NO903235L - N,n'-bis(alkoksy-alkyl)-pyridin-2,4-dikarboksylsyre-diamider, fremgangsmaater for deres fremstilling og anvendelse derav. - Google Patents

N,n'-bis(alkoksy-alkyl)-pyridin-2,4-dikarboksylsyre-diamider, fremgangsmaater for deres fremstilling og anvendelse derav.

Info

Publication number: NO903235L
Authority: NO; Norway
Prior art keywords: pyridine; bis; dicarboxylic acid; alkyl; diamids
Prior art date: 1989-07-20

Application number

NO90903235A

Other languages

English (en)

Other versions

NO177187C (no

NO903235D0 (no

NO177187B (no

Inventor

Ekkehard Baader

Martin Bickel

Volkmar Guenzler-Pukall

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-20

Filing date

1990-07-19

Publication date

1991-01-21

1990-07-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1990-07-19 Publication of NO903235D0 publication Critical patent/NO903235D0/no

1991-01-21 Publication of NO903235L publication Critical patent/NO903235L/no

1995-04-24 Publication of NO177187B publication Critical patent/NO177187B/no

1995-08-02 Publication of NO177187C publication Critical patent/NO177187C/no

Links

238000000034 method Methods 0.000 title 1
102000008109 Mixed Function Oxygenases Human genes 0.000 abstract 2
108010074633 Mixed Function Oxygenases Proteins 0.000 abstract 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
NCSNKLYQUVNTRG-UHFFFAOYSA-N 2-n,4-n-bis(2-hydroxyethyl)pyridine-2,4-dicarboxamide Chemical compound OCCNC(=O)C1=CC=NC(C(=O)NCCO)=C1 NCSNKLYQUVNTRG-UHFFFAOYSA-N 0.000 abstract 1
JUCNGMPTCXPMNB-UHFFFAOYSA-N 2-n,4-n-bis(2-methoxyethyl)pyridine-2,4-dicarboxamide Chemical compound COCCNC(=O)C1=CC=NC(C(=O)NCCOC)=C1 JUCNGMPTCXPMNB-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
-1 pyridine-2,4-dicarboxylic acid diamides Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Transplantation (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO903235A 1989-07-20 1990-07-19 Analogifremgangsmåte for fremstilling av terapautisk aktive N,N'-bis(alkoksy-alkyl)-pyridin-2,4-dikarboksylsyrediamider NO177187C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3924093A DE3924093A1 (de)	1989-07-20	1989-07-20	N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung

Publications (4)

Publication Number	Publication Date
NO903235D0 NO903235D0 (no)	1990-07-19
NO903235L true NO903235L (no)	1991-01-21
NO177187B NO177187B (no)	1995-04-24
NO177187C NO177187C (no)	1995-08-02

Family

ID=6385494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903235A NO177187C (no)	1989-07-20	1990-07-19	Analogifremgangsmåte for fremstilling av terapautisk aktive N,N'-bis(alkoksy-alkyl)-pyridin-2,4-dikarboksylsyrediamider

Country Status (26)

Country	Link
EP (1)	EP0409119B1 (no)
JP (1)	JPH0776213B2 (no)
KR (1)	KR0181945B1 (no)
AT (1)	ATE104280T1 (no)
AU (1)	AU624978B2 (no)
CA (1)	CA2021529C (no)
CY (1)	CY1997A (no)
CZ (1)	CZ280129B6 (no)
DD (1)	DD300429A5 (no)
DE (2)	DE3924093A1 (no)
DK (1)	DK0409119T3 (no)
ES (1)	ES2052112T3 (no)
FI (1)	FI94630C (no)
HU (1)	HU218274B (no)
IE (1)	IE64438B1 (no)
IL (1)	IL95121A (no)
LT (1)	LT3798B (no)
LV (1)	LV10430B (no)
NO (1)	NO177187C (no)
NZ (1)	NZ234563A (no)
PL (1)	PL166307B1 (no)
PT (1)	PT94779B (no)
RU (1)	RU1836350C (no)
SK (1)	SK279199B6 (no)
UA (1)	UA19056A (no)
ZA (1)	ZA905680B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3707429A1 (de) *	1987-03-07	1988-09-15	Hoechst Ag	Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE58908519D1 (de) *	1988-08-04	1994-11-24	Hoechst Ag	Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden.
DE4020570A1 (de)	1990-06-28	1992-01-02	Hoechst Ag	2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
DE4030999A1 (de) *	1990-10-01	1992-04-09	Hoechst Ag	4- oder 5-substituierte pyridin-2-carbonsaeuren, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
YU9492A (sh) *	1991-02-05	1995-03-27	Hoechst Ag.	2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
TW199147B (no) *	1991-03-18	1993-02-01	Hoechst Ag
EP0541042A1 (de) *	1991-11-05	1993-05-12	Hoechst Aktiengesellschaft	Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
TW222585B (no) *	1992-09-11	1994-04-21	Hoechst Ag
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3432094A1 (de)	1984-08-31	1986-03-06	Hoechst Ag, 6230 Frankfurt	Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
DE3703963A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703959A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3826471A1 (de)	1988-08-04	1990-02-22	Hoechst Ag	Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE58908519D1 (de) *	1988-08-04	1994-11-24	Hoechst Ag	Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden.
DE3828140A1 (de)	1988-08-19	1990-03-01	Hoechst Ag	Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden sowie verwendung dieser verbindungen zur herstellung oralverabreichbarer arzneimittel

