NO884818L - Fremgangsmaate og mellomprodukter for fremstilling av halogenerte proteasehemmere. - Google Patents

Fremgangsmaate og mellomprodukter for fremstilling av halogenerte proteasehemmere.

Info

Publication number: NO884818L
Authority: NO; Norway
Prior art keywords: product; formula; carbon atoms; acid; branched chain
Prior art date: 1987-10-29

Application number

NO88884818A

Other languages

English (en)

Norwegian (no)

Other versions

NO884818D0 (no

Inventor

Richard August Mueller

Richard Allen Partis

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-29

Filing date

1988-10-28

Publication date

1989-05-02

1988-10-28 Application filed by Searle & Co filed Critical Searle & Co

1988-10-28 Publication of NO884818D0 publication Critical patent/NO884818D0/no

1989-05-02 Publication of NO884818L publication Critical patent/NO884818L/no

Links

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239000012634 fragment Substances 0.000 description 1
238000013467 fragmentation Methods 0.000 description 1
238000006062 fragmentation reaction Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
230000009395 genetic defect Effects 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
150000005171 halobenzenes Chemical class 0.000 description 1
150000003977 halocarboxylic acids Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229910000042 hydrogen bromide Inorganic materials 0.000 description 1
JEGUKCSWCFPDGT-UHFFFAOYSA-M hydroxide;hydrate Chemical compound O.[OH-] JEGUKCSWCFPDGT-UHFFFAOYSA-M 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000028993 immune response Effects 0.000 description 1
208000026278 immune system disease Diseases 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
230000003960 inflammatory cascade Effects 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000011630 iodine Chemical group 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
125000000468 ketone group Chemical group 0.000 description 1
210000000867 larynx Anatomy 0.000 description 1
VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 description 1
YEESKJGWJFYOOK-IJHYULJSSA-N leukotriene D4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@H](N)C(=O)NCC(O)=O YEESKJGWJFYOOK-IJHYULJSSA-N 0.000 description 1
210000003041 ligament Anatomy 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
229940040692 lithium hydroxide monohydrate Drugs 0.000 description 1
GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 description 1
HTAPNOLUCXKCTN-UHFFFAOYSA-N lithium;n-propan-2-ylcyclohexanamine Chemical compound [Li].CC(C)NC1CCCCC1 HTAPNOLUCXKCTN-UHFFFAOYSA-N 0.000 description 1
238000011866 long-term treatment Methods 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
239000000463 material Substances 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
RDKOJYLCEGDWKL-UHFFFAOYSA-N methyl 2-chloro-4-octadecanoylbenzoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)C1=CC=C(C(=O)OC)C(Cl)=C1 RDKOJYLCEGDWKL-UHFFFAOYSA-N 0.000 description 1
LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 description 1
244000005700 microbiome Species 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000005087 mononuclear cell Anatomy 0.000 description 1
235000010460 mustard Nutrition 0.000 description 1
UYYCVBASZNFFRX-UHFFFAOYSA-N n-propan-2-ylcyclohexanamine Chemical compound CC(C)NC1CCCCC1 UYYCVBASZNFFRX-UHFFFAOYSA-N 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
239000012038 nucleophile Substances 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
230000007170 pathology Effects 0.000 description 1
IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
229910000105 potassium hydride Inorganic materials 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
HLPGMTXXLGGTNN-UHFFFAOYSA-N propan-2-yl 2-chloro-4-octadecanoylbenzoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)C1=CC=C(C(=O)OC(C)C)C(Cl)=C1 HLPGMTXXLGGTNN-UHFFFAOYSA-N 0.000 description 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
210000001147 pulmonary artery Anatomy 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
238000010956 selective crystallization Methods 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000000779 smoke Substances 0.000 description 1
210000000329 smooth muscle myocyte Anatomy 0.000 description 1
239000003998 snake venom Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
230000007306 turnover Effects 0.000 description 1
210000001260 vocal cord Anatomy 0.000 description 1
238000010792 warming Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
- C07C69/72—Acetoacetic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO88884818A 1987-10-29 1988-10-28 Fremgangsmaate og mellomprodukter for fremstilling av halogenerte proteasehemmere. NO884818L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/114,186 US4803294A (en)	1987-10-29	1987-10-29	Process and intermediates for the preparation of halogenated protease inhibitors

Publications (2)

Publication Number	Publication Date
NO884818D0 NO884818D0 (no)	1988-10-28
NO884818L true NO884818L (no)	1989-05-02

Family

ID=22353816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO88884818A NO884818L (no)	1987-10-29	1988-10-28	Fremgangsmaate og mellomprodukter for fremstilling av halogenerte proteasehemmere.

Country Status (12)

Country	Link
US (1)	US4803294A (da)
EP (1)	EP0314126A3 (da)
JP (1)	JPH01149754A (da)
KR (1)	KR890006562A (da)
AU (1)	AU2437488A (da)
DK (1)	DK602288A (da)
FI (1)	FI884958A7 (da)
IL (1)	IL88183A0 (da)
NO (1)	NO884818L (da)
NZ (1)	NZ226749A (da)
PT (1)	PT88870B (da)
ZA (1)	ZA888113B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7063838B1 (en) *	1999-09-24	2006-06-20	Proteon Therapeutics Llc	Methods for treating an artery or vein in a human subject
US7632494B2 (en) *	1999-09-24	2009-12-15	Proteon Therapeutics, Inc.	Methods for enlarging the diameter of a biological conduit in a human subject
AU7612100A (en) *	1999-09-24	2001-04-24	Johns Hopkins University, The	Systems and methods for opening obstructed biological conduits

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4469885A (en) *	1983-05-09	1984-09-04	G. D. Searle & Co.	Halogenated protease inhibitors
US4499295A (en) *	1983-05-09	1985-02-12	G. D. Searle & Co.	Protease inhibitors
US4501895A (en) *	1983-05-09	1985-02-26	G.D. Searle & Co.	[Halo-4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-phenyl]octadecan-ols and -ones

1987
- 1987-10-29 US US07/114,186 patent/US4803294A/en not_active Expired - Lifetime
1988
- 1988-10-27 IL IL88183A patent/IL88183A0/xx unknown
- 1988-10-27 AU AU24374/88A patent/AU2437488A/en not_active Withdrawn
- 1988-10-27 PT PT88870A patent/PT88870B/pt not_active IP Right Cessation
- 1988-10-27 KR KR1019880014026A patent/KR890006562A/ko not_active Withdrawn
- 1988-10-27 EP EP88117897A patent/EP0314126A3/en not_active Ceased
- 1988-10-27 NZ NZ226749A patent/NZ226749A/xx unknown
- 1988-10-27 FI FI884958A patent/FI884958A7/fi not_active IP Right Cessation
- 1988-10-28 DK DK602288A patent/DK602288A/da not_active Application Discontinuation
- 1988-10-28 JP JP63271108A patent/JPH01149754A/ja active Pending
- 1988-10-28 ZA ZA888113A patent/ZA888113B/xx unknown
- 1988-10-28 NO NO88884818A patent/NO884818L/no unknown

Also Published As

Publication number	Publication date
EP0314126A2 (en)	1989-05-03
FI884958A7 (fi)	1989-04-30
EP0314126A3 (en)	1990-01-31
JPH01149754A (ja)	1989-06-12
AU2437488A (en)	1989-05-04
PT88870B (pt)	1993-01-29
NZ226749A (en)	1989-10-27
FI884958A0 (fi)	1988-10-27
IL88183A0 (en)	1989-06-30
DK602288A (da)	1989-04-30
KR890006562A (ko)	1989-06-14
DK602288D0 (da)	1988-10-28
ZA888113B (en)	1989-12-27
US4803294A (en)	1989-02-07
NO884818D0 (no)	1988-10-28

Publication	Publication Date	Title
IL135495A (en)	2002-12-01	Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
CA1261868A (en)	1989-09-26	Salicyclic acid derivatives as protease inhibitors
Rekka et al.	2002	Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity
US4551279A (en)	1985-11-05	Protease inhibitors
KR20080059681A (ko)	2008-06-30	신규한 만델산 유도체 및 트롬빈 억제제로서 이들의 용도
CN100379722C (zh)	2008-04-09	新化合物
HU217612B (hu)	2000-03-28	Eljárás elasztáz és katepszin G inhibitor hatású peptidek előállítására
NO175714B (no)	1994-08-15	Analogifremgangsmåte for fremstilling av terapeutisk aktive, aromatiske estere
FR2468570A1 (fr)	1981-05-08	2,5-bis (2,2,2-trifluorethoxy)-a, a-dichloracetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
EP1140820B1 (en)	2004-03-17	New amidino derivatives and their use as thrombin inhibitors
JPS59210046A (ja)	1984-11-28	プロテア−ゼ阻害剤
JPH0662500B2 (ja)	1994-08-17	抗アレルギ−剤
NO884818L (no)	1989-05-02	Fremgangsmaate og mellomprodukter for fremstilling av halogenerte proteasehemmere.
US3732292A (en)	1973-05-08	Indenyl compounds
US7129233B2 (en)	2006-10-31	Mandelic acid derivatives and their use as thrombin inhibitors
US3856956A (en)	1974-12-24	17-acyloxysteroids and their manufacture
Zbinden et al.	2006	Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
KR100928285B1 (ko)	2009-11-25	신규한 만델산 유도체 및 이것의 트롬빈 억제제로서의 용도
EP0156100B1 (en)	1989-12-27	3-substituted hydroxypentanedioic acids, -hemiesters or -anhydrides
US3433837A (en)	1969-03-18	Method of producing adamantane-2-one
Kudo et al.	1995	Carboxylation of cesium 2-naphthoate in the alkali metal molten salts of carbonate and formate with CO2 under high pressure
JPS62178543A (ja)	1987-08-05	光学活性なα−（４−ヒドロキシフエノキシ）プロピオン酸エステルの製法
JP2005504057A (ja)	2005-02-10	新規マンデル酸誘導体とトロンビン阻害剤としてのその使用
FR2503152A1 (fr)	1982-10-08	Procede de preparation de l'a-(3,4,5-trimethoxybenzoylthio)-propionyl glycine
Buckle et al.	1971	An improved synthesis of substituted benzoyl acetates