NO910214L - Diastereoselektiv fremstilling av fosfinatestere. - Google Patents

Diastereoselektiv fremstilling av fosfinatestere.

Info

Publication number: NO910214L
Authority: NO; Norway
Prior art keywords: chem; reaction; formula; resulting; phosphinate
Prior art date: 1990-01-19

Application number

NO91910214A

Other languages

English (en)

Other versions

NO179915C (no

NO179915B (no

NO910214D0 (no

Inventor

Thomas C Sedergran

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-19

Filing date

1991-01-18

Publication date

1991-07-22

1991-01-18 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1991-01-18 Publication of NO910214D0 publication Critical patent/NO910214D0/no

1991-07-22 Publication of NO910214L publication Critical patent/NO910214L/no

1996-09-30 Publication of NO179915B publication Critical patent/NO179915B/no

1997-01-08 Publication of NO179915C publication Critical patent/NO179915C/no

Links

ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 title 1
-1 phosphinic acid ester Chemical class 0.000 abstract 3
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
NFDXQGNDWIPXQL-UHFFFAOYSA-N 1-cyclooctyldiazocane Chemical compound C1CCCCCCC1N1NCCCCCC1 NFDXQGNDWIPXQL-UHFFFAOYSA-N 0.000 abstract 1
AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
KMPWYEUPVWOPIM-KODHJQJWSA-N cinchonidine Chemical compound C1=CC=C2C([C@H]([C@H]3[N@]4CC[C@H]([C@H](C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-KODHJQJWSA-N 0.000 abstract 1
KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012973 diazabicyclooctane Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229960001880 fosinopril sodium Drugs 0.000 abstract 1
238000001640 fractional crystallisation Methods 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 abstract 1
TVTJZMHAIQQZTL-WATAJHSMSA-M sodium;(2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate Chemical compound [Na+].C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C([O-])=O)CCCC1=CC=CC=C1 TVTJZMHAIQQZTL-WATAJHSMSA-M 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO910214A 1990-01-19 1991-01-18 Fremgangsmåte for diastereoselektiv fremstilling av fosfinatestere NO179915C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/467,451 US5008399A (en)	1990-01-19	1990-01-19	Diastereoselective preparation of phosphinate esters

Publications (4)

Publication Number	Publication Date
NO910214D0 NO910214D0 (no)	1991-01-18
NO910214L true NO910214L (no)	1991-07-22
NO179915B NO179915B (no)	1996-09-30
NO179915C NO179915C (no)	1997-01-08

Family

ID=23855753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO910214A NO179915C (no)	1990-01-19	1991-01-18	Fremgangsmåte for diastereoselektiv fremstilling av fosfinatestere

Country Status (19)

Country	Link
US (1)	US5008399A (no)
EP (1)	EP0437799B1 (no)
JP (1)	JP2846484B2 (no)
KR (2)	KR0179368B1 (no)
CN (1)	CN1026791C (no)
AT (1)	ATE118779T1 (no)
AU (1)	AU623562B2 (no)
CA (1)	CA2032900C (no)
DE (1)	DE69017183T2 (no)
DK (1)	DK0437799T3 (no)
ES (1)	ES2068321T3 (no)
FI (1)	FI101539B (no)
HU (1)	HU208142B (no)
IE (1)	IE67354B1 (no)
IL (1)	IL96838A (no)
NO (1)	NO179915C (no)
PT (1)	PT96519B (no)
RU (1)	RU2044740C1 (no)
ZA (1)	ZA9196B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9304619D0 (en) *	1993-03-06	1993-04-21	Ciba Geigy Ag	Esters
US6555139B2 (en)	1999-06-28	2003-04-29	Wockhardt Europe Limited	Preparation of micron-size pharmaceutical particles by microfluidization
US7078532B2 (en) *	2001-04-30	2006-07-18	Lupin Laboratories Limited	Process for manufacture of fosinopril sodium
CN100497335C (zh) *	2005-10-27	2009-06-10	上海医药工业研究院	取代氧膦基乙酸的光学拆分方法
CN100488969C (zh) *	2005-10-27	2009-05-20	上海医药工业研究院	光学活性的取代氧膦基乙酸盐及其用途
IT1394407B1 (it) *	2009-05-25	2012-06-15	Dipharma Francis Srl	Procedimento per la preparazione di fosinopril e suoi intermedi
IT1406151B1 (it)	2010-12-06	2014-02-14	Dipharma Francis Srl	Procedimento per la preparazione di fosinopril e suoi intermedi
CN114380861B (zh) *	2020-10-19	2026-05-08	浙江华海药业股份有限公司	一种福辛普利钠中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4337201A (en) *	1980-12-04	1982-06-29	E. R. Squibb & Sons, Inc.	Phosphinylalkanoyl substituted prolines
US4384123A (en) *	1980-12-04	1983-05-17	E. R. Squibb & Sons, Inc.	Phosphinylalkanoyl substituted prolines
US4873356A (en) *	1987-09-30	1989-10-10	E. R. Squibb & Sons, Inc.	Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby

1990
- 1990-01-19 US US07/467,451 patent/US5008399A/en not_active Expired - Lifetime
- 1990-12-20 CA CA002032900A patent/CA2032900C/en not_active Expired - Lifetime
- 1990-12-20 AU AU68319/90A patent/AU623562B2/en not_active Expired
- 1990-12-21 ES ES90125061T patent/ES2068321T3/es not_active Expired - Lifetime
- 1990-12-21 DK DK90125061.3T patent/DK0437799T3/da active
- 1990-12-21 EP EP90125061A patent/EP0437799B1/en not_active Expired - Lifetime
- 1990-12-21 AT AT90125061T patent/ATE118779T1/de not_active IP Right Cessation
- 1990-12-21 DE DE69017183T patent/DE69017183T2/de not_active Expired - Lifetime
- 1990-12-31 IL IL9683890A patent/IL96838A/en not_active IP Right Cessation
1991
- 1991-01-04 ZA ZA9196A patent/ZA9196B/xx unknown
- 1991-01-07 IE IE4791A patent/IE67354B1/en not_active IP Right Cessation
- 1991-01-16 FI FI910231A patent/FI101539B/fi active
- 1991-01-18 HU HU91179A patent/HU208142B/hu unknown
- 1991-01-18 JP JP3019468A patent/JP2846484B2/ja not_active Expired - Lifetime
- 1991-01-18 RU SU914894275A patent/RU2044740C1/ru active
- 1991-01-18 PT PT96519A patent/PT96519B/pt not_active IP Right Cessation
- 1991-01-18 KR KR1019910000782A patent/KR0179368B1/ko not_active Expired - Lifetime
- 1991-01-18 NO NO910214A patent/NO179915C/no not_active IP Right Cessation
- 1991-01-19 CN CN91100404A patent/CN1026791C/zh not_active Expired - Lifetime
1998
- 1998-09-28 KR KR1019980040259A patent/KR0179470B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
RU2044740C1 (ru)	1995-09-27
FI910231A0 (fi)	1991-01-16
CN1053431A (zh)	1991-07-31
IE67354B1 (en)	1996-03-20
CA2032900C (en)	2000-06-06
DE69017183D1 (de)	1995-03-30
NO179915C (no)	1997-01-08
KR0179368B1 (ko)	1999-05-15
PT96519A (pt)	1991-10-15
CN1026791C (zh)	1994-11-30
FI101539B1 (fi)	1998-07-15
EP0437799A1 (en)	1991-07-24
PT96519B (pt)	1998-06-30
JP2846484B2 (ja)	1999-01-13
FI910231L (fi)	1991-07-20
AU6831990A (en)	1991-07-25
NO179915B (no)	1996-09-30
KR910014389A (ko)	1991-08-31
NO910214D0 (no)	1991-01-18
IL96838A (en)	1995-11-27
KR0179470B1 (ko)	1999-05-15
FI101539B (fi)	1998-07-15
DK0437799T3 (da)	1995-03-27
ATE118779T1 (de)	1995-03-15
HU208142B (en)	1993-08-30
EP0437799B1 (en)	1995-02-22
HU910179D0 (en)	1991-08-28
ES2068321T3 (es)	1995-04-16
HUT56573A (en)	1991-09-30
US5008399A (en)	1991-04-16
IL96838A0 (en)	1991-09-16
JPH04235191A (ja)	1992-08-24
IE910047A1 (en)	1991-07-31
DE69017183T2 (de)	1995-06-14
AU623562B2 (en)	1992-05-14
CA2032900A1 (en)	1991-07-20
ZA9196B (en)	1991-10-30

Legal Events

Date	Code	Title	Description
2011-02-14	MK1K	Patent expired

Publication	Publication Date	Title
NO302028B1 (no)	1998-01-12	Substituerte heterocykliske karboksylsyreamidestere og deres anvendelse for fremstilling av legemidler
DK163120C (da)	1992-06-15	Analogifremgangsmaade til fremstilling af substituerede acylderivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyre (s,s,s) eller et farmaceutisk acceptabelt salt deraf
DE69231874D1 (de)	2001-07-19	Verfahren zur herstellung von 4-substituierten azetidinon-derivaten
NO910214D0 (no)	1991-01-18	Diastereoselektiv fremstilling av fosfinatestere.
HUT54156A (en)	1991-01-28	Process for producing new n-heteroarylpurine-6-amine derivatives and pharmaceutical compositions comprising such compounds
EP0124186A3 (en)	1985-05-15	Imidazole-ethanol esters
SE9300013D0 (sv)	1992-12-30	Novel process and intermediates for the preparation of prodrugs
MA21450A1 (fr)	1989-07-01	Nouveaux derives antiviraux puriniques et leur procede de preparation.
HUT49613A (en)	1989-10-30	Process for producing new 8-aza-1,4-dioxaspiro/4,5/decan-2-ylmethyl ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids and pharmaceutical compositions comprising same
ES8700658A1 (es)	1986-10-16	Un procedimiento para preparar compuestos relacionados con histargina
AU686104B2 (en)	1998-02-05	Substituted amidinonaphthyl ester derivatives
DE3851783D1 (de)	1994-11-17	Verfahren zur Herstellung von 6-[D(-)-alpha-(4-Äthyl-2,3-dioxo-1-piperazin-carboxamido)-phenylacetamido]penicillansäure.
DK0556909T3 (da)	1998-08-24	Fremgangsmåde til fremstilling af (R) - og (S) - 1,2-isopropylildenglycol
ATE258158T1 (de)	2004-02-15	Verfahren zum reinigen von milchsäureestern
DK93089D0 (da)	1989-02-27	Fremgangsmaade til fremstilling af phthalazineddikesyreesterederivater og mellemprodukt ved fremsgangsmaaden
NO941757L (no)	1994-05-10	1-fenylpyrrolidon-derivater med optisk aktivitet, mellomprodukter for fremstilling derav og fremgangsmåter for deres fremstilling
DK638289A (da)	1990-06-17	Fremgangsmaade til fremstilling af optisk aktive 2-oxoimidazolidinderivater
IT8621290A1 (it)	1988-01-29	2-(aciltio)metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
DK0501713T3 (da)	1997-09-08	Optisk aktivt aminoketonderivat og fremgangsmåde til fremstilling af samme
DK54180A (da)	1980-08-10	Fremgangsmaade til fremstilling af xanthonderivater
ES8303428A1 (es)	1983-02-01	"un procedimiento para preparar nuevos compuestos de cefem".