ES2079469T3 - (pirrolidin-2-ona-l-il) acetamidas como mejoradores de aprendimiento y memoria y composiciones farmaceuticas que las comprenden. - Google Patents

(pirrolidin-2-ona-l-il) acetamidas como mejoradores de aprendimiento y memoria y composiciones farmaceuticas que las comprenden.

Info

Publication number
ES2079469T3
ES2079469T3 ES90830317T ES90830317T ES2079469T3 ES 2079469 T3 ES2079469 T3 ES 2079469T3 ES 90830317 T ES90830317 T ES 90830317T ES 90830317 T ES90830317 T ES 90830317T ES 2079469 T3 ES2079469 T3 ES 2079469T3
Authority
ES
Spain
Prior art keywords
ona
acetamides
learning
memory
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90830317T
Other languages
English (en)
Inventor
Fabio Giannessi
Orlando Ghirardi
Domenico Misiti
Maria Ornella Tinti
Carlo Scolastico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2079469T3 publication Critical patent/ES2079469T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)

Abstract

ACETAMIDAS DE (PIRROLIDINA-2-ONA-L-IL) DE LA FORMULA GENERAL (I) EN DONDE R ES HIDROGENO O HIDROXILO, R1 ES HIDROGENO, R2 SE SELECCIONA DEL GRUPO QUE CONSTA DE: 2-AMINOMETILO, 2-(N,N-DIISOPROPILO) AMINOETILO, 3-(PIRROLIDINA-2-ONA-1-IL) PROPILO, 2-[N-(PIRROLIDINA-2-ONA-D1-IL) ACETIL] AMINOETILO, 2-HIDROXIETILO, (GLICEROFOSFORILETANOLAMINO) CARBONILMETILO, CLORURO DE 1-TRIMETILAMONIO-3-CARBOXI-2-PROPILOXI-CARBONILMETILO, (PROLINOL-1-IL) CARBONILMETILO, 1-TRIMETILAMONIO-3-CARBOXISOPROPIL), Y 3-PIRIDILCARBAMIDA; O R1 Y R2, JUNTOS, SON TALES QUE FORMAN UN CICLO DE LA FORMULA EN DONDE R3 SE SELECCIONA DEL GRUPO QUE CONSTA DE FENILO SUSTITUIDO POR HALOGENOS O ALQUILOS (C1-C4) INFERIORES SUSTITUIDOS POR HALOGENO Y 4-MORFOLINOCARBONILMETILO, QUE SON POTENTES ACTIVADORES DEL APRENDIZAJE Y LA MEMORIA. TAMBIEN SE REVELAN COMPOSICIONES FARMACEUTICAS ADMINISTRABLES POR VIA ORAL O PARENTERAL EN DOSIS DE CERCA DE 100 A 500 MG DE UNO DE LOS COMPUESTOS DE LA FORMULA (I).
ES90830317T 1989-07-12 1990-07-10 (pirrolidin-2-ona-l-il) acetamidas como mejoradores de aprendimiento y memoria y composiciones farmaceuticas que las comprenden. Expired - Lifetime ES2079469T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8948180A IT1231477B (it) 1989-07-12 1989-07-12 (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Publications (1)

Publication Number Publication Date
ES2079469T3 true ES2079469T3 (es) 1996-01-16

Family

ID=11265047

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90830317T Expired - Lifetime ES2079469T3 (es) 1989-07-12 1990-07-10 (pirrolidin-2-ona-l-il) acetamidas como mejoradores de aprendimiento y memoria y composiciones farmaceuticas que las comprenden.

Country Status (9)

