NO981503L - Anvendelsen av 2-amino-4-(4-fluorbenzylamino)-1-etoksy-karbonylaminobenzen for profylakse og behandling av f÷lgene av akutt og kronisk cerebral redusert gjennombl÷dning samt neurodegenerative sykdommer - Google Patents

Anvendelsen av 2-amino-4-(4-fluorbenzylamino)-1-etoksy-karbonylaminobenzen for profylakse og behandling av f÷lgene av akutt og kronisk cerebral redusert gjennombl÷dning samt neurodegenerative sykdommer

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Publication number
NO981503L
NO981503L NO981503A NO981503A NO981503L NO 981503 L NO981503 L NO 981503L NO 981503 A NO981503 A NO 981503A NO 981503 A NO981503 A NO 981503A NO 981503 L NO981503 L NO 981503L
Authority
NO
Norway
Prior art keywords
ethoxycarbonylaminobenzene
fluorobenzylamino
prophylaxis
consequences
acute
Prior art date
Application number
NO981503A
Other languages
English (en)
Other versions
NO316493B1 (no
NO981503D0 (no
Inventor
Angelika Rostock
Christine Tober
Chris Rundfeldt
Reni Bartsch
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of NO981503L publication Critical patent/NO981503L/no
Publication of NO981503D0 publication Critical patent/NO981503D0/no
Publication of NO316493B1 publication Critical patent/NO316493B1/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO981503A 1995-10-26 1998-04-02 Anvendelsen av 2-amino-4-(4-fluorbenzylamino)-1-etoksy-karbonylaminobenzen for profylakse og behandling av følgene av akutt og kronisk cerebral redusert gjennomblødning samt neurodegenerative sykdommer NO316493B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19539861A DE19539861A1 (de) 1995-10-26 1995-10-26 Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
PCT/DE1996/001951 WO1997015300A2 (de) 1995-10-26 1996-10-15 Verwendung von 4-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen zur prophylaxe und behandlung der folgen der akuten und chronischen zerebralen minderdurchblutung sowie neurodegenerativer erkrankungen

Publications (3)

Publication Number Publication Date
NO981503L true NO981503L (no) 1998-04-02
NO981503D0 NO981503D0 (no) 1998-04-02
NO316493B1 NO316493B1 (no) 2004-02-02

Family

ID=7775835

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981503A NO316493B1 (no) 1995-10-26 1998-04-02 Anvendelsen av 2-amino-4-(4-fluorbenzylamino)-1-etoksy-karbonylaminobenzen for profylakse og behandling av følgene av akutt og kronisk cerebral redusert gjennomblødning samt neurodegenerative sykdommer

Country Status (26)

Country Link
US (2) US5852053A (no)
EP (1) EP0857065B1 (no)
JP (2) JP4567101B2 (no)
KR (1) KR100423823B1 (no)
AR (1) AR004108A1 (no)
AT (1) ATE178487T1 (no)
AU (1) AU706735B2 (no)
BR (1) BR9610899A (no)
CA (1) CA2188841C (no)
CZ (1) CZ291456B6 (no)
DE (2) DE19539861A1 (no)
DK (1) DK0857065T3 (no)
ES (1) ES2131973T3 (no)
GR (1) GR3030336T3 (no)
HU (1) HU228014B1 (no)
ID (1) ID16489A (no)
IL (1) IL123523A (no)
NO (1) NO316493B1 (no)
NZ (1) NZ326754A (no)
PL (1) PL185714B1 (no)
RU (1) RU2201227C2 (no)
SK (1) SK283222B6 (no)
TW (1) TW457084B (no)
UA (1) UA51681C2 (no)
WO (1) WO1997015300A2 (no)
ZA (1) ZA968991B (no)

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DE19539861A1 (de) * 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
GB9915414D0 (en) * 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
US6472165B1 (en) * 1999-08-03 2002-10-29 Arzneimittelwerk Dresden Gmbh Modulatory binding site in potassium channels for screening and finding new active ingredients
US6117900A (en) * 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
TWI287984B (en) 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
AR033095A1 (es) * 2001-04-04 2003-12-03 Wyeth Corp Metodos para el tratamiento de motilidad gastrica hiperactiva
US7205307B2 (en) * 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
SI1578740T1 (sl) * 2002-12-27 2007-08-31 Lundbeck & Co As H Derivati 1,2,4-triaminobenzena, uporabni pri zdravljenju motenj osrednjega ĺ˝iväśnega sistema
WO2004058739A1 (en) * 2002-12-27 2004-07-15 H. Lundbeck A/S 1,2,4-triaminobenzene derivatives useful for treating disorders of the central nervous system
AU2004233941A1 (en) * 2003-04-25 2004-11-11 H. Lundbeck A/S Sustituted indoline and indole derivatives
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
TWI349666B (en) 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
CA2599890C (en) 2005-03-03 2011-05-03 H. Lundbeck A/S Substituted pyridine derivatives
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
BRPI0716715B1 (pt) * 2006-08-23 2021-07-06 Xenon Pharmaceuticals, Inc Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
US8030518B2 (en) * 2006-11-28 2011-10-04 Valeant Pharmaceuticals International 1,4 diamino bicyclic retigabine analogues as potassium channel modulators
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
AU2009270768A1 (en) * 2008-07-18 2010-01-21 Valeant Pharmaceuticals International Modified release formulation and methods of use
US20100323016A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
US20100323015A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
WO2013011518A1 (en) 2011-07-21 2013-01-24 Arch Pharmalabs Limited Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
CN103073455B (zh) * 2011-10-25 2015-08-19 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CA2881464C (en) 2012-08-07 2021-12-21 Children's Medical Center Corporation Potassium channel openers for treating neurodegenerative diseases
CN105017085B (zh) * 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
CN114667146A (zh) 2019-11-08 2022-06-24 泽农医药公司 治疗抑郁症的方法
PE20231815A1 (es) 2021-02-09 2023-11-16 Xenon Pharmaceuticals Inc Abridor de canales de potasio controlado por voltaje para uso en el tratamiento de la anhedonia

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JP2817334B2 (ja) * 1990-03-29 1998-10-30 株式会社ツムラ 神経細胞保護剤
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
TW280819B (no) * 1993-11-17 1996-07-11 Sumitomo Pharma
DE19539861A1 (de) * 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen

Also Published As

Publication number Publication date
KR100423823B1 (ko) 2004-08-25
ATE178487T1 (de) 1999-04-15
GR3030336T3 (en) 1999-09-30
WO1997015300A2 (de) 1997-05-01
CZ122598A3 (cs) 1998-09-16
HUP9900508A3 (en) 1999-11-29
NO316493B1 (no) 2004-02-02
AU706735B2 (en) 1999-06-24
HUP9900508A2 (hu) 1999-06-28
AR004108A1 (es) 1998-09-30
JPH11515007A (ja) 1999-12-21
PL185714B1 (pl) 2003-07-31
KR19990067021A (ko) 1999-08-16
NZ326754A (en) 2000-03-27
CA2188841A1 (en) 1997-04-27
SK283222B6 (sk) 2003-03-04
JP4567101B2 (ja) 2010-10-20
SK52098A3 (en) 1998-09-09
ID16489A (id) 1997-10-02
PL325956A1 (en) 1998-08-17
EP0857065A2 (de) 1998-08-12
US5852053A (en) 1998-12-22
ZA968991B (en) 1997-06-10
IL123523A0 (en) 1998-10-30
HU228014B1 (en) 2012-08-28
IL123523A (en) 2001-12-23
CZ291456B6 (cs) 2003-03-12
CA2188841C (en) 2006-05-23
TW457084B (en) 2001-10-01
MX9803172A (es) 1998-09-30
NO981503D0 (no) 1998-04-02
DK0857065T3 (da) 1999-10-18
BR9610899A (pt) 1999-07-13
AU1540097A (en) 1997-05-15
UA51681C2 (uk) 2002-12-16
WO1997015300A3 (de) 1997-07-03
US5849789A (en) 1998-12-15
DE19539861A1 (de) 1997-04-30
JP2009007366A (ja) 2009-01-15
ES2131973T3 (es) 1999-08-01
DE59601624D1 (de) 1999-05-12
EP0857065B1 (de) 1999-04-07
RU2201227C2 (ru) 2003-03-27

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