuretic factors
JPS60136596A (ja) *	1983-12-26	1985-07-20	Suntory Ltd	ペプチド及びこれを有効成分とする利尿剤
US4952561A (en) *	1984-02-07	1990-08-28	Merck & Co., Inc.	Cardiac atrial peptides
JPH0794473B2 (ja) *	1984-03-02	1995-10-11	サントリー株式会社	新規なペプチド及びこれを有効成分とする利尿剤
JPH0780907B2 (ja) *	1984-04-19	1995-08-30	シオス・ノバ・インク	新規な心房性ナトリウム尿排泄亢進性及び血管拡張性ポリペプチド
US5212286A (en) *	1984-04-19	1993-05-18	Scios Nova Inc.	Atrial natriuretic/vasodilator peptide compounds
US4618600A (en) *	1984-04-19	1986-10-21	Biotechnology Research Associates, J.V.	Novel polypeptide diuretic/vasodilators
WO1985004872A1 (fr) *	1984-04-24	1985-11-07	The Salk Institute For Biological Studies	Analogues peptidiques atriaux
JPH0672157B2 (ja) *	1984-08-29	1994-09-14	味の素株式会社	新規ペプチド
US4652549A (en) *	1985-01-22	1987-03-24	Merck & Co., Inc.	Cardiac anti-hypertrophic agents
US5087564A (en) *	1985-06-20	1992-02-11	Monsanto Company	Release of recombinant peptides from polypeptides using V8 endopeptidase
AU597919B2 (en) *	1985-11-05	1990-06-14	Scios Nova Inc.	Analogs of atrial natriuretic peptides
JP3042782B2 (ja) *	1985-11-05	2000-05-22	サイオスインコーポレイテッド	心房性ナトリウム尿排泄亢進ペプチド類似化合物
US4757048A (en) *	1985-11-05	1988-07-12	Biotechnology Research Associates J.V.	Synthetic analogs of atrial natriuretic peptides
DE3614833A1 (de) *	1986-01-16	1987-07-23	Hoechst Ag	Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4716147A (en) *	1986-03-27	1987-12-29	Monsanto Company	Synthetic airial peptides
US4721704A (en) *	1986-05-09	1988-01-26	Peninsula Laboratories, Inc.	Potent synthetic atrial peptide analogs
EP0246795A3 (fr) *	1986-05-20	1990-04-04	Advanced Peptide Development Limited	Peptides natriurétiques synthétiques
US4740499A (en) *	1986-07-28	1988-04-26	Monsanto Company	Method of enhancing the bioactivity of atrial peptides
US5565606A (en) *	1986-10-21	1996-10-15	Hoechst Aktiengesellschaft	Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
DE3723551A1 (de) *	1987-07-16	1989-01-26	Hoechst Ag	Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4804650A (en) *	1986-10-28	1989-02-14	Biotechnology Research Associates, J.V.	Analogs of atrial natriuretic peptides
DE3856401D1 (de) *	1987-01-23	2000-05-04	Gen Hospital Corp	Hydralazin zur topischen Behandlung von Glaukom
US5500230A (en) *	1987-01-23	1996-03-19	The General Hospital Corporation	Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators
IT1216865B (it)	1987-02-03	1990-03-14	Eniricerche Spa	Derivato argininico, procedimento per la sua preparazione e suo impiego nelle sintesi peptidiche.
DE3881467T2 (de) *	1987-10-09	1993-10-21	Agency Ind Science Techn	Vasokonstriktor-Peptid.
US4935492A (en) *	1987-12-24	1990-06-19	California Biotechnology Inc.	Cyclic analogs of atrial natriuretic peptides
US5047397A (en) *	1988-08-26	1991-09-10	California Biotechnology Inc.	Linear analogs of atrial natriuretic peptides
CA1339210C (fr)	1988-05-31	1997-08-05	John Lewicki	Techniques recombinantes pour la production de nouveaux natriuretiques et de peptides vasodilatateurs
US5114923A (en) *	1988-05-31	1992-05-19	California Biotechnology Inc.	Recombinant techniques for production of novel natriuretic and vasodilator peptides
JP2801079B2 (ja) *	1990-11-14	1998-09-21	サントリー株式会社	Ａｎｐ関連新規ペプチド
JP2809533B2 (ja) *	1991-01-31	1998-10-08	壽之松尾	Ｃｎｐ類似体ペプチド
US5846932A (en) *	1993-11-12	1998-12-08	Genentech, Inc.	Receptor specific atrial natriuretic peptides
US5665704A (en) *	1993-11-12	1997-09-09	Genentech, Inc.	Receptor specific atrial natriuretic peptides
US6525022B1 (en)	1993-11-12	2003-02-25	Genentech, Inc.	Receptor specific atrial natriuretic peptides
US5486519A (en) *	1994-08-22	1996-01-23	Greenwald; James E.	Method for treatment of acute renal failure
US5521191A (en) *	1994-10-17	1996-05-28	Washington University	Method for treatment of arterial stenosis
WO2004097368A2 (fr) *	2003-04-28	2004-11-11	Ciphergen Biosystems, Inc.	Dosages immunologiques ameliores
CN101208353B (zh)	2003-06-20	2011-12-14	梅约医学教育与研究基金会	脑利尿钠肽的同种型
US8580746B2 (en)	2006-03-30	2013-11-12	Palatin Technologies, Inc.	Amide linkage cyclic natriuretic peptide constructs
MX2008012663A (es) *	2006-03-30	2008-10-13	Palatin Technologies Inc	Constructos ciclicos de peptidos natriureticos.
AU2007233123A1 (en) *	2006-03-30	2007-10-11	Palatin Technologies, Inc.	Linear natriuretic peptide constructs
BRPI0716416A2 (pt)	2006-08-08	2016-10-11	Mayo Foundation	polipeptídeo substancialmente puro entre 37 e 47 besíduos de aminoácido de comprimento, ácido nucléico isolado, vetor: célula hospedeira e composição farmacêutica
WO2009036448A2 (fr) *	2007-09-15	2009-03-19	Mayo Foundation For Medical Education And Research	Agonistes des récepteurs peptidiques natriurétiques de type c
CN107090028A (zh)	2011-08-30	2017-08-25	梅约医学教育与研究基金会	利钠多肽
WO2013103896A1 (fr)	2012-01-06	2013-07-11	Mayo Foundation For Medical Education And Research	Traitement de maladies cardiovasculaires ou rénales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA846084B (en) *	1983-08-29	1985-05-29	Montreal Inst Rech Cliniques	Natriuretic factors

1984
- 1984-01-10 US US06/569,684 patent/US4496544A/en not_active Expired - Lifetime
- 1984-11-08 ES ES537520A patent/ES8606390A1/es not_active Expired
- 1984-11-09 DE DE8484870149T patent/DE3480930D1/de not_active Expired - Lifetime
- 1984-11-09 IL IL73466A patent/IL73466A/xx not_active IP Right Cessation
- 1984-11-09 GR GR80905A patent/GR80905B/el unknown
- 1984-11-09 EP EP84870149A patent/EP0142487B1/fr not_active Expired - Lifetime
- 1984-11-09 DK DK533484A patent/DK533484A/da not_active Application Discontinuation
- 1984-11-09 NO NO844489A patent/NO844489L/no unknown
- 1984-11-09 AU AU35252/84A patent/AU566235B2/en not_active Ceased
- 1984-11-09 JP JP59236542A patent/JPH0672156B2/ja not_active Expired - Lifetime
- 1984-11-09 FI FI844424A patent/FI83661C/fi not_active IP Right Cessation
- 1984-11-09 IE IE288184A patent/IE58819B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI844424L (fi)	1985-05-11
EP0142487B1 (fr)	1990-01-03
DK533484D0 (da)	1984-11-09
US4496544A (en)	1985-01-29
FI844424A0 (fi)	1984-11-09
ES537520A0 (es)	1986-04-01
DE3480930D1 (de)	1990-02-08
JPH0672156B2 (ja)	1994-09-14
EP0142487A2 (fr)	1985-05-22
FI83661B (fi)	1991-04-30
IE842881L (en)	1985-05-10
DK533484A (da)	1985-05-11
JPS60214797A (ja)	1985-10-28
ES8606390A1 (es)	1986-04-01
IE58819B1 (en)	1993-11-17
EP0142487A3 (en)	1986-04-30
GR80905B (en)	1985-04-02
AU566235B2 (en)	1987-10-15
AU3525284A (en)	1985-05-16
IL73466A (en)	1989-03-31
FI83661C (fi)	1991-08-12
IL73466A0 (en)	1985-02-28

Publication	Publication Date	Title
EP0142487B1 (fr)	1990-01-03	Peptides concernant l'oreillette
Kangawa et al.	1985	Structural identification of β-and γ-human atrial natriuretic polypeptides
Sudoh et al.	1988	Brain natriuretic peptide-32: N-terminal six amino acid extended form of brain natriuretic peptide identified in porcine brain
US4508712A (en)	1985-04-02	Atrial peptide
Kangawa et al.	1984	Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Forssmann et al.	1984	The auricular myocardiocytes of the heart constitute an endocrine organ characterization of a porcine cardiac peptide hormone, cardiodilatin-126
DK2402369T3 (en)	2016-02-01	Peptide fragments for inducing synthesis of extracellular matrix proteins
US4935492A (en)	1990-06-19	Cyclic analogs of atrial natriuretic peptides
St-Pierre et al.	1981	Synthesis of peptides by the solid-phase method. 6. Neurotensin, fragments, and analogs
EP0289287A2 (fr)	1988-11-02	Peptides amyloides
US20060122371A1 (en)	2006-06-08	Process for preparing cardiodilatin fragments; highly purified cardiodilatin fragments and intermediate products for the preparation of same
US5336759A (en)	1994-08-09	Biologically active peptide derived from frog (frog CNP)
WO1994020534A1 (fr)	1994-09-15	Peptide vasonatrine et analogues de ce dernier
KR20010103772A (ko)	2001-11-23	공유적으로 가교결합된 인슐린 이량체
Rioux et al.	1980	Pharmacological characterization of neurotensin receptors in the rat isolated portal vein using analogues and fragments of neurotensin
AU614738B2 (en)	1991-09-12	New cardiodilatin fragment, process for preparing same and use thereof
DE3782073T2 (de)	1993-05-06	Synthetische atriale peptide.
US4557864A (en)	1985-12-10	Atrial peptides
CONLON et al.	1991	Primary structure and conformational analysis of peptide methionine—tyrosine, a peptide related to neuropeptide Y and peptide YY isolated from lamprey intestine
JP2002511067A (ja)	2002-04-09	環式ｃｒｆアゴニスト
Zhang et al.	2010	Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2
Takei et al.	1994	Eel ventricular natriuretic peptide: isolation of a low molecular size form and characterization of plasma form by homologous radioimmunoassay
Nokihara et al.	1988	Solid-phase synthesis of porcine cardiodilatin 88
US4732972A (en)	1988-03-22	Polypeptides having growth hormone releasing activity
Iwamuro et al.	1991	Arginine vasotocin (AVT) and AVT-related peptide are major aldosterone-releasing factors in the bullfrog neurointermediate lobe