PT906262E - Compostos com o esqueleto da colchicina, sua utilizacao como medicamentos e composicoes que os contem - Google Patents

Compostos com o esqueleto da colchicina, sua utilizacao como medicamentos e composicoes que os contem

Info

Publication number: PT906262E
Authority: PT; Portugal
Prior art keywords: pct; colchicine; medicines; compositions; contain
Prior art date: 1996-06-07

Application number

PT97924965T

Other languages

English (en)

Inventor

Ezio Bompardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-07

Filing date

1997-05-21

Publication date

2002-11-29

1997-05-21 Application filed by Indena Spa filed Critical Indena Spa

2002-11-29 Publication of PT906262E publication Critical patent/PT906262E/pt

Links

IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical group C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 3
239000003814 drug Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
238000007306 functionalization reaction Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000002634 anti-blastic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229960001338 colchicine Drugs 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT97924965T 1996-06-07 1997-05-21 Compostos com o esqueleto da colchicina, sua utilizacao como medicamentos e composicoes que os contem PT906262E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT96MI001168A IT1283110B1 (it)	1996-06-07	1996-06-07	Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono

Publications (1)

Publication Number	Publication Date
PT906262E true PT906262E (pt)	2002-11-29

Family

ID=11374396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97924965T PT906262E (pt)	1996-06-07	1997-05-21	Compostos com o esqueleto da colchicina, sua utilizacao como medicamentos e composicoes que os contem

Country Status (19)

Country	Link
US (1)	US6080739A (pt)
EP (1)	EP0906262B1 (pt)
JP (1)	JP3285361B2 (pt)
KR (1)	KR100306430B1 (pt)
CN (1)	CN1122657C (pt)
AT (1)	ATE222228T1 (pt)
AU (1)	AU723752B2 (pt)
CZ (1)	CZ294365B6 (pt)
DE (1)	DE69714735T2 (pt)
DK (1)	DK0906262T3 (pt)
ES (1)	ES2182084T3 (pt)
HU (1)	HUP0001827A3 (pt)
IT (1)	IT1283110B1 (pt)
NO (1)	NO311252B1 (pt)
PL (1)	PL187528B1 (pt)
PT (1)	PT906262E (pt)
RU (1)	RU2181354C2 (pt)
SK (2)	SK283736B6 (pt)
WO (1)	WO1997047577A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9714249D0 (en) *	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
FR2774290B1 (fr) *	1998-02-05	2000-06-16	Synthelabo	Composition pharmaceutique pour l'administration par voie nasale de thiocolchicoside
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
IT1318401B1 (it)	2000-03-17	2003-08-25	Indena Spa	Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
US6720323B2 (en)	2000-07-07	2004-04-13	Angiogene Pharmaceuticals Limited	Colchinol derivatives as angiogenesis inhibitors
US6825236B2 (en)	2003-04-14	2004-11-30	California Pacific Medical Center	Colchicine derivatives
ITMI20040164A1 (it) *	2004-02-03	2004-05-03	Indena Spa	Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
DE502004011941D1 (de) *	2004-12-22	2011-01-05	Mestex Ag	Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels
ITRM20070088A1 (it)	2007-02-19	2008-08-20	Francesco Fringuelli	Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico.
US20110178180A1 (en) *	2010-01-18	2011-07-21	Kurt Nielsen	Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
EP2562156B1 (en) *	2010-02-18	2018-11-07	The Asan Foundation	Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives
KR101130754B1 (ko)	2010-06-25	2012-03-28	제일약품주식회사	난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL279678A (pt) *	1961-06-14
FR3032M (fr) *	1963-06-19	1964-12-28	Roussel Uclaf	Nouveaux médicaments doués notamment d'activité antimitotique.
US3442953A (en) *	1963-06-19	1969-05-06	Roussel Uclaf	Novel 7-oxo-7-desacetylaminocolchicine compounds
US4349548A (en) *	1981-11-20	1982-09-14	Merck & Co., Inc.	Octahydrobenzo[6,7]cyclohept[1,2-b]-1,4-oxazines, compositions and use

1996
- 1996-06-07 IT IT96MI001168A patent/IT1283110B1/it active IP Right Grant
1997
- 1997-05-21 HU HU0001827A patent/HUP0001827A3/hu unknown
- 1997-05-21 WO PCT/EP1997/002577 patent/WO1997047577A1/en not_active Ceased
- 1997-05-21 KR KR1019980709961A patent/KR100306430B1/ko not_active Expired - Fee Related
- 1997-05-21 SK SK1679-98A patent/SK283736B6/sk not_active IP Right Cessation
- 1997-05-21 CN CN97194988A patent/CN1122657C/zh not_active Expired - Fee Related
- 1997-05-21 SK SK41-2003A patent/SK283737B6/sk not_active IP Right Cessation
- 1997-05-21 DK DK97924965T patent/DK0906262T3/da active
- 1997-05-21 AU AU30278/97A patent/AU723752B2/en not_active Ceased
- 1997-05-21 AT AT97924965T patent/ATE222228T1/de not_active IP Right Cessation
- 1997-05-21 US US09/180,875 patent/US6080739A/en not_active Expired - Fee Related
- 1997-05-21 ES ES97924965T patent/ES2182084T3/es not_active Expired - Lifetime
- 1997-05-21 EP EP97924965A patent/EP0906262B1/en not_active Expired - Lifetime
- 1997-05-21 RU RU99100326/04A patent/RU2181354C2/ru not_active IP Right Cessation
- 1997-05-21 PT PT97924965T patent/PT906262E/pt unknown
- 1997-05-21 PL PL97330284A patent/PL187528B1/pl not_active IP Right Cessation
- 1997-05-21 CZ CZ19984010A patent/CZ294365B6/cs not_active IP Right Cessation
- 1997-05-21 JP JP50110898A patent/JP3285361B2/ja not_active Expired - Fee Related
- 1997-05-21 DE DE69714735T patent/DE69714735T2/de not_active Expired - Lifetime
1998
- 1998-12-04 NO NO19985676A patent/NO311252B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6080739A (en)	2000-06-27
AU723752B2 (en)	2000-09-07
KR100306430B1 (ko)	2001-11-30
EP0906262A1 (en)	1999-04-07
CN1122657C (zh)	2003-10-01
NO311252B1 (no)	2001-11-05
JP2000503669A (ja)	2000-03-28
KR20000016387A (ko)	2000-03-25
DE69714735D1 (de)	2002-09-19
DK0906262T3 (da)	2002-12-16
AU3027897A (en)	1998-01-07
IT1283110B1 (it)	1998-04-07
SK167998A3 (en)	1999-07-12
CZ294365B6 (cs)	2004-12-15
HK1019587A1 (en)	2000-02-18
HUP0001827A2 (hu)	2001-05-28
PL330284A1 (en)	1999-05-10
SK283737B6 (sk)	2003-12-02
CZ401098A3 (cs)	1999-05-12
SK283736B6 (sk)	2003-12-02
DE69714735T2 (de)	2003-04-24
EP0906262B1 (en)	2002-08-14
ES2182084T3 (es)	2003-03-01
ITMI961168A0 (it)	1996-06-07
ITMI961168A1 (it)	1997-12-07
JP3285361B2 (ja)	2002-05-27
RU2181354C2 (ru)	2002-04-20
WO1997047577A1 (en)	1997-12-18
PL187528B1 (pl)	2004-07-30
NO985676L (no)	1998-12-04
CN1219924A (zh)	1999-06-16
ATE222228T1 (de)	2002-08-15
NO985676D0 (no)	1998-12-04
HUP0001827A3 (en)	2001-07-30

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