NO991388L - Sulfonamider og derivater derav som modulerer aktiviteten av endotelin - Google Patents
Sulfonamider og derivater derav som modulerer aktiviteten av endotelinInfo
- Publication number
- NO991388L NO991388L NO991388A NO991388A NO991388L NO 991388 L NO991388 L NO 991388L NO 991388 A NO991388 A NO 991388A NO 991388 A NO991388 A NO 991388A NO 991388 L NO991388 L NO 991388L
- Authority
- NO
- Norway
- Prior art keywords
- endothelin
- sulfonamides
- modulate
- derivatives
- activity
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/721,183 US5962490A (en) | 1987-09-25 | 1996-09-27 | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| PCT/US1997/017402 WO1998013366A1 (en) | 1996-09-27 | 1997-09-26 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO991388D0 NO991388D0 (no) | 1999-03-22 |
| NO991388L true NO991388L (no) | 1999-05-27 |
Family
ID=24896894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO991388A NO991388L (no) | 1996-09-27 | 1999-03-22 | Sulfonamider og derivater derav som modulerer aktiviteten av endotelin |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US5962490A (de) |
| EP (2) | EP0946552B1 (de) |
| JP (2) | JP3743520B2 (de) |
| KR (1) | KR100372195B1 (de) |
| CN (2) | CN1215069C (de) |
| AP (1) | AP9901471A0 (de) |
| AT (1) | ATE270669T1 (de) |
| AU (1) | AU736269B2 (de) |
| BR (1) | BR9711550A (de) |
| CA (1) | CA2261760C (de) |
| CZ (1) | CZ85499A3 (de) |
| DE (1) | DE69729803T2 (de) |
| EA (2) | EA004146B1 (de) |
| ES (1) | ES2224271T3 (de) |
| IL (1) | IL128145A0 (de) |
| NO (1) | NO991388L (de) |
| NZ (1) | NZ334797A (de) |
| OA (1) | OA11024A (de) |
| PL (1) | PL332323A1 (de) |
| PT (1) | PT946552E (de) |
| SK (1) | SK36599A3 (de) |
| TR (1) | TR199900705T2 (de) |
| WO (1) | WO1998013366A1 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| TR200202738T2 (tr) | 1997-04-28 | 2003-03-21 | Texas Biotechnology Corporation | Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler |
| EP1533311B1 (de) * | 1999-12-31 | 2007-04-25 | Encysive Pharmaceuticals, Inc | Sulfonamide und deren Derivate als Modulatoren der Endothelin-Aktivität |
| SK9532002A3 (en) | 1999-12-31 | 2003-06-03 | Texas Biotechnology Corp | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| JP4155561B2 (ja) * | 2000-12-26 | 2008-09-24 | 国立大学法人佐賀大学 | アレルギー性疾患検査方法 |
| DE60100055T2 (de) * | 2001-03-21 | 2003-07-24 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| US20030176356A1 (en) * | 2001-04-24 | 2003-09-18 | University Of North Texas Health Science Center | Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma |
| US20030130279A1 (en) * | 2001-11-22 | 2003-07-10 | Guido Kurz | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| RS44204A (sr) * | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
| AU2002353716A1 (en) * | 2001-11-22 | 2003-06-10 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| EA200400707A1 (ru) * | 2001-11-22 | 2004-10-28 | Биовитрум Аб | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 |
| AU2002358390A1 (en) * | 2001-12-18 | 2003-06-30 | Astrazeneca Ab | Novel compounds |
| TWI328007B (en) | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
| AU2003237518B8 (en) * | 2002-06-11 | 2009-03-12 | Arqule, Inc. | Substituted phenylsulfonamide inhibitors of beta amyloid production |
| JP4335136B2 (ja) * | 2002-08-09 | 2009-09-30 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害薬 |
| US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
| US7288538B2 (en) * | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| WO2004073634A2 (en) * | 2003-02-20 | 2004-09-02 | Encysive Pharmaceuticals Inc. | Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists |
| MXPA05011503A (es) * | 2003-04-25 | 2006-05-31 | Johnson & Johnson | Inhibidores de la c-fms cinasa. |
| US20050113566A1 (en) * | 2003-04-25 | 2005-05-26 | Player Mark R. | Inhibitors of C-FMS kinase |
| US7790724B2 (en) * | 2003-04-25 | 2010-09-07 | Janssen Pharmaceutica N.V. | c-fms kinase inhibitors |
| US7427683B2 (en) * | 2003-04-25 | 2008-09-23 | Ortho-Mcneil Pharmaceutical, Inc. | c-fms kinase inhibitors |
