NO996178L - 4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister - Google Patents
4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonisterInfo
- Publication number
- NO996178L NO996178L NO996178A NO996178A NO996178L NO 996178 L NO996178 L NO 996178L NO 996178 A NO996178 A NO 996178A NO 996178 A NO996178 A NO 996178A NO 996178 L NO996178 L NO 996178L
- Authority
- NO
- Norway
- Prior art keywords
- neuropeptide
- aminopyrrole
- pyrimidines
- receptor antagonists
- excess
- Prior art date
Links
- PLSDWRYNZIVQKX-BGKYVOMCSA-N (3S)-3-amino-4-[[(2S)-1-[[2-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CC4=CNC=N4)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N PLSDWRYNZIVQKX-BGKYVOMCSA-N 0.000 title 1
- WAUGGYPDCQZJKK-UHFFFAOYSA-N 1h-pyrrol-3-amine Chemical compound NC=1C=CNC=1 WAUGGYPDCQZJKK-UHFFFAOYSA-N 0.000 title 1
- 102100024304 Protachykinin-1 Human genes 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 108010073085 tachykinin neuropeptide gamma Proteins 0.000 title 1
- 101710151321 Melanostatin Proteins 0.000 abstract 1
- 102400000064 Neuropeptide Y Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Det er beskrevet forbindelser med formel (I) som er effektive for behandling av tilstander assosiert med et overskudd av neuropeptid Y.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5473497P | 1997-08-05 | 1997-08-05 | |
| PCT/IB1998/001053 WO1999007703A1 (en) | 1997-08-05 | 1998-07-10 | 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO996178D0 NO996178D0 (no) | 1999-12-14 |
| NO996178L true NO996178L (no) | 2000-02-14 |
Family
ID=21993163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO996178A NO996178L (no) | 1997-08-05 | 1999-12-14 | 4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6187778B1 (no) |
| EP (1) | EP1003744B1 (no) |
| JP (1) | JP3711238B2 (no) |
| KR (1) | KR20010022583A (no) |
| CN (1) | CN1264381A (no) |
| AP (1) | AP9801312A0 (no) |
| AT (1) | ATE296825T1 (no) |
| AU (1) | AU7927498A (no) |
| BG (1) | BG104107A (no) |
| BR (1) | BR9811844A (no) |
| CA (1) | CA2293621C (no) |
| CO (1) | CO4960634A1 (no) |
| DE (1) | DE69830409T2 (no) |
| EA (1) | EA200000098A1 (no) |
| ES (1) | ES2241146T3 (no) |
| GT (1) | GT199800114A (no) |
| HR (1) | HRP980434A2 (no) |
| HU (1) | HUP0002956A3 (no) |
| ID (1) | ID24300A (no) |
| IL (1) | IL133430A0 (no) |
| IS (1) | IS5294A (no) |
| MA (1) | MA24629A1 (no) |
| NO (1) | NO996178L (no) |
| OA (1) | OA11277A (no) |
| PA (1) | PA8456601A1 (no) |
| PE (1) | PE106199A1 (no) |
| PL (1) | PL338575A1 (no) |
| SA (1) | SA98190435A (no) |
| TN (1) | TNSN98148A1 (no) |
| TR (1) | TR200000333T2 (no) |
| WO (1) | WO1999007703A1 (no) |
| ZA (1) | ZA986968B (no) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| YU23602A (sh) * | 1999-09-30 | 2004-09-03 | Neurogen Corporation | Amino supstituisani pirazolo /1,5/a/-1,5-pirimidini i pirazolo /1,5-a/-1,3,5-triazini |
| EP1990343B1 (en) * | 1999-12-24 | 2012-04-04 | Aventis Pharma Limited | Azaindoles |
| GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| WO2005118588A1 (ja) | 2004-06-02 | 2005-12-15 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物 |
| WO2006009734A1 (en) | 2004-06-17 | 2006-01-26 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
| WO2006009736A1 (en) | 2004-06-17 | 2006-01-26 | Wyeth | Processes for preparing gonadotropin releasing hormone receptor antagonists |
| US7465726B2 (en) * | 2004-08-02 | 2008-12-16 | Osi Pharmaceuticals, Inc. | Substituted pyrrolo[2.3-B]pyridines |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| AU2006209117B2 (en) * | 2005-01-28 | 2009-12-10 | Daewoong Pharmaceutical Co., Ltd. | Novel benzoimidazole derivatives and pharmaceutical composition comprising the same |
| KR20060087386A (ko) * | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| WO2006108218A1 (en) * | 2005-04-15 | 2006-10-19 | Regenertech Pty Limited | Use of neuropeptide y (npy) and agonists and antagonists thereof for tissue regeneration |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| CA2614544C (en) * | 2005-07-13 | 2013-09-10 | Banyu Pharmaceutical Co., Ltd. | Heterocycle-substituted benzimidazole derivative |
| AR057525A1 (es) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| WO2007067537A1 (en) * | 2005-12-07 | 2007-06-14 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine kinase inhibiting compounds |
| EP1963315B1 (en) * | 2005-12-22 | 2014-10-08 | Cancer Research Technology Limited | Enzyme inhibitors |
| JP2009528989A (ja) | 2006-02-17 | 2009-08-13 | ファイザー・リミテッド | Ｔｌｒ７変調剤としての３−デアザプリン誘導体 |
| JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| KR101134239B1 (ko) | 2006-07-11 | 2012-04-10 | 주식회사 대웅제약 | 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물 |
