NO994806L - Peptidfragmenter av myelin basisprotein, deres farmasöytiske preparater og deres anvendelse for å behandle multippel sklerose - Google Patents
Peptidfragmenter av myelin basisprotein, deres farmasöytiske preparater og deres anvendelse for å behandle multippel skleroseInfo
- Publication number
- NO994806L NO994806L NO994806A NO994806A NO994806L NO 994806 L NO994806 L NO 994806L NO 994806 A NO994806 A NO 994806A NO 994806 A NO994806 A NO 994806A NO 994806 L NO994806 L NO 994806L
- Authority
- NO
- Norway
- Prior art keywords
- mbp
- residues
- levels
- amino acid
- synthetic peptides
- Prior art date
Links
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 title 1
- 102000047918 Myelin Basic Human genes 0.000 title 1
- 101710107068 Myelin basic protein Proteins 0.000 title 1
- 108010033276 Peptide Fragments Proteins 0.000 title 1
- 102000007079 Peptide Fragments Human genes 0.000 title 1
- 201000006417 multiple sclerosis Diseases 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 101001018318 Homo sapiens Myelin basic protein Proteins 0.000 abstract 5
- 102000054064 human MBP Human genes 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 230000002411 adverse Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000007913 intrathecal administration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rehabilitation Therapy (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2201841A CA2201841C (en) | 1997-04-04 | 1997-04-04 | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| PCT/CA1998/000290 WO1998045327A1 (en) | 1997-04-04 | 1998-04-03 | Peptide fragments of myelin basic protein, their pharmaceutical compositions and their use in treating multiple sclerosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994806D0 NO994806D0 (no) | 1999-10-01 |
| NO994806L true NO994806L (no) | 1999-12-06 |
| NO325018B1 NO325018B1 (no) | 2008-01-14 |
Family
ID=4160340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994806A NO325018B1 (no) | 1997-04-04 | 1999-10-01 | Anvendelse av et peptid for fremstilling av et farmasoytisk preparat for behandling av multippel sklerose. |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP0970121B1 (no) |
| JP (1) | JP4173557B2 (no) |
| AT (2) | ATE400582T1 (no) |
| AU (1) | AU751303B2 (no) |
| CA (2) | CA2201841C (no) |
| CY (2) | CY1107445T1 (no) |
| CZ (1) | CZ299535B6 (no) |
| DE (2) | DE69839163T2 (no) |
| DK (2) | DK1394178T3 (no) |
| ES (2) | ES2307317T3 (no) |
| HU (1) | HU226768B1 (no) |
| NO (1) | NO325018B1 (no) |
| NZ (1) | NZ338091A (no) |
| PL (1) | PL191965B1 (no) |
| PT (2) | PT1394178E (no) |
| RO (1) | RO119303B1 (no) |
| RU (1) | RU2198893C2 (no) |
| SK (1) | SK285815B6 (no) |
| UA (1) | UA60331C2 (no) |
| WO (1) | WO1998045327A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004536819A (ja) | 2001-06-11 | 2004-12-09 | トランジション・セラピューティックス・インコーポレーテッド | ウイルス性、増殖性および炎症性の疾患の治療のためにビタミンb12および治療薬を用いた複合治療 |
| RU2261713C1 (ru) * | 2004-04-27 | 2005-10-10 | Государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Министерства здравоохранения Российской Федерации" | Способ лечения тяжелой формы острого оптического неврита у пациентов с рассеянным склерозом |
| EP2488196B1 (en) | 2009-10-12 | 2015-12-16 | LIFEBio Laboratories LLC | Composition for treatment of multiple sclerosis |
| RU2646817C1 (ru) * | 2016-12-27 | 2018-03-07 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Пептид из состава тяжелой цепи иммуноглобулина человека, пригодный для лечения рассеянного склероза |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2021611C1 (ru) * | 1991-04-19 | 1994-10-15 | Михайленко Анатолий Андреевич | Способ диагностики рассеянного склероза |
| US5817629A (en) * | 1991-10-22 | 1998-10-06 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| CA2053799C (en) * | 1991-10-22 | 2002-03-12 | Kenneth G. Warren | Synthetic peptide specificity of anti-myelin basic protein from multiple sclerosis cerebrospinal fluid |
| CA2133749A1 (en) * | 1992-04-09 | 1993-10-28 | Howard L. Weiner | Suppression of t-cell proliferation using peptide fragments of myelin basic protein |
| US5824315A (en) * | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
| IL115766A0 (en) * | 1994-10-25 | 1996-01-19 | Immulogic Pharma Corp | Composition and treatment for multiple sclerosis |
| US6329499B1 (en) * | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
-
1997
- 1997-04-04 CA CA2201841A patent/CA2201841C/en not_active Expired - Fee Related
- 1997-04-04 CA CA002494338A patent/CA2494338C/en not_active Expired - Fee Related
-
1998
- 1998-03-04 UA UA99116049A patent/UA60331C2/uk unknown
- 1998-04-03 DK DK03022727T patent/DK1394178T3/da active
- 1998-04-03 PT PT03022727T patent/PT1394178E/pt unknown
- 1998-04-03 ES ES98914725T patent/ES2307317T3/es not_active Expired - Lifetime
- 1998-04-03 AT AT98914725T patent/ATE400582T1/de not_active IP Right Cessation
- 1998-04-03 EP EP98914725A patent/EP0970121B1/en not_active Expired - Lifetime
- 1998-04-03 DE DE69839163T patent/DE69839163T2/de not_active Expired - Lifetime
- 1998-04-03 RO RO99-01064A patent/RO119303B1/ro unknown
- 1998-04-03 PL PL336085A patent/PL191965B1/pl not_active IP Right Cessation
- 1998-04-03 CZ CZ0346499A patent/CZ299535B6/cs not_active IP Right Cessation
- 1998-04-03 WO PCT/CA1998/000290 patent/WO1998045327A1/en not_active Ceased
- 1998-04-03 RU RU99122954/04A patent/RU2198893C2/ru not_active IP Right Cessation
- 1998-04-03 NZ NZ338091A patent/NZ338091A/en unknown
- 1998-04-03 SK SK1329-99A patent/SK285815B6/sk not_active IP Right Cessation
- 1998-04-03 DK DK98914725T patent/DK0970121T3/da active
- 1998-04-03 EP EP03022727A patent/EP1394178B1/en not_active Expired - Lifetime
- 1998-04-03 PT PT98914725T patent/PT970121E/pt unknown
- 1998-04-03 DE DE69839694T patent/DE69839694D1/de not_active Expired - Lifetime
- 1998-04-03 JP JP54217098A patent/JP4173557B2/ja not_active Expired - Fee Related
- 1998-04-03 AU AU69130/98A patent/AU751303B2/en not_active Ceased
- 1998-04-03 ES ES03022727T patent/ES2299657T3/es not_active Expired - Lifetime
- 1998-04-03 HU HU0000812A patent/HU226768B1/hu not_active IP Right Cessation
- 1998-04-03 AT AT03022727T patent/ATE386941T1/de not_active IP Right Cessation
-
1999
- 1999-10-01 NO NO19994806A patent/NO325018B1/no not_active IP Right Cessation
-
2008
- 2008-04-24 CY CY20081100462T patent/CY1107445T1/el unknown
- 2008-08-05 CY CY20081100818T patent/CY1108239T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |