NO923456L - N-fenylglycinamidderivater, deres fremstilling og medikamenter inneholdende derivatene - Google Patents

N-fenylglycinamidderivater, deres fremstilling og medikamenter inneholdende derivatene

Info

Publication number
NO923456L
NO923456L NO92923456A NO923456A NO923456L NO 923456 L NO923456 L NO 923456L NO 92923456 A NO92923456 A NO 92923456A NO 923456 A NO923456 A NO 923456A NO 923456 L NO923456 L NO 923456L
Authority
NO
Norway
Prior art keywords
optionally substituted
residue
derivatives
compounds
phenyl
Prior art date
Application number
NO92923456A
Other languages
English (en)
Other versions
NO923456D0 (no
Inventor
Jean-Dominique Bourzat
Marc Capet
Claude Cotrel
Claude Guyon
Franco Manfre
Gerard Roussel
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9002889A external-priority patent/FR2659334B1/fr
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO923456L publication Critical patent/NO923456L/no
Publication of NO923456D0 publication Critical patent/NO923456D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formelen: R4-N-CO-CH2-NH-CO-R3 der R, betyr et hydrogenatom eller en alkyl- eller karbonyl rest, eller en eventuelt substituert fenylrest, R2 betyr en alkoksyrest, en eventuelt substituert cykloal- kyloksyrest, eller en cykloalkylalkyloksy-, fenylalkyloksy-, poyfluoralkyloksy-, cinnamyloksy- eller -NRjR6-rest, R3 betyr en fenylaminorest der fenylkjernen eventuelt er substituert, fenyl som eventuelt er substituert, naftyl, indolyl eller kinolyl, R4 betyr en substituert fenylrest, og Rj og R6 er like eller forskjellige og betyr et hydrogenatom, en alkylrest, eventuelt substituert fenylrest, indanyl-, cykloalkylalkyl-, cykloalkyl- eller fenylalkylrest, eller Rj og R6 sammen med nitrogenatomet hvor til de er bundet, danner en heterocykel. Forbindelsene med formel (I) rapporteres å ha interessante farmakologiske egenskaper, særlig i forbindelse med behandling eller prevensjon av mangler forbundet med CCK og gastrin i sentralnervesystemet eller den gastrointestinale kanal. Forbindelsenes fremstilling beskrives.
NO923456A 1990-03-07 1992-09-04 N-fenylglycinamidderivater, deres fremstilling og medikamenter inneholdende derivatene NO923456D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9002889A FR2659334B1 (fr) 1990-03-07 1990-03-07 Derives de n-phenyl glycinamide, leur preparation et les medicaments les contenant.
FR909012727A FR2667864B2 (fr) 1990-03-07 1990-10-16 Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant.
PCT/FR1991/000174 WO1991013907A1 (fr) 1990-03-07 1991-03-05 Derives de n-phenyl glycinamide, leur preparation et les medicaments les contenant

Publications (2)

Publication Number Publication Date
NO923456L true NO923456L (no) 1992-09-04
NO923456D0 NO923456D0 (no) 1992-09-04

Family

ID=26227911

Family Applications (1)

Application Number Title Priority Date Filing Date
NO923456A NO923456D0 (no) 1990-03-07 1992-09-04 N-fenylglycinamidderivater, deres fremstilling og medikamenter inneholdende derivatene

Country Status (18)

Country Link
US (1) US5475106A (no)
EP (1) EP0518960B1 (no)
JP (1) JPH05504967A (no)
AT (1) ATE111482T1 (no)
AU (1) AU635832B2 (no)
CA (1) CA2074375A1 (no)
DE (1) DE69104034T2 (no)
DK (1) DK0518960T3 (no)
ES (1) ES2059128T3 (no)
FR (1) FR2667864B2 (no)
HU (1) HUT61576A (no)
IE (1) IE65296B1 (no)
IL (1) IL97476A (no)
NO (1) NO923456D0 (no)
NZ (1) NZ237341A (no)
PT (1) PT96969B (no)
RU (1) RU2076108C1 (no)
WO (1) WO1991013907A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658518B1 (fr) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant.
WO1991013874A1 (fr) * 1990-03-07 1991-09-19 Rhone-Poulenc Rorer S.A. Derives de glycinamide, leur preparation et les medicaments les contenant
FR2695640B1 (fr) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa Dérivés d'(amino-3 phényl)-1 éthanesulfonate d'alkylammonium optiquement actifs, leur préparation et leur utilisation.
FR2695642A1 (fr) * 1992-09-11 1994-03-18 Rhone Poulenc Rorer Sa Dérivé d'uréido-acétamide optiquement actif, sa préparation et les médicaments les contenant.
FR2695643B1 (fr) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant.
FR2695641B1 (fr) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation.
FR2700165B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2700166B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
DE69525145T2 (de) * 1994-02-09 2002-08-29 SHIONOGI & CO., LTD. Carbamoylmethylharnstoffderivate
US5756502A (en) * 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
FR2723739B1 (fr) * 1994-08-19 1997-02-14 Sanofi Sa Derives de glycinamide, procedes pour leur preparation et medicaments les contenant.
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
AU6530796A (en) * 1995-08-07 1997-03-05 Shionogi & Co., Ltd. Process for producing carbamoylmethylurea derivatives
FR2744364B1 (fr) * 1996-02-07 1998-02-27 Rhone Poulenc Rorer Sa Application d'ureidoacetamides a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif
DK1007546T3 (da) * 1997-08-27 2009-03-16 Novartis Vaccines & Diagnostic Molekylære mimetika af meningokok-B-epitoper
US6197339B1 (en) * 1997-09-30 2001-03-06 Pharmacia & Upjohn Company Sustained release tablet formulation to treat Parkinson's disease
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
ATE479676T1 (de) * 2005-01-10 2010-09-15 Bristol Myers Squibb Co Als antikoagulanzien verwendbare phenylglycinamid-derivate
US7456195B2 (en) * 2005-06-24 2008-11-25 Bristol-Myers Squibb Company Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3515744A (en) * 1966-01-07 1970-06-02 Basf Ag Substituted n-phenyl carbamates
US4055414A (en) * 1976-03-11 1977-10-25 Monsanto Company Herbicidal composition and method of use
MA19111A1 (fr) * 1979-10-26 1981-12-31 Ciba Geigy Ag Derives de l'homoserine,procede pour leur preparation et leur utilisation en tant que microbicides
US4377587A (en) * 1980-07-25 1983-03-22 Ciba-Geigy Corporation Arylamine derivatives and use thereof as microbicides
US4448773A (en) * 1981-04-29 1984-05-15 Ciba-Geigy Corporation Microbicidal N-alkoxycarbonyl-alkyl-N-substituted acetyl-anilines and -naphthylamines
US4492683A (en) * 1982-08-06 1985-01-08 Buffalo Color Corporation Method for inhibiting the growth of fungi with phenyl glycine compounds
DE3414881A1 (de) * 1984-04-19 1985-10-24 Bayer Ag, 5090 Leverkusen Allophanat-derivate
EP0166355A2 (en) * 1984-06-26 1986-01-02 Merck & Co. Inc. Substituted aminophenyl compounds and acylaminophenyl compounds and pharmaceutical compositions containing them
EP0175498A2 (en) * 1984-08-23 1986-03-26 The Administrators Of The Tulane University Educational Fund Peptides, their use in medicine and methods for their preparation
FR2646847B1 (fr) * 1989-05-12 1991-07-12 Rhone Poulenc Sante N-phenyl amides, leurs procedes de preparation et les medicaments les contenant
FR2658518B1 (fr) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant.
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5324747A (en) * 1992-07-15 1994-06-28 Hoffmann-La Roche Inc. N-substituted anilines, inhibitors of phospholipases A2

Also Published As

Publication number Publication date
US5475106A (en) 1995-12-12
PT96969B (pt) 1998-07-31
IL97476A0 (en) 1992-06-21
EP0518960A1 (fr) 1992-12-23
EP0518960B1 (fr) 1994-09-14
DE69104034T2 (de) 1995-01-26
FR2667864B2 (fr) 1994-08-05
DK0518960T3 (da) 1994-10-17
ES2059128T3 (es) 1994-11-01
AU7492091A (en) 1991-10-10
ATE111482T1 (de) 1994-09-15
NO923456D0 (no) 1992-09-04
WO1991013907A1 (fr) 1991-09-19
PT96969A (pt) 1991-10-31
CA2074375A1 (fr) 1991-09-08
HUT61576A (en) 1993-01-28
DE69104034D1 (de) 1994-10-20
AU635832B2 (en) 1993-04-01
IL97476A (en) 1996-07-23
JPH05504967A (ja) 1993-07-29
RU2076108C1 (ru) 1997-03-27
HU9202865D0 (en) 1992-11-30
IE910746A1 (en) 1991-09-11
FR2667864A2 (fr) 1992-04-17
IE65296B1 (en) 1995-10-18
NZ237341A (en) 1992-07-28

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