NO945074L - 17-Alkyleton-steroider anvendelige som 5- itorer - Google Patents

17-Alkyleton-steroider anvendelige som 5- itorer

Info

Publication number: NO945074L
Authority: NO; Norway
Prior art keywords: compounds; steroid; itators; alkylethone; steroids useful
Prior art date: 1992-06-30

Application number

NO945074A

Other languages

English (en)

Norwegian (no)

Other versions

NO945074D0 (no

Inventor

Dennis Alan Holt

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1994-12-29

Publication date

1995-02-16

1994-12-29 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1994-12-29 Publication of NO945074D0 publication Critical patent/NO945074D0/no

1995-02-16 Publication of NO945074L publication Critical patent/NO945074L/no

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO945074A 1992-06-30 1994-12-29 17-Alkyleton-steroider anvendelige som 5- itorer NO945074L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213835A GB9213835D0 (en)	1992-06-30	1992-06-30	Compounds
PCT/US1993/006238 WO1994000125A1 (en)	1992-06-30	1993-06-30	17-ALKYLKETONE STEROIDS USEFUL AS 5-α-REDUCTASE INHIBITORS

Publications (2)

Publication Number	Publication Date
NO945074D0 NO945074D0 (no)	1994-12-29
NO945074L true NO945074L (no)	1995-02-16

Family

ID=10717920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO945074A NO945074L (no)	1992-06-30	1994-12-29	17-Alkyleton-steroider anvendelige som 5- itorer

Country Status (23)

Country	Link
EP (1)	EP0651643A4 (cs)
JP (1)	JPH08500821A (cs)
KR (1)	KR950702118A (cs)
CN (1)	CN1095382A (cs)
AP (1)	AP412A (cs)
AU (1)	AU4545993A (cs)
BG (1)	BG99313A (cs)
BR (1)	BR9306748A (cs)
CA (1)	CA2138956A1 (cs)
CZ (1)	CZ334694A3 (cs)
FI (1)	FI946189A7 (cs)
GB (1)	GB9213835D0 (cs)
HU (1)	HUT69409A (cs)
IL (1)	IL106158A0 (cs)
MA (1)	MA22927A1 (cs)
MX (1)	MX9303970A (cs)
NO (1)	NO945074L (cs)
OA (1)	OA10122A (cs)
RU (1)	RU94046378A (cs)
SI (1)	SI9300350A (cs)
SK (1)	SK159994A3 (cs)
WO (1)	WO1994000125A1 (cs)
ZA (1)	ZA934645B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925774A (en)	1991-01-07	1999-07-20	Pherin Corporation	Estrenes for inducing hypothalamic effects
US5510351A (en) *	1992-05-20	1996-04-23	Merck & Co., Inc.	Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic
JP2015129095A (ja)	2013-12-19	2015-07-16	ロレアル	組成物
KR102917075B1 (ko) *	2018-02-11	2026-01-26	장쑤 한서 파마슈티칼 그룹 캄파니 리미티드	스테로이드 유도체 조절제, 그의 제조 방법 및 그의 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954446A (en) *	1988-05-25	1990-09-04	Smithkline Beecham Corporation	Aromatic steroid 5-α-reductase inhibitors

1992
- 1992-06-30 GB GB929213835A patent/GB9213835D0/en active Pending
1993
- 1993-06-26 ZA ZA934645A patent/ZA934645B/xx unknown
- 1993-06-28 MA MA23217A patent/MA22927A1/fr unknown
- 1993-06-28 IL IL106158A patent/IL106158A0/xx unknown
- 1993-06-30 MX MX9303970A patent/MX9303970A/es unknown
- 1993-06-30 CZ CZ943346A patent/CZ334694A3/cs unknown
- 1993-06-30 RU RU94046378/04A patent/RU94046378A/ru unknown
- 1993-06-30 CN CN93109540A patent/CN1095382A/zh active Pending
- 1993-06-30 CA CA002138956A patent/CA2138956A1/en not_active Abandoned
- 1993-06-30 JP JP6502660A patent/JPH08500821A/ja active Pending
- 1993-06-30 HU HU9403833A patent/HUT69409A/hu unknown
- 1993-06-30 AP APAP/P/1993/000542A patent/AP412A/en active
- 1993-06-30 EP EP93915499A patent/EP0651643A4/en not_active Withdrawn
- 1993-06-30 SI SI9300350A patent/SI9300350A/sl unknown
- 1993-06-30 WO PCT/US1993/006238 patent/WO1994000125A1/en not_active Ceased
- 1993-06-30 AU AU45459/93A patent/AU4545993A/en not_active Abandoned
- 1993-06-30 SK SK1599-94A patent/SK159994A3/sk unknown
- 1993-06-30 BR BR9306748A patent/BR9306748A/pt not_active Application Discontinuation
- 1993-06-30 FI FI946189A patent/FI946189A7/fi not_active Application Discontinuation
1994
- 1994-12-29 BG BG99313A patent/BG99313A/xx unknown
- 1994-12-29 OA OA60599A patent/OA10122A/en unknown
- 1994-12-29 NO NO945074A patent/NO945074L/no unknown
- 1994-12-29 KR KR1019940704802A patent/KR950702118A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
RU94046378A (ru)	1996-10-10
BR9306748A (pt)	1998-12-08
NO945074D0 (no)	1994-12-29
HUT69409A (en)	1995-09-28
AP9300542A0 (en)	1993-07-31
MX9303970A (es)	1994-04-29
AP412A (en)	1995-09-29
JPH08500821A (ja)	1996-01-30
EP0651643A4 (en)	1995-10-04
OA10122A (en)	1996-12-18
GB9213835D0 (en)	1992-08-12
SI9300350A (sl)	1993-12-31
IL106158A0 (en)	1993-10-20
EP0651643A1 (en)	1995-05-10
SK159994A3 (en)	1996-01-10
KR950702118A (ko)	1995-06-19
MA22927A1 (fr)	1994-04-01
BG99313A (en)	1995-09-29
CA2138956A1 (en)	1994-01-06
CZ334694A3 (en)	1995-10-18
FI946189L (fi)	1994-12-30
ZA934645B (en)	1994-01-25
FI946189A0 (fi)	1994-12-30
AU4545993A (en)	1994-01-24
CN1095382A (zh)	1994-11-23
WO1994000125A1 (en)	1994-01-06
FI946189A7 (fi)	1994-12-30

Publication	Publication Date	Title
MX9301525A (es)	1994-02-28	Esteriodes substituidos en la posicion 17 y composicion farmaceutica que los contiene.
ES2149350T3 (es)	2000-11-01	Compuestos y liposomas farmaceuticamente activos y metodos para su utilizacion.
AU2960292A (en)	1993-01-21	Intermediates useful in the preparation of sulfonic acid substituted aromatic A ring analogues of steroidal synthetic compounds
AU640396B2 (en)	1993-08-26	7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase
ZA899671B (en)	1990-11-28	Phosphinic acid substituted steroids as inhibitors of steroid 5-alpha-reductase
CY1700A (en)	1994-01-14	Oxidized analogs of 17 beta-N-monosubstituted carbamoyl- 4-aza 5 alpha-androst-1-en-3-ones
EE03194B1 (et)	1999-06-15	Ühendid, nende kasutamine magustavate toimeainetena ja nende valmistamise meetod
ES8603376A1 (es)	1985-12-16	Un metodo para preparar derivados de alcanol aromaticos policiclicos
ES8608535A1 (es)	1986-06-16	Procedimiento para preparar una composicion para el tratamiento topico de acne
ES8607914A1 (es)	1986-01-01	Un procedimiento de preparar un derivado de trans-1,2-diaminociclohexil-amida.
IE811434L (en)	1981-12-27	10-alkynyl steroids
IL72702A0 (en)	1984-11-30	Steroidal carboxylic acid esters,their manufacture and pharmaceutical compositions containing them
AU641701B2 (en)	1993-09-30	11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase
ES2140381T3 (es)	2000-03-01	Nuevas 4h-pirido-(1,2-a)pirimidin-4-onas disustituidas en 2,9.
AU618506B2 (en)	1991-12-19	Suppression of parathyroid hormone synthesis and secretion
ZA899670B (en)	1990-11-28	Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors
MX9303139A (es)	1994-06-30	Procedimiento para la preparacion de derivados esteroides 11-ceto.
IL88396A (en)	1992-12-01	Preparation of 6-methylene derivatives of androsta-1,4- diene-3,17-diones and pharmaceutical compositions containing them
GB1477293A (en)	1977-06-22	Tetralone and indanone derivatives and process for their preparations
AP9300589A0 (en)	1994-01-31	Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase.
MX9306394A (es)	1994-05-31	Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene
HU9202100D0 (en)	1992-10-28	New 16-methyl-pregna-1,4-diene-3,20-dione derivatives
Rodney et al.	1965	The common mode of action of three new classes of inhibitors of cholesterol biosynthesis
AU668161B2 (en)	1996-04-26	Novel process and intermediates
NO20031444L (no)	2003-05-28	17<alfa>-fluoralkylsteroider, fremgangsmåte for fremstilling av disse, og farmasöytiske preparater som inneholder disse forbindelser