NO990497L - Modifiserte oligosakkarider - Google Patents

Modifiserte oligosakkarider

Info

Publication number: NO990497L
Authority: NO; Norway
Prior art keywords: modified oligosaccharides; natural; oligosaccharides; modified; sialyl
Prior art date: 1996-08-08

Application number

NO990497A

Other languages

English (en)

Norwegian (no)

Other versions

NO990497D0 (no

Inventor

Gebhard Thoma

Rolf Bonteli

Willy Kinzy

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-08

Filing date

1999-02-03

Publication date

1999-03-24

1999-02-03 Application filed by Novartis Ag filed Critical Novartis Ag

1999-02-03 Publication of NO990497D0 publication Critical patent/NO990497D0/no

1999-03-24 Publication of NO990497L publication Critical patent/NO990497L/no

Links

229920001542 oligosaccharide Polymers 0.000 title 1
150000002482 oligosaccharides Chemical class 0.000 title 1
OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
XBSNXOHQOTUENA-KRAHZTDDSA-N alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)C(O)O[C@@H]1CO XBSNXOHQOTUENA-KRAHZTDDSA-N 0.000 abstract 1
NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical class O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
229950006780 n-acetylglucosamine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO990497A 1996-08-08 1999-02-03 Modifiserte oligosakkarider NO990497L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP96810527		1996-08-08
EP96810526		1996-08-08
EP96810636		1996-09-26
PCT/EP1997/004279 WO1998006730A1 (en)	1996-08-08	1997-08-06	Modified oligosaccharides

Publications (2)

Publication Number	Publication Date
NO990497D0 NO990497D0 (no)	1999-02-03
NO990497L true NO990497L (no)	1999-03-24

Family

ID=27237868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO990497A NO990497L (no)	1996-08-08	1999-02-03	Modifiserte oligosakkarider

Country Status (19)

Country	Link
EP (1)	EP0920437A1 (id)
JP (1)	JP2000516224A (id)
KR (1)	KR20000029862A (id)
CN (1)	CN1227563A (id)
AR (1)	AR008283A1 (id)
AU (1)	AU720381B2 (id)
BR (1)	BR9711117A (id)
CA (1)	CA2260854A1 (id)
CO (1)	CO4900075A1 (id)
CZ (1)	CZ39099A3 (id)
ID (1)	ID18010A (id)
IL (1)	IL127908A0 (id)
NO (1)	NO990497L (id)
NZ (1)	NZ334048A (id)
PE (1)	PE99298A1 (id)
PL (1)	PL331286A1 (id)
SK (1)	SK15699A3 (id)
TR (1)	TR199900245T2 (id)
WO (1)	WO1998006730A1 (id)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5888984A (en) *	1994-05-12	1999-03-30	Dermal Research Laboratories, Inc.	Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
EP1165097B1 (en)	1999-02-01	2007-05-02	Dermal Research Laboratories, Inc.	A pharmaceutical composition of complex carbohydrates and their use
US7879824B2 (en)	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
AU2003245595A1 (en) *	2002-07-03	2004-01-23	Glycomimetics, Inc.	Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
ATE444301T1 (de)	2002-10-11	2009-10-15	Astellas Pharma Europ B V	Verbindungen auf glukosebasis mit affinitüt für p-selektin
CA2546784A1 (en) *	2003-11-19	2005-06-16	Glycomimetics, Inc.	Glycomimetic antagonists for both e- and p-selectins
DE602004011272T2 (de)	2003-11-19	2008-12-24	Glycomimetics, Inc.	Spezifischer antagonist sowohl für e- als auch p-selektine
US20090036386A1 (en) *	2005-05-25	2009-02-05	Glycomimetics, Inc	Heterobifunctional compounds for selectin inhibition
WO2007021721A2 (en)	2005-08-09	2007-02-22	Glycomimetics, Inc.	Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
SI2264043T1 (en)	2005-09-02	2018-01-31	Glycomimetics, Inc.	HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
WO2008100453A1 (en) *	2007-02-09	2008-08-21	Glycomimetics, Inc.	Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
AU2008336249B2 (en)	2007-12-10	2015-01-29	The University Of Queensland	Treatment and prophylaxis
US8895510B2 (en)	2008-04-08	2014-11-25	Glycomimetics, Inc.	Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en)	2010-09-14	2014-12-30	Glycomimetics, Inc.	E-selectin antagonists
EP2794626B3 (en)	2011-12-22	2020-08-05	GlycoMimetics, Inc.	E-selectin antagonist compounds
HUE038423T2 (hu)	2012-12-07	2018-10-29	Glycomimetics Inc	E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh)	2014-12-03	2020-10-23	糖模拟物有限公司	E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
WO2017127422A1 (en)	2016-01-22	2017-07-27	Glycomimetics, Inc.	Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en)	2016-03-02	2022-04-05	Glycomimetics, Inc	Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en)	2016-08-08	2022-09-06	Glycomimetics, Inc.	Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt)	2016-10-07	2019-07-02	Glycomimetics Inc	antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en)	2017-03-15	2018-09-20	Glycomimetics, Inc.	Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en)	2017-11-30	2020-10-07	GlycoMimetics, Inc.	Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en)	2017-12-29	2023-01-10	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3
CN108299525B (zh) *	2018-01-05	2021-03-26	佛山科学技术学院	路易斯寡糖-x的合成方法
AU2019230013A1 (en)	2018-03-05	2020-09-10	Glycomimetics, Inc.	Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en)	2018-12-27	2023-12-19	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3
CN109762032A (zh) *	2019-01-16	2019-05-17	天津科技大学	一种磺酸化路易斯x三糖及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993023031A1 (en) *	1992-05-08	1993-11-25	The Biomembrane Institute	Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
US5763413A (en) *	1993-03-04	1998-06-09	Mect Corporation	Lewis-associated compound, process for producing the same, and anti-inflammatory
CN1125449A (zh) *	1993-05-14	1996-06-26	萨依特尔有限公司	作为细胞粘附抑制剂的唾液基Lex类似物
EP0801071A4 (en) *	1994-12-28	1999-01-13	Sumitomo Pharma	LEWIS DERIVATIVE X AND PRODUCTION METHOD THEREOF