| CN101490037B (zh) * | 2006-07-11 | 2013-06-12 | 大熊制药株式会社 | 联芳基苯并咪唑衍生物以及包含该衍生物的药物组合物 |
| CL2007002617A1 (es) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
| WO2008121064A1 (en) * | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705 |
| DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| BRPI0818533B8 (pt) | 2007-10-11 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
| WO2009098715A2 (en) | 2008-01-11 | 2009-08-13 | Natco Pharma Limited | Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents |
| WO2012131399A1 (en) | 2011-04-01 | 2012-10-04 | Astrazeneca Ab | Therapeutic treatment |
| PT2785349T (pt) | 2011-11-30 | 2019-12-11 | Astrazeneca Ab | Tratamento combinado de cancro |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| CN113271938A (zh) * | 2018-11-30 | 2021-08-17 | 林伯士拉克许米公司 | Tyk2抑制剂和其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274213A (en) | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
| DE2818676A1 (de) * | 1978-04-27 | 1979-11-08 | Troponwerke Gmbh & Co Kg | Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB9022644D0 (en) * | 1990-10-18 | 1990-11-28 | Ici Plc | Heterocyclic compounds |
| US5877178A (en) * | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
| US5235053A (en) * | 1992-06-22 | 1993-08-10 | Eli Lilly And Company | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates |
| US5284971A (en) | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
| EP0580550B1 (en) | 1992-07-21 | 1997-10-22 | Novartis AG | Oxamic acid derivatives as hypocholesteremic agents |
| DE59500788D1 (de) * | 1994-05-03 | 1997-11-20 | Ciba Geigy Ag | Pyrrolopyrimidinderivate mit antiproliferativer Wirkung |
| JP4145955B2 (ja) * | 1994-09-29 | 2008-09-03 | ノバルティス アクチェンゲゼルシャフト | ピロロ〔２，３−ｄ〕ピリミジン及びその使用 |
| US6562862B1 (en) | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
| PL321136A1 (en) | 1994-11-07 | 1997-11-24 | Pfizer | Some substituted derivatives of bencylamine as a new class of specific ligands of neuropeptide y1 |
| US5644057A (en) * | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| EP0759441A3 (en) | 1995-06-30 | 1999-06-30 | Eli Lilly And Company | Methods of treating neuropeptide Y-associated conditions |
| EP0871442A1 (en) | 1996-01-09 | 1998-10-21 | Eli Lilly And Company | Benzimidzolyl neuropeptide y receptor antagonists |
-
1998
- 1998-07-10 IL IL13343098A patent/IL133430A0/xx unknown
- 1998-07-10 ID IDW20000021A patent/ID24300A/id unknown
- 1998-07-10 US US09/380,901 patent/US6187778B1/en not_active Expired - Fee Related
- 1998-07-10 DE DE69830409T patent/DE69830409T2/de not_active Expired - Fee Related
- 1998-07-10 PL PL98338575A patent/PL338575A1/xx unknown
- 1998-07-10 CA CA002293621A patent/CA2293621C/en not_active Expired - Fee Related
- 1998-07-10 JP JP2000506207A patent/JP3711238B2/ja not_active Expired - Fee Related
- 1998-07-10 EA EA200000098A patent/EA200000098A1/ru unknown
- 1998-07-10 TR TR2000/00333T patent/TR200000333T2/xx unknown
- 1998-07-10 KR KR1020007001174A patent/KR20010022583A/ko not_active Ceased
- 1998-07-10 ES ES98929573T patent/ES2241146T3/es not_active Expired - Lifetime
- 1998-07-10 CN CN98807398A patent/CN1264381A/zh active Pending
- 1998-07-10 HU HU0002956A patent/HUP0002956A3/hu unknown
- 1998-07-10 WO PCT/IB1998/001053 patent/WO1999007703A1/en not_active Ceased
- 1998-07-10 EP EP98929573A patent/EP1003744B1/en not_active Expired - Lifetime
- 1998-07-10 BR BR9811844-7A patent/BR9811844A/pt not_active Application Discontinuation
- 1998-07-10 AT AT98929573T patent/ATE296825T1/de not_active IP Right Cessation
- 1998-07-10 AU AU79274/98A patent/AU7927498A/en not_active Abandoned
- 1998-07-27 GT GT199800114A patent/GT199800114A/es unknown
- 1998-07-30 PE PE1998000678A patent/PE106199A1/es not_active Application Discontinuation
- 1998-07-30 AP APAP/P/1998/001312A patent/AP9801312A0/en unknown
- 1998-08-03 PA PA19988456601A patent/PA8456601A1/es unknown
- 1998-08-04 ZA ZA9806968A patent/ZA986968B/xx unknown
- 1998-08-04 TN TNTNSN98148A patent/TNSN98148A1/fr unknown
- 1998-08-04 MA MA25203A patent/MA24629A1/fr unknown
- 1998-08-04 HR HR60/054,734A patent/HRP980434A2/hr not_active Application Discontinuation
- 1998-08-05 CO CO98044925A patent/CO4960634A1/es unknown
- 1998-08-19 SA SA98190435A patent/SA98190435A/ar unknown
-
1999
- 1999-12-10 IS IS5294A patent/IS5294A/is unknown
- 1999-12-14 NO NO996178A patent/NO996178L/no not_active Application Discontinuation
-
2000
- 2000-01-14 OA OA1200000007A patent/OA11277A/en unknown
- 2000-01-26 BG BG104107A patent/BG104107A/bg unknown
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