NO930505L - Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav - Google Patents

Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav

Info

Publication number: NO930505L
Authority: NO; Norway
Prior art keywords: cycloalkyl; alkyl; optionally substituted; preparation; phenyl
Prior art date: 1992-02-14

Application number

NO93930505A

Other languages

English (en)

Norwegian (no)

Other versions

NO930505D0 (no

Inventor

Didier Festal

Denis Descours

Jacques Decerprit

Original Assignee

Lipha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-14

Filing date

1993-02-12

Publication date

1993-08-16

1993-02-12 Application filed by Lipha filed Critical Lipha

1993-02-12 Publication of NO930505D0 publication Critical patent/NO930505D0/no

1993-08-16 Publication of NO930505L publication Critical patent/NO930505L/no

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
150000002475 indoles Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
-1 R5 and R6 denote H Chemical group 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
230000000055 hyoplipidemic effect Effects 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

NO93930505A 1992-02-14 1993-02-12 Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav NO930505L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9201701A FR2687402B1 (fr)	1992-02-14	1992-02-14	Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (2)

Publication Number	Publication Date
NO930505D0 NO930505D0 (no)	1993-02-12
NO930505L true NO930505L (no)	1993-08-16

Family

ID=9426663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO93930505A NO930505L (no)	1992-02-14	1993-02-12	Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav

Country Status (27)

Country	Link
US (1)	US5338849A (lt)
EP (1)	EP0557171B1 (lt)
JP (1)	JPH061788A (lt)
KR (1)	KR930017905A (lt)
AT (1)	ATE125257T1 (lt)
AU (1)	AU658475B2 (lt)
CA (1)	CA2089470A1 (lt)
CZ (1)	CZ16893A3 (lt)
DE (1)	DE69300268T2 (lt)
DK (1)	DK0557171T3 (lt)
ES (1)	ES2076827T3 (lt)
FR (1)	FR2687402B1 (lt)
GR (1)	GR3017614T3 (lt)
HR (1)	HRP930180A2 (lt)
HU (1)	HUT64067A (lt)
IL (1)	IL104573A0 (lt)
LT (1)	LT3065B (lt)
LV (1)	LV10453B (lt)
MA (1)	MA22797A1 (lt)
MX (1)	MX9300745A (lt)
NO (1)	NO930505L (lt)
NZ (1)	NZ245869A (lt)
OA (1)	OA09775A (lt)
SI (1)	SI9300076A (lt)
SK (1)	SK9093A3 (lt)
TN (1)	TNSN93016A1 (lt)
ZA (1)	ZA93844B (lt)

