DK0960105T3 - Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet - Google Patents

Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet

Info

Publication number: DK0960105T3
Authority: DK; Denmark
Prior art keywords: compounds; ampa receptor; receptor activity; receptors; ampa
Prior art date: 1997-02-13

Application number

DK98906358T

Other languages

English (en)

Inventor

Gary A Rogers

Christopher M Marrs

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-13

Filing date

1998-02-13

Publication date

2004-08-30

1998-02-13 Application filed by Univ California filed Critical Univ California

2004-08-30 Application granted granted Critical

2004-08-30 Publication of DK0960105T3 publication Critical patent/DK0960105T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Hydrogenated Pyridines (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Luminescent Compositions (AREA)
Furan Compounds (AREA)

DK98906358T 1997-02-13 1998-02-13 Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet DK0960105T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/800,108 US6110935A (en)	1997-02-13	1997-02-13	Benzofurazan compounds for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number	Publication Date
DK0960105T3 true DK0960105T3 (da)	2004-08-30

Family

ID=25177504

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK98906358T DK0960105T3 (da)	1997-02-13	1998-02-13	Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet
DK04075259T DK1428534T3 (da)	1997-02-13	1998-02-13	Benzofurazanderivater til forögelse af glutaminerge synaptiske responser

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK04075259T DK1428534T3 (da)	1997-02-13	1998-02-13	Benzofurazanderivater til forögelse af glutaminerge synaptiske responser

Country Status (24)

Country	Link
US (3)	US6110935A (da)
EP (2)	EP1428534B1 (da)
JP (1)	JP4446023B2 (da)
KR (1)	KR100544295B1 (da)
CN (1)	CN1085206C (da)
AT (2)	ATE266649T1 (da)
AU (1)	AU737802C (da)
BR (1)	BR9807333B1 (da)
CA (1)	CA2279319C (da)
CZ (1)	CZ299765B6 (da)
DE (2)	DE69834590T2 (da)
DK (2)	DK0960105T3 (da)
ES (2)	ES2264078T3 (da)
GB (1)	GB2325225B (da)
HU (1)	HUP0002303A3 (da)
ID (1)	ID22342A (da)
IL (1)	IL131200A (da)
NO (1)	NO318935B1 (da)
NZ (1)	NZ336980A (da)
PL (1)	PL199135B1 (da)
PT (2)	PT960105E (da)
RU (1)	RU2189984C2 (da)
TR (1)	TR199901941T2 (da)
WO (1)	WO1998035950A1 (da)

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IN188837B (da)	1998-05-22	2002-11-09	Torrent Pharmaceuticals Ltd
AU2002366756A1 (en) *	2001-12-20	2003-07-09	Alangudi Sankaranarayanan	Use of benzofuroxan derivatives as antiplatelet agents
EP1592464A4 (en) *	2003-01-13	2011-03-09	Cortex Pharma Inc	METHOD OF TREATING COGNITIVE DECLINE FROM LACK OF SLEEP AND STRESS
DK1636215T3 (da) *	2003-05-23	2008-06-02	Basilea Pharmaceutica Ag	Furazanobenzimidazoler
JP2007519733A (ja) *	2004-01-26	2007-07-19	コーテックスファーマシューティカルズインコーポレーティッド	アンパカインにより誘導されるシナプス応答促通のコリンエステラーゼ阻害剤による増強方法
JP2010501597A (ja)	2006-08-31	2010-01-21	ザガバナーズオブザユニバーシティーオブアルバータ	正のアロステリックａｍｐａ受容体モジュレーターを用いて呼吸抑制を阻害する方法
CN101626686A (zh) *	2007-01-03	2010-01-13	科泰克斯药品公司	用于提高谷氨酸性突触反应的3-取代基-1,2,3-苯并三嗪酮类化合物
AP2502A (en) *	2007-01-03	2012-10-23	Servier Lab	3-substituted-[1,2,3]-benzotriazinone compound forenhancing glutamatergic synaptic responses
WO2008143963A1 (en) *	2007-05-17	2008-11-27	Cortex Pharmaceuticals, Inc.	Di-substituted amides for enhancing glutamatergic synaptic responses
US8119632B2 (en)	2007-08-10	2012-02-21	Cortex Pharmaceuticals, Inc.	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US8263591B2 (en) *	2007-08-10	2012-09-11	Cortex Pharmaceuticals, Inc.	Bicyclic amides for enhancing glutamatergic synaptic responses
US8071914B2 (en) *	2007-12-26	2011-12-06	Noboru Oshima	Heating apparatus
US20110218190A1 (en) *	2008-11-10	2011-09-08	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
BRPI1005316A2 (pt) *	2009-02-02	2019-09-24	Cortex Pharmaceuticals, Inc.	composto, composição farmacêuttca, métodos para tratamento e uso de um composto
WO2011109398A2 (en)	2010-03-02	2011-09-09	President And Fellows Of Harvard College	Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110257186A1 (en) *	2010-04-15	2011-10-20	Staubli Ursula V	Compositions and methods for treating visual disorders
EP2801377B1 (en)	2011-03-04	2019-08-07	The Regents of The University of California	Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke
CN102633731B (zh) *	2012-03-13	2014-04-30	四川大学华西医院	6-喹喔啉甲酸酰胺化合物、制备方法和应用
KR101421032B1 (ko) *	2012-12-28	2014-07-22	주식회사 레고켐 바이오사이언스	(2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법
US20150011554A1 (en)	2013-06-13	2015-01-08	Veroscience Llc	Compositions and Methods for Treating Metabolic Disorders
EP3436021A4 (en)	2016-03-29	2019-11-06	RespireRx Pharmaceuticals Inc.	COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER
CN107286114B (zh)	2016-04-13	2020-08-18	中国人民解放军军事医学科学院毒物药物研究所	Ampa受体增效剂的脑靶向前药及其医药用途

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US3981864A (en) *	1973-09-08	1976-09-21	Eisai Co., Ltd.	1,3-Benzodioxol derivatives
FR2499991A1 (fr) *	1981-02-19	1982-08-20	Sandoz Sa	Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4420485A (en) *	1982-09-29	1983-12-13	Hoechst-Roussel Pharmaceuticals Inc.	1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
SU1657189A1 (ru) *	1988-05-23	1991-06-23	Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср	Способ коррекции апато-абулических состо ний при шизофрении
SU1587050A1 (ru) *	1988-12-23	1990-08-23	Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского	Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью
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IL96507A0 (en) *	1989-12-08	1991-08-16	Merck & Co Inc	Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP1367056A1 (en) *	1992-07-24	2003-12-03	The Regents Of The University Of California	Drugs that enhance synaptic responses mediated by AMPA receptors
ATE174915T1 (de) *	1994-10-31	1999-01-15	Merck Patent Gmbh	Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
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1997
- 1997-02-13 US US08/800,108 patent/US6110935A/en not_active Expired - Lifetime
1998
- 1998-02-13 DK DK98906358T patent/DK0960105T3/da active
- 1998-02-13 CA CA002279319A patent/CA2279319C/en not_active Expired - Fee Related
- 1998-02-13 ES ES04075259T patent/ES2264078T3/es not_active Expired - Lifetime
- 1998-02-13 AU AU61599/98A patent/AU737802C/en not_active Ceased
- 1998-02-13 JP JP53589698A patent/JP4446023B2/ja not_active Expired - Fee Related
- 1998-02-13 WO PCT/US1998/002713 patent/WO1998035950A1/en not_active Ceased
- 1998-02-13 TR TR1999/01941T patent/TR199901941T2/xx unknown
- 1998-02-13 DE DE69834590T patent/DE69834590T2/de not_active Expired - Lifetime
- 1998-02-13 GB GB9809221A patent/GB2325225B/en not_active Expired - Fee Related
- 1998-02-13 EP EP04075259A patent/EP1428534B1/en not_active Expired - Lifetime
- 1998-02-13 AT AT98906358T patent/ATE266649T1/de active
- 1998-02-13 KR KR1019997007369A patent/KR100544295B1/ko not_active Expired - Fee Related
- 1998-02-13 EP EP98906358A patent/EP0960105B1/en not_active Expired - Lifetime
- 1998-02-13 HU HU0002303A patent/HUP0002303A3/hu unknown
- 1998-02-13 ES ES98906358T patent/ES2221152T3/es not_active Expired - Lifetime
- 1998-02-13 ID IDW990855A patent/ID22342A/id unknown
- 1998-02-13 PL PL335058A patent/PL199135B1/pl not_active IP Right Cessation
- 1998-02-13 US US09/355,139 patent/US6313115B1/en not_active Expired - Fee Related
- 1998-02-13 PT PT98906358T patent/PT960105E/pt unknown
- 1998-02-13 AT AT04075259T patent/ATE326221T1/de active
- 1998-02-13 DE DE69823803T patent/DE69823803T2/de not_active Expired - Lifetime
- 1998-02-13 RU RU99119488/04A patent/RU2189984C2/ru not_active IP Right Cessation
- 1998-02-13 CZ CZ0279599A patent/CZ299765B6/cs not_active IP Right Cessation
- 1998-02-13 IL IL13120098A patent/IL131200A/xx not_active IP Right Cessation
- 1998-02-13 CN CN98802541A patent/CN1085206C/zh not_active Expired - Fee Related
- 1998-02-13 PT PT04075259T patent/PT1428534E/pt unknown
- 1998-02-13 DK DK04075259T patent/DK1428534T3/da active
- 1998-02-13 NZ NZ336980A patent/NZ336980A/xx not_active IP Right Cessation
- 1998-02-13 BR BRPI9807333-8A patent/BR9807333B1/pt not_active IP Right Cessation
1999
- 1999-08-04 NO NO19993768A patent/NO318935B1/no not_active IP Right Cessation
2001
- 2001-04-27 US US09/845,128 patent/US6730677B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL131200A0 (en)	2001-01-28
AU6159998A (en)	1998-09-08
ES2221152T3 (es)	2004-12-16
EP0960105A1 (en)	1999-12-01
CZ299765B6 (cs)	2008-11-19
CN1085206C (zh)	2002-05-22
GB2325225A8 (en)	1999-02-17
GB9809221D0 (da)	1998-07-01
RU2189984C2 (ru)	2002-09-27
GB2325225A (en)	1998-11-18
NO993768L (no)	1999-09-23
NZ336980A (en)	2000-08-25
EP0960105B1 (en)	2004-05-12
KR20000071082A (ko)	2000-11-25
BR9807333A (pt)	2000-04-18
NO993768D0 (no)	1999-08-04
BR9807333B1 (pt)	2011-10-18
ID22342A (id)	1999-09-30
CA2279319C (en)	2008-08-05
DE69823803D1 (de)	2004-06-17
PT960105E (pt)	2004-09-30
PL199135B1 (pl)	2008-08-29
US6110935A (en)	2000-08-29
ATE266649T1 (de)	2004-05-15
AU737802B2 (en)	2001-08-30
US6313115B1 (en)	2001-11-06
PL335058A1 (en)	2000-03-27
PT1428534E (pt)	2006-07-31
ATE326221T1 (de)	2006-06-15
DE69823803T2 (de)	2005-04-14
US20020055508A1 (en)	2002-05-09
GB2325225B (en)	1999-03-03
ES2264078T3 (es)	2006-12-16
CZ279599A3 (cs)	2000-01-12
JP4446023B2 (ja)	2010-04-07
DK1428534T3 (da)	2006-06-12
IL131200A (en)	2005-06-19
KR100544295B1 (ko)	2006-01-23
DE69834590D1 (de)	2006-06-22
CA2279319A1 (en)	1998-08-20
TR199901941T2 (xx)	1999-12-21
DE69834590T2 (de)	2007-04-26
HUP0002303A2 (hu)	2001-04-28
EP1428534B1 (en)	2006-05-17
EP1428534A1 (en)	2004-06-16
JP2001512459A (ja)	2001-08-21
WO1998035950A1 (en)	1998-08-20
AU737802C (en)	2005-05-12
CN1247534A (zh)	2000-03-15
NO318935B1 (no)	2005-05-30
HUP0002303A3 (en)	2002-09-30
US6730677B2 (en)	2004-05-04

