ATE125257T1 - Azaindole, deren herstellungsverfahren und sie enthaltende arzneimittel. - Google Patents

Azaindole, deren herstellungsverfahren und sie enthaltende arzneimittel.

Info

Publication number: ATE125257T1
Authority: AT; Austria
Prior art keywords: cycloalkyl; alkyl; optionally substituted; phenyl; benzyl
Prior art date: 1992-02-14

Application number

AT93400366T

Other languages

English (en)

Inventor

Didier Festal

Denis Descours

Jacques Decerprit

Original Assignee

Lipha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-14

Filing date

1993-02-12

Publication date

1995-08-15

1993-02-12 Application filed by Lipha filed Critical Lipha

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125257T1 publication Critical patent/ATE125257T1/de

Links

BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
-1 R5 and R6 denote H Chemical group 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
230000000055 hyoplipidemic effect Effects 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

AT93400366T 1992-02-14 1993-02-12 Azaindole, deren herstellungsverfahren und sie enthaltende arzneimittel. ATE125257T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9201701A FR2687402B1 (fr)	1992-02-14	1992-02-14	Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (1)

Publication Number	Publication Date
ATE125257T1 true ATE125257T1 (de)	1995-08-15

Family

ID=9426663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93400366T ATE125257T1 (de)	1992-02-14	1993-02-12	Azaindole, deren herstellungsverfahren und sie enthaltende arzneimittel.

Country Status (27)

Country	Link
US (1)	US5338849A (de)
EP (1)	EP0557171B1 (de)
JP (1)	JPH061788A (de)
KR (1)	KR930017905A (de)
AT (1)	ATE125257T1 (de)
AU (1)	AU658475B2 (de)
CA (1)	CA2089470A1 (de)
CZ (1)	CZ16893A3 (de)
DE (1)	DE69300268T2 (de)
DK (1)	DK0557171T3 (de)
ES (1)	ES2076827T3 (de)
FR (1)	FR2687402B1 (de)
GR (1)	GR3017614T3 (de)
HR (1)	HRP930180A2 (de)
HU (1)	HUT64067A (de)
IL (1)	IL104573A0 (de)
LT (1)	LT3065B (de)
LV (1)	LV10453B (de)
MA (1)	MA22797A1 (de)
MX (1)	MX9300745A (de)
NO (1)	NO930505L (de)
NZ (1)	NZ245869A (de)
OA (1)	OA09775A (de)
SI (1)	SI9300076A (de)
SK (1)	SK9093A3 (de)
TN (1)	TNSN93016A1 (de)
ZA (1)	ZA93844B (de)

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ES2364340T3 (es)	2004-03-30	2011-08-31	Vertex Pharmaceuticals Incorporated	Azaindoles útiles como inhibidores de jak y otras proteína quinasas.
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US7626021B2 (en) *	2004-07-27	2009-12-01	Sgx Pharmaceuticals, Inc.	Fused ring heterocycle kinase modulators
US7361764B2 (en)	2004-07-27	2008-04-22	Sgx Pharmaceuticals, Inc.	Pyrrolo-pyridine kinase modulators
JP4977465B2 (ja) *	2004-07-28	2012-07-18	武田薬品工業株式会社	ピロロ［２，３−ｃ］ピリジン化合物、その製造方法および用途
US20060183758A1 (en) *	2005-02-17	2006-08-17	Cb Research And Development, Inc.	Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
AU2006272951A1 (en) *	2005-05-17	2007-02-01	Plexxikon, Inc.	Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) *	2005-06-22	2015-04-15	Plexxikon Inc	Compounds and methods for kinase modulation, and indications therefor
NZ592968A (en)	2006-01-17	2012-08-31	Vertex Pharma	Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079346A1 (en)	2006-12-21	2008-07-03	Vertex Pharmaceuticals Incorporated	5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
RU2009122670A (ru)	2006-12-21	2011-01-27	Плекссикон, Инк. (Us)	Соединения и способы для модуляции киназ и показания к их применению
WO2008079909A1 (en) *	2006-12-21	2008-07-03	Plexxikon, Inc.	Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) *	2006-12-21	2012-08-24	Plexxikon Inc	Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
JP2010533729A (ja)	2007-07-17	2010-10-28	プレキシコン，インコーポレーテッド	キナーゼ調節のための化合物と方法、及びそのための適応
FR2946342B1 (fr)	2009-06-05	2011-06-24	Galderma Res & Dev	Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946346B1 (fr)	2009-06-05	2011-05-20	Galderma Res & Dev	Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr)	2009-06-05	2011-06-24	Galderma Res & Dev	Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946345B1 (fr)	2009-06-05	2011-05-20	Galderma Res & Dev	Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
CA2738573C (en) *	2009-04-03	2013-02-19	F. Hoffmann-La Roche Ag	Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
GEP20207129B (en)	2009-06-17	2020-07-10	Vertex Pharma	Inhibitors of influenza viruses replication
US8329724B2 (en)	2009-08-03	2012-12-11	Hoffmann-La Roche Inc.	Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja)	2009-11-06	2013-03-21	プレキシコンインコーポレーテッド	キナーゼ調節のための化合物、方法およびその適用
JP5810157B2 (ja) *	2010-07-09	2015-11-11	ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ	プロテインキナーゼ阻害剤および処置の方法
RU2013132681A (ru)	2010-12-16	2015-01-27	Вертекс Фармасьютикалз Инкорпорейтед	Ингибиторы репликации вирусов гриппа
PE20141360A1 (es)	2011-02-07	2014-10-13	Plexxikon Inc	Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh)	2011-02-21	2016-11-21	普雷辛肯公司	醫藥活性物質的固態形式
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
PT3068776T (pt)	2013-11-13	2019-08-26	Vertex Pharma	Inibidores da replicação de vírus da gripe
HUE038820T2 (hu)	2013-11-13	2018-11-28	Vertex Pharma	Eljárás influenzavírusok replikációjának inhibitorai elõállítására
EP3294717B1 (de)	2015-05-13	2020-07-29	Vertex Pharmaceuticals Inc.	Verfahren zur herstellung von inhibitoren der influenzavirenreplikation
WO2016183120A1 (en)	2015-05-13	2016-11-17	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication

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FR1261179A (fr) *	1959-02-04	1961-05-19	Chimiotherapie Lab Franc	12-aza déserpidine et son procédé de préparation
US3354174A (en) *	1964-02-19	1967-11-21	Sterling Drug Inc	1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines
NZ221717A (en) *	1986-09-10	1990-08-28	Sandoz Ltd	Azaindole and indolizine derivatives and pharmaceutical compositions
ES2059408T3 (es) *	1987-02-10	1994-11-16	Abbott Lab	Un proceso para la preparacion de un compuesto.
US5153226A (en) *	1989-08-31	1992-10-06	Warner-Lambert Company	Acat inhibitors for treating hypocholesterolemia
WO1991004027A1 (en) *	1989-09-15	1991-04-04	Pfizer Inc.	New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
DE4022414A1 (de) *	1990-07-13	1992-01-16	Bayer Ag	Substituierte pyrrolo-pyridine
FR2674522B1 (fr) *	1991-03-26	1993-07-16	Lipha	Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

1992
- 1992-02-14 FR FR9201701A patent/FR2687402B1/fr not_active Expired - Fee Related
1993
- 1993-02-01 IL IL104573A patent/IL104573A0/xx unknown
- 1993-02-04 US US08/013,427 patent/US5338849A/en not_active Expired - Fee Related
- 1993-02-08 ZA ZA93844A patent/ZA93844B/xx unknown
- 1993-02-09 NZ NZ245869A patent/NZ245869A/en unknown
- 1993-02-10 OA OA60340A patent/OA09775A/fr unknown
- 1993-02-10 CZ CZ93168A patent/CZ16893A3/cs unknown
- 1993-02-11 MX MX9300745A patent/MX9300745A/es unknown
- 1993-02-12 AT AT93400366T patent/ATE125257T1/de not_active IP Right Cessation
- 1993-02-12 ES ES93400366T patent/ES2076827T3/es not_active Expired - Lifetime
- 1993-02-12 HU HU9300372A patent/HUT64067A/hu unknown
- 1993-02-12 DK DK93400366.6T patent/DK0557171T3/da active
- 1993-02-12 HR HR930180A patent/HRP930180A2/hr not_active Application Discontinuation
- 1993-02-12 AU AU33005/93A patent/AU658475B2/en not_active Ceased
- 1993-02-12 NO NO93930505A patent/NO930505L/no unknown
- 1993-02-12 EP EP93400366A patent/EP0557171B1/de not_active Expired - Lifetime
- 1993-02-12 SI SI19939300076A patent/SI9300076A/sl unknown
- 1993-02-12 JP JP5023965A patent/JPH061788A/ja active Pending
- 1993-02-12 DE DE69300268T patent/DE69300268T2/de not_active Expired - Fee Related
- 1993-02-12 SK SK9093A patent/SK9093A3/sk unknown
- 1993-02-12 LT LTIP339A patent/LT3065B/lt not_active IP Right Cessation
- 1993-02-12 TN TNTNSN93016A patent/TNSN93016A1/fr unknown
- 1993-02-12 MA MA23089A patent/MA22797A1/fr unknown
- 1993-02-12 LV LVP-93-119A patent/LV10453B/en unknown
- 1993-02-12 CA CA002089470A patent/CA2089470A1/en not_active Abandoned
- 1993-02-13 KR KR1019930001980A patent/KR930017905A/ko not_active Withdrawn
1995
- 1995-10-04 GR GR950402727T patent/GR3017614T3/el unknown