1997
- 1997-08-06 CA CA002260854A patent/CA2260854A1/en not_active Abandoned
- 1997-08-06 SK SK156-99A patent/SK15699A3/sk unknown
- 1997-08-06 JP JP10509358A patent/JP2000516224A/ja active Pending
- 1997-08-06 CZ CZ99390A patent/CZ39099A3/cs unknown
- 1997-08-06 BR BR9711117-1A patent/BR9711117A/pt not_active Application Discontinuation
- 1997-08-06 WO PCT/EP1997/004279 patent/WO1998006730A1/en not_active Ceased
- 1997-08-06 AR ARP970103580A patent/AR008283A1/es unknown
- 1997-08-06 PL PL97331286A patent/PL331286A1/xx unknown
- 1997-08-06 IL IL12790897A patent/IL127908A0/xx unknown
- 1997-08-06 EP EP97941916A patent/EP0920437A1/en not_active Withdrawn
- 1997-08-06 AU AU43788/97A patent/AU720381B2/en not_active Ceased
- 1997-08-06 KR KR1019997001025A patent/KR20000029862A/ko not_active Withdrawn
- 1997-08-06 NZ NZ334048A patent/NZ334048A/xx unknown
- 1997-08-06 TR TR1999/00245T patent/TR199900245T2/xx unknown
- 1997-08-06 CN CN97197077A patent/CN1227563A/zh active Pending
- 1997-08-07 PE PE1997000688A patent/PE99298A1/es not_active Application Discontinuation
- 1997-08-08 ID IDP972766A patent/ID18010A/id unknown
- 1997-08-08 CO CO97045596A patent/CO4900075A1/es unknown
1999
- 1999-02-03 NO NO990497A patent/NO990497L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0920437A1 (en)	1999-06-09
BR9711117A (pt)	1999-09-08
PL331286A1 (en)	1999-07-05
PE99298A1 (es)	1999-01-21
AU4378897A (en)	1998-03-06
TR199900245T2 (xx)	1999-05-21
SK15699A3 (en)	1999-07-12
KR20000029862A (ko)	2000-05-25
WO1998006730A1 (en)	1998-02-19
JP2000516224A (ja)	2000-12-05
AU720381B2 (en)	2000-06-01
ID18010A (id)	1998-02-19
NO990497D0 (no)	1999-02-03
CO4900075A1 (es)	2000-03-27
CZ39099A3 (cs)	1999-05-12
NZ334048A (en)	2000-05-26
IL127908A0 (en)	1999-11-30
AR008283A1 (es)	1999-12-29
CN1227563A (zh)	1999-09-01
CA2260854A1 (en)	1998-02-19

Legal Events

Date	Code	Title	Description
2002-05-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
BR9711117A (pt)	1999-09-08	Oligossacarídios modificados.
HU9300486D0 (en)	1993-05-28	Hydroxi-urea derivatives
AU660282B2 (en)	1995-06-22	Water insoluble derivatives of hyaluronic acid
TW325547B (en)	1998-01-21	Modular bus with single or double parallel termination
AU5062199A (en)	2000-02-14	Suppository formulations comprising anionic polysaccharide
NZ332345A (en)	2000-03-27	Thermostable xylanases isolated from Microtetraspora
MX9709146A (es)	1998-03-31	Compuestos novedosos, preparacion y uso de los mismos.
HUP9802337A3 (en)	1999-03-29	Process for activating polysaccharides, polysaccharides produced by this process, and use thereof
BG101966A (en)	1998-09-30	Application of 1l-agonist for the treatment of lack of urine retention
MY120511A (en)	2005-11-30	New pesticides
AU1121700A (en)	2000-05-08	Generating a nonlinear model and generating drive signals for simulation testingusing the same
DE69737496D1 (de)	2007-05-03	SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGE
NO975557L (no)	1998-02-05	Immortalisering og dissimortalisering av celler
NO931297D0 (no)	1993-04-05	Alginat-oligosakkarid, og framgangsmaate for framstilling av samme
IT9022341A0 (it)	1990-12-11	Estratti da tessuti animali, utili in terapia e in diagnostica.
ES2186807T3 (es)	2003-05-16	Inhibidores de trombina.
TR200001745T2 (tr)	2000-09-21	Keton peroksit türevleri, bunların hazırlanması ve kullanılması
BR9813465A (pt)	2002-01-22	Polissacarìdeos modificados que exibem reconhecimento biológico alterado
EP1143917A3 (en)	2002-01-02	Anticonvulsant derivatives useful in treating post traumatic stress disorder
EP0820278A4 (en)	2004-06-09	NON-IMMUNOGENIC BIOCOMPATIBLE MACROMOLECULAR MENBRANE COMPOSITIONS AND METHOD FOR THE PRODUCTION AND USE THEREOF
AU2895797A (en)	1998-01-05	Carbohydrate derivatives and their solid-phase synthesis
MX9603087A (es)	1997-01-31	Procedimiento para la obtencion de aminocarboniltriazolinonas substituidas.
MX9804068A (es)	1998-09-30	Nuevos derivados de quinoxalindiona, su preparacion y empleo en medicamentos.
ECSP972214A (es)	1998-11-30	Oligosacaridos modificados
FR2720751B1 (fr)	1996-07-19	Copolymère polyoléfinique greffe.