DK0651743T3 - Indolinyl-N-hydroxyurinstof- og N-hydroxamsyrederivater som lipoxygenaseinhibitorer - Google Patents

Indolinyl-N-hydroxyurinstof- og N-hydroxamsyrederivater som lipoxygenaseinhibitorer

Info

Publication number: DK0651743T3
Authority: DK; Denmark
Prior art keywords: alkyl; aryl; halosubstituted; alkoxy; independently
Prior art date: 1992-07-23

Application number

DK93915230.2T

Other languages

English (en)

Inventor

Takafumi Ikeda

Rodney W Stevens

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-23

Filing date

1993-06-10

Publication date

1998-02-02

1993-06-10 Application filed by Pfizer filed Critical Pfizer

1998-02-02 Application granted granted Critical

1998-02-02 Publication of DK0651743T3 publication Critical patent/DK0651743T3/da

Links

XMAJVIWRPWFTEB-UHFFFAOYSA-N 1-(2,3-dihydroindol-1-yl)-1-hydroxyurea Chemical compound C1=CC=C2N(N(O)C(=O)N)CCC2=C1 XMAJVIWRPWFTEB-UHFFFAOYSA-N 0.000 title 1
239000000867 Lipoxygenase Inhibitor Substances 0.000 title 1
239000002253 acid Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
206010027654 Allergic conditions Diseases 0.000 abstract 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
125000003320 C2-C6 alkenyloxy group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000005128 aryl amino alkyl group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000005164 aryl thioalkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
-1 arylsulfinylalkyl Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Immunology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK93915230.2T 1992-07-23 1993-06-10 Indolinyl-N-hydroxyurinstof- og N-hydroxamsyrederivater som lipoxygenaseinhibitorer DK0651743T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4197242A JP2661841B2 (ja)	1992-07-23	1992-07-23	インドリン誘導体

Publications (1)

Publication Number	Publication Date
DK0651743T3 true DK0651743T3 (da)	1998-02-02

Family

ID=16371216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93915230.2T DK0651743T3 (da)	1992-07-23	1993-06-10	Indolinyl-N-hydroxyurinstof- og N-hydroxamsyrederivater som lipoxygenaseinhibitorer

Country Status (24)

Country	Link
EP (1)	EP0651743B1 (da)
JP (1)	JP2661841B2 (da)
KR (1)	KR950702533A (da)
CN (1)	CN1085894A (da)
AT (1)	ATE161250T1 (da)
AU (1)	AU675654B2 (da)
BR (1)	BR9306762A (da)
CA (1)	CA2140344C (da)
CZ (1)	CZ15995A3 (da)
DE (1)	DE69315841T2 (da)
DK (1)	DK0651743T3 (da)
ES (1)	ES2110101T3 (da)
FI (1)	FI104068B (da)
GR (1)	GR3025809T3 (da)
HU (1)	HUT70182A (da)
IL (1)	IL106359A0 (da)
MX (1)	MX9304441A (da)
NZ (1)	NZ253881A (da)
PL (1)	PL307229A1 (da)
SK (1)	SK8695A3 (da)
TW (1)	TW227556B (da)
WO (1)	WO1994002459A1 (da)
YU (1)	YU50893A (da)
ZA (1)	ZA935304B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992006573A1 (en) *	1990-10-02	1992-04-16	Stat-Tech International Corporation	Electric charge discharge and dissipation device
AU4400597A (en) *	1996-10-08	1998-05-05	Fujisawa Pharmaceutical Co., Ltd.	Indole derivatives
US5952322A (en) *	1996-12-05	1999-09-14	Pfizer Inc.	Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
AU4653199A (en) *	1998-07-17	2000-02-07	Daiichi Fine Chemical Co., Ltd.	Novel remedies for allergic diseases
CA2408913A1 (en) *	2000-05-16	2001-11-22	Takeda Chemical Industries, Ltd.	Melanin-concentrating hormone antagonist
CN101331117B (zh) *	2005-11-04	2012-09-05	阿米拉制药公司	5-脂氧合酶活化蛋白（flap）抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0279263B1 (en) *	1987-02-10	1993-08-04	Abbott Laboratories	Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
IL95584A (en) *	1989-09-07	1995-03-15	Abbott Lab	Indole-, benzoporene- and benzothiophene compounds including lipoxygenase-inhibiting compounds and pharmaceutical compounds containing them
KR900016822A (ko) *	1990-04-20	1990-11-14	하라 레이노스께	슬라이드 프로젝터
US5132319A (en) *	1991-03-28	1992-07-21	Merck Frosst Canada, Inc.	1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis

1992
- 1992-07-23 JP JP4197242A patent/JP2661841B2/ja not_active Expired - Fee Related
1993
- 1993-06-10 CZ CZ95159A patent/CZ15995A3/cs unknown
- 1993-06-10 AU AU45291/93A patent/AU675654B2/en not_active Expired - Fee Related
- 1993-06-10 EP EP93915230A patent/EP0651743B1/en not_active Expired - Lifetime
- 1993-06-10 SK SK86-95A patent/SK8695A3/sk unknown
- 1993-06-10 DK DK93915230.2T patent/DK0651743T3/da active
- 1993-06-10 NZ NZ253881A patent/NZ253881A/en unknown
- 1993-06-10 WO PCT/US1993/005391 patent/WO1994002459A1/en not_active Ceased
- 1993-06-10 AT AT93915230T patent/ATE161250T1/de not_active IP Right Cessation
- 1993-06-10 BR BR9306762A patent/BR9306762A/pt not_active Application Discontinuation
- 1993-06-10 PL PL93307229A patent/PL307229A1/xx unknown
- 1993-06-10 DE DE69315841T patent/DE69315841T2/de not_active Expired - Fee Related
- 1993-06-10 ES ES93915230T patent/ES2110101T3/es not_active Expired - Lifetime
- 1993-06-10 CA CA002140344A patent/CA2140344C/en not_active Expired - Fee Related
- 1993-06-12 TW TW082104672A patent/TW227556B/zh active
- 1993-07-15 IL IL106359A patent/IL106359A0/xx unknown
- 1993-07-22 CN CN93108985A patent/CN1085894A/zh active Pending
- 1993-07-22 MX MX9304441A patent/MX9304441A/es unknown
- 1993-07-22 ZA ZA935304A patent/ZA935304B/xx unknown
- 1993-07-22 FI FI933307A patent/FI104068B/fi not_active IP Right Cessation
- 1993-07-22 YU YU50893A patent/YU50893A/sh unknown
- 1993-07-22 HU HU9302126A patent/HUT70182A/hu unknown
1994
- 1994-01-25 KR KR1019940700233A patent/KR950702533A/ko not_active Withdrawn
1997
- 1997-12-30 GR GR970403456T patent/GR3025809T3/el unknown

Also Published As

Publication number	Publication date
ZA935304B (en)	1995-01-23
MX9304441A (es)	1994-07-29
FI933307A0 (fi)	1993-07-22
PL307229A1 (en)	1995-05-15
DE69315841T2 (de)	1998-04-09
GR3025809T3 (en)	1998-03-31
HUT70182A (en)	1995-09-28
FI104068B1 (fi)	1999-11-15
KR950702533A (ko)	1995-07-29
TW227556B (da)	1994-08-01
FI933307L (fi)	1994-01-24
IL106359A0 (en)	1993-11-15
BR9306762A (pt)	1998-12-08
AU4529193A (en)	1994-02-14
YU50893A (sh)	1996-07-24
DE69315841D1 (de)	1998-01-29
CN1085894A (zh)	1994-04-27
CA2140344A1 (en)	1994-02-03
EP0651743B1 (en)	1997-12-17
JP2661841B2 (ja)	1997-10-08
ES2110101T3 (es)	1998-02-01
ATE161250T1 (de)	1998-01-15
HU9302126D0 (en)	1993-10-28
JPH0641068A (ja)	1994-02-15
CZ15995A3 (en)	1995-09-13
EP0651743A1 (en)	1995-05-10
NZ253881A (en)	1996-01-26
FI104068B (fi)	1999-11-15
SK8695A3 (en)	1995-07-11
WO1994002459A1 (en)	1994-02-03
AU675654B2 (en)	1997-02-13
CA2140344C (en)	1997-08-26

Publication	Publication Date	Title
DK0862567T3 (da)	2001-10-08	5-azabicyclo[3.1.0]hexylalkyl-2-piperidoner og-glutarimider som neurokininreceptorantagonister
ATE169008T1 (de)	1998-08-15	3,5-dioxo-(2h,4h)-1,2,4-triazinderivate ihre herstellung und verwendung als medikament
NO20015447D0 (no)	2001-11-07	Kinolinderivater som inhibitorer av MEK enzymer
MXPA05007496A (es)	2005-09-21	Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes.
NO20015446L (no)	2001-12-12	Kinolin-derivater som inhibitorer for MEK-enzymer
HUT60271A (en)	1992-08-28	Process for producing tricyclic compounds, functioning as enzyme inhibitior and comprising amino or nitro group and pharmaceutical compositions comprising same as active ingredient
AU2736088A (en)	1989-06-29	Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
EP1184373A4 (en)	2004-10-20	TRICYCLIC CONNECTIONS
GR3025809T3 (en)	1998-03-31	Indolinyl n-hydrozyurea and n-hydroxamic acid derivatives as lipoxygenase inhibitors.
ATE113942T1 (de)	1994-11-15	Lipoxygenase inhibierende hydroxamsäure und n- hydroxyharnstoff-derivate.
ATE215075T1 (de)	2002-04-15	Hydroxylamin-derivate mit anti-ischämischer wirkung und pharmazeutische zusammensetzungen diese enthaltend
CA2267800A1 (en)	1998-04-16	Tricyclic compounds having activity as ras-fpt inhibitors
DE69207597D1 (de)	1996-02-22	Lipoxygenase inhibierende tetrahydrobenzazepinderivate
ATE159933T1 (de)	1997-11-15	Phenylsubstituierte cycloalkyl- hydroxyharnstoffderivate als lipoxygenase-hemmer
NO20004679L (no)	2000-10-26	Farmasøytisk sammensetning inneholdende en cystein- proteasehemmer for forebygging og terapi av hjernevevsforringelse
ATE131162T1 (de)	1995-12-15	Lipoxygenase inhibierende n- hydroyharnstoffderivate.