Also Published As

Publication number	Publication date
MX9300745A (es)	1993-09-01
DK0557171T3 (da)	1995-12-04
DE69300268T2 (de)	1996-04-04
CA2089470A1 (en)	1993-08-15
AU3300593A (en)	1993-08-19
ZA93844B (en)	1994-08-08
LV10453B (en)	1995-10-20
LTIP339A (en)	1994-06-15
NZ245869A (en)	1995-05-26
HU9300372D0 (en)	1993-04-28
JPH061788A (ja)	1994-01-11
HUT64067A (en)	1993-11-29
DE69300268D1 (de)	1995-08-24
LT3065B (en)	1994-10-25
MA22797A1 (fr)	1993-10-01
EP0557171A1 (de)	1993-08-25
OA09775A (fr)	1993-11-30
NO930505D0 (no)	1993-02-12
NO930505L (no)	1993-08-16
HRP930180A2 (en)	1995-10-31
FR2687402A1 (fr)	1993-08-20
GR3017614T3 (en)	1996-01-31
ES2076827T3 (es)	1995-11-01
CZ16893A3 (en)	1993-12-15
SK9093A3 (en)	1993-09-08
EP0557171B1 (de)	1995-07-19
AU658475B2 (en)	1995-04-13
IL104573A0 (en)	1993-06-10
US5338849A (en)	1994-08-16
FR2687402B1 (fr)	1995-06-30
KR930017905A (ko)	1993-09-20
TNSN93016A1 (fr)	1994-03-17
SI9300076A (en)	1993-09-30
LV10453A (lv)	1995-02-20

Legal Events

Date	Code	Title	Description
1996-03-15	UEP	Publication of translation of european patent specification
1997-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69300268D1 (de)	1995-08-24	Azaindole, deren Herstellungsverfahren und sie enthaltende Arzneimittel.
DE69130683D1 (de)	1999-02-04	PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
FR2678938B1 (fr)	1993-10-08	Derives de pyrrolidine, leur preparation et les medicaments les contenant.
ATE170510T1 (de)	1998-09-15	3-(hydroxybenzylidenyl)-indolin-2-one und diese enthaltende arzneimittel
PT734383E (pt)	2002-12-31	Derivados de amidas ciclicas como antagonistas da neuroquinina a
KR860004894A (ko)	1986-07-14	벤조옥사졸- 및 벤조티아졸아민 유도체의 제조방법
FI946073A0 (fi)	1994-12-23	Vitamiini D-sarjan, 20-asemassa modifioituja johdannaisia, menetelmä tällaisten johdannaisten valmistamiseksi, menetelmässä käytettäviä välituotteita, mainittuja johdannaisia sisältäviä farmaseuttisia valmisteita ja johdannaisten käyttö lääkeaineiden valmistamiseen
ATE113282T1 (de)	1994-11-15	Heteroaryl piperazine als antipsychotische mittel.
NO179834C (no)	1996-12-27	Substituerte cykloheksanderivater og anvendelse av forbindelsene for fremstilling av legemidler
ATE101612T1 (de)	1994-03-15	Serotonin-antagonisten, ihre herstellung und sie enthaltende arzneimittel.
DE69210091D1 (de)	1996-05-30	Leukotrien-B4-Antagonisten
DE69009195D1 (de)	1994-07-07	Isoxazol-Derivate mit Anti-Serotonin-Aktivität, deren Herstellungsverfahren und diese enthaltende Zusammensetzungen.
ZA937308B (en)	1994-04-22	Ellipticine compounds a process for their preparation and pharmaceutical compositions containing them
FI103046B1 (fi)	1999-04-15	Menetelmä lääkeaineina käyttökelpoisten pyrrolidinyylitiokarbapeneemijohdannaisten valmistamiseksi
ZA932359B (en)	1994-06-15	3-Aminochroman spiro compounds processes for preparing them and pharmaceutical compositions containing them
DE69416540D1 (de)	1999-03-25	Heterocyclische Verbindungen und pharmazeutische Verwendung
ATE188212T1 (de)	2000-01-15	2-pyrazinylethylamin-derivate und ihre verwendung als arzneimittel.
PL352172A1 (en)	2003-07-28	Derivatives of n-alkoxyalkylo-n,n-dialkyloamine or salts thereof and the agents containing these compounds used in treatment of neurodegenerative diseases
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