NO924929L - Farmasoeytisk aktive benzoquinazolinforbindelser - Google Patents

Farmasoeytisk aktive benzoquinazolinforbindelser

Info

Publication number: NO924929L
Authority: NO; Norway
Prior art keywords: group; compounds; pharmasoeytic; active; optionally substituted
Prior art date: 1990-06-19

Application number

NO92924929A

Other languages

English (en)

Norwegian (no)

Other versions

NO924929D0 (no

Inventor

William Pendergast

Scott Howard Dickerson

Julius Vass Johnson

Robert Ferone

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-19

Filing date

1992-12-18

Publication date

1992-12-18

1992-12-18 Application filed by Wellcome Found filed Critical Wellcome Found

1992-12-18 Publication of NO924929D0 publication Critical patent/NO924929D0/no

1992-12-18 Publication of NO924929L publication Critical patent/NO924929L/no

Links

PQIUGRLKNKSKTC-UHFFFAOYSA-N benzo[h]quinazoline Chemical class N1=CN=C2C3=CC=CC=C3C=CC2=C1 PQIUGRLKNKSKTC-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002831 pharmacologic agent Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO92924929A 1990-06-19 1992-12-18 Farmasoeytisk aktive benzoquinazolinforbindelser NO924929L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909013615A GB9013615D0 (en)	1990-06-19	1990-06-19	Pharmaceutical compounds
PCT/GB1991/000977 WO1991019700A1 (en)	1990-06-19	1991-06-18	Pharmaceutically active benzoquinazoline compounds

Publications (2)

Publication Number	Publication Date
NO924929D0 NO924929D0 (no)	1992-12-18
NO924929L true NO924929L (no)	1992-12-18

Family

ID=10677828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO92924929A NO924929L (no)	1990-06-19	1992-12-18	Farmasoeytisk aktive benzoquinazolinforbindelser

Country Status (26)

Country	Link
US (4)	US6090941A (cs)
EP (2)	EP0535034B1 (cs)
JP (1)	JP2966929B2 (cs)
KR (1)	KR0183042B1 (cs)
CN (1)	CN1049215C (cs)
AP (1)	AP218A (cs)
AT (2)	ATE222243T1 (cs)
AU (1)	AU639815B2 (cs)
CA (1)	CA2085589C (cs)
CS (1)	CS186391A3 (cs)
DE (2)	DE69133088T2 (cs)
DK (2)	DK0535034T3 (cs)
ES (2)	ES2211851T3 (cs)
FI (1)	FI925778A0 (cs)
GB (1)	GB9013615D0 (cs)
HU (2)	HUT62273A (cs)
IE (1)	IE912073A1 (cs)
IL (1)	IL98542A (cs)
MC (1)	MC2290A1 (cs)
MY (1)	MY107001A (cs)
NO (1)	NO924929L (cs)
NZ (1)	NZ238582A (cs)
PL (1)	PL169927B1 (cs)
PT (1)	PT98021B (cs)
WO (1)	WO1991019700A1 (cs)
ZA (1)	ZA914676B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9013615D0 (en) *	1990-06-19	1990-08-08	Wellcome Found	Pharmaceutical compounds
US6762188B1 (en)	1990-06-19	2004-07-13	Smithkline Beecham Corporation	Pharmaceutically active benzoquinazoline compounds
GB9223352D0 (en) *	1992-11-06	1992-12-23	Ici Plc	Tricyclic compounds
GB9226842D0 (en) *	1992-12-23	1993-02-17	Wellcome Found	Pharmaceutical compounds
GB9408936D0 (en) *	1994-05-05	1994-06-22	Cancer Res Inst	Anti-cancer compounds
AU3883600A (en)	1999-03-16	2000-10-04	Regents Of The University Of California, The	Glycosylated polyamines
US6531454B1 (en)	1999-03-16	2003-03-11	The Regents Of The University Of California	Glycosylated polyamines and methods of use therefor
WO2001095884A2 (en) *	2000-06-09	2001-12-20	Osi Pharmaceuticals, Inc.	Liposomal benzoquinazoline thymidylate synthase inhibitor formulations
KR20040041177A (ko) *	2001-09-26	2004-05-14	바이엘 파마슈티칼스 코포레이션	당뇨병 치료제로서의 1,6-나프티리딘 유도체
CN100434425C (zh) *	2005-03-09	2008-11-19	首都师范大学	4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
EP1754484A1 (en) *	2005-08-17	2007-02-21	Dan Stoicescu	Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes
DE602006007177D1 (de)	2005-12-05	2009-07-16	Nitto Denko Corp	Polyglutamat-aminosäure-konjugate und verfahren
GB0525069D0 (en) *	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
JP2010505811A (ja)	2006-10-04	2010-02-25	ファイザー・プロダクツ・インク	カルシウム受容体アンタゴニストとしてのピリド［４，３−ｄ］ピリミジン−４（３Ｈ）−オン誘導体
EP1958632A1 (en)	2007-02-14	2008-08-20	Dan Stoicescu	Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases
CN101707869A (zh) *	2007-05-09	2010-05-12	日东电工株式会社	具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物
DK2155254T3 (da) *	2007-05-09	2013-03-04	Nitto Denko Corp	Med platinlægemidler konjugerede polymere
EP2155255B1 (en)	2007-05-09	2013-08-14	Nitto Denko Corporation	Compositions that include a hydrophobic compound and a polyamino acid conjugate
US8517760B2 (en)	2007-08-20	2013-08-27	Ford Global Technologies, Llc	Cord wrap and power plug receptacle arrangement for inflator
US8146622B2 (en)	2007-08-20	2012-04-03	Ford Global Technologies, Llc	Switch and hose-valve connection arrangement for vehicle temporary mobility kit
WO2010138955A2 (en)	2009-05-29	2010-12-02	University Of Florida Research Foundation, Inc.	Methods and compositions for treating neoplasia
CN101580501B (zh)	2009-06-01	2011-03-09	南京卡文迪许生物工程技术有限公司	3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
WO2011078226A1 (ja) *	2009-12-22	2011-06-30	協和発酵キリン株式会社	三環系化合物
CN116547280A (zh) *	2020-10-08	2023-08-04	雷多纳治疗公司	用于治疗癌症的苯并[h]喹唑啉-4-胺和噻吩并[3,2-h]喹唑啉-4-胺衍生物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UST862021I4 (en) *	1969-01-27	1969-05-27		Defensive publication
DE2202847A1 (de) *	1971-02-05	1972-08-17	Apaw Sa	Speiseeismaschine,insbesondere fuer Familiengebrauch,Kleinbetriebe od.dgl.
EP0031237B1 (en) *	1979-12-19	1984-10-17	National Research Development Corporation	Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4814335A (en) *	1982-12-30	1989-03-21	Biomeasure, Incorporated	Antiviral compounds
GB8513754D0 (en) *	1985-05-31	1985-07-03	Jones T R	Anti-cancer quinazoline derivatives
US4603186A (en)	1985-10-21	1986-07-29	The Standard Oil Company	Tetrapolymers containing indene
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
US4818819A (en) *	1986-10-20	1989-04-04	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
GB8707053D0 (en) *	1987-03-25	1987-04-29	Ici Plc	Anti-tumour agents
US4857530A (en) *	1987-11-03	1989-08-15	Warner-Lambert Company	Substituted quinazolinones as anticancer agents
US4902624A (en) *	1987-11-23	1990-02-20	Eastman Kodak Company	Temperature cycling cuvette
GB8727737D0 (en) *	1987-11-26	1987-12-31	Ici Plc	Antitumour agents
GB8829296D0 (en) *	1988-12-15	1989-01-25	Ici Plc	Anti-tumour compounds
GB9013615D0 (en) *	1990-06-19	1990-08-08	Wellcome Found	Pharmaceutical compounds
US5405851A (en) *	1990-06-19	1995-04-11	Burroughs Wellcome Co.	Pharmaceutical compounds

