NO975664L - Imidazolderivater som er nyttige som syntesemellomprodukter - Google Patents

Imidazolderivater som er nyttige som syntesemellomprodukter

Info

Publication number
NO975664L
NO975664L NO975664A NO975664A NO975664L NO 975664 L NO975664 L NO 975664L NO 975664 A NO975664 A NO 975664A NO 975664 A NO975664 A NO 975664A NO 975664 L NO975664 L NO 975664L
Authority
NO
Norway
Prior art keywords
group
synthesis intermediates
imidazole derivatives
derivatives useful
hydrogen atom
Prior art date
Application number
NO975664A
Other languages
English (en)
Other versions
NO975664D0 (no
Inventor
Gilbert Lassalle
Thomas Purcell
Daniel Galtier
Paul Howard Williams
Frederic Galli
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO975664L publication Critical patent/NO975664L/no
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO975664D0 publication Critical patent/NO975664D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Forbindelse med formel (la) JCH.1. Ph-.C' (la) hvori R! representerer enten et hydrogenatom eller en (CL- C4) alkylgruppe, X representerer et svovelatom, et oksygenatom eller en metylengruppe , Zx representerer enten et hydrogenatom eller en 1,1- dimetyl-etylgruppe, Z2 representerer enten et hydrogenatom, en trif enylmetyl- gruppe eller en fenylmetoksykarbonylgruppe, og n =1 eller 2, eller et uorganisk eller organisk syreaddisjonssalt derav. Forbindelsene er anvendbare som syntese-mellomprodukter .
NO975664A 1992-03-30 1997-12-05 Imidazolderivater som er nyttige som syntesemellomprodukter NO975664D0 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203828A FR2689130B1 (fr) 1992-03-30 1992-03-30 Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
NO975664L true NO975664L (no) 1993-10-01
NO975664D0 NO975664D0 (no) 1997-12-05

Family

ID=9428242

Family Applications (2)

Application Number Title Priority Date Filing Date
NO931166A NO302572B1 (no) 1992-03-30 1993-03-29 Piperidinforbindelser, og farmasöytiske preparater inneholdende slike
NO975664A NO975664D0 (no) 1992-03-30 1997-12-05 Imidazolderivater som er nyttige som syntesemellomprodukter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO931166A NO302572B1 (no) 1992-03-30 1993-03-29 Piperidinforbindelser, og farmasöytiske preparater inneholdende slike

Country Status (21)

