NZ530137A - 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives - Google Patents

4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives

Info

Publication number
NZ530137A
NZ530137A NZ530137A NZ53013700A NZ530137A NZ 530137 A NZ530137 A NZ 530137A NZ 530137 A NZ530137 A NZ 530137A NZ 53013700 A NZ53013700 A NZ 53013700A NZ 530137 A NZ530137 A NZ 530137A
Authority
NZ
New Zealand
Prior art keywords
dihydro
piperazin
compounds
receptors
halogen
Prior art date
Application number
NZ530137A
Other languages
English (en)
Inventor
Benny Bang-Andersen
Jan Kehler
Jakob Felding
Original Assignee
H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H filed Critical H
Priority to NZ540801A priority Critical patent/NZ540801A/en
Publication of NZ530137A publication Critical patent/NZ530137A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NZ530137A 1999-12-30 2000-12-22 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives NZ530137A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ540801A NZ540801A (en) 1999-12-30 2000-12-22 4-Phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199901887 1999-12-30

Publications (1)

Publication Number Publication Date
NZ530137A true NZ530137A (en) 2005-09-30

Family

ID=8108820

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ530137A NZ530137A (en) 1999-12-30 2000-12-22 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
NZ519740A NZ519740A (en) 1999-12-30 2000-12-22 4-phenyl-1-piperazinyl, -piperidinyl and - tetrahydropyridyl derivatives having affinity for dopamine D3 & D4 receptors

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ519740A NZ519740A (en) 1999-12-30 2000-12-22 4-phenyl-1-piperazinyl, -piperidinyl and - tetrahydropyridyl derivatives having affinity for dopamine D3 & D4 receptors

Country Status (31)

Country Link
US (2) US7074796B2 (fr)
EP (2) EP1464641B1 (fr)
JP (1) JP2003519225A (fr)
KR (2) KR100792186B1 (fr)
CN (2) CN1803784A (fr)
AR (1) AR029461A1 (fr)
AT (2) ATE395333T1 (fr)
AU (2) AU783786B2 (fr)
BG (1) BG106960A (fr)
BR (1) BR0016953A (fr)
CA (1) CA2395869C (fr)
CZ (1) CZ20022603A3 (fr)
DE (2) DE60038911D1 (fr)
DK (2) DK1464641T3 (fr)
EA (2) EA005013B1 (fr)
ES (2) ES2302992T3 (fr)
HR (1) HRP20020567A2 (fr)
HU (1) HUP0203839A3 (fr)
IL (3) IL150366A0 (fr)
IS (1) IS6432A (fr)
MX (1) MXPA02006590A (fr)
NO (2) NO323401B1 (fr)
NZ (2) NZ530137A (fr)
PL (1) PL355502A1 (fr)
PT (2) PT1464641E (fr)
SG (1) SG152900A1 (fr)
SK (1) SK11072002A3 (fr)
TR (2) TR200201690T2 (fr)
UA (1) UA73756C2 (fr)
WO (1) WO2001049679A1 (fr)
ZA (1) ZA200205019B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE402704T1 (de) * 2000-03-27 2008-08-15 Abbott Gmbh & Co Kg Dopamin-d3-rezeptor-liganden zur behandlung von sucht
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
FR2831166B1 (fr) 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
US7550459B2 (en) * 2001-12-28 2009-06-23 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
ES2251624T3 (es) 2001-12-28 2006-05-01 Acadia Pharmaceuticals Inc. Analogos de la tetrahidroquinolina como los agonistas muscarinicos.
PL1701940T3 (pl) 2003-12-23 2008-11-28 H Lundbeck As Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI
DE102004027358A1 (de) * 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
FR2878524B1 (fr) * 2004-12-01 2007-01-19 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
EP1870405A1 (fr) * 2006-06-22 2007-12-26 Bioprojet (Aza)cyclohexanes carbonylées comme ligands du récepteur D3 de la dopamine
WO2015014256A1 (fr) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryle substitués et procédés d'utilisation
EP3083589B1 (fr) 2013-12-20 2019-12-18 Sunshine Lake Pharma Co., Ltd. Composés pipéraziniques substitués et leurs procédés d'utilisation
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (fr) * 1959-09-25 1900-01-01
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
US4950664A (en) * 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
US5556857A (en) * 1991-05-08 1996-09-17 Otsuka Pharmaceutical Co., Ltd. Disturbance-of-consciousness improving agent
IT1255178B (it) * 1992-06-26 1995-10-20 Pierrel Spa N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica
AU6435594A (en) * 1993-04-15 1994-11-08 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
DE69429895T2 (de) * 1993-06-28 2002-08-29 American Home Products Corp., Madison Neue Behandlungsmethoden durch Verwendung von Phenethylderivaten
WO1996017831A1 (fr) * 1994-12-07 1996-06-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Derives d'uracile
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
IL133960A0 (en) * 1997-08-15 2001-04-30 Pfizer Prod Inc 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives
US6355644B1 (en) * 1999-06-14 2002-03-12 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
TW580446B (en) * 2003-05-15 2004-03-21 Benq Corp Color electrode array printer

Also Published As

Publication number Publication date
ATE269857T1 (de) 2004-07-15
TR200402408T4 (tr) 2004-12-21
US20030027832A1 (en) 2003-02-06
DK1464641T3 (da) 2008-08-18
PT1246817E (pt) 2004-11-30
NO20023151L (no) 2002-08-02
NZ519740A (en) 2004-03-26
IS6432A (is) 2002-06-19
DK1246817T3 (da) 2004-10-18
DE60011817T2 (de) 2005-07-14
EP1246817B1 (fr) 2004-06-23
IL150366A (en) 2008-06-05
MXPA02006590A (es) 2002-12-13
EP1464641A1 (fr) 2004-10-06
SG152900A1 (en) 2009-06-29
JP2003519225A (ja) 2003-06-17
NO323401B1 (no) 2007-04-23
EA005013B1 (ru) 2004-10-28
PL355502A1 (en) 2004-05-04
BG106960A (bg) 2003-04-30
KR100729536B1 (ko) 2007-06-18
TR200201690T2 (tr) 2002-11-21
EA008627B1 (ru) 2007-06-29
AU2006201000A1 (en) 2006-04-06
US7074796B2 (en) 2006-07-11
AU2152701A (en) 2001-07-16
EP1464641B1 (fr) 2008-05-14
CZ20022603A3 (cs) 2002-10-16
CN1244577C (zh) 2006-03-08
SK11072002A3 (sk) 2003-03-04
AR029461A1 (es) 2003-07-02
CN1803784A (zh) 2006-07-19
BR0016953A (pt) 2003-02-25
IL150366A0 (en) 2002-12-01
CN1434819A (zh) 2003-08-06
ATE395333T1 (de) 2008-05-15
ZA200205019B (en) 2003-09-22
EA200400641A1 (ru) 2004-10-28
PT1464641E (pt) 2008-07-01
NO20065681L (no) 2002-08-02
KR20020063285A (ko) 2002-08-01
IL186954A0 (en) 2009-02-11
HK1055960A1 (en) 2004-01-30
KR100792186B1 (ko) 2008-01-08
EA200200729A1 (ru) 2002-12-26
HUP0203839A2 (hu) 2003-02-28
EP1246817A1 (fr) 2002-10-09
US7223765B2 (en) 2007-05-29
HUP0203839A3 (en) 2004-07-28
KR20070014234A (ko) 2007-01-31
WO2001049679A1 (fr) 2001-07-12
ES2302992T3 (es) 2008-08-01
US20060148815A1 (en) 2006-07-06
CA2395869C (fr) 2006-07-25
UA73756C2 (en) 2005-09-15
DE60011817D1 (de) 2004-07-29
DE60038911D1 (de) 2008-06-26
ES2223628T3 (es) 2005-03-01
HRP20020567A2 (en) 2005-04-30
CA2395869A1 (fr) 2001-07-12
AU783786B2 (en) 2005-12-08
NO20023151D0 (no) 2002-06-28

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