ATE215088T1 - Pyrrolo(3,4-d)pyrimidinon-derivate und ihre verwendung als immunosuppressoren - Google Patents

Pyrrolo(3,4-d)pyrimidinon-derivate und ihre verwendung als immunosuppressoren

Info

Publication number: ATE215088T1
Authority: AT; Austria
Prior art keywords: pct; pyrrolo; immunosuppressors; sec; pyrimidinone derivatives
Prior art date: 1996-12-21

Application number

AT97952146T

Other languages

English (en)

Inventor

Martin Cooper

David Cheshire

David Donald

Mark Furber

Matthew Perry

Richard Harrison

Nicholas Tomkinson

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-21

Filing date

1997-12-18

Publication date

2002-04-15

1997-12-18 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215088T1 publication Critical patent/ATE215088T1/de

Links

TUWOCBICGNGPKL-UHFFFAOYSA-N pyrrolo[3,4-d]pyrimidin-2-one Chemical class O=C1N=CC2=CN=CC2=N1 TUWOCBICGNGPKL-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
-1 5-substituted pyrrolo[3,4-d]pyrimidine-2,4-diones Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Dermatology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97952146T 1996-12-21 1997-12-18 Pyrrolo(3,4-d)pyrimidinon-derivate und ihre verwendung als immunosuppressoren ATE215088T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9626643.2A GB9626643D0 (en)	1996-12-21	1996-12-21	Compounds
PCT/SE1997/002157 WO1998028301A1 (en)	1996-12-21	1997-12-18	Pyrrolo[3,4-d]pyrimidinone derivatives and their use as medicaments

Publications (1)

Publication Number	Publication Date
ATE215088T1 true ATE215088T1 (de)	2002-04-15

Family

ID=10804862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97952146T ATE215088T1 (de)	1996-12-21	1997-12-18	Pyrrolo(3,4-d)pyrimidinon-derivate und ihre verwendung als immunosuppressoren

Country Status (23)

Country	Link
US (8)	US6046204A (de)
EP (1)	EP0946562B1 (de)
JP (1)	JP2001507687A (de)
KR (1)	KR20000069605A (de)
CN (1)	CN1246119A (de)
AT (1)	ATE215088T1 (de)
AU (1)	AU717429B2 (de)
BR (1)	BR9714063A (de)
CA (1)	CA2275312A1 (de)
CZ (1)	CZ289925B6 (de)
DE (1)	DE69711430T2 (de)
EE (1)	EE9900315A (de)
GB (1)	GB9626643D0 (de)
HU (1)	HUP0002839A3 (de)
ID (1)	ID21682A (de)
IL (1)	IL130538A0 (de)
IS (1)	IS5082A (de)
NO (1)	NO993027L (de)
NZ (1)	NZ336124A (de)
PL (1)	PL334228A1 (de)
SK (1)	SK76699A3 (de)
TR (1)	TR199901433T2 (de)
WO (1)	WO1998028301A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9801399D0 (sv)	1998-04-21	1998-04-21	Astra Pharma Prod	Method and apparatus for filling containers
AU2107700A (en)	1999-01-15	2000-08-01	Byk Gulden Lomberg Chemische Fabrik Gmbh	Phenanthridine-n-oxides with pde-iv inhibiting activity
EP1147103B1 (de)	1999-01-15	2005-05-04	ALTANA Pharma AG	Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
ATE356810T1 (de)	1999-01-15	2007-04-15	Altana Pharma Ag	Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
US6361486B1 (en) *	2000-02-29	2002-03-26	Agilent Technologies, Inc.	Coaxial-drive centrifuge providing tilt control relative to centrifugal force
US20070105841A1 (en) *	2000-08-14	2007-05-10	Breitenbucher J G	Method for treating allergies using substituted pyrazoles
US7589202B2 (en) *	2000-08-14	2009-09-15	Ortho Mcneil Pharmaceutical, Inc.	Substituted pyrazoles
TW200407315A (en) *	2002-04-23	2004-05-16	Sankyo Co	Pyrimidine derivatives
CA2533534C (en) *	2003-07-24	2013-03-19	Tecomet, Inc.	Assembled non-random foams
EP1768662A2 (de)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Immunstimulatoren kleiner moleküle und assays für deren nachweis
MY140748A (en)	2004-12-06	2010-01-15	Astrazeneca Ab	Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
DK2024367T3 (da)	2006-05-04	2011-01-03	Pulmagen Therapeutics Inflammation Ltd	Tetrahydropyrrolopyrimidindioner og deres anvendelse som inhibitorer af human neutrofil elastase
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
AU2007256633B2 (en)	2006-06-06	2013-09-12	Intra-Cellular Therapies, Inc.	Organic compounds
ES2588238T3 (es)	2007-12-06	2016-10-31	Intra-Cellular Therapies, Inc.	Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico
WO2009100403A1 (en) *	2008-02-07	2009-08-13	Neurogen Corporation	Substituted aryl pyrimidinones
MX2011005934A (es)	2008-12-06	2011-12-16	Intra Cellular Therapies Inc	Compuestos organicos.
BRPI0922700A2 (pt)	2008-12-06	2015-08-11	Intracellular Therapies Inc	Compostos orgânicos
AU2009322899A1 (en)	2008-12-06	2010-06-10	Intra-Cellular Therapies, Inc.	Organic compounds
EP2464354B1 (de)	2009-08-10	2015-04-01	The Regents of The University of California	Pyrimido-pyrrolo-chinoxalindionhemmer des regulatorproteins für die transmembranen-leitfähigkeit zystischer fibrose und verwendungen davon
EP2575817A4 (de)	2010-05-31	2014-01-08	Intra Cellular Therapies Inc	Organische verbindungen
US9371327B2 (en)	2010-05-31	2016-06-21	Intra-Cellular Therapies, Inc.	PDE1 inhibitor compounds
USRE48842E1 (en)	2011-05-27	2021-12-07	The Regents Of The University Of California	Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor
US9546175B2 (en)	2014-08-07	2017-01-17	Intra-Cellular Therapies, Inc.	Organic compounds
CN108129486B (zh) *	2018-01-25	2020-06-05	华东理工大学	嘧啶酮衍生物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993004047A1 (en) *	1991-08-16	1993-03-04	Merck & Co., Inc.	Quinazoline derivatives as inhibitors of hiv reverse transcriptase
GB9424842D0 (en) *	1994-12-09	1995-02-08	British Tech Group	Pharmaceutical compositions

