NO974270L - Insulinderivater - Google Patents

Insulinderivater

Info

Publication number: NO974270L
Authority: NO; Norway
Prior art keywords: insulin derivatives; group; chain; amino acid; terminal amino
Prior art date: 1995-03-17

Application number

NO974270A

Other languages

English (en)

Norwegian (no)

Other versions

NO974270D0 (no

Inventor

Jan Markussen

Ib Jonassen

Svend Havelund

Jakob Brandt

Peter Kurtzhals

Peter Hertz Hansen

Niels Christian Kaarsholm

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1997-09-16

Publication date

1997-11-14

1997-09-16 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-09-16 Publication of NO974270D0 publication Critical patent/NO974270D0/no

1997-11-14 Publication of NO974270L publication Critical patent/NO974270L/no

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 2
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000005923 long-lasting effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Zoology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Hospice & Palliative Care (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO974270A 1995-03-17 1997-09-16 Insulinderivater NO974270L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK27695		1995-03-17
PCT/DK1996/000107 WO1996029344A1 (en)	1995-03-17	1996-03-18	Insulin derivatives

Publications (2)

Publication Number	Publication Date
NO974270D0 NO974270D0 (no)	1997-09-16
NO974270L true NO974270L (no)	1997-11-14

Family

ID=8091725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO974270A NO974270L (no)	1995-03-17	1997-09-16	Insulinderivater

Country Status (14)

Country	Link
EP (1)	EP0871665B1 (de)
JP (1)	JP3872105B2 (de)
KR (1)	KR19980703039A (de)
CN (1)	CN1196061A (de)
AT (1)	ATE245659T1 (de)
AU (1)	AU720966B2 (de)
BR (1)	BR9607647A (de)
CA (1)	CA2215694A1 (de)
CZ (1)	CZ289343B6 (de)
DE (1)	DE69629210T2 (de)
HU (1)	HUP9800523A3 (de)
NO (1)	NO974270L (de)
PL (1)	PL183698B1 (de)
WO (1)	WO1996029344A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5693609A (en) *	1994-11-17	1997-12-02	Eli Lilly And Company	Acylated insulin analogs
US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives
US6458924B2 (en)	1996-08-30	2002-10-01	Novo Nordisk A/S	Derivatives of GLP-1 analogs
US7235627B2 (en)	1996-08-30	2007-06-26	Novo Nordisk A/S	Derivatives of GLP-1 analogs
US6268343B1 (en)	1996-08-30	2001-07-31	Novo Nordisk A/S	Derivatives of GLP-1 analogs
JP2001521006A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	不溶性インシュリン組成物
US6531448B1 (en)	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
AU776910B2 (en) *	1998-12-08	2004-09-23	Merck Patent Gesellschaft Mit Beschrankter Haftung	Modifying protein immunogenicity
TWI242000B (en) *	1998-12-10	2005-10-21	Univ Southern California	Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
JP5599543B2 (ja)	2002-05-07	2014-10-01	ノヴォノルディスクアー／エス	単量体インスリン及びアシル化インスリンを含む可溶性製剤
CN1247616C (zh) *	2002-07-19	2006-03-29	上海中科生龙达生物技术（集团）有限公司	新的单体胰岛素，药物组合物及其制法
CA2531988C (en)	2003-08-05	2016-06-28	Novo Nordisk A/S	Novel insulin derivatives
EP1687428A1 (de) *	2003-11-14	2006-08-09	Novo Nordisk A/S	Verfahren zur herstellung von acyliertem insulin
ES2642214T3 (es)	2004-01-21	2017-11-15	Novo Nordisk Health Care Ag	Conjugación de péptidos mediante transglutaminasa
EP2060266B1 (de)	2004-03-17	2011-08-10	7TM Pharma A/S	Y4-selektiver Rezeptoragonist PP2-36 für therapeutische Eingriffe
EA011860B1 (ru)	2004-03-17	2009-06-30	7ТиЭм ФАРМА А/С	Селективные агонисты рецептора y2 для терапевтического воздействия
EP2256130B1 (de)	2005-02-02	2013-09-25	Novo Nordisk A/S	Neuartige Insulinderivate
US20080171695A1 (en)	2005-02-02	2008-07-17	Novo Nordisk A/S	Insulin Derivatives
ES2371361T3 (es)	2005-12-28	2011-12-30	Novo Nordisk A/S	Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
DE602007009496D1 (de)	2006-02-27	2010-11-11	Novo Nordisk As	Insulinderivate
EP2015770B1 (de) *	2006-05-09	2012-09-26	Novo Nordisk A/S	Insulinderivate
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
RU2524150C2 (ru)	2006-09-22	2014-07-27	Ново Нордиск А/С	Аналоги инсулина, устойчивые к протеазам
JP5496082B2 (ja)	2007-04-30	2014-05-21	ノボ・ノルデイスク・エー／エス	タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
EP2058330A1 (de) *	2007-11-08	2009-05-13	Novo Nordisk A/S	Insulinderivat
EP2217621B1 (de)	2007-11-08	2015-04-22	Novo Nordisk A/S	Insulinderivat
WO2009112583A2 (en) *	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
JP4959005B2 (ja)	2008-10-30	2012-06-20	ノボ・ノルデイスク・エー／エス	毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
EP2991672A1 (de)	2013-04-30	2016-03-09	Novo Nordisk A/S	Neuartiges verabreichungsschema
JP6499184B2 (ja)	2013-10-07	2019-04-10	ノヴォノルディスクアー／エス	インスリン類似体の新規な誘導体
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina
KR102665710B1 (ko)	2017-08-24	2024-05-14	노보 노르디스크 에이/에스	Glp-1 조성물 및 그 용도
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
KR20210102347A (ko)	2018-12-11	2021-08-19	사노피	인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
JP7761567B2 (ja)	2020-02-18	2025-10-28	ノヴォノルディスクアー／エス	医薬製剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK155690D0 (da) *	1990-06-28	1990-06-28	Novo Nordisk As	Nye peptider
EP1132404A3 (de) *	1993-09-17	2002-03-27	Novo Nordisk A/S	Acyliertes Insulin