| SE0301650D0 (sv) * | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
| SE0301654D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0301653D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| US7794987B2 (en) * | 2003-12-02 | 2010-09-14 | Ucb Pharma Gmbh | Method for treating central neuropathic pain |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| EP1604655A1 (de) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen zur Behandlung von Trigeminusneuralgie |
| DE102005005397B4 (de) * | 2005-02-05 | 2008-08-21 | Lts Lohmann Therapie-Systeme Ag | Isolierung von N-Butylbenzolsulfonamid, Synthese von Benzolsulfonamid-Derivaten sowie Verwendung von N-Butylbenzolsulfonamid und Benzolsulfonamid-Derivaten zur Behandlung der benignen Prostatahyperplasie und/oder des Prostatakarzinoms |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1754476A1 (de) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamid (SPM 927) zur Behandlung von Myalgien, z.B. Fibromyalgie |
| US8541592B2 (en) * | 2005-11-22 | 2013-09-24 | Amgen Inc. | Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 |
| TW200730512A (en) * | 2005-12-12 | 2007-08-16 | Astrazeneca Ab | Novel compounds |
| EP1996588A4 (de) * | 2006-03-03 | 2011-10-05 | Torrent Pharmaceuticals Ltd | Neue dual-action-rezeptorantagonisten (dara) an den ati- und eta-rezeptoren |
| BRPI0708879A2 (pt) * | 2006-03-13 | 2011-06-14 | Encysive Pharmaceuticals | peocessos e composiÇÕes para o tratamento de insufiÊncia cardÍaca diastàlica |
| WO2007106468A2 (en) * | 2006-03-13 | 2007-09-20 | Encysive Pharmaceuticals, Inc. | Formulations of sitaxsentan sodium |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
| AU2007283404B2 (en) * | 2006-08-11 | 2013-04-18 | Merck Canada Inc. | Thiophenecarboxamide derivatives as EP4 receptor ligands |
| JP4891111B2 (ja) * | 2007-02-16 | 2012-03-07 | 富士フイルム株式会社 | ズームレンズ |
| US9298721B2 (en) * | 2007-02-28 | 2016-03-29 | Qualcomm Incorporated | Prioritized search results based on monitored data |
| CL2008000835A1 (es) | 2007-03-23 | 2008-10-03 | Icagen Inc Pfizer Ltd | Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm |
| ES2620634T3 (es) | 2008-10-09 | 2017-06-29 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activadores de piruvato quinasa humana |
| JP5756457B2 (ja) | 2009-04-06 | 2015-07-29 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼm2調節剤、治療組成物および関連する使用方法 |
| PL2427441T3 (pl) | 2009-05-04 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Aktywatory PKM2 do stosowania w leczeniu raka |
| DK2448581T3 (en) | 2009-06-29 | 2017-03-13 | Agios Pharmaceuticals Inc | Therapeutic compositions and methods for their applications |
| PE20120693A1 (es) * | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
| US20130109672A1 (en) | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| US9221792B2 (en) | 2010-12-17 | 2015-12-29 | Agios Pharmaceuticals, Inc | N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators |
| WO2012088314A1 (en) | 2010-12-21 | 2012-06-28 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| EP2511263A1 (de) | 2011-04-14 | 2012-10-17 | Phenex Pharmaceuticals AG | Pyrrolosulfonamid-Verbindungen zur Modulierung von mit Orphan-Nuklearrezeptor RAR zusammenhängender Orphan-Rezeptor-Gamma-Aktivität (ROR-Gamma-NR1F3-Aktivität) und zur Behandlung chronischer Entzündungs- und Autoimmunerkrankungen |
| PT3406251T (pt) | 2011-05-03 | 2024-01-24 | Agios Pharmaceuticals Inc | Ativadores da piruvato-cinase para utilização em terapia |
| MX384883B (es) | 2015-06-11 | 2025-03-14 | Agios Pharmaceuticals Inc | Métodos para usar activadores de piruvato cinasa. |
| US11447460B2 (en) * | 2016-04-18 | 2022-09-20 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
| EP3241874B1 (de) | 2016-05-04 | 2019-08-14 | Agfa Nv | Acylphosphinoxid-fotoinitiatoren |
| US10463656B2 (en) | 2017-01-05 | 2019-11-05 | Iowa State University Research Foundation, Inc. | Methods and compositions for prevention of feedlot bovine respiratory disease |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| MX2021012250A (es) | 2019-04-11 | 2022-01-18 | Angion Biomedica Corp | Formas solidas de (e)-3-[2-(2-tienil)vinil]-1h-pirazol. |
