NO931841L - Forbedrede matriksmetallproteasehemmere - Google Patents
Forbedrede matriksmetallproteasehemmereInfo
- Publication number
- NO931841L NO931841L NO93931841A NO931841A NO931841L NO 931841 L NO931841 L NO 931841L NO 93931841 A NO93931841 A NO 93931841A NO 931841 A NO931841 A NO 931841A NO 931841 L NO931841 L NO 931841L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- matrix metal
- metal protease
- protease inhibitors
- substituted
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyclic amine Chemical class 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Forbindelser med formelene:. der hver R^ er uavhengig av hverandre H eller alkyl (1-8C) og Rer alkyl (1-8C) eller der proksimal Rog Rtatt sammen er -(CH)p- hvori p = 3-5;. Rer H eller alkyl (1-4C);. R 4 er sammensmeltet eller konjugert usubstituert eller substituert bicykloarylmetylen;. n er 0, 1 eller 2;. m er 0 eller 1; og. X er OReller NHR, der Rer H eller substituert eller usubstituert alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); eller. X er en aminosyreresidie eller amid derav; eller. X er resten av et cyklisk amin eller heterocyklisk amin;. der Rer H eller laverealkyl (1-4C) og Rer E, laverealkyl (1-4C) eller en acylglruppe, og der —CONRer eventuelt i modifisert isosterisk form.Forbindelsene er nyttige i behandling av tilstander som er kjennetegnet ved uønsket matriksmetallprotease-aktivitet.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/615,798 US5183900A (en) | 1990-11-21 | 1990-11-21 | Matrix metalloprotease inhibitors |
| US07/747,752 US5189178A (en) | 1990-11-21 | 1991-08-20 | Matrix metalloprotease inhibitors |
| PCT/US1991/008723 WO1992009556A1 (en) | 1990-11-21 | 1991-11-21 | Improved matrix metalloprotease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO931841D0 NO931841D0 (no) | 1993-05-19 |
| NO931841L true NO931841L (no) | 1993-05-19 |
Family
ID=27376844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93931841A NO931841L (no) | 1990-11-21 | 1993-05-19 | Forbedrede matriksmetallproteasehemmere |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO931841L (no) |
-
1993
- 1993-05-19 NO NO93931841A patent/NO931841L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO931841D0 (no) | 1993-05-19 |
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