NO993027L - Pyrrolo[3,4-D]pyrimidinonderivater og deres anvendelse som legemidler - Google Patents

Pyrrolo[3,4-D]pyrimidinonderivater og deres anvendelse som legemidler

Info

Publication number: NO993027L
Authority: NO; Norway
Prior art keywords: pyrrolo; drugs; pyrimidinone derivatives; preparation; pyrimidinone
Prior art date: 1996-12-21

Application number

NO993027A

Other languages

English (en)

Norwegian (no)

Other versions

NO993027D0 (no

Inventor

Martin Cooper

David Cheshire

David Donald

Mark Furber

Matthew Perry

Richard Harrison

Nicholas Tomkinson

Original Assignee

Astra Pharma Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-21

Filing date

1999-06-18

Publication date

1999-08-20

1999-06-18 Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod

1999-06-18 Publication of NO993027D0 publication Critical patent/NO993027D0/no

1999-08-20 Publication of NO993027L publication Critical patent/NO993027L/no

Links

239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
TUWOCBICGNGPKL-UHFFFAOYSA-N pyrrolo[3,4-d]pyrimidin-2-one Chemical class O=C1N=CC2=CN=CC2=N1 TUWOCBICGNGPKL-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 abstract 3
238000002360 preparation method Methods 0.000 abstract 2
-1 5-substituted pyrrolo [3,4-d] pyrimidine-2,4-dione Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Dermatology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO993027A 1996-12-21 1999-06-18 Pyrrolo[3,4-D]pyrimidinonderivater og deres anvendelse som legemidler NO993027L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9626643.2A GB9626643D0 (en)	1996-12-21	1996-12-21	Compounds
PCT/SE1997/002157 WO1998028301A1 (en)	1996-12-21	1997-12-18	Pyrrolo[3,4-d]pyrimidinone derivatives and their use as medicaments

Publications (2)

Publication Number	Publication Date
NO993027D0 NO993027D0 (no)	1999-06-18
NO993027L true NO993027L (no)	1999-08-20

Family

ID=10804862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO993027A NO993027L (no)	1996-12-21	1999-06-18	Pyrrolo[3,4-D]pyrimidinonderivater og deres anvendelse som legemidler

Country Status (23)

Country	Link
US (8)	US6046204A (de)
EP (1)	EP0946562B1 (de)
JP (1)	JP2001507687A (de)
KR (1)	KR20000069605A (de)
CN (1)	CN1246119A (de)
AT (1)	ATE215088T1 (de)
AU (1)	AU717429B2 (de)
BR (1)	BR9714063A (de)
CA (1)	CA2275312A1 (de)
CZ (1)	CZ289925B6 (de)
DE (1)	DE69711430T2 (de)
EE (1)	EE9900315A (de)
GB (1)	GB9626643D0 (de)
HU (1)	HUP0002839A3 (de)
ID (1)	ID21682A (de)
IL (1)	IL130538A0 (de)
IS (1)	IS5082A (de)
NO (1)	NO993027L (de)
NZ (1)	NZ336124A (de)
PL (1)	PL334228A1 (de)
SK (1)	SK76699A3 (de)
TR (1)	TR199901433T2 (de)
WO (1)	WO1998028301A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9801399D0 (sv)	1998-04-21	1998-04-21	Astra Pharma Prod	Method and apparatus for filling containers
AU2107700A (en)	1999-01-15	2000-08-01	Byk Gulden Lomberg Chemische Fabrik Gmbh	Phenanthridine-n-oxides with pde-iv inhibiting activity
EP1147103B1 (de)	1999-01-15	2005-05-04	ALTANA Pharma AG	Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
ATE356810T1 (de)	1999-01-15	2007-04-15	Altana Pharma Ag	Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
US6361486B1 (en) *	2000-02-29	2002-03-26	Agilent Technologies, Inc.	Coaxial-drive centrifuge providing tilt control relative to centrifugal force
US20070105841A1 (en) *	2000-08-14	2007-05-10	Breitenbucher J G	Method for treating allergies using substituted pyrazoles
US7589202B2 (en) *	2000-08-14	2009-09-15	Ortho Mcneil Pharmaceutical, Inc.	Substituted pyrazoles
TW200407315A (en) *	2002-04-23	2004-05-16	Sankyo Co	Pyrimidine derivatives
CA2533534C (en) *	2003-07-24	2013-03-19	Tecomet, Inc.	Assembled non-random foams
EP1768662A2 (de)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Immunstimulatoren kleiner moleküle und assays für deren nachweis
MY140748A (en)	2004-12-06	2010-01-15	Astrazeneca Ab	Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
DK2024367T3 (da)	2006-05-04	2011-01-03	Pulmagen Therapeutics Inflammation Ltd	Tetrahydropyrrolopyrimidindioner og deres anvendelse som inhibitorer af human neutrofil elastase
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
AU2007256633B2 (en)	2006-06-06	2013-09-12	Intra-Cellular Therapies, Inc.	Organic compounds
ES2588238T3 (es)	2007-12-06	2016-10-31	Intra-Cellular Therapies, Inc.	Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico
WO2009100403A1 (en) *	2008-02-07	2009-08-13	Neurogen Corporation	Substituted aryl pyrimidinones
MX2011005934A (es)	2008-12-06	2011-12-16	Intra Cellular Therapies Inc	Compuestos organicos.
BRPI0922700A2 (pt)	2008-12-06	2015-08-11	Intracellular Therapies Inc	Compostos orgânicos
AU2009322899A1 (en)	2008-12-06	2010-06-10	Intra-Cellular Therapies, Inc.	Organic compounds
EP2464354B1 (de)	2009-08-10	2015-04-01	The Regents of The University of California	Pyrimido-pyrrolo-chinoxalindionhemmer des regulatorproteins für die transmembranen-leitfähigkeit zystischer fibrose und verwendungen davon
EP2575817A4 (de)	2010-05-31	2014-01-08	Intra Cellular Therapies Inc	Organische verbindungen
US9371327B2 (en)	2010-05-31	2016-06-21	Intra-Cellular Therapies, Inc.	PDE1 inhibitor compounds
USRE48842E1 (en)	2011-05-27	2021-12-07	The Regents Of The University Of California	Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor
US9546175B2 (en)	2014-08-07	2017-01-17	Intra-Cellular Therapies, Inc.	Organic compounds
CN108129486B (zh) *	2018-01-25	2020-06-05	华东理工大学	嘧啶酮衍生物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993004047A1 (en) *	1991-08-16	1993-03-04	Merck & Co., Inc.	Quinazoline derivatives as inhibitors of hiv reverse transcriptase
GB9424842D0 (en) *	1994-12-09	1995-02-08	British Tech Group	Pharmaceutical compositions