1990
- 1990-06-19 GB GB909013615A patent/GB9013615D0/en active Pending
1991
- 1991-06-18 KR KR1019920703287A patent/KR0183042B1/ko not_active Expired - Fee Related
- 1991-06-18 IE IE207391A patent/IE912073A1/en unknown
- 1991-06-18 JP JP3510950A patent/JP2966929B2/ja not_active Expired - Fee Related
- 1991-06-18 DK DK91910823T patent/DK0535034T3/da active
- 1991-06-18 AU AU80943/91A patent/AU639815B2/en not_active Ceased
- 1991-06-18 AT AT91910823T patent/ATE222243T1/de not_active IP Right Cessation
- 1991-06-18 ES ES02075192T patent/ES2211851T3/es not_active Expired - Lifetime
- 1991-06-18 WO PCT/GB1991/000977 patent/WO1991019700A1/en not_active Ceased
- 1991-06-18 NZ NZ238582A patent/NZ238582A/en unknown
- 1991-06-18 DE DE69133088T patent/DE69133088T2/de not_active Expired - Fee Related
- 1991-06-18 MC MC91@@D patent/MC2290A1/xx unknown
- 1991-06-18 CA CA002085589A patent/CA2085589C/en not_active Expired - Lifetime
- 1991-06-18 AP APAP/P/1991/000283A patent/AP218A/en active
- 1991-06-18 PL PL91297195A patent/PL169927B1/pl unknown
- 1991-06-18 ZA ZA914676A patent/ZA914676B/xx unknown
- 1991-06-18 MY MYPI91001094A patent/MY107001A/en unknown
- 1991-06-18 DK DK02075192T patent/DK1199307T3/da active
- 1991-06-18 PT PT98021A patent/PT98021B/pt not_active IP Right Cessation
- 1991-06-18 CS CS911863A patent/CS186391A3/cs unknown
- 1991-06-18 EP EP91910823A patent/EP0535034B1/en not_active Expired - Lifetime
- 1991-06-18 AT AT02075192T patent/ATE260262T1/de not_active IP Right Cessation
- 1991-06-18 HU HU924011A patent/HUT62273A/hu unknown
- 1991-06-18 CN CN91105021A patent/CN1049215C/zh not_active Expired - Fee Related
- 1991-06-18 ES ES91910823T patent/ES2178632T3/es not_active Expired - Lifetime
- 1991-06-18 EP EP02075192A patent/EP1199307B1/en not_active Expired - Lifetime
- 1991-06-18 DE DE69133371T patent/DE69133371T2/de not_active Expired - Fee Related
- 1991-06-18 IL IL9854291A patent/IL98542A/en not_active IP Right Cessation
1992
- 1992-12-18 NO NO92924929A patent/NO924929L/no unknown
- 1992-12-18 FI FI925778A patent/FI925778A0/fi not_active Application Discontinuation
1993
- 1993-01-13 US US07/956,018 patent/US6090941A/en not_active Expired - Fee Related
1995
- 1995-05-12 HU HU95P/P00133P patent/HU211265A9/hu unknown
- 1995-05-25 US US08/449,959 patent/US5663337A/en not_active Expired - Lifetime
- 1995-05-26 US US08/452,337 patent/US5661155A/en not_active Expired - Lifetime
2000
- 2000-06-06 US US09/588,790 patent/US6306865B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0535034A1 (en)	1993-04-07
DE69133371D1 (de)	2004-04-01
US6090941A (en)	2000-07-18
ZA914676B (en)	1993-02-24
IL98542A0 (en)	1992-07-15
GB9013615D0 (en)	1990-08-08
AP9100283A0 (en)	1991-07-31
ATE260262T1 (de)	2004-03-15
MC2290A1 (fr)	1993-07-14
PT98021B (pt)	1998-11-30
HUT62273A (en)	1993-04-28
CA2085589A1 (en)	1991-12-20
EP0535034B1 (en)	2002-08-14
ES2211851T3 (es)	2004-07-16
DK1199307T3 (da)	2004-06-14
PL169927B1 (pl)	1996-09-30
NZ238582A (en)	1993-12-23
NO924929D0 (no)	1992-12-18
US6306865B1 (en)	2001-10-23
AP218A (en)	1992-09-27
US5663337A (en)	1997-09-02
WO1991019700A1 (en)	1991-12-26
ATE222243T1 (de)	2002-08-15
IL98542A (en)	1995-05-26
CN1058208A (zh)	1992-01-29
DE69133088T2 (de)	2003-03-20
HU9204011D0 (en)	1993-03-29
DE69133088D1 (de)	2002-09-19
AU639815B2 (en)	1993-08-05
IE912073A1 (en)	1992-01-01
US5661155A (en)	1997-08-26
HU211265A9 (en)	1995-11-28
FI925778A7 (fi)	1992-12-18
DK0535034T3 (da)	2002-12-09
PT98021A (pt)	1992-04-30
CA2085589C (en)	2001-12-18
EP1199307A1 (en)	2002-04-24
CS186391A3 (en)	1992-04-15
MY107001A (en)	1995-08-30
KR930701415A (ko)	1993-06-11
KR0183042B1 (ko)	1999-05-01
JP2966929B2 (ja)	1999-10-25
EP1199307B1 (en)	2004-02-25
ES2178632T3 (es)	2003-01-01
FI925778A0 (fi)	1992-12-18
AU8094391A (en)	1992-01-07
JPH05507704A (ja)	1993-11-04
DE69133371T2 (de)	2005-01-27
CN1049215C (zh)	2000-02-09

