NZ586552A - Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same - Google Patents

Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same

Info

Publication number: NZ586552A
Authority: NZ; New Zealand
Prior art keywords: dioxo; dihydro; quinazolin; propyl; butyl
Prior art date: 2008-01-30

Application number

NZ586552A

Other languages

English (en)

Inventor

Il Hwan Cho

Eun Bang Lee

Sin Cheol Kang

Won Seok Kim

Chul Kyu Lee

Original Assignee

Shin Poong Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-01-30

Filing date

2009-01-08

Publication date

2012-06-29

2009-01-08 Application filed by Shin Poong Pharmaceutical Co Ltd filed Critical Shin Poong Pharmaceutical Co Ltd

2012-06-29 Publication of NZ586552A publication Critical patent/NZ586552A/en

Links

SDQJTWBNWQABLE-UHFFFAOYSA-N 1h-quinazoline-2,4-dione Chemical class C1=CC=C2C(=O)NC(=O)NC2=C1 SDQJTWBNWQABLE-UHFFFAOYSA-N 0.000 title claims abstract description 17
238000011282 treatment Methods 0.000 title abstract description 12
239000000203 mixture Substances 0.000 title abstract description 9
208000019736 Cranial nerve disease Diseases 0.000 title abstract description 5
208000014826 cranial nerve neuropathy Diseases 0.000 title abstract description 3
238000011321 prophylaxis Methods 0.000 title abstract description 3
150000001875 compounds Chemical class 0.000 claims abstract description 151
150000003839 salts Chemical class 0.000 claims abstract description 51
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 123
125000006308 propyl amino group Chemical group 0.000 claims description 51
-1 hydroxy, methoxy, ethoxy Chemical group 0.000 claims description 49
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 30
239000001257 hydrogen Substances 0.000 claims description 30
229910052739 hydrogen Inorganic materials 0.000 claims description 30
125000000217 alkyl group Chemical group 0.000 claims description 29
125000006309 butyl amino group Chemical group 0.000 claims description 23
238000006243 chemical reaction Methods 0.000 claims description 22
210000002569 neuron Anatomy 0.000 claims description 20
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 20
239000008194 pharmaceutical composition Substances 0.000 claims description 17
LFKDJXLFVYVEFG-UHFFFAOYSA-N tert-butyl carbamate Chemical compound CC(C)(C)OC(N)=O LFKDJXLFVYVEFG-UHFFFAOYSA-N 0.000 claims description 15
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
125000003545 alkoxy group Chemical group 0.000 claims description 14
229910052736 halogen Inorganic materials 0.000 claims description 13
239000002904 solvent Substances 0.000 claims description 13
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
150000002367 halogens Chemical group 0.000 claims description 11
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
208000006011 Stroke Diseases 0.000 claims description 10
239000004480 active ingredient Substances 0.000 claims description 10
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
208000024827 Alzheimer disease Diseases 0.000 claims description 7
206010015037 epilepsy Diseases 0.000 claims description 7
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 claims description 7
150000002431 hydrogen Chemical class 0.000 claims description 7
208000032382 Ischaemic stroke Diseases 0.000 claims description 6
201000010099 disease Diseases 0.000 claims description 6
125000001245 hexylamino group Chemical group [H]N([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 6
MLAJKFBHELLQJC-UHFFFAOYSA-N 3-[4-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]butyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCCCCN1C(=O)C2=CC=CC=C2NC1=O MLAJKFBHELLQJC-UHFFFAOYSA-N 0.000 claims description 5
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DMGJYMZSBLSOAU-UHFFFAOYSA-N 3-[3-[4-(3-aminopropylamino)butylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)N(CCCNCCCCNCCCN)C(=O)NC2=C1 DMGJYMZSBLSOAU-UHFFFAOYSA-N 0.000 claims description 4
QXSAKPUBHTZHKW-UHFFFAOYSA-N 4-hydroxybenzamide Chemical compound NC(=O)C1=CC=C(O)C=C1 QXSAKPUBHTZHKW-UHFFFAOYSA-N 0.000 claims description 4
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WLDXKRHMTJRSGL-UHFFFAOYSA-N n-[3-(2,4-dioxo-1h-quinazolin-3-yl)propyl]-n-[4-[3-(2,4-dioxo-1h-quinazolin-3-yl)propyl-methylamino]butyl]acetamide Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCN(C)CCCCN(C(C)=O)CCCN1C(=O)C2=CC=CC=C2NC1=O WLDXKRHMTJRSGL-UHFFFAOYSA-N 0.000 claims description 4
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JBZGLYIWQCCGSY-UHFFFAOYSA-N 3-[2-[3-[2-(2,4-dioxo-1h-quinazolin-3-yl)ethylamino]propylamino]ethyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCNCCCNCCN1C(=O)C2=CC=CC=C2NC1=O JBZGLYIWQCCGSY-UHFFFAOYSA-N 0.000 claims description 3
HAXIGGFPEXYILL-UHFFFAOYSA-N 3-[3-[4-[3-(2,5-dioxopyrrolidin-1-yl)propylamino]butylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound O=C1CCC(=O)N1CCCNCCCCNCCCN1C(=O)C2=CC=CC=C2NC1=O HAXIGGFPEXYILL-UHFFFAOYSA-N 0.000 claims description 3
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JWAZCOLPZRXAMX-UHFFFAOYSA-N 1-hexyl-3-[3-[4-[3-(1-hexyl-2,4-dioxoquinazolin-3-yl)propylamino]butylamino]propyl]quinazoline-2,4-dione Chemical compound O=C1N(CCCCCC)C2=CC=CC=C2C(=O)N1CCCNCCCCNCCCN1C(=O)C2=CC=CC=C2N(CCCCCC)C1=O JWAZCOLPZRXAMX-UHFFFAOYSA-N 0.000 claims description 2
KKARFJXBDDKSOI-UHFFFAOYSA-N 3-[3-[2-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]ethylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCCNCCCN1C(=O)C2=CC=CC=C2NC1=O KKARFJXBDDKSOI-UHFFFAOYSA-N 0.000 claims description 2
BBVXOMSJMHOIQX-UHFFFAOYSA-N 3-[3-[4-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]but-2-enylamino]propyl]-1h-quinazoline-2,4-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCC=CCNCCCN1C(=O)C2=CC=CC=C2NC1=O BBVXOMSJMHOIQX-UHFFFAOYSA-N 0.000 claims description 2
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206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 2
TWLLPUMZVVGILS-UHFFFAOYSA-N Ethyl 2-aminobenzoate Chemical compound CCOC(=O)C1=CC=CC=C1N TWLLPUMZVVGILS-UHFFFAOYSA-N 0.000 claims description 2
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208000016988 Hemorrhagic Stroke Diseases 0.000 claims description 2
206010021143 Hypoxia Diseases 0.000 claims description 2
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201000008450 Intracranial aneurysm Diseases 0.000 claims description 2
208000009829 Lewy Body Disease Diseases 0.000 claims description 2
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206010033892 Paraplegia Diseases 0.000 claims description 2
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WJBRXOKCHRCZAZ-UHFFFAOYSA-N benzyl n-[3-(2,4-dioxo-1h-quinazolin-3-yl)propyl]-n-[4-[3-(2,4-dioxo-1h-quinazolin-3-yl)propylamino]butyl]carbamate Chemical compound O=C1NC2=CC=CC=C2C(=O)N1CCCNCCCCN(CCCN1C(C2=CC=CC=C2NC1=O)=O)C(=O)OCC1=CC=CC=C1 WJBRXOKCHRCZAZ-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms

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Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NZ586552A 2008-01-30 2009-01-08 Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same NZ586552A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR20080009390		2008-01-30
PCT/KR2009/000083 WO2009096667A2 (fr)	2008-01-30	2009-01-08	Nouveau dérivé de quinazoline-2,4-dione et compositions médicales pour la prophylaxie et le traitement de la maladie du nerf crânien contenant ledit dérivé

Publications (1)

Publication Number	Publication Date
NZ586552A true NZ586552A (en)	2012-06-29

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NZ586552A NZ586552A (en)	2008-01-30	2009-01-08	Novel quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same

Country Status (20)

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US (2)	US8404696B2 (fr)
EP (1)	EP2239257B1 (fr)
JP (1)	JP5291124B2 (fr)
KR (1)	KR101075435B1 (fr)
CN (1)	CN101925585B (fr)
AR (1)	AR074372A1 (fr)
AU (1)	AU2009209811B2 (fr)
BR (1)	BRPI0906996B1 (fr)
CA (1)	CA2712819C (fr)
CO (1)	CO6290762A2 (fr)
DK (1)	DK2239257T3 (fr)
EA (1)	EA018142B1 (fr)
ES (1)	ES2387539T3 (fr)
IL (1)	IL206738A (fr)
MY (1)	MY153733A (fr)
NZ (1)	NZ586552A (fr)
PL (1)	PL2239257T3 (fr)
PT (1)	PT2239257E (fr)
WO (1)	WO2009096667A2 (fr)
ZA (1)	ZA201004546B (fr)

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PT2239257E (pt)	2008-01-30	2012-09-12	Shin Poong Pharmaceutical Co Ltd	Novo derivado de quinazolina-2,4-diona e composições médicas para a profilaxia e tratamento da doença dos nervos cranianos contendo o dito derivado
US8337902B2 (en) *	2008-09-25	2012-12-25	Wisconsin Alumni Research Foundation	Degradation of prion protein and reduced prion infectivity by earthworm homogenates
CN103517890B (zh) *	2011-05-02	2016-08-17	弗纳技术股份有限公司	乙苯生产方法
KR102061183B1 (ko) *	2014-01-20	2019-12-31	웰 스톤 유겐가이샤	카테콜라민 생산 촉진제, 카테콜라민의 결핍에 기인하는 질환의 치료약·예방약 및 치료용·예방용 식품 조성물
JP7203495B2 (ja) *	2015-06-15	2023-01-13	コーニンクレッカフィリップスエヌヴェ	改善されたノズル設計を具備する口腔清掃装置

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GB9400680D0 (en) *	1994-01-14	1994-03-09	Sandoz Ltd	Improvements in or relating to organic compounds
CN1103772C (zh)	1996-05-15	2003-03-26	辉瑞大药厂	新的2,3－二取代－4(3h)－喹唑啉酮类化合物
US6060479A (en)	1997-06-09	2000-05-09	Pfizer Inc	Quinazoline-4-one AMPA antagonists
ATE360423T1 (de) *	1999-11-01	2007-05-15	Daiichi Asubio Pharma Co Ltd	Verwendung von chymase hemmern gegen vaskuläre lipidablagerung
SK10572002A3 (sk) *	2000-01-24	2003-10-07	Warner-Lambert Company	3-Aminochinazolín-2,4-diónové antibakteriálne činidlá
JP2004527535A (ja) *	2001-04-11	2004-09-09	クイーンズ　ユニバーシティ　アット　キングストン	抗発作発生剤および／または抗癲癇誘発剤としてのピリミジン化合物
DE10201240A1 (de) *	2002-01-15	2003-07-24	Bayer Ag	Substituierte Alkyluracile und ihre Verwendung
GB0416730D0 (en) *	2004-07-27	2004-09-01	Novartis Ag	Organic compounds
TWI396543B (zh) *	2005-05-12	2013-05-21	Sankyo Co	取代丙烯醯胺衍生物及含有它之醫藥組成物
US8586619B2 (en)	2007-03-12	2013-11-19	Vm Therapeutics Llc	Agents of calcium ion channel modulators
PT2239257E (pt)	2008-01-30	2012-09-12	Shin Poong Pharmaceutical Co Ltd	Novo derivado de quinazolina-2,4-diona e composições médicas para a profilaxia e tratamento da doença dos nervos cranianos contendo o dito derivado

2009
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- 2009-01-08 AU AU2009209811A patent/AU2009209811B2/en active Active
- 2009-01-08 EA EA201070898A patent/EA018142B1/ru not_active IP Right Cessation
- 2009-01-08 US US12/863,332 patent/US8404696B2/en active Active
- 2009-01-08 KR KR1020090001655A patent/KR101075435B1/ko active Active
- 2009-01-08 EP EP09705187A patent/EP2239257B1/fr active Active
- 2009-01-08 JP JP2010544881A patent/JP5291124B2/ja active Active
- 2009-01-08 PL PL09705187T patent/PL2239257T3/pl unknown
- 2009-01-08 CN CN2009801032365A patent/CN101925585B/zh active Active
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2010
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Also Published As

Publication number	Publication date
EA018142B1 (ru)	2013-05-30
CA2712819C (fr)	2013-07-23
EP2239257A2 (fr)	2010-10-13
IL206738A (en)	2014-05-28
BRPI0906996B1 (pt)	2021-06-22
KR101075435B1 (ko)	2011-10-24
CO6290762A2 (es)	2011-06-20
WO2009096667A4 (fr)	2009-12-03
CN101925585A (zh)	2010-12-22
CA2712819A1 (fr)	2009-08-06
IL206738A0 (en)	2010-12-30
HK1149263A1 (en)	2011-09-30
US8404696B2 (en)	2013-03-26
JP2011510978A (ja)	2011-04-07
WO2009096667A2 (fr)	2009-08-06
ES2387539T3 (es)	2012-09-25
KR20090083848A (ko)	2009-08-04
AU2009209811B2 (en)	2011-07-21
US9290480B2 (en)	2016-03-22
PL2239257T3 (pl)	2012-10-31
WO2009096667A3 (fr)	2009-10-08
BRPI0906996A2 (pt)	2015-07-07
ZA201004546B (en)	2011-04-28
DK2239257T3 (da)	2012-08-13
US20130102622A1 (en)	2013-04-25
AU2009209811A1 (en)	2009-08-06
EP2239257B1 (fr)	2012-06-06
EP2239257A4 (fr)	2011-06-22
MY153733A (en)	2015-03-13
PT2239257E (pt)	2012-09-12
US20100311769A1 (en)	2010-12-09
CN101925585B (zh)	2013-04-17
JP5291124B2 (ja)	2013-09-18
AR074372A1 (es)	2011-01-12
EA201070898A1 (ru)	2011-02-28

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