1996
- 1996-12-21 GB GBGB9626643.2A patent/GB9626643D0/en active Pending
1997
- 1997-12-18 AU AU55809/98A patent/AU717429B2/en not_active Ceased
- 1997-12-18 EP EP97952146A patent/EP0946562B1/de not_active Expired - Lifetime
- 1997-12-18 TR TR1999/01433T patent/TR199901433T2/xx unknown
- 1997-12-18 CN CN97181811A patent/CN1246119A/zh active Pending
- 1997-12-18 IL IL13053897A patent/IL130538A0/xx unknown
- 1997-12-18 JP JP52869798A patent/JP2001507687A/ja not_active Ceased
- 1997-12-18 BR BR9714063-5A patent/BR9714063A/pt not_active IP Right Cessation
- 1997-12-18 ID IDW990507A patent/ID21682A/id unknown
- 1997-12-18 KR KR1019997005595A patent/KR20000069605A/ko not_active Withdrawn
- 1997-12-18 AT AT97952146T patent/ATE215088T1/de active
- 1997-12-18 WO PCT/SE1997/002157 patent/WO1998028301A1/en not_active Ceased
- 1997-12-18 CZ CZ19992204A patent/CZ289925B6/cs not_active IP Right Cessation
- 1997-12-18 NZ NZ336124A patent/NZ336124A/en unknown
- 1997-12-18 US US09/011,780 patent/US6046204A/en not_active Expired - Fee Related
- 1997-12-18 EE EEP199900315A patent/EE9900315A/xx unknown
- 1997-12-18 PL PL97334228A patent/PL334228A1/xx unknown
- 1997-12-18 HU HU0002839A patent/HUP0002839A3/hu unknown
- 1997-12-18 CA CA002275312A patent/CA2275312A1/en not_active Abandoned
- 1997-12-18 DE DE69711430T patent/DE69711430T2/de not_active Expired - Fee Related
- 1997-12-18 SK SK766-99A patent/SK76699A3/sk unknown
1999
- 1999-06-14 IS IS5082A patent/IS5082A/is unknown
- 1999-06-18 NO NO993027A patent/NO993027L/no not_active Application Discontinuation
2000
- 2000-02-17 US US09/506,091 patent/US6229013B1/en not_active Expired - Fee Related
- 2000-02-17 US US09/505,857 patent/US6136974A/en not_active Expired - Fee Related
- 2000-02-17 US US09/506,090 patent/US6166206A/en not_active Expired - Fee Related
- 2000-02-17 US US09/505,862 patent/US6211368B1/en not_active Expired - Fee Related
- 2000-11-08 US US09/707,880 patent/US6306863B1/en not_active Expired - Fee Related
2001
- 2001-10-09 US US09/971,709 patent/US20020025966A1/en not_active Abandoned
2003
- 2003-03-05 US US10/378,913 patent/US20030162798A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL334228A1 (en)	2000-02-14
US6136974A (en)	2000-10-24
AU717429B2 (en)	2000-03-23
US6211368B1 (en)	2001-04-03
CN1246119A (zh)	2000-03-01
GB9626643D0 (en)	1997-02-12
CA2275312A1 (en)	1998-07-02
AU5580998A (en)	1998-07-17
US6306863B1 (en)	2001-10-23
EP0946562A1 (de)	1999-10-06
US6046204A (en)	2000-04-04
BR9714063A (pt)	2002-01-02
TR199901433T2 (xx)	1999-09-21
CZ289925B6 (cs)	2002-04-17
NZ336124A (en)	2001-03-30
ID21682A (id)	1999-07-08
NO993027D0 (no)	1999-06-18
IL130538A0 (en)	2000-06-01
JP2001507687A (ja)	2001-06-12
KR20000069605A (ko)	2000-11-25
EP0946562B1 (de)	2002-03-27
US6166206A (en)	2000-12-26
SK76699A3 (en)	2000-05-16
DE69711430T2 (de)	2002-10-31
US20030162798A1 (en)	2003-08-28
US20020025966A1 (en)	2002-02-28
EE9900315A (et)	2000-02-15
IS5082A (is)	1999-06-14
DE69711430D1 (de)	2002-05-02
HUP0002839A2 (hu)	2001-02-28
CZ220499A3 (cs)	2000-02-16
WO1998028301A1 (en)	1998-07-02
HUP0002839A3 (en)	2001-04-28
NO993027L (no)	1999-08-20
US6229013B1 (en)	2001-05-08

