NO990497L - Modifiserte oligosakkarider - Google Patents

Modifiserte oligosakkarider

Info

Publication number: NO990497L
Authority: NO; Norway
Prior art keywords: modified oligosaccharides; natural; oligosaccharides; modified; sialyl
Prior art date: 1996-08-08

Application number

NO990497A

Other languages

English (en)

Norwegian (no)

Other versions

NO990497D0 (no

Inventor

Gebhard Thoma

Rolf Bonteli

Willy Kinzy

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-08

Filing date

1999-02-03

Publication date

1999-03-24

1999-02-03 Application filed by Novartis Ag filed Critical Novartis Ag

1999-02-03 Publication of NO990497D0 publication Critical patent/NO990497D0/no

1999-03-24 Publication of NO990497L publication Critical patent/NO990497L/no

Links

229920001542 oligosaccharide Polymers 0.000 title 1
150000002482 oligosaccharides Chemical class 0.000 title 1
OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
XBSNXOHQOTUENA-KRAHZTDDSA-N alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)C(O)O[C@@H]1CO XBSNXOHQOTUENA-KRAHZTDDSA-N 0.000 abstract 1
NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical class O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
229950006780 n-acetylglucosamine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO990497A 1996-08-08 1999-02-03 Modifiserte oligosakkarider NO990497L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP96810526		1996-08-08
EP96810527		1996-08-08
EP96810636		1996-09-26
PCT/EP1997/004279 WO1998006730A1 (en)	1996-08-08	1997-08-06	Modified oligosaccharides

Publications (2)

Publication Number	Publication Date
NO990497D0 NO990497D0 (no)	1999-02-03
NO990497L true NO990497L (no)	1999-03-24

Family

ID=27237868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO990497A NO990497L (no)	1996-08-08	1999-02-03	Modifiserte oligosakkarider

Country Status (19)

Country	Link
EP (1)	EP0920437A1 (id)
JP (1)	JP2000516224A (id)
KR (1)	KR20000029862A (id)
CN (1)	CN1227563A (id)
AR (1)	AR008283A1 (id)
AU (1)	AU720381B2 (id)
BR (1)	BR9711117A (id)
CA (1)	CA2260854A1 (id)
CO (1)	CO4900075A1 (id)
CZ (1)	CZ39099A3 (id)
ID (1)	ID18010A (id)
IL (1)	IL127908A0 (id)
NO (1)	NO990497L (id)
NZ (1)	NZ334048A (id)
PE (1)	PE99298A1 (id)
PL (1)	PL331286A1 (id)
SK (1)	SK15699A3 (id)
TR (1)	TR199900245T2 (id)
WO (1)	WO1998006730A1 (id)

Families Citing this family (28)

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US5888984A (en) *	1994-05-12	1999-03-30	Dermal Research Laboratories, Inc.	Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
EP1165097B1 (en)	1999-02-01	2007-05-02	Dermal Research Laboratories, Inc.	A pharmaceutical composition of complex carbohydrates and their use
US7879824B2 (en)	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
JP2006502986A (ja) *	2002-07-03	2006-01-26	グリコミメティクス，インコーポレイテッド	新脈管形成に関与する医学的状態の診断および治療のための組成物および方法
JP4603888B2 (ja)	2002-10-11	2010-12-22	アステラスファルマユーロープベスローテンフェンノートシャップ	Ｐ−セレクチンに対する親和性を有しグルコースをベースとする化合物
WO2005054264A2 (en) *	2003-11-19	2005-06-16	Glycomimetics, Inc.	Glycomimetic antagonists for both e- and p-selectins
EP1763533B1 (en)	2003-11-19	2008-01-09	GlycoMimetics, Inc.	Specific antagonist for both e- and p-selectins
US20090036386A1 (en) *	2005-05-25	2009-02-05	Glycomimetics, Inc	Heterobifunctional compounds for selectin inhibition
CN101291946B (zh)	2005-08-09	2011-06-29	糖模拟物有限公司	对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂
PL2264043T3 (pl)	2005-09-02	2018-04-30	Glycomimetics, Inc.	Heterobifunkcyjne inhibitory pan-selektyny
AU2008216794A1 (en) *	2007-02-09	2008-08-21	Glycomimetics, Inc.	Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines
WO2009073911A1 (en)	2007-12-10	2009-06-18	Mater Medical Research Institute	Treatment and prophylaxis
WO2009126556A1 (en)	2008-04-08	2009-10-15	Glycomimetics, Inc.	Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en)	2010-09-14	2014-12-30	Glycomimetics, Inc.	E-selectin antagonists
KR102055958B1 (ko)	2011-12-22	2019-12-13	글리코미메틱스, 인크.	E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
US9867841B2 (en)	2012-12-07	2018-01-16	Glycomimetics, Inc.	Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
JP6689854B2 (ja)	2014-12-03	2020-04-28	グリコミメティクス，インコーポレイテッド	Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
JP2019502727A (ja)	2016-01-22	2019-01-31	グリコミメティクス，インコーポレイテッド	Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en)	2016-03-02	2017-09-08	Glycomimetics, Inc.	Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en)	2016-08-08	2022-09-06	Glycomimetics, Inc.	Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en)	2016-10-07	2023-04-06	Crescent Biopharma, Inc.	Highly potent multimeric E-selectin antagonists
EP3596096A1 (en)	2017-03-15	2020-01-22	GlycoMimetics, Inc.	Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (ja)	2017-11-30	2023-05-17	グリコミメティクス，インコーポレイテッド	骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko)	2017-12-29	2020-09-04	글리코미메틱스, 인크.	E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
CN108299525B (zh) *	2018-01-05	2021-03-26	佛山科学技术学院	路易斯寡糖-x的合成方法
KR20200128025A (ko)	2018-03-05	2020-11-11	글리코미메틱스, 인크.	급성 골수성 백혈병 및 관련 병태의 치료 방법
US11845771B2 (en)	2018-12-27	2023-12-19	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3
CN109762032A (zh) *	2019-01-16	2019-05-17	天津科技大学	一种磺酸化路易斯x三糖及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993023031A1 (en) *	1992-05-08	1993-11-25	The Biomembrane Institute	Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
CA2157489A1 (en) *	1993-03-04	1994-09-15	Masaaki Numata	Lewis-associated compound, process for producing the same, and anti-inflammatory
CZ298895A3 (en) *	1993-05-14	1996-04-17	Cytel Corp	Compound analogous to sialyl lex, pharmaceutical composition containing thereof and process for preparing lactosammonium salt
MX9704893A (es) *	1994-12-28	1997-10-31	Sumitomo Pharma	Derivados de lewis x y procesos para producir los mismos.

1997
- 1997-08-06 IL IL12790897A patent/IL127908A0/xx unknown
- 1997-08-06 NZ NZ334048A patent/NZ334048A/xx unknown
- 1997-08-06 KR KR1019997001025A patent/KR20000029862A/ko not_active Withdrawn
- 1997-08-06 CN CN97197077A patent/CN1227563A/zh active Pending
- 1997-08-06 TR TR1999/00245T patent/TR199900245T2/xx unknown
- 1997-08-06 CZ CZ99390A patent/CZ39099A3/cs unknown
- 1997-08-06 CA CA002260854A patent/CA2260854A1/en not_active Abandoned
- 1997-08-06 JP JP10509358A patent/JP2000516224A/ja active Pending
- 1997-08-06 PL PL97331286A patent/PL331286A1/xx unknown
- 1997-08-06 AU AU43788/97A patent/AU720381B2/en not_active Ceased
- 1997-08-06 AR ARP970103580A patent/AR008283A1/es unknown
- 1997-08-06 EP EP97941916A patent/EP0920437A1/en not_active Withdrawn
- 1997-08-06 WO PCT/EP1997/004279 patent/WO1998006730A1/en not_active Ceased
- 1997-08-06 BR BR9711117-1A patent/BR9711117A/pt not_active Application Discontinuation
- 1997-08-06 SK SK156-99A patent/SK15699A3/sk unknown
- 1997-08-07 PE PE1997000688A patent/PE99298A1/es not_active Application Discontinuation
- 1997-08-08 CO CO97045596A patent/CO4900075A1/es unknown
- 1997-08-08 ID IDP972766A patent/ID18010A/id unknown
1999
- 1999-02-03 NO NO990497A patent/NO990497L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ39099A3 (cs)	1999-05-12
AR008283A1 (es)	1999-12-29
WO1998006730A1 (en)	1998-02-19
CN1227563A (zh)	1999-09-01
CA2260854A1 (en)	1998-02-19
SK15699A3 (en)	1999-07-12
NZ334048A (en)	2000-05-26
TR199900245T2 (xx)	1999-05-21
CO4900075A1 (es)	2000-03-27
PL331286A1 (en)	1999-07-05
JP2000516224A (ja)	2000-12-05
IL127908A0 (en)	1999-11-30
ID18010A (id)	1998-02-19
AU4378897A (en)	1998-03-06
AU720381B2 (en)	2000-06-01
KR20000029862A (ko)	2000-05-25
EP0920437A1 (en)	1999-06-09
NO990497D0 (no)	1999-02-03
BR9711117A (pt)	1999-09-08
PE99298A1 (es)	1999-01-21

Legal Events

Date	Code	Title	Description
2002-05-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO990497L (no)	1999-03-24	Modifiserte oligosakkarider
AU5062299A (en)	2000-02-14	Formulations of anionic polysaccharides
HU9300486D0 (en)	1993-05-28	Hydroxi-urea derivatives
AU660282B2 (en)	1995-06-22	Water insoluble derivatives of hyaluronic acid
TW325547B (en)	1998-01-21	Modular bus with single or double parallel termination
NZ332345A (en)	2000-03-27	Thermostable xylanases isolated from Microtetraspora
MX9709146A (es)	1998-03-31	Compuestos novedosos, preparacion y uso de los mismos.
BG101966A (en)	1998-09-30	Application of 1l-agonist for the treatment of lack of urine retention
DE69534759D1 (de)	2006-04-13	Polyanionische Polysaccharide und hydrophobe, bioabsorbierbare Polymere enthaltende Zusammensetzungen
MY120511A (en)	2005-11-30	New pesticides
AU1121700A (en)	2000-05-08	Generating a nonlinear model and generating drive signals for simulation testingusing the same
DE69737496D1 (de)	2007-05-03	SIALYL-LEWISa UND SIALYL LEWISx EPITOP-ANALOGE
NO931297L (no)	1993-10-29	Alginat-oligosakkarid, og framgangsmaate for framstilling av samme
MX9703372A (es)	1998-02-28	Composiciones polimericas claras opticamente que contienen un interpenetrante.
ES2186807T3 (es)	2003-05-16	Inhibidores de trombina.
TR200001745T2 (tr)	2000-09-21	Keton peroksit türevleri, bunların hazırlanması ve kullanılması
BR9813465A (pt)	2002-01-22	Polissacarìdeos modificados que exibem reconhecimento biológico alterado
EP0820278A4 (en)	2004-06-09	NON-IMMUNOGENIC BIOCOMPATIBLE MACROMOLECULAR MENBRANE COMPOSITIONS AND METHOD FOR THE PRODUCTION AND USE THEREOF
IL126425A0 (en)	1999-05-09	Carbohydrate derivatives and their solid-phase synthesis
MX9603087A (es)	1997-01-31	Procedimiento para la obtencion de aminocarboniltriazolinonas substituidas.
DK1032580T3 (da)	2004-08-02	Fremgangsmåde til N-desmethylering af erythromyciner og derivater deraf
NL1002204C2 (nl)	1996-12-11	Demonstratiekast.
FR2720751B1 (fr)	1996-07-19	Copolymère polyoléfinique greffe.
MY113423A (en)	2002-02-28	Substituted thiophenesulfonylureas and -thioureas processes for their preparation, their use as amedicament or diagnostic, and medicament contiaining them
BR9708029A (pt)	2000-02-01	Uma enxima.