OA06003A - Procédé amélioré de synthèse d'oligonucléotides par la voie triester. - Google Patents

Procédé amélioré de synthèse d'oligonucléotides par la voie triester.

Info

Publication number: OA06003A
Authority: OA; OAPI
Prior art keywords: triester; oligonucleotides; route; synthesis; improved process
Prior art date: 1977-11-08

Application number

OA56653A

Other languages

English (en)

French (fr)

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-08

Filing date

1978-11-08

Publication date

1981-06-30

1978-11-08 Application filed by Genentech Inc filed Critical Genentech Inc

1981-06-30 Publication of OA06003A publication Critical patent/OA06003A/xx

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000005691 triesters Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

OA56653A 1977-11-08 1978-11-08 Procédé amélioré de synthèse d'oligonucléotides par la voie triester. OA06003A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84960877A	1977-11-08	1977-11-08

Publications (1)

Publication Number	Publication Date
OA06003A true OA06003A (fr)	1981-06-30

Family

ID=25306107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA56653A OA06003A (fr)	1977-11-08	1978-11-08	Procédé amélioré de synthèse d'oligonucléotides par la voie triester.

Country Status (22)

Country	Link
EP (1)	EP0002322A3 (pl)
JP (1)	JPS5473787A (pl)
AU (1)	AU4136078A (pl)
BE (1)	BE871781A (pl)
BR (1)	BR7807288A (pl)
DD (1)	DD141836A5 (pl)
DE (1)	DE2848054A1 (pl)
DK (1)	DK493678A (pl)
ES (1)	ES474850A1 (pl)
FI (1)	FI783364A7 (pl)
FR (1)	FR2407939A1 (pl)
GB (1)	GB2007670A (pl)
IL (1)	IL55893A0 (pl)
LU (1)	LU80483A1 (pl)
NL (1)	NL7811043A (pl)
NO (1)	NO783721L (pl)
OA (1)	OA06003A (pl)
PL (1)	PL210786A1 (pl)
PT (1)	PT68754A (pl)
SE (1)	SE7811459L (pl)
ZA (1)	ZA786303B (pl)
ZM (1)	ZM9478A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU527165B2 (en) *	1977-02-08	1983-02-17	Genentech Inc.	Method and means for microbial polypeptide expression; synthetic DNA and process therefor
US4342832A (en) *	1979-07-05	1982-08-03	Genentech, Inc.	Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4474947A (en) *	1982-04-08	1984-10-02	Biosearch	Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes
JPS61152695A (ja) *	1984-12-26	1986-07-11	Nippon Shinyaku Co Ltd	長鎖ｄｎａの合成法
CN102282155B (zh)	2008-12-02	2017-06-09	日本波涛生命科学公司	磷原子修饰的核酸的合成方法
RU2612521C2 (ru)	2009-07-06	2017-03-09	Онтории, Инк.	Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja)	2010-09-24	2016-02-24	株式会社Wave Life Sciences Japan	不斉補助基
CN103796657B (zh)	2011-07-19	2017-07-11	波涛生命科学有限公司	合成官能化核酸的方法
CA2879066C (en)	2012-07-13	2019-08-13	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant
PL2872485T3 (pl)	2012-07-13	2021-05-31	Wave Life Sciences Ltd.	Asymetryczna grupa pomocnicza
KR102213609B1 (ko)	2012-07-13	2021-02-08	웨이브 라이프 사이언시스 리미티드	키랄 제어
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108048A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108047A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
BR112016016400A2 (pt)	2014-01-16	2017-10-03	Wave Life Sciences Ltd	Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos

1978
- 1978-09-06 BR BR7807288A patent/BR7807288A/pt unknown
- 1978-11-06 DK DK493678A patent/DK493678A/da unknown
- 1978-11-06 AU AU41360/78A patent/AU4136078A/en active Pending
- 1978-11-06 JP JP13721478A patent/JPS5473787A/ja active Pending
- 1978-11-06 BE BE1009120A patent/BE871781A/xx unknown
- 1978-11-06 EP EP78300595A patent/EP0002322A3/en not_active Withdrawn
- 1978-11-06 NL NL7811043A patent/NL7811043A/xx not_active Application Discontinuation
- 1978-11-06 FI FI783364A patent/FI783364A7/fi unknown
- 1978-11-06 ES ES474850A patent/ES474850A1/es not_active Expired
- 1978-11-06 FR FR7831349A patent/FR2407939A1/fr not_active Withdrawn
- 1978-11-06 SE SE7811459A patent/SE7811459L/xx unknown
- 1978-11-06 GB GB7843445A patent/GB2007670A/en not_active Withdrawn
- 1978-11-06 IL IL55893A patent/IL55893A0/xx unknown
- 1978-11-06 DE DE19782848054 patent/DE2848054A1/de not_active Withdrawn
- 1978-11-06 NO NO783721A patent/NO783721L/no unknown
- 1978-11-07 PT PT68754A patent/PT68754A/pt unknown
- 1978-11-07 DD DD78208919A patent/DD141836A5/de unknown
- 1978-11-08 OA OA56653A patent/OA06003A/xx unknown
- 1978-11-08 ZA ZA00786303A patent/ZA786303B/xx unknown
- 1978-11-08 LU LU80483A patent/LU80483A1/xx unknown
- 1978-11-08 PL PL21078678A patent/PL210786A1/pl unknown
- 1978-11-08 ZM ZM94/78A patent/ZM9478A1/xx unknown