| SI4299135T1 (sl) | 2019-06-18 | 2025-12-31 | Pfizer Inc. | Benzizoksazolni sulfonamidni derivati |
| CN117255791B (zh) | 2021-06-22 | 2026-06-19 | 亚克医药株式会社 | 化合物、内皮素a受体拮抗剂及医药组合物 |
| EP4559461A1 (de) * | 2023-11-22 | 2025-05-28 | Servicio Andaluz De Salud | Duale nlrp1- und nlrp3-inhibitoren zur verwendung als medikament |
Family Cites Families (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US91270A (en) * | 1869-06-15 | Henry hi ohm ann | ||
| GB804036A (en) * | 1956-03-02 | 1958-11-05 | Hoffmann La Roche | A process for the manufacture of a sulphanilamide of the isoxazole series |
| US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
| US3300488A (en) * | 1963-12-23 | 1967-01-24 | Shionogi & Co | Nu, nu'-bis [4-halogenated-5-alkyl-3-isoxazolylsulfamoyl)-phenyl]-ureas |
| US3660383A (en) * | 1968-08-14 | 1972-05-02 | Shionogi & Co | Production of iodoisoxazole compounds |
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US4044126A (en) * | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
| GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| US3883393A (en) | 1972-05-18 | 1975-05-13 | Us Health Education & Welfare | Cell culture on semi-permeable tubular membranes |
| US3821087A (en) | 1972-05-18 | 1974-06-28 | Dedrick R | Cell culture on semi-permeable tubular membranes |
| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| GB1473433A (de) * | 1975-10-09 | 1977-05-11 | Banyu Pharmaceutical Co Ltd Hi | |
| FR2395271A1 (fr) | 1977-06-21 | 1979-01-19 | Parcor | Procede de preparation de thieno (2,3-c) et thieno (3,2-c) pyridines |
| US4191554A (en) | 1977-10-03 | 1980-03-04 | E. I. Du Pont De Nemours And Company | Herbicidal benzamides |
| WO1979000540A1 (en) | 1978-01-28 | 1979-08-09 | Croda Synthetic Chem Ltd | Heterocyclic compounds |
| FR2471983A1 (fr) | 1979-12-20 | 1981-06-26 | Sanofi Sa | Procede de preparation catalytique de la thieno(3,2-c)pyridine |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4406898A (en) | 1981-09-08 | 1983-09-27 | Eli Lilly And Company | Oxazole and oxadiazole cephalosporins |
| US4577014A (en) | 1981-09-08 | 1986-03-18 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
| EP0076072B1 (de) * | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulfonamide |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JPS60188084A (ja) | 1984-03-08 | 1985-09-25 | Otsuka Pharmaceut Factory Inc | アステリリン酸誘導体 |
| JPS6018808A (ja) * | 1984-06-12 | 1985-01-30 | Matsushita Electric Ind Co Ltd | 磁気ヘツド |
| US4585773A (en) | 1984-07-11 | 1986-04-29 | Bristol-Myers Company | Isoindolinyl-alkyl-piperazines |
| US4659369A (en) | 1984-08-27 | 1987-04-21 | E. I. Du Pont De Nemours And Company | Herbicidal acetals and ketals |
| US4861366A (en) | 1984-08-27 | 1989-08-29 | E. I. Du Pont De Nemours And Company | Herbicidal acetals and ketals |
| US4753672A (en) | 1985-07-16 | 1988-06-28 | E. I. Du Pont De Nemours And Company | Herbicidal acetals and ketals |
| EP0194548A3 (de) * | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US4914112A (en) | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
| US4763672A (en) * | 1986-12-16 | 1988-08-16 | Philip Morris Incorporated | Apparatus for injecting liquid-type material in the chimney of a cigarette maker |
| JPS63238006A (ja) | 1987-03-26 | 1988-10-04 | Shionogi & Co Ltd | イモチ防除剤 |
| US4769371A (en) | 1987-05-01 | 1988-09-06 | E. R. Squibb & Sons, Inc. | Dihydropyrimidine carboxylic acid esters |
| US4752613A (en) * | 1987-08-03 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Sulphonamidothienylcarboxylic acid compounds |
| US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5023090A (en) * | 1989-08-16 | 1991-06-11 | Levin Robert H | Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE |
| US5246931A (en) | 1988-10-25 | 1993-09-21 | Bristol-Myers Squibb Company | Carbocyclic nucleoside analogs |
