NO982473L - 5'-Deoksy-cytidin derivater - Google Patents

5'-Deoksy-cytidin derivater

Info

Publication number
NO982473L
NO982473L NO982473A NO982473A NO982473L NO 982473 L NO982473 L NO 982473L NO 982473 A NO982473 A NO 982473A NO 982473 A NO982473 A NO 982473A NO 982473 L NO982473 L NO 982473L
Authority
NO
Norway
Prior art keywords
deoxy
cytidine derivatives
cytidine
derivatives
Prior art date
Application number
NO982473A
Other languages
English (en)
Other versions
NO316609B1 (no
NO982473D0 (no
Inventor
Kazuo Hattori
Tohru Ishikawa
Hideo Ishitsuka
Yasunori Kohchi
Nobuhiro Oikawa
Nobuo Shimma
Hitomi Suda
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO982473D0 publication Critical patent/NO982473D0/no
Publication of NO982473L publication Critical patent/NO982473L/no
Publication of NO316609B1 publication Critical patent/NO316609B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO982473A 1997-06-02 1998-05-29 5'-Deoksy-cytidinderivater, anvendelse og fremstilling derav, samt farmasøytisk preparat og sett NO316609B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97108791 1997-06-02

Publications (3)

Publication Number Publication Date
NO982473D0 NO982473D0 (no) 1998-05-29
NO982473L true NO982473L (no) 1998-12-03
NO316609B1 NO316609B1 (no) 2004-03-08

Family

ID=8226859

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982473A NO316609B1 (no) 1997-06-02 1998-05-29 5'-Deoksy-cytidinderivater, anvendelse og fremstilling derav, samt farmasøytisk preparat og sett

Country Status (33)

Country Link
US (2) US6114520A (no)
JP (1) JP3081185B2 (no)
KR (1) KR100312899B1 (no)
CN (1) CN1197871C (no)
AR (1) AR012878A1 (no)
AT (1) ATE440854T1 (no)
AU (1) AU746170B2 (no)
BR (1) BR9801744A (no)
CA (1) CA2237368C (no)
CO (1) CO4940436A1 (no)
CZ (1) CZ295706B6 (no)
DE (2) DE69841086D1 (no)
ES (2) ES2329428T3 (no)
FR (1) FR2763953B1 (no)
GB (1) GB2325931B (no)
HR (1) HRP980290A2 (no)
HU (1) HU227852B1 (no)
ID (1) ID19801A (no)
IL (1) IL124661A0 (no)
IT (1) ITMI981196A1 (no)
MA (1) MA26503A1 (no)
MY (1) MY128985A (no)
NO (1) NO316609B1 (no)
NZ (1) NZ330360A (no)
PE (1) PE79599A1 (no)
PL (1) PL192832B1 (no)
RS (1) RS50010B (no)
RU (1) RU2238278C2 (no)
SA (1) SA98190103B1 (no)
SG (1) SG66466A1 (no)
TR (1) TR199800988A3 (no)
TW (1) TW584636B (no)
ZA (1) ZA984478B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
ATE277064T1 (de) * 1999-05-26 2004-10-15 Hoffmann La Roche Verfahren zur herstellung von vinylpyrimidinderivaten
US6906182B2 (en) 2000-12-01 2005-06-14 Cell Works Therapeutics, Inc. Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
NZ555176A (en) * 2004-12-03 2010-03-26 Adherex Technologies Inc Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
ATE525386T1 (de) * 2006-07-24 2011-10-15 Taiho Pharmaceutical Co Ltd 3'-ethynylcytidinderivat
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
KR101013312B1 (ko) * 2007-11-19 2011-02-09 한미홀딩스 주식회사 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009114814A2 (en) * 2008-03-14 2009-09-17 Retrotope, Inc. Therapeutic substances that modulate genome methylation
WO2010063080A1 (en) 2008-12-05 2010-06-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CA2777546C (en) * 2009-10-14 2019-11-05 Elion Oncology Llc Treating neurotoxicity associated with combinations of 5-fu or its prodrugs and dpd inhibitors
CN104926890B (zh) * 2015-06-04 2018-04-03 新乡学院 一种1,2‑o‑二乙酰基‑3,5‑o‑二苯甲酰基核糖的合成方法
PE20210367A1 (es) 2018-02-02 2021-02-26 Maverix Oncology Inc Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726278B2 (no) * 1973-03-13 1982-06-03
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
JPS5677226A (en) * 1979-11-27 1981-06-25 Taiho Yakuhin Kogyo Kk Antitumorigenic agent
EP0160079B1 (en) * 1983-10-26 1990-01-31 GREER, Sheldon B. Method and materials for sensitizing neoplastic tissue to radiation
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
WO1992021345A1 (en) * 1991-05-27 1992-12-10 Taiho Pharmaceutical Co., Ltd. Composition, method and kit for potentiating antitumor activity and for curing tumor
DE4123520A1 (de) * 1991-07-16 1993-01-21 Inst Molekularbiologie Ak Mittel zur regeneration des blutbildes durch foerderung der leukozytenproliferation
TW254946B (no) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
WO1994026761A1 (en) * 1993-05-14 1994-11-24 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
EP0719271B1 (en) * 1993-09-14 1997-11-26 Merrell Pharmaceuticals Inc. 5-(1-fluoro-vinyl)-1h-pyrimidine-2,4-dione derivatives useful as antineoplastic agents
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
WO1996037214A2 (en) * 1995-05-26 1996-11-28 F. Hoffmann-La Roche Ag Compositions of interleukin and pyrimidine nucleosides

Also Published As

Publication number Publication date
RU2238278C2 (ru) 2004-10-20
ID19801A (id) 1998-08-06
FR2763953B1 (fr) 2005-01-07
JP3081185B2 (ja) 2000-08-28
ZA984478B (en) 1998-12-02
HU227852B1 (en) 2012-05-02
ITMI981196A1 (it) 1999-11-29
TR199800988A2 (xx) 1998-12-21
HRP980290A2 (en) 1999-04-30
KR19990006547A (ko) 1999-01-25
PL192832B1 (pl) 2006-12-29
BR9801744A (pt) 2000-03-21
AR012878A1 (es) 2000-11-22
FR2763953A1 (fr) 1998-12-04
NO316609B1 (no) 2004-03-08
GB9811762D0 (en) 1998-07-29
PE79599A1 (es) 1999-08-25
CZ167598A3 (cs) 1998-12-16
NO982473D0 (no) 1998-05-29
AU6798598A (en) 1998-12-03
ES2142763B1 (es) 2001-04-01
HU9801256D0 (en) 1998-07-28
RS50010B (sr) 2008-09-29
AU746170B2 (en) 2002-04-18
MA26503A1 (fr) 2004-12-20
US6114520A (en) 2000-09-05
KR100312899B1 (ko) 2002-03-08
GB2325931B (en) 2001-07-25
CN1197871C (zh) 2005-04-20
TR199800988A3 (tr) 1998-12-21
DE19823484A1 (de) 1998-12-03
DE69841086D1 (de) 2009-10-08
JPH10330395A (ja) 1998-12-15
CO4940436A1 (es) 2000-07-24
NZ330360A (en) 1999-03-29
ATE440854T1 (de) 2009-09-15
US6211166B1 (en) 2001-04-03
ES2329428T3 (es) 2009-11-25
CN1201037A (zh) 1998-12-09
SG66466A1 (en) 1999-07-20
CA2237368A1 (en) 1998-12-02
HUP9801256A3 (en) 2004-03-01
CZ295706B6 (cs) 2005-10-12
HUP9801256A2 (hu) 1999-05-28
YU22598A (sh) 2001-12-26
MY128985A (en) 2007-03-30
GB2325931A (en) 1998-12-09
IL124661A0 (en) 1998-12-06
CA2237368C (en) 2009-03-03
SA98190103B1 (ar) 2006-04-18
ES2142763A1 (es) 2000-04-16
TW584636B (en) 2004-04-21
PL326604A1 (en) 1998-12-07

Similar Documents

Publication Publication Date Title
PT988310E (pt) Derivados 4"-substituido-9-desoxo-9a-aza-9a-homoeritromicina a
PT919655E (pt) Malha tricotada de "schuss" modificado
NO983169L (no) Hetrosykel-kondenserte morfinoidderivater (31)
DK1000048T3 (da) Substituerede 1,2,3,4-tetrahydronapthalenderivater
NO996108D0 (no) 9-oksinerytromycinderivater
DK0966477T3 (da) 3'-N-oxid, 3'-N-dimethylamin, 9-oxim-erythromycin A-derivater
NO982473L (no) 5'-Deoksy-cytidin derivater
PT921125E (pt) Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
FI970081L (fi) Dinukleosidi-5',5'-pyrofosfaatit
EP1046648A4 (en) 3'-deoxyribonucleotide DERIVATIVES
PT1060183E (pt) Derivados de 5'-desoxicitidina
BR9709521A (pt) "3-Cianoaril-pirazóis"
DE69828937D1 (de) Piece d' interposition
DK1077984T3 (da) 2'-Deoxyhygromycin derivater
MA26481A1 (fr) Derives d'arylsecocholadiene
FR2758444B1 (fr) Boucles d'oreille
NO996127D0 (no) 13-dihydro-3'-aziridino-antracykliner
ITCS970006V0 (it) "1 m"
NO972978D0 (no) Tomrock 5000
BR9606017A (pt) "Enrotrilan"
UA1894S (uk) З'єднувальна колодка
SE9700389D0 (sv) Vattenpipa "Karlsborgspipan"
ES1038172Y (es) "caja-contenedor".
UA25661A (uk) Hастояhка гірка "клюква"
FI980765A0 (fi) Tillrinningsvask "skyddssystem"

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees