OA10204A - Squalene synthetase inhibitors - Google Patents
Squalene synthetase inhibitors Download PDFInfo
- Publication number
- OA10204A OA10204A OA60759A OA60759A OA10204A OA 10204 A OA10204 A OA 10204A OA 60759 A OA60759 A OA 60759A OA 60759 A OA60759 A OA 60759A OA 10204 A OA10204 A OA 10204A
- Authority
- OA
- OAPI
- Prior art keywords
- neopentyl
- compound
- oxo
- chloro
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36271394A | 1994-12-23 | 1994-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA10204A true OA10204A (en) | 1996-12-18 |
Family
ID=23427229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA60759A OA10204A (en) | 1994-12-23 | 1995-12-22 | Squalene synthetase inhibitors |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5770594A (fr) |
| JP (1) | JPH10500702A (fr) |
| KR (1) | KR960022510A (fr) |
| CN (1) | CN1133287A (fr) |
| AU (1) | AU4067795A (fr) |
| BG (1) | BG100248A (fr) |
| BR (1) | BR9505995A (fr) |
| CA (1) | CA2207772A1 (fr) |
| CZ (1) | CZ344795A3 (fr) |
| FI (1) | FI972696L (fr) |
| GT (1) | GT199500058A (fr) |
| HU (1) | HUT74672A (fr) |
| IL (1) | IL116399A0 (fr) |
| IS (1) | IS4312A (fr) |
| LV (1) | LV11325B (fr) |
| MA (1) | MA23746A1 (fr) |
| MX (1) | MX9704683A (fr) |
| NO (1) | NO955288L (fr) |
| OA (1) | OA10204A (fr) |
| PE (1) | PE60096A1 (fr) |
| PL (1) | PL311997A1 (fr) |
| SI (1) | SI9500393A (fr) |
| SK (1) | SK158795A3 (fr) |
| TN (1) | TNSN95133A1 (fr) |
| TR (1) | TR199501644A2 (fr) |
| WO (1) | WO1996020184A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997048701A1 (fr) * | 1996-06-20 | 1997-12-24 | Pfizer Inc. | 4,1-benzoxazepines ou 4,1-benzothiazepines et leur utilisation comme inhibiteurs de squalene synthetase |
| US5965553A (en) * | 1996-06-20 | 1999-10-12 | Pfizer Inc. | Squalene synthetase inhibitors |
| DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
| US20060141036A1 (en) * | 1997-12-12 | 2006-06-29 | Andrx Labs Llc | HMG-CoA reductase inhibitor extended release formulation |
| US6403576B1 (en) * | 1998-08-24 | 2002-06-11 | The United States Of America As Represented By The Secretary Of The Navy | Antifungal and antiparasitic compounds |
| US20020054871A1 (en) * | 1999-04-12 | 2002-05-09 | Yadong Huang | Methods and compositions for use in the treatment of hyperlipidemia |
| CA2389973A1 (fr) * | 1999-11-04 | 2001-05-10 | Andrx Corporation | Methode de traitement de troubles lies au precurseur beta-amyloide |
| US20020107173A1 (en) * | 1999-11-04 | 2002-08-08 | Lawrence Friedhoff | Method of treating amyloid beta precursor disorders |
| ES2328225T3 (es) * | 2000-11-21 | 2009-11-11 | Janssen Pharmaceutica Nv | Derivados benzoheterociclicos inhibidores de la farnesil-transferasa. |
| WO2008121602A1 (fr) * | 2007-03-29 | 2008-10-09 | Smithkline Beecham Corporation | Composés chimiques |