| US5231166A (en) | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
| US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
| ES2097142T3 (es) | 1989-02-10 | 1997-04-01 | Otsuka Pharma Co Ltd | Derivados de indol, su preparacion y medicamento que los contiene destinado para la prevencion y para el tratamiento de la nefritis. |
| US5026700A (en) | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
| US5082838A (en) * | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
| JPH0347163A (ja) * | 1989-06-30 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | アントラキノン誘導体およびその製造 |
| US5230999A (en) * | 1989-07-24 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Monoclonal antibody to endothelin-3 or precursor thereof and use thereof |
| CA2032559C (en) | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
| JPH05505822A (ja) | 1990-03-30 | 1993-08-26 | メルク・エンド・カムパニー・インコーポレーテツド | ピラゾール類、イソキサゾール類及びイソチアゾール置換体 |
| US5430022A (en) | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
| US5284828A (en) | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| CA2043741C (en) | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
| JPH04134084A (ja) * | 1990-09-21 | 1992-05-07 | Tousou Sangyo Kk | ケイ酸エステルおよびその製造方法 |
| CA2056142A1 (en) * | 1990-11-27 | 1992-05-28 | Hirotomo Masuya | Pyridopyridazine compounds and their use |
| CA2059380A1 (en) * | 1991-01-24 | 1992-07-25 | Yiu-Kuen T. Lam | Endothelin receptor antagonists isolated from microbispora |
| US5248807A (en) * | 1991-01-29 | 1993-09-28 | Shionogi & Co., Ltd. | Triterpene derivatives |
| EP0569487A1 (de) | 1991-01-31 | 1993-11-18 | Abbott Laboratories | Endothelin konvertierende enzyminhibitoren |
| ATE156120T1 (de) | 1991-02-07 | 1997-08-15 | Roussel Uclaf | Bizyklische stickstoffverbindungen, ihre herstellung, erhaltene zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen |
| US5352659A (en) * | 1991-02-15 | 1994-10-04 | Takeda Chemical Industries | Endothelin analogs and uses thereof |
| EP0574530A4 (en) | 1991-03-08 | 1996-04-03 | Res Corp Technologies Inc | Endothelin antagonists |
| TW270116B (de) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| US5382569A (en) * | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| US5260276A (en) | 1991-06-14 | 1993-11-09 | Warner-Lambert Company | Linear and monocyclic endothelin antagonists |
| FR2679906B1 (fr) * | 1991-07-31 | 1995-01-20 | Adir | Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB2259450A (en) * | 1991-09-11 | 1993-03-17 | Fujisawa Pharmaceutical Co | Compositions with endothelin antagonist activity |
| FI942059L (fi) * | 1991-11-05 | 1994-07-04 | Smithkline Beecham Corp | Endoteliinireseptoreiden antagonisteja |
| US5198548A (en) * | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
| FR2687675B1 (fr) * | 1992-01-31 | 1997-04-18 | Roussel Uclaf | Nouveaux derives bicycliques de la pyridine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| FR2687156B1 (fr) | 1992-02-12 | 1994-04-01 | Roussel Uclaf | Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives. |
| US5378715A (en) * | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| TW224462B (de) * | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
| LT3200B (en) * | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
| US5235045A (en) * | 1992-03-19 | 1993-08-10 | Microbiomed Corporation | Non-azo naphthalimide dyes |
| US5240910A (en) * | 1992-04-17 | 1993-08-31 | Merck & Co., Inc. | Antihypertensive compounds produced by fermentation |
| US5514696A (en) | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
| NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| AU4376893A (en) | 1992-05-19 | 1993-12-13 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
| ES2042421B1 (es) * | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina. |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US5783701A (en) * | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| TW287160B (de) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| US5420123A (en) * | 1992-12-21 | 1995-05-30 | Bristol-Myers Squibb Company | Dibenzodiazepine endothelin antagonists |