1989
- 1989-07-20 DE DE3924093A patent/DE3924093A1/de not_active Withdrawn
1990
- 1990-07-14 ES ES90113528T patent/ES2052112T3/es not_active Expired - Lifetime
- 1990-07-14 DE DE59005328T patent/DE59005328D1/de not_active Expired - Fee Related
- 1990-07-14 EP EP90113528A patent/EP0409119B1/de not_active Expired - Lifetime
- 1990-07-14 AT AT90113528T patent/ATE104280T1/de not_active IP Right Cessation
- 1990-07-14 DK DK90113528.5T patent/DK0409119T3/da active
- 1990-07-18 CZ CS903576A patent/CZ280129B6/cs not_active IP Right Cessation
- 1990-07-18 NZ NZ234563A patent/NZ234563A/xx unknown
- 1990-07-18 FI FI903624A patent/FI94630C/fi not_active IP Right Cessation
- 1990-07-18 DD DD342874A patent/DD300429A5/de not_active IP Right Cessation
- 1990-07-18 SK SK3576-90A patent/SK279199B6/sk unknown
- 1990-07-18 IL IL9512190A patent/IL95121A/en not_active IP Right Cessation
- 1990-07-19 NO NO903235A patent/NO177187C/no not_active IP Right Cessation
- 1990-07-19 PL PL90286132A patent/PL166307B1/pl unknown
- 1990-07-19 ZA ZA905680A patent/ZA905680B/xx unknown
- 1990-07-19 IE IE264290A patent/IE64438B1/en not_active IP Right Cessation
- 1990-07-19 JP JP2189620A patent/JPH0776213B2/ja not_active Expired - Lifetime
- 1990-07-19 CA CA002021529A patent/CA2021529C/en not_active Expired - Fee Related
- 1990-07-19 UA UA4830947A patent/UA19056A/uk unknown
- 1990-07-19 KR KR1019900010938A patent/KR0181945B1/ko not_active Expired - Fee Related
- 1990-07-19 AU AU59144/90A patent/AU624978B2/en not_active Ceased
- 1990-07-19 RU SU904830947A patent/RU1836350C/ru active
- 1990-07-19 HU HU549/90A patent/HU218274B/hu not_active IP Right Cessation
- 1990-07-20 PT PT94779A patent/PT94779B/pt not_active IP Right Cessation
1993
- 1993-05-07 LV LVP-93-301A patent/LV10430B/lv unknown
- 1993-11-12 LT LTIP1462A patent/LT3798B/lt not_active IP Right Cessation
1997
- 1997-09-05 CY CY199797A patent/CY1997A/xx unknown

Also Published As

Publication number	Publication date
IE902642A1 (en)	1991-02-27
HU218274B (en)	2000-07-28
EP0409119A1 (de)	1991-01-23
FI94630C (fi)	1995-10-10
UA19056A (uk)	1997-12-25
SK357690A3 (en)	1998-07-08
FI94630B (fi)	1995-06-30
JPH0776213B2 (ja)	1995-08-16
KR0181945B1 (ko)	1999-05-01
JPH0358973A (ja)	1991-03-14
PL166307B1 (pl)	1995-05-31
AU624978B2 (en)	1992-06-25
CZ357690A3 (en)	1995-06-14
DD300429A5 (de)	1992-06-11
FI903624A0 (fi)	1990-07-18
ZA905680B (en)	1991-04-24
IL95121A (en)	1994-08-26
DE3924093A1 (de)	1991-02-07
PL286132A1 (en)	1991-07-29
CA2021529A1 (en)	1991-01-21
HUT54653A (en)	1991-03-28
CZ280129B6 (cs)	1995-11-15
KR910002799A (ko)	1991-02-26
NO177187C (no)	1995-08-02
CA2021529C (en)	1997-12-30
ATE104280T1 (de)	1994-04-15
PT94779B (pt)	1997-04-30
CY1997A (en)	1997-09-05
LV10430B (en)	1996-02-20
LTIP1462A (en)	1995-05-25
ES2052112T3 (es)	1994-07-01
IL95121A0 (en)	1991-06-10
SK279199B6 (sk)	1998-07-08
LT3798B (en)	1996-03-25
HU904549D0 (en)	1990-12-28
EP0409119B1 (de)	1994-04-13
NO903235D0 (no)	1990-07-19
IE64438B1 (en)	1995-08-09
RU1836350C (ru)	1993-08-23
DK0409119T3 (da)	1994-08-08
NO177187B (no)	1995-04-24
NZ234563A (en)	1992-12-23
PT94779A (pt)	1991-03-20
DE59005328D1 (de)	1994-05-19
AU5914490A (en)	1991-01-24
LV10430A (lv)	1995-02-20

Legal Events

Date	Code	Title	Description
2003-03-10	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN JANUARY 2003

Publication	Publication Date	Title
NO891698D0 (no)	1989-04-25	Pyridonkarboksylsyrederivater og fremgangsmaate for deres fremstilling.
FI925100A0 (fi)	1992-11-10	Substituerade bifenylpyridoner
ES2081340T3 (es)	1996-03-01	Derivados de n-(3-hidroxi-4-piperidinil)(dihidrobenzofurano, dihidro-2h-benzopirano o dihidrobenzodioxin)carboxamida.
ZA907535B (en)	1991-06-26	Pyrimidine-4,6-dicarboxylic acid diamides,processes for their preparation and the use thereof,and pharmaceuticals based on these compounds
ES2164639T3 (es)	2002-03-01	Quinoxalinas, procedimiento para su preparacion y su empleo.
NO903235L (no)	1991-01-21	N,n'-bis(alkoksy-alkyl)-pyridin-2,4-dikarboksylsyre-diamider, fremgangsmaater for deres fremstilling og anvendelse derav.
DK26289A (da)	1989-07-22	Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia
NO881308L (no)	1988-10-10	Dihydropyridinamider, fremgangsmaate til deres fremstilling og deres anvendelse i legemidler.
DK425487A (da)	1987-08-14	Pharmaceutisk aktive derivater af glutamin- og asparginsyre
ATE32221T1 (de)	1988-02-15	3 n-substituierte 3,4-dihydropyrimidinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen.
IE880628L (en)	1988-09-07	Substituted pyridine-2,4-dicarboxylic acid derivatives,¹processes for their preparation, the use thereof and¹medicaments based on these compounds
GB2023137A (en)	1979-12-28	Derivatives of cyclohexene-1,2- dicarboxylic acid diamide and the herbicidal compositions containing them
ZA871757B (en)	1987-09-01	1-phenylimidazolecarboxylic acid amides,their preparation and their use as growth regulators
DK0398427T3 (da)	1994-04-05	Antirhinovirale pyridazinaminer
ATE158576T1 (de)	1997-10-15	Alpha-aryl-alpha-hydroxy-beta- imidazolinylpropionsäureamide
MX9206997A (es)	1993-06-01	Procedimiento para la preparacion de derivados de trifluorobenceno.
ES2108894T3 (es)	1998-01-01	Procedimiento para la preparacion de 5-cloroimidazoles eventualmente sustituidos en posicion 2.
DE3887611D1 (de)	1994-03-17	Butensäure-Amide, deren Salze, diese enthaltende pharmazeutische Zusammensetzungen und Verfahren zu deren Herstellung.
ATE231161T1 (de)	2003-02-15	6-deoxy-erythromycin-derivate, ihrer herstellung, und ihrer verwendung als arzneimitteln
MX9201156A (es)	1992-10-01	Diamidas mixtas de acidos piridina -2,4- y 2,5 dicarboxilicos, procedimiento para su preparacion, utilizacion de las mismas asi como medicamentos a base de estos compuestos.