ATE245659T1 - Insulinabkömmlinge - Google Patents

Insulinabkömmlinge

Info

Publication number: ATE245659T1
Authority: AT; Austria
Prior art keywords: insulin derivatives; group; chain; amino acid; terminal amino
Prior art date: 1995-03-17

Application number

AT96905764T

Other languages

English (en)

Inventor

Jan Markussen

Ib Jonassen

Svend Havelund

Jakob Brandt

Peter Kurtzhals

Per Hertz Hansen

Niels Christian Kaarsholm

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1996-03-18

Publication date

2003-08-15

1996-03-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245659T1 publication Critical patent/ATE245659T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 2
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Hematology (AREA)
Biophysics (AREA)
Emergency Medicine (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96905764T 1995-03-17 1996-03-18 Insulinabkömmlinge ATE245659T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK27695		1995-03-17
PCT/DK1996/000107 WO1996029344A1 (en)	1995-03-17	1996-03-18	Insulin derivatives

Publications (1)

Publication Number	Publication Date
ATE245659T1 true ATE245659T1 (de)	2003-08-15

Family

ID=8091725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96905764T ATE245659T1 (de)	1995-03-17	1996-03-18	Insulinabkömmlinge

Country Status (14)

Country	Link
EP (1)	EP0871665B1 (de)
JP (1)	JP3872105B2 (de)
KR (1)	KR19980703039A (de)
CN (1)	CN1196061A (de)
AT (1)	ATE245659T1 (de)
AU (1)	AU720966B2 (de)
BR (1)	BR9607647A (de)
CA (1)	CA2215694A1 (de)
CZ (1)	CZ289343B6 (de)
DE (1)	DE69629210T2 (de)
HU (1)	HUP9800523A3 (de)
NO (1)	NO974270L (de)
PL (1)	PL183698B1 (de)
WO (1)	WO1996029344A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5693609A (en) *	1994-11-17	1997-12-02	Eli Lilly And Company	Acylated insulin analogs
US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives
US6458924B2 (en)	1996-08-30	2002-10-01	Novo Nordisk A/S	Derivatives of GLP-1 analogs
US7235627B2 (en)	1996-08-30	2007-06-26	Novo Nordisk A/S	Derivatives of GLP-1 analogs
US6268343B1 (en)	1996-08-30	2001-07-31	Novo Nordisk A/S	Derivatives of GLP-1 analogs
SV1998000125A (es)	1997-10-24	1999-05-24	Lilly Co Eli	Composiciones de insulina insoluble ref. x-11232
US6531448B1 (en)	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
AU776910B2 (en) *	1998-12-08	2004-09-23	Merck Patent Gesellschaft Mit Beschrankter Haftung	Modifying protein immunogenicity
TWI242000B (en) *	1998-12-10	2005-10-21	Univ Southern California	Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
ATE496064T1 (de)	2002-05-07	2011-02-15	Novo Nordisk As	Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
CN1247616C (zh) *	2002-07-19	2006-03-29	上海中科生龙达生物技术（集团）有限公司	新的单体胰岛素，药物组合物及其制法
KR101159559B1 (ko)	2003-08-05	2012-06-26	노보 노르디스크 에이/에스	신규의 인슐린 유도체
EP1687428A1 (de) *	2003-11-14	2006-08-09	Novo Nordisk A/S	Verfahren zur herstellung von acyliertem insulin
EP2368579A1 (de)	2004-01-21	2011-09-28	Novo Nordisk Health Care AG	Tranglutaminase vermittelte konjugation von peptiden.
ATE519495T1 (de)	2004-03-17	2011-08-15	7Tm Pharma As	Y4-selektiver rezeptoragonist pp2-36 für therapeutische eingriffe
CA2559838A1 (en)	2004-03-17	2005-09-29	7Tm Pharma A/S	Y2 selective receptor agonists for therapeutic interventions
EP2256130B1 (de)	2005-02-02	2013-09-25	Novo Nordisk A/S	Neuartige Insulinderivate
JP5410020B2 (ja)	2005-02-02	2014-02-05	ノヴォノルディスクアー／エス	インスリン誘導体
US20090074882A1 (en)	2005-12-28	2009-03-19	Novo Nordisk A/S	Insulin compositions and method of making a composition
DE602007009496D1 (de)	2006-02-27	2010-11-11	Novo Nordisk As	Insulinderivate
EP2015770B1 (de) *	2006-05-09	2012-09-26	Novo Nordisk A/S	Insulinderivate
EP2049149B1 (de)	2006-07-31	2015-04-15	Novo Nordisk A/S	Pegylierte verlängerte insuline
EP2404934A1 (de)	2006-09-22	2012-01-11	Novo Nordisk A/S	Proteaseresistente Insulinanaloga
ES2563038T3 (es)	2007-04-30	2016-03-10	Novo Nordisk A/S	Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
WO2008152106A1 (en)	2007-06-13	2008-12-18	Novo Nordisk A/S	Pharmaceutical formulation comprising an insulin derivative
EP2058330A1 (de) *	2007-11-08	2009-05-13	Novo Nordisk A/S	Insulinderivat
WO2009060071A1 (en) *	2007-11-08	2009-05-14	Novo Nordisk A/S	Insulin derivative
ES2618073T3 (es) *	2008-03-14	2017-06-20	Novo Nordisk A/S	Análogos de insulina estabilizados frente a proteasas
MX2010009850A (es)	2008-03-18	2010-09-30	Novo Nordisk As	Analogos de insulina acilados y etabilizados contra proteasas.
CA2738615A1 (en)	2008-10-30	2010-05-06	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
KR20150002777A (ko)	2012-04-11	2015-01-07	노보 노르디스크 에이/에스	인슐린 제제
WO2014177623A1 (en)	2013-04-30	2014-11-06	Novo Nordisk A/S	Novel administration regime
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
MA49116A (fr)	2016-12-16	2020-03-25	Novo Nordisk As	Compositions pharmaceutiques contenant de l'insuline
TWI847306B (zh)	2017-08-24	2024-07-01	丹麥商諾佛儂迪克股份有限公司	Ｇｌｐ-１組成物及其用途
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
SG11202106168VA (en)	2018-12-11	2021-07-29	Sanofi Sa	Insulin analogs having reduced insulin receptor binding affinity
CN114096269B (zh)	2019-07-12	2024-06-11	诺和诺德股份有限公司	高浓度胰岛素制剂
BR112022013795A2 (pt)	2020-02-18	2022-09-13	Novo Nordisk As	Composição farmacêutica líquida, e, kit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK155690D0 (da) *	1990-06-28	1990-06-28	Novo Nordisk As	Nye peptider
SI0792290T1 (en) *	1993-09-17	2001-12-31	Novo Nordisk As	Acylated insulin

1996
- 1996-03-18 CA CA002215694A patent/CA2215694A1/en not_active Abandoned
- 1996-03-18 PL PL96322299A patent/PL183698B1/pl unknown
- 1996-03-18 BR BR9607647A patent/BR9607647A/pt not_active Application Discontinuation
- 1996-03-18 WO PCT/DK1996/000107 patent/WO1996029344A1/en not_active Ceased
- 1996-03-18 KR KR1019970706447A patent/KR19980703039A/ko not_active Ceased
- 1996-03-18 AT AT96905764T patent/ATE245659T1/de not_active IP Right Cessation
- 1996-03-18 DE DE69629210T patent/DE69629210T2/de not_active Expired - Lifetime
- 1996-03-18 CZ CZ19972899A patent/CZ289343B6/cs not_active IP Right Cessation
- 1996-03-18 EP EP96905764A patent/EP0871665B1/de not_active Expired - Lifetime
- 1996-03-18 AU AU49396/96A patent/AU720966B2/en not_active Ceased
- 1996-03-18 HU HU9800523A patent/HUP9800523A3/hu unknown
- 1996-03-18 JP JP52799596A patent/JP3872105B2/ja not_active Expired - Fee Related
- 1996-03-18 CN CN96193362A patent/CN1196061A/zh active Pending
1997
- 1997-09-16 NO NO974270A patent/NO974270L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR9607647A (pt)	1999-04-06
KR19980703039A (ko)	1998-09-05
NO974270D0 (no)	1997-09-16
AU4939696A (en)	1996-10-08
JPH11502110A (ja)	1999-02-23
EP0871665B1 (de)	2003-07-23
DE69629210D1 (de)	2003-08-28
WO1996029344A1 (en)	1996-09-26
CA2215694A1 (en)	1996-09-26
CN1196061A (zh)	1998-10-14
JP3872105B2 (ja)	2007-01-24
CZ289343B6 (cs)	2002-01-16
DE69629210T2 (de)	2004-04-22
PL183698B1 (pl)	2002-06-28
AU720966B2 (en)	2000-06-22
HUP9800523A2 (hu)	1998-06-29
HUP9800523A3 (en)	1998-09-28
MX9707056A (es)	1997-11-29
NO974270L (no)	1997-11-14
CZ289997A3 (cs)	1998-01-14
EP0871665A1 (de)	1998-10-21
PL322299A1 (en)	1998-01-19

Legal Events

Date	Code	Title	Description
2004-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69629210D1 (de)	2003-08-28	Insulinabkömmlinge
MXPA97007050A (es)	2004-08-23	Derivados de hormona pepticida lipofilica.
ES2169251T3 (es)	2002-07-01	Peptidos de somatostatina.
GB9108652D0 (en)	1991-06-12	Immunoreactive compounds
DE60045524D1 (de)	2011-02-24	Ein Huhn GnRH-II Analog zur Verwendung in der Reduktion des Tumorzellwachstums
NO912438D0 (no)	1991-06-21	Humaninsulinanaloger.
PL312989A1 (en)	1996-05-27	Therapeutic derivatives of peptides
DE59007517D1 (de)	1994-11-24	Neue proteine mit tnf-hemmender wirkung und ihre herstellung.
AU5963290A (en)	1991-01-17	Inhibition of the n-end rule pathway in living cells
ATE171712T1 (de)	1998-10-15	Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten
FI961044A0 (fi)	1996-03-06	Kininogeeni-inhibiittorit
IT1212508B (it)	1989-11-22	Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
ES2012720A6 (es)	1990-04-01	Procedimiento para la obtencion de sales de adicion de acido de taurina o glicina amidada.
ES2095255T3 (es)	1997-02-16	Analogos de sustitucion de peptidos magainina.
KR850001775A (ko)	1985-04-01	인슐린 유도체의 제조방법
ATE481420T1 (de)	2010-10-15	Il-21-derivate
ATE195147T1 (de)	2000-08-15	Aminosäuren konjugaten
DE69834929D1 (de)	2006-07-27	Verwendung eines organspezifischen ernährungmittels
ES2097368T3 (es)	1997-04-01	Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas terrestres.
EA200100314A1 (ru)	2001-10-22	Пептидные фрагменты холерного экзотоксина в или энтеротоксина в в качестве адъювантов вакцины
ES2054942T3 (es)	1994-08-16	Procedimiento para la determinacion de fructuosaminas.
AU1993201A (en)	2001-04-23	Nucleic acid sequences of hyperplasia and tumours of the thyroid
MX9205978A (es)	1993-04-01	Nuevas proteinas inhibidoras de trombina de garrapatas.
DK119391A (da)	1991-08-22	Humaninsulinanaloger