Country Link
US (1) US5453430A (no)
EP (2) EP0579277A1 (no)
JP (2) JP2550276B2 (no)
KR (1) KR930019664A (no)
CN (1) CN1076928A (no)
AT (1) ATE161839T1 (no)
AU (1) AU655876B2 (no)
CA (1) CA2092867A1 (no)
CZ (1) CZ52893A3 (no)
DE (1) DE69316068T2 (no)
FI (1) FI931413A7 (no)
FR (1) FR2689130B1 (no)
HU (1) HUT64758A (no)
IL (1) IL105028A0 (no)
MX (1) MX9301783A (no)
NO (2) NO302572B1 (no)
NZ (1) NZ247277A (no)
PL (1) PL298299A1 (no)
SK (1) SK26393A3 (no)
TW (1) TW234717B (no)
ZA (1) ZA932228B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
CA2122397A1 (en) * 1993-05-03 1994-11-04 Spencer D. Kimball Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors
FR2710061B1 (fr) * 1993-09-14 1995-12-29 Synthelabo Acides et chlorures d'acides 1,2,3, 4-tétrahydroquinoléine-8-sulfoniques, et leur utilisation comme intermédiaires de synthèse.
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2718442B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de 5-(1H-imidazol-4-yl)-1-oxopentylpipéridine, leur préparation et leur application en thérapeutique.
FR2718443B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de 1-[2-[[(3-méthyl-1, 2, 3, 4-tétrahydroquinoléin-8-yl)sulfonyl] amino]-1-oxo-5-(1H-imidazol-4-yl)pentyl]pipéridine, leur préparation et leur application en thérapeutique.
FR2718439B3 (fr) * 1994-04-12 1996-02-09 Synthelabo Dérivés de l'acide pipécolique, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2718444B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de (3-méthyl-1, 2, 3, 4-tétrahydroquinoléin-8-yl)sulfonyle, leur préparation et leur application en thérapeutique.
DE4424828A1 (de) * 1994-07-14 1996-01-18 Thomae Gmbh Dr K Neue substituierte Arylsulfonamide, ihre Herstellung und ihre Verwendung als Arzneimittel
FR2727413B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Derives de 5-(1h-imidazol-4-yl)-1-oxo-2-(phenylsulfonamino)- pentylpiperidine, leur preparation et leur application en therapeutique
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
GB9505538D0 (en) * 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
FR2747676B1 (fr) * 1996-04-22 1998-06-05 Synthelabo Derives de [1-oxo-2-(sulfonylamino)ethyl] piperidine, leur preparation et leur application en therapeutique
WO1997040052A1 (fr) * 1996-04-22 1997-10-30 Synthelabo Derives de propargylglycine, leur preparation et leur utilisation comme intermediaires de synthese
FR2747677B1 (fr) * 1996-04-22 1998-06-05 Synthelabo Derives de propargylglycine, leur preparation et leur utilisation comme intermediaires de synthese
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
FR2756285B1 (fr) * 1996-11-22 1998-12-18 Synthelabo Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
US5773089A (en) * 1996-12-18 1998-06-30 E. I. Du Pont De Nemours And Company Process for treating aramid surfaces to be plated
FR2765220B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 1-oxo-2-(phenylsulfonyl)aminopentyle, leur preparation et leur application en therapeutique
FR2771094B1 (fr) * 1997-11-19 2000-02-04 Synthelabo Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique
US20100048549A1 (en) * 2005-05-18 2010-02-25 Siegfried Wurster Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4
SG171722A1 (en) * 2008-12-22 2011-07-28 Pola Chem Ind Inc Melanin production inhibitor
CN101794567B (zh) * 2010-02-10 2014-01-01 中兴通讯股份有限公司 图片加载的方法及终端
CN104098647B (zh) * 2014-06-24 2017-12-08 安徽省逸欣铭医药科技有限公司 阿加曲班类似物及其制备方法和医药用途
CN118724766A (zh) * 2023-03-28 2024-10-01 南京华狮新材料有限公司 一种氨基酸衍生物及其制备方法和作为中间体合成l-草铵膦的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
EP0008596A1 (fr) * 1978-09-04 1980-03-19 DEVINTER Europe S.A. Société anonyme dite: Procédé de préparation de dérivés du type 4-hydroxyméthyl imidazole à partir d'esters d'acides 4-imidazole carboxyliques correspondants
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
DE3771376D1 (de) 1986-03-17 1991-08-22 Glaxo Group Ltd Indol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
FR2689130B1 (fr) 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
FI931413L (fi) 1993-10-01
ZA932228B (en) 1993-10-28
EP0565396B1 (fr) 1998-01-07
KR930019664A (ko) 1993-10-18
NO931166D0 (no) 1993-03-29
JPH0798807B2 (ja) 1995-10-25
CZ52893A3 (en) 1994-02-16
NZ247277A (en) 1995-07-26
DE69316068T2 (de) 1998-08-13
PL298299A1 (en) 1993-10-18
FI931413A0 (fi) 1993-03-29
AU3556093A (en) 1993-10-07
SK26393A3 (en) 1993-12-08
FR2689130B1 (fr) 1994-05-27
NO931166L (no) 1993-10-01
CA2092867A1 (fr) 1993-10-01
FR2689130A1 (fr) 1993-10-01
EP0579277A1 (fr) 1994-01-19
HUT64758A (en) 1994-02-28
CN1076928A (zh) 1993-10-06
MX9301783A (es) 1994-02-28
DE69316068D1 (de) 1998-02-12
NO302572B1 (no) 1998-03-23
NO975664D0 (no) 1997-12-05
ATE161839T1 (de) 1998-01-15
FI931413A7 (fi) 1993-10-01
TW234717B (en) 1994-11-21
JPH06157514A (ja) 1994-06-03
AU655876B2 (en) 1995-01-12
IL105028A0 (en) 1993-07-08
HU9300915D0 (en) 1993-06-28
EP0565396A1 (fr) 1993-10-13
JP2550276B2 (ja) 1996-11-06
JPH06199807A (ja) 1994-07-19
US5453430A (en) 1995-09-26

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