Also Published As

Publication number	Publication date
EP0002322A2 (en)	1979-06-13
ZM9478A1 (en)	1980-03-21
NL7811043A (nl)	1979-05-10
PT68754A (en)	1978-12-01
FI783364A7 (fi)	1979-05-09
LU80483A1 (fr)	1979-03-22
EP0002322A3 (en)	1979-06-27
BE871781A (fr)	1979-05-07
AU4136078A (en)	1979-05-17
BR7807288A (pt)	1979-06-12
JPS5473787A (en)	1979-06-13
GB2007670A (en)	1979-05-23
DK493678A (da)	1979-07-12
SE7811459L (sv)	1979-05-09
ES474850A1 (es)	1979-12-01
NO783721L (no)	1979-05-09
ZA786303B (en)	1979-10-31
DE2848054A1 (de)	1979-05-10
PL210786A1 (pl)	1979-07-16
IL55893A0 (en)	1979-01-31
DD141836A5 (de)	1980-05-21
FR2407939A1 (fr)	1979-06-01

Publication	Publication Date	Title
PT68573A (fr)	1978-10-01	Procede de preparation des derivatifs d'imidazole.
LU79926A1 (fr)	1979-04-09	Procede de preparation d'amides derives du trimethoxy-3,4,5 benzene
PT72331B (fr)	1982-07-23	Procede de preparation de nouvelles oximes derives de l'erythromycine a
OA06003A (fr)	1981-06-30	Procédé amélioré de synthèse d'oligonucléotides par la voie triester.
IT1102413B (it)	1985-10-07	Processo continuo per la produzione di alchilen-glicoli da alchilencarbonati
BE877197A (fr)	1979-10-15	Procede de preparation de derives de 14,15-methylene de la serie des oestranes
BE877243A (fr)	1979-12-27	Procede de preparation de l'o-methallyloxyphenol par monoetherification selective de la pyrocatechine
BE869395A (fr)	1978-11-16	Procede de production de nouveaux derives d'anthracycline
BE857706R (fr)	1978-02-13	Procede de preparation continue d'aldehydes par hydroformylation
RO81685A (ro)	1983-04-29	Procedeu de preparare a unor derivati de antrachinonsulfonamide cu formula generala i
RO77321A (ro)	1981-08-17	Procedeu de preparare a unor derivati de 3(2-hidroxi-4-substituit-fenil)-cicloalcanone
LU80567A1 (fr)	1979-03-22	Procede pour la preparation de 3-iodo-et de 3 bromorifamycine s
OA06479A (fr)	1981-07-31	Procédé de transformation de l'hydragilitte boehmite.
BE863268R (fr)	1978-07-24	Procede de preparation continue d'aldehydes par hydroformylation
LU78953A1 (fr)	1978-09-28	Procede de preparation de nouvelles glycoproteines isolees d'hafnia
FR2408661B1 (fr)	1985-09-13	Procede de production d'aciers resulfures
BE863267R (fr)	1978-07-24	Procede de preparation continue d'aldehydes par hydroformylation
FR2296609A1 (fr)	1976-07-30	Procede d'obtention catalytique de polyalcools
BE867414A (fr)	1978-09-18	Procede pour la preparation d'hydroxy-alpha-aminobenzylpenicillines
BE882626A (fr)	1980-10-03	Procede de preparation d'alkoxy alanates de metaux alcalino-terreux
BE867228A (fr)	1978-11-20	Procede pour la preparation d'hydroxyphenylglycocolles
LU78874A1 (fr)	1979-09-06	Procede de preparation de nouvelles sulfonylhydrazones de 1,4-dioxo-et 4-oxoquinoxaline-2-carboxaldehyde
BE865429A (fr)	1978-09-29	Procede de production d'alcane-polyols
BE866662A (fr)	1978-11-03	Procede de preparation de 3,5-dihalogenanilines
BE852700R (fr)	1977-09-21	Procede de preparation d'oxaphospholannes-1,2