| US5352800A (en) * | 1993-03-11 | 1994-10-04 | Merck & Co., Inc. | Process for the production of a novel endothelin antagonist |
| US5334598A (en) * | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| US5420133A (en) * | 1993-03-19 | 1995-05-30 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
| US5565485A (en) * | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| ES2062943B1 (es) * | 1993-03-23 | 1995-11-16 | Uriach & Cia Sa J | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
| FI941826L (fi) | 1993-04-21 | 1994-10-22 | Takeda Chemical Industries Ltd | Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi |
| US6030991A (en) | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| FR2707089B1 (fr) * | 1993-06-30 | 1995-08-18 | Adir | Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5389620A (en) * | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
| JPH09501920A (ja) | 1993-08-19 | 1997-02-25 | ワーナー−ランバート・コンパニー | 非ペプチドエンドセリンアンタゴニスト▲i▼ |
| US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| US6063911A (en) | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| US5546485A (en) * | 1993-12-20 | 1996-08-13 | At&T Corp. | Repeater for soliton transmission system using sliding-frequency guiding filter |
| MX9603909A (es) * | 1994-03-07 | 1997-03-29 | Vertex Pharma | Derivados de sulfonamida como inhibidores de proteasa aspartilo. |
| GB9504854D0 (en) | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
| US5675628A (en) | 1994-08-01 | 1997-10-07 | Nokia Telecommunications Oy | Method and apparatus for enabling roaming of subscriber among plural mobile radio systems, using mobile equipment accepting removable subscriber identity module |
| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| NZ297774A (en) | 1994-12-20 | 1998-10-28 | Hoffmann La Roche | Aryl and heteroaryl sulphonamide derivatives; preparation and medicaments |
| IL116916A (en) * | 1995-02-06 | 2000-09-28 | Bristol Myers Squibb Co | Substituted biphenyl sulfonamide derivatives and pharmaceutical compositions containing the same |
| US5599811A (en) * | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
| DE19509950A1 (de) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| EP0819125B1 (de) * | 1995-04-04 | 2003-06-18 | Texas Biotechnology Corporation | Thienyl-, furyl-, pyrrolyl- und biphenylsulfonamide und derivate zur modulation der endothelin-aktivität |
| UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
| GB9512697D0 (en) * | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
| US5922759A (en) | 1996-06-21 | 1999-07-13 | Warner-Lambert Company | Butenolide endothelin antagonists |
| JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
| KR100456650B1 (ko) | 1995-12-20 | 2005-06-20 | 야마노우치세이야쿠 가부시키가이샤 | 아릴에텐설폰아미드유도체 |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| AU2529297A (en) | 1996-04-10 | 1997-10-29 | Warner-Lambert Company | Ketoacid endothelin antagonists |
| US6133263A (en) | 1996-04-10 | 2000-10-17 | Warner-Lambert Company | Endothelin antagonists with ether-linked groups |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| TR200202738T2 (tr) * | 1997-04-28 | 2003-03-21 | Texas Biotechnology Corporation | Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| US6087724A (en) | 1997-12-18 | 2000-07-11 | Advanced Micro Devices, Inc. | HSQ with high plasma etching resistance surface for borderless vias |
| ATE257827T1 (de) * | 1999-07-21 | 2004-01-15 | Hoffmann La Roche | Triazolderivate |
| SK9532002A3 (en) * | 1999-12-31 | 2003-06-03 | Texas Biotechnology Corp | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
-
1996
- 1996-09-27 US US08/721,183 patent/US5962490A/en not_active Expired - Lifetime
-
1997
- 1997-09-26 PL PL97332323A patent/PL332323A1/xx unknown
- 1997-09-26 KR KR10-1999-7002629A patent/KR100372195B1/ko not_active Expired - Lifetime
- 1997-09-26 IL IL12814597A patent/IL128145A0/xx unknown
- 1997-09-26 ES ES97943629T patent/ES2224271T3/es not_active Expired - Lifetime
- 1997-09-26 EP EP97943629A patent/EP0946552B1/de not_active Expired - Lifetime
- 1997-09-26 NZ NZ334797A patent/NZ334797A/en unknown
- 1997-09-26 AP APAP/P/1999/001471A patent/AP9901471A0/en unknown
- 1997-09-26 PT PT97943629T patent/PT946552E/pt unknown
- 1997-09-26 TR TR1999/00705T patent/TR199900705T2/xx unknown
- 1997-09-26 US US08/938,325 patent/US6420567B1/en not_active Expired - Fee Related
- 1997-09-26 BR BR9711550-9A patent/BR9711550A/pt not_active IP Right Cessation
- 1997-09-26 JP JP51597998A patent/JP3743520B2/ja not_active Expired - Lifetime
- 1997-09-26 WO PCT/US1997/017402 patent/WO1998013366A1/en not_active Ceased
- 1997-09-26 SK SK365-99A patent/SK36599A3/sk unknown
- 1997-09-26 CZ CZ99854A patent/CZ85499A3/cs unknown
- 1997-09-26 CN CNB971983437A patent/CN1215069C/zh not_active Expired - Lifetime
- 1997-09-26 EA EA199900294A patent/EA004146B1/ru not_active IP Right Cessation
- 1997-09-26 CA CA002261760A patent/CA2261760C/en not_active Expired - Lifetime
- 1997-09-26 CN CNB031584780A patent/CN100558724C/zh not_active Expired - Lifetime
- 1997-09-26 EA EA200300824A patent/EA200300824A1/ru unknown
- 1997-09-26 AU AU45059/97A patent/AU736269B2/en not_active Ceased
- 1997-09-26 EP EP03007240A patent/EP1342721A1/de not_active Withdrawn
- 1997-09-26 AT AT97943629T patent/ATE270669T1/de not_active IP Right Cessation
- 1997-09-26 DE DE69729803T patent/DE69729803T2/de not_active Expired - Lifetime
-
1999
- 1999-03-12 OA OA9900058A patent/OA11024A/en unknown
- 1999-03-22 US US09/274,280 patent/US6331637B1/en not_active Expired - Fee Related
- 1999-03-22 NO NO991388A patent/NO991388L/no unknown
-
2001
- 2001-11-05 US US10/011,610 patent/US6632829B2/en not_active Expired - Fee Related
-
2002
- 2002-04-03 JP JP2002101613A patent/JP2002308875A/ja active Pending
-
2003
- 2003-05-28 US US10/447,763 patent/US20030208084A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO991388D0 (no) | Sulfonamider og derivater derav som modulerer endothelin aktiviteten | |
| DK0832082T3 (da) | N-heteroaryl-pyridinsulfonamidderivater og deres anvendelse som endotelinantagonister | |
| NO972983L (no) | Sulfonamider og deres anvendelse | |
| NO993868D0 (no) | 3-piperidyl-4-oksokinazolin-derivater og medisinske preparater som inneholder slike | |
| IT1296619B1 (it) | Procedimento per il trattamento di protesi a struttura aperturata e relativi dispositivi. | |
| AU1532497A (en) | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin | |
| ATE284385T1 (de) | Sulfonamidderivate | |
| EP0619982A3 (de) | Chirurgisches Befestigungselement. | |
| DE69716296D1 (de) | Indan- oder dihydroindolderivate | |
| NO984094D0 (no) | Utladningsreaktor og anvendelse av samme | |
| NO971811D0 (no) | Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler | |
| NO993467D0 (no) | Granuler som innbefatter klavulanat og en eller flere eksipienter | |
| HUP0203935A3 (en) | Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use | |
| NO984761D0 (no) | Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler | |
| NO995513L (no) | N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK- | |
| NO994510D0 (no) | Substituerte isokinolin-derivater og deres anvendelse som antikonvulsanter | |
| NO992997D0 (no) | Promedikamentformer og nye analoger av camptotecin, samt anvendelse derav som medikamenter | |
| NO985891D0 (no) | Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler | |
| DE69803531D1 (de) | Niederdruck-hydroxydealkylierung von ethylbenzol und xylol-isomerisierung | |
| NO20003142D0 (no) | Substituerte isokinolin-derivater og anvendelse derav som antikrampemidler | |
| FI974460A0 (fi) | Foerfarande foer val av frekvensomraodet foer radiotelefoner som fungerar pao flera frekvensomraoden och mobilteleapparat | |
| NO972256D0 (no) | O-Benzyloksimeterderivater og deres anvendelse som pesticider | |
| DK1032559T3 (da) | Aminoalkylphenolderivater til behandling af depression og hukommelsessvigt | |
| PT1140994E (pt) | Proteinas da superficie externa, suas genes e sua utilizacao | |
| NO985993D0 (no) | Polypeptider som etteraper aktiviteten til humant erytropoietin |