NO905067L - Nye isoindolonderivater og deres fremstilling. - Google Patents

Nye isoindolonderivater og deres fremstilling.

Info

Publication number: NO905067L
Authority: NO; Norway
Prior art keywords: derivatives; preparation; new; isoindolond; radicals
Prior art date: 1989-11-23

Application number

NO90905067A

Other languages

English (en)

Other versions

NO174148C (no

NO174148B (no

NO905067D0 (no

Inventor

Marie-Christine Dubroeucq

Claude Moutonnier

Jean-Francois Peyronel

Michel Tabart

Alain Truchon

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-23

Filing date

1990-11-22

Publication date

1991-05-24

1990-11-22 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1990-11-22 Publication of NO905067D0 publication Critical patent/NO905067D0/no

1991-05-24 Publication of NO905067L publication Critical patent/NO905067L/no

1993-12-13 Publication of NO174148B publication Critical patent/NO174148B/no

1994-03-23 Publication of NO174148C publication Critical patent/NO174148C/no

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
XTBAPWCYTNCZTO-UHFFFAOYSA-N isoindol-1-one Chemical class C1=CC=C2C(=O)N=CC2=C1 XTBAPWCYTNCZTO-UHFFFAOYSA-N 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
-1 phenyl radicals Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

NO905067A 1989-11-23 1990-11-22 Nye isoindolonderivater NO174148C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8915407A FR2654726B1 (fr)	1989-11-23	1989-11-23	Nouveaux derives de l'isoindolone et leur preparation.

Publications (4)

Publication Number	Publication Date
NO905067D0 NO905067D0 (no)	1990-11-22
NO905067L true NO905067L (no)	1991-05-24
NO174148B NO174148B (no)	1993-12-13
NO174148C NO174148C (no)	1994-03-23

Family

ID=9387708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO905067A NO174148C (no)	1989-11-23	1990-11-22	Nye isoindolonderivater

Country Status (23)