1996
- 1996-03-18 CZ CZ19972899A patent/CZ289343B6/cs not_active IP Right Cessation
- 1996-03-18 AT AT96905764T patent/ATE245659T1/de not_active IP Right Cessation
- 1996-03-18 BR BR9607647A patent/BR9607647A/pt not_active Application Discontinuation
- 1996-03-18 EP EP96905764A patent/EP0871665B1/de not_active Expired - Lifetime
- 1996-03-18 JP JP52799596A patent/JP3872105B2/ja not_active Expired - Fee Related
- 1996-03-18 CN CN96193362A patent/CN1196061A/zh active Pending
- 1996-03-18 CA CA002215694A patent/CA2215694A1/en not_active Abandoned
- 1996-03-18 HU HU9800523A patent/HUP9800523A3/hu unknown
- 1996-03-18 AU AU49396/96A patent/AU720966B2/en not_active Ceased
- 1996-03-18 WO PCT/DK1996/000107 patent/WO1996029344A1/en not_active Ceased
- 1996-03-18 PL PL96322299A patent/PL183698B1/pl unknown
- 1996-03-18 KR KR1019970706447A patent/KR19980703039A/ko not_active Ceased
- 1996-03-18 DE DE69629210T patent/DE69629210T2/de not_active Expired - Lifetime
1997
- 1997-09-16 NO NO974270A patent/NO974270L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MX9707056A (es)	1997-11-29
CN1196061A (zh)	1998-10-14
AU720966B2 (en)	2000-06-22
AU4939696A (en)	1996-10-08
BR9607647A (pt)	1999-04-06
HUP9800523A2 (hu)	1998-06-29
CZ289343B6 (cs)	2002-01-16
WO1996029344A1 (en)	1996-09-26
JP3872105B2 (ja)	2007-01-24
JPH11502110A (ja)	1999-02-23
EP0871665A1 (de)	1998-10-21
PL322299A1 (en)	1998-01-19
ATE245659T1 (de)	2003-08-15
CA2215694A1 (en)	1996-09-26
HUP9800523A3 (en)	1998-09-28
DE69629210T2 (de)	2004-04-22
CZ289997A3 (cs)	1998-01-14
KR19980703039A (ko)	1998-09-05
EP0871665B1 (de)	2003-07-23
DE69629210D1 (de)	2003-08-28
NO974270D0 (no)	1997-09-16
PL183698B1 (pl)	2002-06-28

Legal Events

Date	Code	Title	Description
2002-10-28	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO974270L (no)	1997-11-14	Insulinderivater
NO974269L (no)	1997-11-14	Lipofile peptidhormonderivater
DE69432758D1 (en)	2003-07-03	Therapeutisch wirksame peptidderivate
NO20061026L (no)	2006-03-02	Nye insulinderivater
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
ATE262037T1 (de)	2004-04-15	Modifizierte liganden für den tie-2-rezeptor
HUP0100928A2 (hu)	2001-08-28	Humán inzulin B láncának részletét tartalmazó peptidanalógok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
AU9315398A (en)	1999-03-29	Chemokine peptides, variants, derivatives and analogs. their use in methods to inhibit or augment an inflammatory response
NO974514L (no)	1997-11-27	Syntetisk HPV6/11 hybrid L1 DNA som koder for humant papillomavirus Type 11 L1-protein
ATE245435T1 (de)	2003-08-15	Totalsynthese des amino hip analogen von didemnin a
BR9609393A (pt)	1999-12-21	Composição injetável de colágeno; segmentos de fibra de colágeno reconstituìdos.
BR9713404A (pt)	2000-01-25	ésteres de n-(aril/heteroarilacetil) aminoácidos, composições farmacêuticas compreendendo os mesmos, e métodos para a inibição da liberação de peptìdeo beta-amilóide e/ou de sua sìntese por uso de tais compostos.
EP1313440A4 (de)	2004-07-14	Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
ATE77628T1 (de)	1992-07-15	Peptidverbindungen.
FR2703054B1 (fr)	1995-06-16	Promoteur vegetal inductible au stress et cellules vegetales contenant une unite d'expression d'une proteine d'interet comprenant ledit promoteur.
CO4700528A1 (es)	1998-12-29	Peptidos de somatostatina
DE68923572D1 (de)	1995-08-31	Peptide.
DE69834929D1 (de)	2006-07-27	Verwendung eines organspezifischen ernährungmittels
ATE195147T1 (de)	2000-08-15	Aminosäuren konjugaten
MX9206732A (es)	1993-05-01	Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas de tierra.
IT1277391B1 (it)	1997-11-10	Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
WO1998050423A3 (fr)	1999-08-19	Analogues peptidiques et leurs utilisations notamment dans des compositions pharmaceutiques et pour le diagnostic
SI1401871T1 (de)	2005-08-31
MX9802268A (es)	1998-08-30	Nuevos derivados de la substancia pf1022 de ciclodepsipeptido.