NO964698L - Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase - Google Patents

Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase

Info

Publication number
NO964698L
NO964698L NO964698A NO964698A NO964698L NO 964698 L NO964698 L NO 964698L NO 964698 A NO964698 A NO 964698A NO 964698 A NO964698 A NO 964698A NO 964698 L NO964698 L NO 964698L
Authority
NO
Norway
Prior art keywords
nitric oxide
inhibitors
oxide synthetase
amine derivatives
compounds
Prior art date
Application number
NO964698A
Other languages
English (en)
Other versions
NO964698D0 (no
Inventor
James Edwin Macdonald
William Calvin Shakespeare
Robert John Murray
James Russell Matz
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9409201A external-priority patent/GB9409201D0/en
Priority claimed from GB9409462A external-priority patent/GB9409462D0/en
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO964698D0 publication Critical patent/NO964698D0/no
Publication of NO964698L publication Critical patent/NO964698L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Forbindelser av formel (I): (I) hvor D representerer en 5-leddet heterocyklisk aromatisk ring inneholdende 1-4 heteroatomer valgt fra O, N eller S, eventuelt substituert ved et karbonatom med halogen, trifluormetyl, alkyl C l-6, nitro eller cyano, og som er forbundet med resten av forbindelsen av formel (I) gjennom et karbonatom; A representerer_N(X) eller CH(- (CH2)m-NXY); U representerer NH, O eller CH2; V representerer (O^V, W representerer (CH2)b! a, b, m, X og Y er som definert heri, samt fremgangsmåter for deres fremstilling og preparater inneholdende disse forbindelsene. Forbindelser av formel (I) er nitrogenoksidsyntetaseinhibitorer og er nyttige i terapi.
NO964698A 1994-05-07 1996-11-06 Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase NO964698L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9409201A GB9409201D0 (en) 1994-05-07 1994-05-07 Pharmaceutically active compounds
GB9409462A GB9409462D0 (en) 1994-05-12 1994-05-12 Pharmaceutically active compounds
PCT/GB1995/001041 WO1996001817A1 (en) 1994-05-07 1995-05-09 Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase

Publications (2)

Publication Number Publication Date
NO964698D0 NO964698D0 (no) 1996-11-06
NO964698L true NO964698L (no) 1996-11-06

Family

ID=26304851

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964698A NO964698L (no) 1994-05-07 1996-11-06 Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase

Country Status (14)

Country Link
US (2) US5807886A (no)
EP (1) EP0759027B1 (no)
JP (1) JPH10500138A (no)
AT (1) ATE182889T1 (no)
AU (1) AU682768B2 (no)
CA (1) CA2188680A1 (no)
DE (1) DE69511260T2 (no)
DK (1) DK0759027T3 (no)
ES (1) ES2137512T3 (no)
FI (1) FI964463A7 (no)
GR (1) GR3031693T3 (no)
MX (1) MX9605366A (no)
NO (1) NO964698L (no)
WO (1) WO1996001817A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT758890E (pt) * 1994-05-11 2005-06-30 Jes Olesen Utilizacao de agentes de captura, inibidores ou antagonistas de no no tratamento da enxaqueca
CZ287969B6 (cs) * 1995-08-10 2001-03-14 Astra Pharmaceuticals Limited Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití
RU2155761C2 (ru) * 1995-08-10 2000-09-10 Астра АБ Бициклические производные амидина, способ их получения, фармацевтическая композиция и способ ингибирования синтетазы окиси азота
EP0914322A1 (en) * 1996-05-27 1999-05-12 Fujisawa Pharmaceutical Co., Ltd. New indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production
FR2764889B1 (fr) * 1997-06-20 2000-09-01 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US6335445B1 (en) 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
FR2761066B1 (fr) * 1997-03-24 2000-11-24 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
SE9701682D0 (sv) * 1997-05-05 1997-05-05 Astra Ab Compounds
DE69908934T2 (de) * 1998-05-04 2003-12-18 Fujisawa Pharmaceutical Co., Ltd. Heterocyclische carbonsäureamid derivate als hemmstoffe der stickstoffmonoxid-produktion
AU4543899A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
FR2784678B1 (fr) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
CA2408913A1 (en) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
US7232822B2 (en) * 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7241774B2 (en) * 2002-03-13 2007-07-10 University Of Tennessee Research Foundation Substituted tetrahydroisoquinoline compounds, methods of making, and their use
TWI417099B (zh) * 2007-03-23 2013-12-01 Neuraxon Inc 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
NL135043C (no) * 1963-10-11
GB1145278A (en) * 1964-07-07 1969-03-12 Wellcome Found Amidine derivatives, processes for their preparation, and compositions incorporating them
GB1188956A (en) * 1967-07-14 1970-04-22 Delalande Sa N-Substituted Aromatic Amidines and process for obtaining same
GB1180629A (en) * 1967-07-14 1970-02-04 Delalande Sa Di-Amidines derived from Aromatic Diamines and process for obtaining same
US3669974A (en) * 1971-03-25 1972-06-13 Usv Pharma Corp N,n1-disubstituted benzamidines
DE2321330A1 (de) * 1973-04-27 1974-11-07 Bayer Ag Azolyl-amidine, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
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DK0690851T3 (da) * 1993-03-23 1999-11-08 Astra Ab Guanidin-derivater, som er anvendelige til behandling
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US5629322A (en) * 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
NO964698D0 (no) 1996-11-06
JPH10500138A (ja) 1998-01-06
DK0759027T3 (da) 2000-03-27
FI964463L (fi) 1996-11-06
DE69511260T2 (de) 2000-03-16
HK1009043A1 (en) 1999-05-21
ES2137512T3 (es) 1999-12-16
EP0759027A1 (en) 1997-02-26
US6117898A (en) 2000-09-12
FI964463A0 (fi) 1996-11-06
AU682768B2 (en) 1997-10-16
US5807886A (en) 1998-09-15
EP0759027B1 (en) 1999-08-04
GR3031693T3 (en) 2000-02-29
CA2188680A1 (en) 1996-01-25
AU2413995A (en) 1996-02-09
DE69511260D1 (en) 1999-09-09
ATE182889T1 (de) 1999-08-15
FI964463A7 (fi) 1996-11-06
WO1996001817A1 (en) 1996-01-25
MX9605366A (es) 1997-12-31

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