Country	Link
US (1)	US5112988A (no)
EP (1)	EP0430771B1 (no)
JP (1)	JPH03176468A (no)
KR (1)	KR910009660A (no)
AT (1)	ATE108774T1 (no)
AU (1)	AU635984B2 (no)
CA (1)	CA2030570A1 (no)
DE (1)	DE69010851T2 (no)
DK (1)	DK0430771T3 (no)
ES (1)	ES2057488T3 (no)
FI (1)	FI94627C (no)
FR (1)	FR2654726B1 (no)
HU (1)	HU214574B (no)
IE (1)	IE64737B1 (no)
IL (1)	IL96447A (no)
NO (1)	NO174148C (no)
NZ (1)	NZ236175A (no)
PL (2)	PL164973B1 (no)
PT (1)	PT95983B (no)
RU (1)	RU2104269C1 (no)
SK (1)	SK278474B6 (no)
YU (1)	YU47437B (no)
ZA (1)	ZA909370B (no)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676442B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2688219B1 (fr)	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2689889B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, et leur preparation.
US5830854A (en) *	1992-12-14	1998-11-03	Merck Sharp & Dohme, Limited	Method of treating cystic fibrosis using a tachykinin receptor antagonist
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5543530A (en) *	1993-12-23	1996-08-06	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2729954B1 (fr)	1995-01-30	1997-08-01	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
FR2755013B1 (fr) *	1996-10-29	1998-11-27	Rhone Poulenc Rorer Sa	Nouvelle application therapeutique des antagonistes de la substance p
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
WO2001032625A1 (en)	1999-11-03	2001-05-10	Du Pont Pharmaceuticals Company	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
JP5132864B2 (ja)	2000-07-11	2013-01-30	アルバニーモレキュラーリサーチ，インコーポレイテッド	４−フェニル置換テトラヒドロイソキノリンおよびその使用方法
AU2005274927B2 (en)	2004-07-15	2011-11-03	Albany Molecular Research, Inc.	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8362075B2 (en)	2005-05-17	2013-01-29	Merck Sharp & Dohme Corp.	Cyclohexyl sulphones for treatment of cancer
KR101594898B1 (ko)	2005-07-15	2016-02-18	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EA016079B1 (ru)	2007-01-10	2012-01-30	Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа	Амидзамещенные индазолы в качестве ингибиторов поли(adp-рибоза)полимеразы (parp)
AU2008269154B2 (en)	2007-06-27	2014-06-12	Merck Sharp & Dohme Llc	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
US8802696B2 (en)	2009-05-12	2014-08-12	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
WO2010132487A1 (en)	2009-05-12	2010-11-18	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
CN102458123A (zh)	2009-05-12	2012-05-16	阿尔巴尼分子研究公司	芳基、杂芳基和杂环取代的四氢异喹啉及其用途
JP5099731B1 (ja)	2009-10-14	2012-12-19	メルク・シャープ・アンド・ドーム・コーポレーション	ｐ５３活性を増大する置換ピペリジン及びその使用
KR101781789B1 (ko) *	2010-01-27	2017-09-26	에이비 파르마 리미티드.	C형 간염 바이러스 억제제로 사용되는 다환 헤테로사이클릭 화합물
AU2011285909B2 (en)	2010-08-02	2016-11-10	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
EP2606134B1 (en)	2010-08-17	2019-04-10	Sirna Therapeutics, Inc.	RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en)	2010-10-29	2021-01-20	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
EP2654748B1 (en)	2010-12-21	2016-07-27	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
EP2699567A1 (en)	2011-04-21	2014-02-26	Merck Sharp & Dohme Corp.	Insulin-like growth factor-1 receptor inhibitors
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP3358013B1 (en)	2012-05-02	2020-06-24	Sirna Therapeutics, Inc.	Short interfering nucleic acid (sina) compositions
KR20150060724A (ko)	2012-09-28	2015-06-03	머크 샤프 앤드 돔 코포레이션	Erk 억제제인 신규 화합물
DK2925888T3 (en)	2012-11-28	2017-12-18	Merck Sharp & Dohme	COMPOSITIONS AND METHODS OF CANCER TREATMENT
EP2935263B1 (en)	2012-12-20	2018-12-05	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en)	2013-01-30	2017-01-10	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as HDM2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
WO2018071283A1 (en)	2016-10-12	2018-04-19	Merck Sharp & Dohme Corp.	Kdm5 inhibitors
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
WO2019094311A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
BR112021002267A8 (pt)	2018-08-07	2023-02-07	Merck Sharp & Dohme	Inibidores de prmt5
EP3833667B1 (en)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5 inhibitors
EP3833668B1 (en)	2018-08-07	2025-03-19	Merck Sharp & Dohme LLC	Prmt5 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2858314A (en) *	1954-06-07	1958-10-28	Georgian Vlasios	Hydrocarbazolenines
US4042707A (en) *	1976-02-19	1977-08-16	E. I. Du Pont De Nemours And Company	3α-Arylhydroisoindoles
IT1113879B (it) *	1979-03-15	1986-01-27	Farmatis Spa	Derivato isoindolinico,processo per la sua preparazione e composizioni terapeutiche che lo comprendono come principio attivo
US4494547A (en) *	1981-03-30	1985-01-22	North Carolina Central University	2H-isoindolediones, their synthesis and use as radiosensitizers
DE3133302A1 (de) *	1981-08-22	1983-03-03	Beiersdorf Ag, 2000 Hamburg	Isoindolin-2-yl-amino-imidazoline und isoindolin-2-yl-guanidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE39483T1 (de) *	1982-04-02	1989-01-15	Takeda Chemical Industries Ltd	Kondensierte pyrrolinon-derivate, und ihre herstellung.
EP0227986B1 (en) *	1985-12-09	1993-03-24	Banyu Pharmaceutical Co., Ltd.	Isoindoline derivatives and processes for their preparation

1989
- 1989-11-23 FR FR8915407A patent/FR2654726B1/fr not_active Expired - Lifetime
1990
- 1990-11-20 US US07/616,044 patent/US5112988A/en not_active Expired - Fee Related
- 1990-11-21 NZ NZ236175A patent/NZ236175A/xx unknown
- 1990-11-22 SK SK5806-90A patent/SK278474B6/sk unknown
- 1990-11-22 DE DE69010851T patent/DE69010851T2/de not_active Expired - Fee Related
- 1990-11-22 AT AT90403300T patent/ATE108774T1/de not_active IP Right Cessation
- 1990-11-22 HU HU907249A patent/HU214574B/hu not_active IP Right Cessation
- 1990-11-22 JP JP2320570A patent/JPH03176468A/ja active Pending
- 1990-11-22 KR KR1019900019099A patent/KR910009660A/ko not_active Abandoned
- 1990-11-22 AU AU66828/90A patent/AU635984B2/en not_active Ceased
- 1990-11-22 ES ES90403300T patent/ES2057488T3/es not_active Expired - Lifetime
- 1990-11-22 ZA ZA909370A patent/ZA909370B/xx unknown
- 1990-11-22 EP EP90403300A patent/EP0430771B1/fr not_active Expired - Lifetime
- 1990-11-22 NO NO905067A patent/NO174148C/no unknown
- 1990-11-22 FI FI905770A patent/FI94627C/fi not_active IP Right Cessation
- 1990-11-22 IE IE423490A patent/IE64737B1/en not_active IP Right Cessation
- 1990-11-22 DK DK90403300.8T patent/DK0430771T3/da active
- 1990-11-22 IL IL9644790A patent/IL96447A/en not_active IP Right Cessation
- 1990-11-22 CA CA002030570A patent/CA2030570A1/fr not_active Abandoned
- 1990-11-23 YU YU223590A patent/YU47437B/sh unknown
- 1990-11-23 PT PT95983A patent/PT95983B/pt not_active IP Right Cessation
- 1990-11-23 PL PL90287908A patent/PL164973B1/pl unknown
- 1990-11-23 PL PL90301462A patent/PL164955B1/pl unknown
1992
- 1992-12-01 RU RU92004482A patent/RU2104269C1/ru active