Publication	Publication Date	Title
NO924929L (no)	1992-12-18	Farmasoeytisk aktive benzoquinazolinforbindelser
HUT74367A (en)	1996-12-30	Fungicidal alpha-aryl-substituted cyclic amide derivatives, fungicid compositions containing these as active ingredients and using thereof
HUP9802814A2 (hu)	1999-10-28	Szelektív béta3 adrenergiás agonista hatású vegyületek, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
CA2036304A1 (en)	1991-08-16	Pyrimidinedione derivatives, their production and use
HUP9903766A2 (en)	2000-09-28	Pyridyl alkene- and pyridyl alkine- acid amides, use of them as cytostatics and immunosuppressives, process for their preparation and pharmaceuticals containing the same
CA2256582A1 (en)	1997-12-11	Oxa acids and related compounds for treating skin conditions
MY119118A (en)	2005-03-31	Thiophenopyrimidines
EP0324387A3 (en)	1990-06-13	Composition for treatment of ischemic disorder in organs
NO996108L (no)	2000-02-10	9-oksinerytromycinderivater
DK142084A (da)	1984-09-26	N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf
DK151627C (da)	1988-06-20	Analogifremgangsmaade til fremstilling af terapeutisk virksomme 4-(fenylalkenyl)-imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf.
HUP9902017A2 (hu)	1999-09-28	Aminosav- és hidroxisav-származékokkal szubsztituált benzamidinszármazékok és antikoagulánsokként történő alkalmazásuk
NO812355L (no)	1982-01-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater
DK597687D0 (da)	1987-11-13	Imidazolidinonforbindelse, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat dermed
DE3362504D1 (en)	1986-04-17	1-carboxyalkanoylindoline-2-carboxylic-acid esters, their preparation, pharmaceutical compositions containing them, and their therapeutic use
HUT53664A (en)	1990-11-28	Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DK469687A (da)	1988-03-11	Derivater af 4,5-dihydrooxazoler og fremgangsmaade til fremstilling af saadanne derivater.
ZA912618B (en)	1992-01-29	3-aminochroman derivatives,process for preparing these and pharmaceutical compositions containing them
IE893956L (en)	1990-06-19	Novel compounds
NO923004L (no)	1993-02-01	6-oxo-azepinoindolforbindelser, saavel som fremgangsmaater og mellomprodukter for fremstilling av disse, og legemidler inneholdende disse forbindelser
AU4304596A (en)	1996-07-10	A process for the preparation of substituted 4-ethyl-piperidines and an intermediate for the preparation of same
NO20003138L (no)	2000-08-18	Ny anvendelse av lokalanestetika mot vaskulære hodepiner
MY106786A (en)	1995-07-31	Novel antiviral tetrahydroimidazo [1,4] benzodiazepin -2- (thi)ones
DK0619817T3 (da)	1999-09-27	Hidtil ukendte farmaceutisk aktive flaviliumforbindelser
IL106862A0 (en)	1993-12-28	Novel oxazolidines and pharmaceutical compositions containing them