1996
- 1996-12-21 GB GBGB9626643.2A patent/GB9626643D0/en active Pending
1997
- 1997-12-18 AU AU55809/98A patent/AU717429B2/en not_active Ceased
- 1997-12-18 EP EP97952146A patent/EP0946562B1/de not_active Expired - Lifetime
- 1997-12-18 TR TR1999/01433T patent/TR199901433T2/xx unknown
- 1997-12-18 CN CN97181811A patent/CN1246119A/zh active Pending
- 1997-12-18 IL IL13053897A patent/IL130538A0/xx unknown
- 1997-12-18 JP JP52869798A patent/JP2001507687A/ja not_active Ceased
- 1997-12-18 BR BR9714063-5A patent/BR9714063A/pt not_active IP Right Cessation
- 1997-12-18 ID IDW990507A patent/ID21682A/id unknown
- 1997-12-18 KR KR1019997005595A patent/KR20000069605A/ko not_active Withdrawn
- 1997-12-18 AT AT97952146T patent/ATE215088T1/de active
- 1997-12-18 WO PCT/SE1997/002157 patent/WO1998028301A1/en not_active Ceased
- 1997-12-18 CZ CZ19992204A patent/CZ289925B6/cs not_active IP Right Cessation
- 1997-12-18 NZ NZ336124A patent/NZ336124A/en unknown
- 1997-12-18 US US09/011,780 patent/US6046204A/en not_active Expired - Fee Related
- 1997-12-18 EE EEP199900315A patent/EE9900315A/xx unknown
- 1997-12-18 PL PL97334228A patent/PL334228A1/xx unknown
- 1997-12-18 HU HU0002839A patent/HUP0002839A3/hu unknown
- 1997-12-18 CA CA002275312A patent/CA2275312A1/en not_active Abandoned
- 1997-12-18 DE DE69711430T patent/DE69711430T2/de not_active Expired - Fee Related
- 1997-12-18 SK SK766-99A patent/SK76699A3/sk unknown
1999
- 1999-06-14 IS IS5082A patent/IS5082A/is unknown
- 1999-06-18 NO NO993027A patent/NO993027L/no not_active Application Discontinuation
2000
- 2000-02-17 US US09/506,091 patent/US6229013B1/en not_active Expired - Fee Related
- 2000-02-17 US US09/505,857 patent/US6136974A/en not_active Expired - Fee Related
- 2000-02-17 US US09/506,090 patent/US6166206A/en not_active Expired - Fee Related
- 2000-02-17 US US09/505,862 patent/US6211368B1/en not_active Expired - Fee Related
- 2000-11-08 US US09/707,880 patent/US6306863B1/en not_active Expired - Fee Related
2001
- 2001-10-09 US US09/971,709 patent/US20020025966A1/en not_active Abandoned
2003
- 2003-03-05 US US10/378,913 patent/US20030162798A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL334228A1 (en)	2000-02-14
US6136974A (en)	2000-10-24
AU717429B2 (en)	2000-03-23
US6211368B1 (en)	2001-04-03
CN1246119A (zh)	2000-03-01
GB9626643D0 (en)	1997-02-12
CA2275312A1 (en)	1998-07-02
AU5580998A (en)	1998-07-17
US6306863B1 (en)	2001-10-23
EP0946562A1 (de)	1999-10-06
US6046204A (en)	2000-04-04
ATE215088T1 (de)	2002-04-15
BR9714063A (pt)	2002-01-02
TR199901433T2 (xx)	1999-09-21
CZ289925B6 (cs)	2002-04-17
NZ336124A (en)	2001-03-30
ID21682A (id)	1999-07-08
NO993027D0 (no)	1999-06-18
IL130538A0 (en)	2000-06-01
JP2001507687A (ja)	2001-06-12
KR20000069605A (ko)	2000-11-25
EP0946562B1 (de)	2002-03-27
US6166206A (en)	2000-12-26
SK76699A3 (en)	2000-05-16
DE69711430T2 (de)	2002-10-31
US20030162798A1 (en)	2003-08-28
US20020025966A1 (en)	2002-02-28
EE9900315A (et)	2000-02-15
IS5082A (is)	1999-06-14
DE69711430D1 (de)	2002-05-02
HUP0002839A2 (hu)	2001-02-28
CZ220499A3 (cs)	2000-02-16
WO1998028301A1 (en)	1998-07-02
HUP0002839A3 (en)	2001-04-28
US6229013B1 (en)	2001-05-08