Also Published As

Publication number	Publication date
ES2057488T3 (es)	1994-10-16
IL96447A (en)	1995-03-15
ATE108774T1 (de)	1994-08-15
ZA909370B (en)	1991-10-30
FI905770L (fi)	1991-05-24
NO174148C (no)	1994-03-23
FI94627C (fi)	1995-10-10
DE69010851D1 (de)	1994-08-25
PT95983A (pt)	1991-09-13
DE69010851T2 (de)	1994-11-24
NO174148B (no)	1993-12-13
IL96447A0 (en)	1991-08-16
CA2030570A1 (fr)	1991-05-24
EP0430771B1 (fr)	1994-07-20
YU47437B (sh)	1995-03-27
AU635984B2 (en)	1993-04-08
PT95983B (pt)	1998-01-30
NZ236175A (en)	1993-03-26
EP0430771A1 (fr)	1991-06-05
US5112988A (en)	1992-05-12
HUT55756A (en)	1991-06-28
FI94627B (fi)	1995-06-30
DK0430771T3 (da)	1994-08-29
JPH03176468A (ja)	1991-07-31
SK580690A3 (en)	1997-07-09
FI905770A0 (fi)	1990-11-22
RU2104269C1 (ru)	1998-02-10
IE64737B1 (en)	1995-09-06
PL287908A1 (en)	1991-12-02
HU907249D0 (en)	1991-05-28
FR2654726A1 (fr)	1991-05-24
PL164973B1 (pl)	1994-10-31
PL164955B1 (en)	1994-10-31
HU214574B (hu)	1998-04-28
AU6682890A (en)	1991-05-30
KR910009660A (ko)	1991-06-28
NO905067D0 (no)	1990-11-22
IE904234A1 (en)	1991-06-05
FR2654726B1 (fr)	1992-02-14
YU223590A (sh)	1993-05-28
SK278474B6 (en)	1997-07-09

Publication	Publication Date	Title
NO905067D0 (no)	1990-11-22	Nye isoindolonderivater og deres fremstilling.
RU92004482A (ru)	1995-06-19	Производные изоиндола
DK0586471T3 (da)	1995-06-06	Perhydroisoindolderivater og deres fremstilling
MX9301986A (es)	1994-05-31	Derivados de perhidroisoindol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
DK213290D0 (da)	1990-09-06	Treatment of cerebrovascular disorders
DK165953C (da)	1993-07-05	Fremgangsmaade til fremstilling af 2,3-dihydrobenzofuranderivater
DK327286A (da)	1987-01-12	Indolcarboxamidderivater og salte deraf, deres fremstilling og anvendelse som laegemidler samt mellemprodukter til deres fremstilling
DK0470686T3 (da)	1996-08-26	(Benzhydryloxyethylpiperidyl)alifatiske syrederivater og deres anvendelse til behandling af allergier og astma
FI861324A0 (fi)	1986-03-26	Nya (4.2.0) bicyclooktanderivat, som har vaerdefulla terapeutiska egenskaper.
DK228086A (da)	1986-11-18	Substituerede isoxazol-derivater med antiviral virkning og fremgangsmaade af saadanne derivater
ES2042727T3 (es)	1993-12-16	Acidos 1,3,4,9-tetrahidropirano(3,4-b)indol-1-acetico.
ES531318A0 (es)	1985-05-16	Procedimiento para la obtencion de derivados quinolinicos
DK356287D0 (da)	1987-07-09	2,6-piperazindionderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
DK104488A (da)	1988-08-28	Acetamider afledt af 2,3-dihydro-3-phenyl-2-benzofuranon, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem
KR970706280A (ko)	1997-11-03	5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists)
DK0424248T3 (da)	1996-03-04	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf