NO950328L - Konjugater med svake immunogene antigener og syntetiske peptidbærere og vaksiner som inneholder disse - Google Patents

Konjugater med svake immunogene antigener og syntetiske peptidbærere og vaksiner som inneholder disse

Info

Publication number
NO950328L
NO950328L NO950328A NO950328A NO950328L NO 950328 L NO950328 L NO 950328L NO 950328 A NO950328 A NO 950328A NO 950328 A NO950328 A NO 950328A NO 950328 L NO950328 L NO 950328L
Authority
NO
Norway
Prior art keywords
conjugates
synthetic peptide
positions
immunogenic antigens
vaccines containing
Prior art date
Application number
NO950328A
Other languages
English (en)
Other versions
NO950328D0 (no
Inventor
Irun Robert Cohen
Matityahu Fridkin
Stephanie Konen-Waisman
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of NO950328D0 publication Critical patent/NO950328D0/no
Publication of NO950328L publication Critical patent/NO950328L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

Oppfinnelsen angår konjugater av svakt Inununogene antigener, f.eks. peptlder, proteiner og polysakkari- der, med en syntetisk peptldbærer som utgjør en T- celleepltope avledet fra sekvensen av human varmesjokk- proteln hsp65, eller en analog derav, nevnte peptld eller analog har evne til å øke vesentlig immunogeni- teten av det svakt Immunogene antigenet. Egnede peptlder Ifølge oppfinnelsen er Pep278h, som tilsvarer posisjoner 458-474 l human hsp65, og Pep II, som tilsvarer posisjonene 437-448 l human hsp65, men der to cystelnresldler l posisjonene 442 og 447 er erstattet med serlnresldler.
NO950328A 1992-07-30 1995-01-27 Konjugater med svake immunogene antigener og syntetiske peptidbærere og vaksiner som inneholder disse NO950328L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL102687A IL102687A (en) 1992-07-30 1992-07-30 Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
PCT/US1993/007096 WO1994003208A1 (en) 1992-07-30 1993-07-28 Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them

Publications (2)

Publication Number Publication Date
NO950328D0 NO950328D0 (no) 1995-01-27
NO950328L true NO950328L (no) 1995-03-23

Family

ID=11063877

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950328A NO950328L (no) 1992-07-30 1995-01-27 Konjugater med svake immunogene antigener og syntetiske peptidbærere og vaksiner som inneholder disse

Country Status (18)

Country Link
EP (1) EP0658120B1 (no)
JP (1) JP4087898B2 (no)
KR (1) KR100290632B1 (no)
AT (1) ATE188612T1 (no)
AU (1) AU683421B2 (no)
BR (1) BR9306820A (no)
CA (1) CA2141454C (no)
CZ (1) CZ22995A3 (no)
DE (1) DE69327587T2 (no)
FI (1) FI950405A7 (no)
HU (1) HU218425B (no)
IL (1) IL102687A (no)
NO (1) NO950328L (no)
NZ (1) NZ255143A (no)
PL (1) PL174082B1 (no)
RU (1) RU95105991A (no)
SK (1) SK11295A3 (no)
WO (1) WO1994003208A1 (no)

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HUT70983A (en) 1995-11-28
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