Legal Events

Date	Code	Title	Description
2002-07-01	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO995006L (no)	1999-10-14	Nye forbindelser
NO20000313L (no)	2000-03-22	Nye forbindelser
AP9901435A0 (en)	1999-03-31	Bicycle heteroaromatic compounds as protein tyrosine kinase inhibitors.
ATE215954T1 (de)	2002-04-15	Pyrazolo(4,3-d)pyrimidin-derivate und diese enthaltende pharmazeutische zubereitungen
DK0624595T3 (da)	1999-05-17	Nor-galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler
TR200000197T2 (tr)	2000-06-21	Yeni bileşimler
GEP20063784B (en)	2006-04-10	Optical Resolution of (1-Benzyl-4- Methylpiperidin-3-Yl) -Methylamine Enantiomers and Use Thereof for Preparation of Pyrrolo 2,3-Pyrimidine Derivatives as Protein Kinases Inhibitors
CA2272705A1 (en)	1998-06-04	Fused bicyclic pyrimidine derivatives
MX9702382A (es)	1998-02-28	Nuevos derivados de pirimidona con actividad antifungica.
AU2002305143A1 (en)	2002-11-11	Pyrazolo'1,5-a!pyridine derivatives
YU29202A (sh)	2004-12-31	Alkilamino supstituisani biciklični azot heterocikli kao inhibitori p38 protein kinaze
SE9702001D0 (sv)	1997-05-28	Novel compounds
NO20030381L (no)	2003-02-24	Bicyklopyrazoler som er aktive som kinaseinhibitorer, fremgangsmåte for deres fremstilling og farmasöytiske preparater som inneholder slikeforbindelser
BR9609617B1 (pt)	2010-07-27	derivados de 7h-pirrol[2,3-d]pirimidina, e composição farmacêutica.
NO993027D0 (no)	1999-06-18	Pyrrolo[3,4-D]pyrimidinonderivater og deres anvendelse som legemidler
DK0495982T3 (da)	1996-07-01	Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel
IL104154A0 (en)	1993-05-13	Saccharin derivatives,their preparation and pharmaceutical compositions containing them
WO2003048164A3 (en)	2003-10-16	Adenosine a2a receptor antagonists
IE873125L (en)	1988-05-21	Benzimidazole derivatives
DK0404283T3 (da)	1996-09-09	11alfa-aryl-4-estrener, fremgangsmåde til fremstilling af disse samt deres anvendelse som lægemidler
ATE242246T1 (de)	2003-06-15	(1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel
NO974150L (no)	1997-11-07	6-arylpyrazolo[3,4-d]pyrimidin-4-oner og preparater og fremgangsmåter for anvendelse derav
NO20004089L (no)	2000-10-16	Nye triazolo(4,5-d)pyrimidinforbindelser
DE69911785D1 (de)	2003-11-06	Triazolo[4,5-d]pyrimidin-verbindungen
AU1998995A (en)	1995-11-29	Substituted fused and bridged bicyclic compounds as therapeutic agents