Publication	Publication Date	Title
DK0960105T3 (da)	2004-08-30	Benzofurazanforbindelser, der foröger AMPA-receptoraktivitet
DK0891365T3 (da)	2003-02-10	Benzoxaziner til forstærkning af synaptiske responser
DE69811363D1 (de)	2003-03-20	Piperazin-derivate und ihre verwendung als entzündungshemmende mittel
DE60024588D1 (de)	2006-01-12	Substituierte porphyrine und deren therapeutische verwendungen
PT839134E (pt)	2004-07-30	Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica
ATE451362T1 (de)	2009-12-15	Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten
DE69829412D1 (de)	2005-04-21	Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen
DE60033530D1 (de)	2007-04-05	Humane antikörper gegen ctla-4 und deren verwendungen
BR0015416A (pt)	2002-07-16	Composições contendo derivados do ácido hidroxieicosa tetraenóico e métodos de uso no tratamento de distúrbios de olhos secos
DE69435303D1 (de)	2010-09-02	Er behandlung von krankheiten bei denen eine cytok
DK1054673T3 (da)	2004-07-05	Benzoxazinforbindelser til forstærkelse af synaptisk reaktion
EA200500934A1 (ru)	2006-04-28	Соединения, модулирующие активность киназного белка множественных линий, и способы лечения нейродегенеративных и воспалительных заболеваний
MX14957A (es)	1993-11-01	Nuevos derivados de tetrazol y procedimiento para su preparacion.
PT1067935E (pt)	2004-01-30	Acilbenzoxazinas para melhorar resposta (s) sinaptica (s)
BR9612074A (pt)	1999-03-30	Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas
ATE112557T1 (de)	1994-10-15	Azetidinderivate, zusammensetzungen und ihre verwendung.
ATE113591T1 (de)	1994-11-15	4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol- - one und ihre verwendung als antikonvulsiva.
BR0015402A (pt)	2002-06-25	Derivados de ácido 15-hidroxieicosatetraenóico de cadeia Èmega modificada e métodos de seu uso para o tratamento de olho seco
DE69827706D1 (de)	2004-12-30	5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
ES2121809T3 (es)	1998-12-16	N-(3-(2-(1h-imidazol-1-il)etoxi)fenil)-4-(2-tienil)-2-pirimidinamina y sales farmacologicamente aceptables.
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