Country Link
US (1) US5061725A (es)
EP (1) EP0408524B1 (es)
JP (1) JPH0348657A (es)
AT (1) ATE129996T1 (es)
DE (1) DE69023400T2 (es)
DK (1) DK0408524T3 (es)
ES (1) ES2079469T3 (es)
GR (1) GR3018032T3 (es)
IT (1) IT1231477B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247698B (it) * 1990-06-21 1994-12-30 Sigma Tau Ind Farmaceuti 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1243702B (it) * 1990-08-08 1994-06-21 Pulitzer Italiana Composti ad attivita' nootropa, procedimento per la loro preparazione e relative composizioni farmaceutiche
CA2067614C (en) * 1991-05-02 2002-07-30 Eiichi Otomo Agent for improving dementia
IT1245870B (it) * 1991-06-05 1994-10-25 Sigma Tau Ind Farmaceuti 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
KR100823668B1 (ko) * 2000-12-28 2008-04-21 해밀턴 파마슈티컬스 인코포레이티드 신경성 통증 치료 및 예방약
DK3260118T3 (da) 2008-10-16 2021-04-19 Univ Johns Hopkins Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
EA202092673A3 (ru) * 2010-02-09 2021-05-31 Дзе Джонс Хопкинс Юниверсити Способы и композиции для улучшения когнитивной функции
AU2012311640B2 (en) * 2011-09-19 2017-04-13 Alfasigma S.P.A. New thio derivatives bearing lactams as potent HDAC inhibitors and their uses as medicaments
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
AU2014228512A1 (en) 2013-03-15 2015-10-01 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CA2986598C (en) 2015-05-22 2023-09-26 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
EP0089900B1 (en) * 1982-03-24 1985-12-27 Prodes S.A. New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
IT1224168B (it) * 1986-08-01 1990-09-26 Finanziaria R F Spa Ora Finanz Derivati del pirrolidin-2-one ad attivita' nootropa
CA1322199C (en) * 1987-07-15 1993-09-14 Masami Eigyo N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia
JPH0696575B2 (ja) * 1987-09-17 1994-11-30 三菱化成株式会社 ４−アミノピリジン誘導体及びその酸付加塩

Also Published As

Publication number Publication date
DE69023400D1 (de) 1995-12-14
EP0408524B1 (en) 1995-11-08
US5061725A (en) 1991-10-29
JPH0348657A (ja) 1991-03-01
DE69023400T2 (de) 1996-05-02
ATE129996T1 (de) 1995-11-15
DK0408524T3 (da) 1995-12-11
GR3018032T3 (en) 1996-02-29
IT8948180A0 (it) 1989-07-12
IT1231477B (it) 1991-12-07
EP0408524A1 (en) 1991-01-16

Similar Documents

Publication Publication Date Title
ES2079469T3 (es) (pirrolidin-2-ona-l-il) acetamidas como mejoradores de aprendimiento y memoria y composiciones farmaceuticas que las comprenden.
NO971383L (no) 1-acyl-4-alifatylaminopiperidinforbindelser
CL2003002756A1 (es) Compuestos derivados de (1-carbamoil-1,1-defenilmetil)-1-[substituido)alquil]purrolidinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del sindrome de intestino irritable o incontinencia.
DK114783A (da) Hidtil ukendte forbindelser, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
ES8305356A1 (es) Un procedimiento para la produccion de un derivado de carbostirilo
UY24429A1 (es) Acetidinas
NO20001402L (no) Substituerte kromanderivater
NO883994L (no) Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidinylaminer.
SE9703378D0 (sv) New compounds
PT75602B (fr) Procede de preparation de nouvelles triazoloquinazolones et de leurs sels
SE7706346L (sv) Bensaminderivat
ES2058572T3 (es) Nuevos derivados de ureileno-2,4,6-triamino-pirimidina-3-oxido, su preparacion y su empleo en cosmetica y dermofarmacia.
SE8303385D0 (sv) 1,4-dihydropyridine derivatives, in optically active or in racemate form and their production and pharmaceutical compositions
MX9304190A (es) Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo.
MX4767E (es) Procedimiento para la preparacion de derivados del 1,8-etano-5-oxo octa y decahidroquinolinas
SE8303913D0 (sv) Heterocykliska foreningar
ATE123487T1 (de) Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen.
ES2058874T3 (es) 1-acil-2-pirrolidinonas como mejoradores del entendimiento y memoria y composiciones farmaceuticas que las contienen.
ATE37368T1 (de) Benzothiazolon-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE139441T1 (de) Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
NO166645C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive diazepinon-derivater.
IL72647A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
ATE117682T1 (de) Substituierte benzothiazolinone, ihre herstellung und sie enthaltende pharmazeutische zusammenstellungen.
NO976101L (no) Nye ellipticinforbindelser, en fremgangsmÕte ved deres fremstilling, samt farmas°ytiske blandinger som inneholder dem
YU31091A (sh) Postupak za dobijanje oksetanona i intermedijeri

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 408524

Country of ref document: ES