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GB9226855D0 (en) *	1992-12-23	1993-02-17	Erba Carlo Spa	Vinylene-azaindole derivatives and process for their preparation
US5547966A (en) *	1993-10-07	1996-08-20	Bristol-Myers Squibb Company	Aryl urea and related compounds
DE69728688T2 (de)	1996-11-19	2004-08-19	Amgen Inc., Thousand Oaks	Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel
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US6187777B1 (en)	1998-02-06	2001-02-13	Amgen Inc.	Compounds and methods which modulate feeding behavior and related diseases
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GB0115109D0 (en) *	2001-06-21	2001-08-15	Aventis Pharma Ltd	Chemical compounds
CN1625555A (zh) *	2002-02-01	2005-06-08	阿斯特拉曾尼卡有限公司	喹唑啉化合物
GB0207637D0 (en) *	2002-04-02	2002-05-15	Karobio Ab	Novel compound
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PL1696920T3 (pl) *	2003-12-19	2015-03-31	Plexxikon Inc	Związki i sposoby opracowywania modulatorów Ret
US20070066641A1 (en) *	2003-12-19	2007-03-22	Prabha Ibrahim	Compounds and methods for development of RET modulators
US7507826B2 (en)	2004-03-30	2009-03-24	Vertex Pharmaceuticals Incorporated	Azaindoles useful as inhibitors of JAK and other protein kinases
JP2008503473A (ja) *	2004-06-17	2008-02-07	プレキシコン，インコーポレーテッド	Ｃ−ｋｉｔ活性を調節する化合物
US7498342B2 (en) *	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
EP2264033A1 (en)	2004-07-27	2010-12-22	SGX Pharmaceuticals, Inc.	3,5-DIPHENYL-SUBSTITUTED PYRROLO[2,3b]PYRIDINES USEFUL AS KINASE INHIBITORS
BRPI0513899A (pt) *	2004-07-27	2008-05-20	Sgx Pharmaceuticals Inc	moduladores de cinase heterocìclica de anel fundido
US7626021B2 (en) *	2004-07-27	2009-12-01	Sgx Pharmaceuticals, Inc.	Fused ring heterocycle kinase modulators
US7361764B2 (en)	2004-07-27	2008-04-22	Sgx Pharmaceuticals, Inc.	Pyrrolo-pyridine kinase modulators
EP1787991B2 (en) *	2004-07-28	2020-06-24	Takeda Pharmaceutical Company Limited	PYRROLO[2,3-c]PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
US20060183758A1 (en) *	2005-02-17	2006-08-17	Cb Research And Development, Inc.	Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
CA2608733A1 (en) *	2005-05-17	2007-02-01	Plexxikon, Inc.	Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
DK2395004T3 (en) *	2005-06-22	2016-03-21	Plexxikon Inc	Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
TW201412738A (zh)	2006-01-17	2014-04-01	Vertex Pharma	適合作為傑納斯激酶（ｊａｎｕｓｋｉｎａｓｅ）抑制劑之氮雜吲哚
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) *	2006-12-21	2008-07-03	Plexxikon, Inc.	Pyrrolo [2,3-b] pyridines as kinase modulators
NZ577798A (en)	2006-12-21	2012-04-27	Vertex Pharma	5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
PE20081581A1 (es) *	2006-12-21	2008-11-12	Plexxikon Inc	COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008080015A2 (en)	2006-12-21	2008-07-03	Plexxikon, Inc.	Compounds and methods for kinase modulation, and indications therefor
US20100190777A1 (en)	2007-07-17	2010-07-29	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
FR2946342B1 (fr)	2009-06-05	2011-06-24	Galderma Res & Dev	Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946345B1 (fr)	2009-06-05	2011-05-20	Galderma Res & Dev	Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946346B1 (fr)	2009-06-05	2011-05-20	Galderma Res & Dev	Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr)	2009-06-05	2011-06-24	Galderma Res & Dev	Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
HUE027598T2 (en) *	2009-04-03	2016-10-28	Hoffmann La Roche	Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
DK2442809T3 (en)	2009-06-17	2016-12-19	Vertex Pharma	Inhibitors of the replication of influenza virus
US8329724B2 (en)	2009-08-03	2012-12-11	Hoffmann-La Roche Inc.	Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es)	2009-11-06	2017-09-20	Plexxikon, Inc.	Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
JP5810157B2 (ja) *	2010-07-09	2015-11-11	ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ	プロテインキナーゼ阻害剤および処置の方法
AU2011343642A1 (en)	2010-12-16	2013-05-02	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
MA34948B1 (fr)	2011-02-07	2014-03-01	Plexxikon Inc	Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh)	2011-02-21	2016-11-21	普雷辛肯公司	醫藥活性物質的固態形式
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
RS57541B1 (sr)	2013-11-13	2018-10-31	Vertex Pharma	Postupci za pripremu inhibitora replikacije virusa gripa
EP3068776B1 (en)	2013-11-13	2019-05-29	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
JP6704416B2 (ja)	2015-05-13	2020-06-03	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	インフルエンザウイルスの複製の阻害剤を調製する方法
MA42422A (fr)	2015-05-13	2018-05-23	Vertex Pharma	Inhibiteurs de la réplication des virus de la grippe

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FR1261179A (fr) *	1959-02-04	1961-05-19	Chimiotherapie Lab Franc	12-aza déserpidine et son procédé de préparation
US3354174A (en) *	1964-02-19	1967-11-21	Sterling Drug Inc	1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines
IL83821A0 (en) *	1986-09-10	1988-02-29	Sandoz Ag	Azaindole and indolizine derivatives,their production and pharmaceutical compositions containing them
EP0279263B1 (en) *	1987-02-10	1993-08-04	Abbott Laboratories	Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US5153226A (en) *	1989-08-31	1992-10-06	Warner-Lambert Company	Acat inhibitors for treating hypocholesterolemia
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DE4022414A1 (de) *	1990-07-13	1992-01-16	Bayer Ag	Substituierte pyrrolo-pyridine
FR2674522B1 (fr) *	1991-03-26	1993-07-16	Lipha	Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

1992
- 1992-02-14 FR FR9201701A patent/FR2687402B1/fr not_active Expired - Fee Related
1993
- 1993-02-01 IL IL104573A patent/IL104573A0/xx unknown
- 1993-02-04 US US08/013,427 patent/US5338849A/en not_active Expired - Fee Related
- 1993-02-08 ZA ZA93844A patent/ZA93844B/xx unknown
- 1993-02-09 NZ NZ245869A patent/NZ245869A/en unknown
- 1993-02-10 CZ CZ93168A patent/CZ16893A3/cs unknown
- 1993-02-10 OA OA60340A patent/OA09775A/fr unknown
- 1993-02-11 MX MX9300745A patent/MX9300745A/es unknown
- 1993-02-12 TN TNTNSN93016A patent/TNSN93016A1/fr unknown
- 1993-02-12 AU AU33005/93A patent/AU658475B2/en not_active Ceased
- 1993-02-12 CA CA002089470A patent/CA2089470A1/en not_active Abandoned
- 1993-02-12 EP EP93400366A patent/EP0557171B1/fr not_active Expired - Lifetime
- 1993-02-12 HU HU9300372A patent/HUT64067A/hu unknown
- 1993-02-12 AT AT93400366T patent/ATE125257T1/de not_active IP Right Cessation
- 1993-02-12 DE DE69300268T patent/DE69300268T2/de not_active Expired - Fee Related
- 1993-02-12 DK DK93400366.6T patent/DK0557171T3/da active
- 1993-02-12 JP JP5023965A patent/JPH061788A/ja active Pending
- 1993-02-12 MA MA23089A patent/MA22797A1/fr unknown
- 1993-02-12 SI SI19939300076A patent/SI9300076A/sl unknown
- 1993-02-12 SK SK9093A patent/SK9093A3/sk unknown
- 1993-02-12 NO NO93930505A patent/NO930505L/no unknown
- 1993-02-12 HR HR930180A patent/HRP930180A2/hr not_active Application Discontinuation
- 1993-02-12 ES ES93400366T patent/ES2076827T3/es not_active Expired - Lifetime
- 1993-02-12 LT LTIP339A patent/LT3065B/lt not_active IP Right Cessation
- 1993-02-12 LV LVP-93-119A patent/LV10453B/en unknown
- 1993-02-13 KR KR1019930001980A patent/KR930017905A/ko not_active Withdrawn
1995
- 1995-10-04 GR GR950402727T patent/GR3017614T3/el unknown

Also Published As

Publication number	Publication date
LV10453A (lv)	1995-02-20
ZA93844B (en)	1994-08-08
LT3065B (en)	1994-10-25
HU9300372D0 (en)	1993-04-28
NZ245869A (en)	1995-05-26
MA22797A1 (fr)	1993-10-01
DK0557171T3 (da)	1995-12-04
SK9093A3 (en)	1993-09-08
HUT64067A (en)	1993-11-29
TNSN93016A1 (fr)	1994-03-17
CZ16893A3 (en)	1993-12-15
MX9300745A (es)	1993-09-01
US5338849A (en)	1994-08-16
CA2089470A1 (en)	1993-08-15
OA09775A (fr)	1993-11-30
DE69300268D1 (de)	1995-08-24
NO930505D0 (no)	1993-02-12
KR930017905A (ko)	1993-09-20
JPH061788A (ja)	1994-01-11
FR2687402A1 (fr)	1993-08-20
EP0557171A1 (fr)	1993-08-25
SI9300076A (en)	1993-09-30
LTIP339A (en)	1994-06-15
IL104573A0 (en)	1993-06-10
AU3300593A (en)	1993-08-19
ATE125257T1 (de)	1995-08-15
LV10453B (en)	1995-10-20
EP0557171B1 (fr)	1995-07-19
HRP930180A2 (en)	1995-10-31
ES2076827T3 (es)	1995-11-01
DE69300268T2 (de)	1996-04-04
FR2687402B1 (fr)	1995-06-30
GR3017614T3 (en)	1996-01-31
AU658475B2 (en)	1995-04-13

Publication	Publication Date	Title
NO930505D0 (no)	1993-02-12	Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav
DE69130683D1 (de)	1999-02-04	PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
DE3881472D1 (de)	1993-07-08	Heterocyclische verbindungen mit therapeutischer wirkung.
ATE221064T1 (de)	2002-08-15	Cyclische amidderivate als neurokinin a antagonisten
ATE185344T1 (de)	1999-10-15	Piperidinderivate von benzimidazole als antihistaminische und antiallergische mittel
FI854768A0 (fi)	1985-12-02	Bensoxazol- och bensotiazolaminderivat.
ATE148464T1 (de)	1997-02-15	Substituierte indole als anti-aids pharmaceutische zubereitungen
ATE101612T1 (de)	1994-03-15	Serotonin-antagonisten, ihre herstellung und sie enthaltende arzneimittel.
ES2129483T3 (es)	1999-06-16	Derivados de indol-7-carboxamida como analgesicos.
ATE87206T1 (de)	1993-04-15	Virusinhibierende heterocyclische verbindungen.
SE8305217D0 (sv)	1983-09-27	Karbapenem-antibiotika
PL352172A1 (en)	2003-07-28	Derivatives of n-alkoxyalkylo-n,n-dialkyloamine or salts thereof and the agents containing these compounds used in treatment of neurodegenerative diseases
ATE201208T1 (de)	2001-06-15	Ellipticinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
ATE243219T1 (de)	2003-07-15	9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin