NO991234L - Trisykliske inhibitorer av farnesylproteintransferase - Google Patents

Trisykliske inhibitorer av farnesylproteintransferase

Info

Publication number
NO991234L
NO991234L NO991234A NO991234A NO991234L NO 991234 L NO991234 L NO 991234L NO 991234 A NO991234 A NO 991234A NO 991234 A NO991234 A NO 991234A NO 991234 L NO991234 L NO 991234L
Authority
NO
Norway
Prior art keywords
protein transferase
farnesyl protein
tricyclic inhibitors
formula
compounds
Prior art date
Application number
NO991234A
Other languages
English (en)
Norwegian (no)
Other versions
NO991234D0 (no
Inventor
Arthur G Taveras
Alan K Mallams
Adriano Afonso
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO991234D0 publication Critical patent/NO991234D0/no
Publication of NO991234L publication Critical patent/NO991234L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Cereal-Derived Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO991234A 1996-09-13 1999-03-12 Trisykliske inhibitorer av farnesylproteintransferase NO991234L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71332396A 1996-09-13 1996-09-13
PCT/US1997/015907 WO1998011093A1 (fr) 1996-09-13 1997-09-11 Inhibiteurs tricycliques de la farnesyl-proteine transferase

Publications (2)

Publication Number Publication Date
NO991234D0 NO991234D0 (no) 1999-03-12
NO991234L true NO991234L (no) 1999-05-12

Family

ID=24865689

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991234A NO991234L (no) 1996-09-13 1999-03-12 Trisykliske inhibitorer av farnesylproteintransferase

Country Status (20)

Country Link
EP (1) EP0929545B1 (fr)
JP (1) JP2001500510A (fr)
KR (1) KR20000036120A (fr)
CN (1) CN1104427C (fr)
AT (1) ATE286046T1 (fr)
AU (1) AU4337997A (fr)
BR (1) BR9712831A (fr)
CA (1) CA2266016C (fr)
CZ (1) CZ84399A3 (fr)
DE (1) DE69732120T2 (fr)
ES (1) ES2235252T3 (fr)
HU (1) HUP0000121A2 (fr)
ID (1) ID21699A (fr)
IL (1) IL128928A0 (fr)
NO (1) NO991234L (fr)
NZ (1) NZ334453A (fr)
PL (1) PL332242A1 (fr)
SK (1) SK33899A3 (fr)
TR (1) TR199901276T2 (fr)
WO (1) WO1998011093A1 (fr)

Families Citing this family (41)

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LT3962B (en) 1993-12-21 1996-05-27 Albright & Wilson Funcional fluids
US5939416A (en) * 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
CA2318088A1 (fr) 1998-01-21 1999-07-29 Yoshisuke Nakasato Antagonistes du recepteur de la chemokine et procedes d'emploi desdits antagonistes
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AU2331999A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US8679096B2 (en) 2007-06-21 2014-03-25 Board Of Regents Of The University Of Nebraska Multifunctional operational component for robotic devices
US9579088B2 (en) 2007-02-20 2017-02-28 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical visualization and device manipulation
TW200902007A (en) * 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
EP2170564A4 (fr) 2007-07-12 2015-10-07 Univ Nebraska Procédés et systèmes d'actionnement dans des dispositifs robotiques
JP2010536435A (ja) 2007-08-15 2010-12-02 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 医療用膨張、取り付けおよび送達装置、ならびに関連する方法
WO2013048595A1 (fr) 2011-06-10 2013-04-04 Board Of Regents Of The University Of Nebraska Procédés, systèmes et dispositifs relatifs à des effecteurs terminaux chirurgicaux
EP3588217A1 (fr) 2011-07-11 2020-01-01 Board of Regents of the University of Nebraska Dispositifs chirurgicaux robotisés, systèmes et procédés associés
EP3730031A1 (fr) 2011-10-03 2020-10-28 Board of Regents of the University of Nebraska Dispositifs chirurgicaux robotisés et systèmes
EP2806941B1 (fr) 2012-01-10 2021-10-27 Board of Regents of the University of Nebraska Systèmes et dispositifs pour accès chirurgical et insertion chirurgicale
WO2014011238A2 (fr) 2012-05-01 2014-01-16 Board Of Regents Of The University Of Nebraska Dispositif robotique à site unique et systèmes et procédés associés
EP4234185A3 (fr) 2012-06-22 2023-09-20 Board of Regents of the University of Nebraska Dispositifs chirurgicaux robotiques de commande locale
US9770305B2 (en) 2012-08-08 2017-09-26 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
CA2880622C (fr) 2012-08-08 2021-01-12 Board Of Regents Of The University Of Nebraska Systemes et dispositifs chirurgicaux robotiques, et procedes associes
US9743987B2 (en) 2013-03-14 2017-08-29 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers
WO2014152418A1 (fr) 2013-03-14 2014-09-25 Board Of Regents Of The University Of Nebraska Procédés, systèmes et dispositifs associés à des systèmes chirurgicaux de commande de force
WO2014144220A1 (fr) 2013-03-15 2014-09-18 Board Of Regents Of The University Of Nebraska Dispositifs chirurgicaux robotiques, systèmes et procédés apparentés
CA2918531A1 (fr) 2013-07-17 2015-01-22 Board Of Regents Of The University Of Nebraska Dispositifs chirurgicaux robotiques, systemes et procedes apparentes
WO2016040946A1 (fr) 2014-09-12 2016-03-17 Board Of Regents Of University Of Nebraska Effecteurs d'extrémité à libération rapide et systèmes et procédés associés
EP3689257B1 (fr) 2014-11-11 2024-01-03 Board of Regents of the University of Nebraska Dispositif robotique avec conception de joint compacte et systèmes et procédés associés
CA2994823A1 (fr) 2015-08-03 2017-02-09 Board Of Regents Of The University Of Nebraska Systemes de dispositifs chirurgicaux robotises et procedes apparentes
EP3457951B1 (fr) 2016-05-18 2024-03-06 Virtual Incision Corporation Dispositifs chirurgicaux robotiques et systèmes
JP2019524371A (ja) 2016-08-25 2019-09-05 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ クイックリリースツールカプラ並びに関連するシステム及び方法
EP4523648B1 (fr) 2016-08-30 2026-02-25 Board of Regents of the University of Nebraska Dispositif robotique à conception d'articulation compacte et à degré de liberté supplémentaire
CN115337111B (zh) 2016-11-22 2025-04-25 内布拉斯加大学董事会 改进的粗定位装置及相关系统和方法
CN115553922A (zh) 2016-11-29 2023-01-03 虚拟切割有限公司 具有用户存在检测的用户控制器及相关系统和方法
WO2018112199A1 (fr) 2016-12-14 2018-06-21 Virtual Incision Corporation Dispositif de fixation libérable destiné à être accouplé à des dispositifs médicaux et systèmes et procédés associés
CA3076625A1 (fr) 2017-09-27 2019-04-04 Virtual Incision Corporation Dispositifs chirurgicaux robotises avec technologie de camera de suivi et systemes et procedes apparentes
US11013564B2 (en) 2018-01-05 2021-05-25 Board Of Regents Of The University Of Nebraska Single-arm robotic device with compact joint design and related systems and methods
JP7546926B2 (ja) 2019-01-07 2024-09-09 バーチャル インシジョン コーポレイション ロボット支援手術システムと関連する装置と方法
CA3186863A1 (fr) 2020-07-06 2022-01-13 Virtual Incision Corporation Systeme de positionnement de robot chirurgical, dispositifs et procedes associes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (fr) * 1993-10-15 2002-02-12 W. Robert Bishop Composes carbamates tricycliques servant a inhiber la fonction de la proteine g et au traitement de maladies proliferatives
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111257A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL125062A (en) * 1995-12-22 2003-11-23 Schering Corp Tricyclic amides and pharmaceutical compositions containing them for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CN1104427C (zh) 2003-04-02
CZ84399A3 (cs) 1999-11-17
ATE286046T1 (de) 2005-01-15
BR9712831A (pt) 1999-11-16
CA2266016A1 (fr) 1998-03-19
ID21699A (id) 1999-07-15
WO1998011093A1 (fr) 1998-03-19
DE69732120D1 (de) 2005-02-03
EP0929545B1 (fr) 2004-12-29
HUP0000121A2 (hu) 2001-04-28
NO991234D0 (no) 1999-03-12
KR20000036120A (ko) 2000-06-26
TR199901276T2 (xx) 1999-09-21
EP0929545A1 (fr) 1999-07-21
NZ334453A (en) 2000-08-25
DE69732120T2 (de) 2005-12-08
SK33899A3 (en) 2000-02-14
AU4337997A (en) 1998-04-02
CN1237165A (zh) 1999-12-01
JP2001500510A (ja) 2001-01-16
PL332242A1 (en) 1999-08-30
ES2235252T3 (es) 2005-07-01
IL128928A0 (en) 2000-02-17
CA2266016C (fr) 2004-06-01

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