| GB0803747D0 (en) * | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG82630A1 (en) * | 1992-04-20 | 2001-08-21 | Takeda Chemical Industries Ltd | 4,1-benzoxazepin derivatives and their use |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| US5807834A (en) * | 1994-09-20 | 1998-09-15 | Pfizer Inc. | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor |
-
1995
- 1995-06-02 CA CA002207772A patent/CA2207772A1/fr not_active Abandoned
- 1995-06-02 SK SK1587-95A patent/SK158795A3/sk unknown
- 1995-06-02 FI FI972696A patent/FI972696L/fi not_active Application Discontinuation
- 1995-06-02 MX MX9704683A patent/MX9704683A/es not_active IP Right Cessation
- 1995-06-02 BR BR9505995A patent/BR9505995A/pt not_active Application Discontinuation
- 1995-06-02 JP JP8520314A patent/JPH10500702A/ja active Pending
- 1995-06-02 WO PCT/IB1995/000424 patent/WO1996020184A1/fr not_active Ceased
- 1995-06-02 US US08/860,155 patent/US5770594A/en not_active Expired - Fee Related
- 1995-12-13 GT GT199500058A patent/GT199500058A/es unknown
- 1995-12-14 IL IL11639995A patent/IL116399A0/xx unknown
- 1995-12-18 PE PE1995287390A patent/PE60096A1/es not_active Application Discontinuation
- 1995-12-18 MA MA24097A patent/MA23746A1/fr unknown
- 1995-12-19 IS IS4312A patent/IS4312A/is unknown
- 1995-12-21 PL PL95311997A patent/PL311997A1/xx unknown
- 1995-12-21 LV LVP-95-379A patent/LV11325B/en unknown
- 1995-12-21 BG BG100248A patent/BG100248A/xx unknown
- 1995-12-21 TN TNTNSN95133A patent/TNSN95133A1/fr unknown
- 1995-12-22 NO NO955288A patent/NO955288L/no unknown
- 1995-12-22 HU HU9503783A patent/HUT74672A/hu unknown
- 1995-12-22 CN CN95120143A patent/CN1133287A/zh active Pending
- 1995-12-22 AU AU40677/95A patent/AU4067795A/en not_active Abandoned
- 1995-12-22 OA OA60759A patent/OA10204A/en unknown
- 1995-12-22 CZ CZ953447A patent/CZ344795A3/cs unknown
- 1995-12-22 SI SI9500393A patent/SI9500393A/sl unknown
- 1995-12-22 KR KR1019950054933A patent/KR960022510A/ko not_active Ceased
- 1995-12-22 TR TR95/01644A patent/TR199501644A2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT74672A (en) | 1997-01-28 |
| MA23746A1 (fr) | 1996-07-01 |
| WO1996020184A1 (fr) | 1996-07-04 |
| KR960022510A (ko) | 1996-07-18 |
| US5770594A (en) | 1998-06-23 |
| IS4312A (is) | 1996-06-24 |
| AU4067795A (en) | 1996-07-04 |
| CN1133287A (zh) | 1996-10-16 |
| TNSN95133A1 (fr) | 1996-02-06 |
| IL116399A0 (en) | 1996-03-31 |
| MX9704683A (es) | 1997-09-30 |
| CA2207772A1 (fr) | 1996-07-04 |
| JPH10500702A (ja) | 1998-01-20 |
| LV11325A (lv) | 1996-06-20 |
| NO955288L (no) | 1996-06-24 |
| CZ344795A3 (en) | 1996-09-11 |
| HU9503783D0 (en) | 1996-04-29 |
| LV11325B (en) | 1997-02-20 |
| FI972696A0 (fi) | 1997-06-23 |
| GT199500058A (es) | 1997-06-05 |
| SK158795A3 (en) | 1997-01-08 |
| FI972696A7 (fi) | 1997-06-23 |
| NO955288D0 (no) | 1995-12-22 |
| TR199501644A2 (tr) | 1996-11-21 |
| SI9500393A (en) | 1997-04-30 |
| FI972696L (fi) | 1997-06-23 |
| PL311997A1 (en) | 1996-06-24 |
| PE60096A1 (es) | 1996-12-28 |
| BG100248A (bg) | 1996-07-31 |
| BR9505995A (pt) | 1997-12-23 |
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