NO931421L - Fremgangsmaate for syntese av (4r-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat - Google Patents

Fremgangsmaate for syntese av (4r-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Info

Publication number
NO931421L
NO931421L NO93931421A NO931421A NO931421L NO 931421 L NO931421 L NO 931421L NO 93931421 A NO93931421 A NO 93931421A NO 931421 A NO931421 A NO 931421A NO 931421 L NO931421 L NO 931421L
Authority
NO
Norway
Prior art keywords
cyanomethyl
dimethylethyl
cis
dimethyl
acetate
Prior art date
Application number
NO93931421A
Other languages
English (en)
Other versions
NO301588B1 (no
NO931421D0 (no
Inventor
Alan Millar
Donald Eugene Butler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO931421D0 publication Critical patent/NO931421D0/no
Publication of NO931421L publication Critical patent/NO931421L/no
Publication of NO301588B1 publication Critical patent/NO301588B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO931421A 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat NO301588B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
PCT/US1991/006697 WO1992006968A1 (en) 1990-10-17 1991-09-11 Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Publications (3)

Publication Number Publication Date
NO931421D0 NO931421D0 (no) 1993-04-16
NO931421L true NO931421L (no) 1993-06-16
NO301588B1 NO301588B1 (no) 1997-11-17

Family

ID=24399962

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931421A NO301588B1 (no) 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Country Status (19)

Country Link
US (1) US5103024A (no)
EP (1) EP0553213B1 (no)
JP (1) JP3105923B2 (no)
KR (1) KR0166385B1 (no)
AT (1) ATE118772T1 (no)
AU (1) AU646311B2 (no)
CA (1) CA2092997C (no)
CZ (5) CZ282922B6 (no)
DE (1) DE69107622T2 (no)
DK (1) DK0553213T3 (no)
ES (1) ES2070519T3 (no)
FI (1) FI108539B (no)
HU (2) HU219237B (no)
IE (1) IE62940B1 (no)
NO (1) NO301588B1 (no)
PT (1) PT99244B (no)
RU (1) RU2067580C1 (no)
SK (5) SK280942B6 (no)
WO (1) WO1992006968A1 (no)

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HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
ES2207202T3 (es) * 1998-04-30 2004-05-16 Kaneka Corporation Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico.
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
SK16002003A3 (sk) 2001-06-29 2004-12-01 Warner-Lambert Company Llc Kryštalické formy vápenatej soli (2:1) [R-(R*,R*)]-2-(4-fluóro- fenyl)-beta,delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4- [(fenylamino)karbonyl]-1H-pyrrol-1-heptánovej kyseliny (atorvastatín)
GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
RU2304139C2 (ru) 2001-07-30 2007-08-10 Д-р Редди'с Лабораторис Лтд Кристаллические формы vi и vii кальциевой соли аторвастатина
PE20030324A1 (es) * 2001-07-31 2003-04-03 Warner Lambert Co Composiciones farmaceuticas de amlodipina y atorvastatina
WO2003018547A2 (en) * 2001-08-31 2003-03-06 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
US7932064B2 (en) 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
WO2004014896A1 (en) * 2002-08-06 2004-02-19 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
US20060122403A1 (en) * 2002-09-03 2006-06-08 Sanjay Suri Atorvastatin calcium form vi or hydrates thereof
KR100529703B1 (ko) * 2002-09-23 2005-11-17 임광민 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
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JP2006523670A (ja) * 2003-04-14 2006-10-19 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法
WO2004110998A1 (en) * 2003-05-16 2004-12-23 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
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US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
GB0317393D0 (en) * 2003-07-25 2003-08-27 Avecia Ltd Process and compounds
US7414141B2 (en) 2003-07-25 2008-08-19 Avecia Pharmaceuticals, Ltd. Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin
RU2315755C2 (ru) * 2003-09-17 2008-01-27 Уорнер-Ламберт Компани Ллс Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
AU2004317570B2 (en) 2004-03-17 2011-01-06 Ranbaxy Laboratories Limited Process for the production of atorvastatin calcium in amorphous form
CA2562844A1 (en) * 2004-04-16 2005-10-27 Pfizer Products Inc. Process for forming amorphous atorvastatin calcium
US7875731B2 (en) 2004-05-05 2011-01-25 Pfizer Inc. Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
JP2008506764A (ja) 2004-07-20 2008-03-06 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ［Ｒ−（Ｒ＊，Ｒ＊）］−２−（４−フルオロフェニル）−β、δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−［（フェニルアミノ）カルボニル］−１Ｈ−ピロール−１−ヘプタン酸カルシウム塩（２：１）の新規形態
CA2578722C (en) * 2004-08-27 2010-02-02 Biocon Limited Process for atorvastatin calcium amorphous
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WO2006054308A2 (en) 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
CA2589537A1 (en) * 2004-12-02 2006-06-08 Stephen Craig Dyar Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
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US20090216029A1 (en) * 2005-09-16 2009-08-27 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
CA2547216A1 (en) * 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
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WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
US7834195B2 (en) * 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
WO2008106662A2 (en) 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
WO2009013633A2 (en) * 2007-07-20 2009-01-29 Actavis Group Ptc Ehf Amorphous coprecipitates of atorvastatin pharmaceutically acceptable salts
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
CN103153976B (zh) * 2010-09-09 2015-07-08 中化帝斯曼制药有限公司荷兰公司 7-氨基-3,5-二羟基庚酸酯的盐
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WO2016056031A1 (en) 2014-10-08 2016-04-14 Council Of Scientific & Industrial Research Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid
CN106008251A (zh) * 2016-05-19 2016-10-12 河南豫辰药业股份有限公司 一种2-苯甲撑-3-氧代-4-甲基-n-苯基戊酰胺的制备方法

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US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
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Also Published As

Publication number Publication date
CZ282993B6 (cs) 1997-12-17
CZ283003B6 (cs) 1997-12-17
DK0553213T3 (da) 1995-07-17
NO301588B1 (no) 1997-11-17
KR930702328A (ko) 1993-09-08
FI931680L (fi) 1993-04-14
CZ282922B6 (cs) 1997-11-12
SK280939B6 (sk) 2000-09-12
PT99244A (pt) 1992-09-30
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
SK33993A3 (en) 1993-10-06
AU8848091A (en) 1992-05-20
SK280940B6 (sk) 2000-09-12
KR0166385B1 (en) 1999-01-15
EP0553213A1 (en) 1993-08-04
JPH06502162A (ja) 1994-03-10
EP0553213B1 (en) 1995-02-22
FI931680A0 (fi) 1993-04-14
HUT64049A (en) 1993-11-29
SK280942B6 (sk) 2000-09-12
HU213731B (en) 1997-09-29
US5103024A (en) 1992-04-07
HU9301122D0 (en) 1993-08-30
HK1005026A1 (en) 1998-12-18
CZ282994B6 (cs) 1997-12-17
DE69107622T2 (de) 1995-07-06
RU2067580C1 (ru) 1996-10-10
CZ61493A3 (en) 1994-02-16
FI108539B (fi) 2002-02-15
CZ124797A3 (en) 1997-12-17
ATE118772T1 (de) 1995-03-15
CA2092997C (en) 2002-05-14
SK280938B6 (sk) 2000-09-12
AU646311B2 (en) 1994-02-17
CZ209495A3 (en) 1997-12-17
PT99244B (pt) 1999-04-30
NO931421D0 (no) 1993-04-16
JP3105923B2 (ja) 2000-11-06
ES2070519T3 (es) 1995-06-01
CZ124697A3 (en) 1997-12-17
CA2092997A1 (en) 1992-04-18
IE62940B1 (en) 1995-03-08
DE69107622D1 (de) 1995-03-30
CZ124597A3 (en) 1997-12-17
CZ282992B6 (cs) 1997-12-17
WO1992006968A1 (en) 1992-04-30
SK280941B6 (sk) 2000-09-12
HU9701183D0 (en) 1997-09-29

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