Publication	Publication Date	Title
DE69711430D1 (de)	2002-05-02	PYRROLO[3,4-d]PYRIMIDINON-DERIVATE UND IHRE VERWENDUNG ALS IMMUNOSUPPRESSOREN
TR200000197T2 (tr)	2000-06-21	Yeni bileşimler
SE9702772D0 (sv)	1997-07-22	Novel compounds
SE9701398D0 (sv)	1997-04-15	Novel compounds
EE200000318A (et)	2001-08-15	Uudsed ühendid
ATE212993T1 (de)	2002-02-15	Pyrolopyrimidine und verfahren zu ihrer herstellung
HUT70505A (en)	1995-10-30	Pyrrolo[2,3-d]pyrimidine derivatives, pharmaceutical compositions containing them and process for preparing them
DE59710417D1 (de)	2003-08-14	N-7 HETEROCYCLYL-PYRROLO[ 2,3-d]PYRIMIDINE UND IHRE VERWENDUNG
AU5273396A (en)	1996-10-23	Pyrazole derivatives and processes for the preparation thereof
TR200002380T2 (tr)	2001-03-21	Yeni triazolo (4,5-d) pirimidin bileşikleri
IL118167A0 (en)	1996-09-12	Pyrazolo (1,5a) pyrimidines their preparation and use
AU1428801A (en)	2001-05-30	Novel (1,2,3)-triazolo(4,5-D)pyrimidine compounds
WO1992007832A3 (en)	1992-06-11	Substituted piperazines as central nervous system agents
SE9802574D0 (sv)	1998-07-17	Novel compounds
MX9303605A (es)	1993-12-01	Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
PT1025101E (pt)	2003-04-30	Derivados de nafto-imidazo¬1,2-a\|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central
MY133140A (en)	2007-10-31	N-substituted azabicycloheptane derivatives, their preparation and use
DK0729469T3 (da)	1999-06-14	Imidazo[1,5-a]quinoliner til behandling af angst og søvnforstyrrelser
MX9605143A (es)	1997-09-30	Heterociclibenzonitrilos.