LV11325B - Squalene synthetase inhibitors - Google Patents
Squalene synthetase inhibitors Download PDFInfo
- Publication number
- LV11325B LV11325B LVP-95-379A LV950379A LV11325B LV 11325 B LV11325 B LV 11325B LV 950379 A LV950379 A LV 950379A LV 11325 B LV11325 B LV 11325B
- Authority
- LV
- Latvia
- Prior art keywords
- compound
- oxo
- neopentyl
- trans
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36271394A | 1994-12-23 | 1994-12-23 | |
| PCT/IB1995/000424 WO1996020184A1 (fr) | 1994-12-23 | 1995-06-02 | Naphtyl-benzoxazepines ou benzothiazepines inhibitant la squalene synthetase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV11325A LV11325A (lv) | 1996-06-20 |
| LV11325B true LV11325B (en) | 1997-02-20 |
Family
ID=23427229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-95-379A LV11325B (en) | 1994-12-23 | 1995-12-21 | Squalene synthetase inhibitors |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5770594A (fr) |
| JP (1) | JPH10500702A (fr) |
| KR (1) | KR960022510A (fr) |
| CN (1) | CN1133287A (fr) |
| AU (1) | AU4067795A (fr) |
| BG (1) | BG100248A (fr) |
| BR (1) | BR9505995A (fr) |
| CA (1) | CA2207772A1 (fr) |
| CZ (1) | CZ344795A3 (fr) |
| FI (1) | FI972696L (fr) |
| GT (1) | GT199500058A (fr) |
| HU (1) | HUT74672A (fr) |
| IL (1) | IL116399A0 (fr) |
| IS (1) | IS4312A (fr) |
| LV (1) | LV11325B (fr) |
| MA (1) | MA23746A1 (fr) |
| MX (1) | MX9704683A (fr) |
| NO (1) | NO955288L (fr) |
| OA (1) | OA10204A (fr) |
| PE (1) | PE60096A1 (fr) |
| PL (1) | PL311997A1 (fr) |
| SI (1) | SI9500393A (fr) |
| SK (1) | SK158795A3 (fr) |
| TN (1) | TNSN95133A1 (fr) |
| TR (1) | TR199501644A2 (fr) |
| WO (1) | WO1996020184A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965553A (en) * | 1996-06-20 | 1999-10-12 | Pfizer Inc. | Squalene synthetase inhibitors |
| AU2401697A (en) * | 1996-06-20 | 1998-01-07 | Pfizer Inc. | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors |
| DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
| US20060141036A1 (en) * | 1997-12-12 | 2006-06-29 | Andrx Labs Llc | HMG-CoA reductase inhibitor extended release formulation |
| US6403576B1 (en) * | 1998-08-24 | 2002-06-11 | The United States Of America As Represented By The Secretary Of The Navy | Antifungal and antiparasitic compounds |
| US20020054871A1 (en) * | 1999-04-12 | 2002-05-09 | Yadong Huang | Methods and compositions for use in the treatment of hyperlipidemia |
| US20020107173A1 (en) * | 1999-11-04 | 2002-08-08 | Lawrence Friedhoff | Method of treating amyloid beta precursor disorders |
| JP2003523948A (ja) * | 1999-11-04 | 2003-08-12 | アンドルクス コーポレーション | アミロイドβ前駆体障害の治療法 |
| JP4348080B2 (ja) * | 2000-11-21 | 2009-10-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体 |
| WO2008121602A1 (fr) * | 2007-03-29 | 2008-10-09 | Smithkline Beecham Corporation | Composés chimiques |
| GB0803747D0 (en) * | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567026B1 (fr) * | 1992-04-20 | 2003-03-26 | Takeda Chemical Industries, Ltd. | Dérivés de 4,1-benzoxazepine comme inhibiteurs de la synthétase du squalène et leur application dans le traitement d'hypercholesteremie et comme fongicides |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| AU2453295A (en) * | 1994-09-20 | 1996-04-19 | Pfizer Inc. | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor |
-
1995
- 1995-06-02 BR BR9505995A patent/BR9505995A/pt not_active Application Discontinuation
- 1995-06-02 MX MX9704683A patent/MX9704683A/es not_active IP Right Cessation
- 1995-06-02 WO PCT/IB1995/000424 patent/WO1996020184A1/fr not_active Ceased
- 1995-06-02 FI FI972696A patent/FI972696L/fi not_active Application Discontinuation
- 1995-06-02 JP JP8520314A patent/JPH10500702A/ja active Pending
- 1995-06-02 CA CA002207772A patent/CA2207772A1/fr not_active Abandoned
- 1995-06-02 US US08/860,155 patent/US5770594A/en not_active Expired - Fee Related
- 1995-06-02 SK SK1587-95A patent/SK158795A3/sk unknown
- 1995-12-13 GT GT199500058A patent/GT199500058A/es unknown
- 1995-12-14 IL IL11639995A patent/IL116399A0/xx unknown
- 1995-12-18 PE PE1995287390A patent/PE60096A1/es not_active Application Discontinuation
- 1995-12-18 MA MA24097A patent/MA23746A1/fr unknown
- 1995-12-19 IS IS4312A patent/IS4312A/is unknown
- 1995-12-21 TN TNTNSN95133A patent/TNSN95133A1/fr unknown
- 1995-12-21 LV LVP-95-379A patent/LV11325B/en unknown
- 1995-12-21 BG BG100248A patent/BG100248A/xx unknown
- 1995-12-21 PL PL95311997A patent/PL311997A1/xx unknown
- 1995-12-22 HU HU9503783A patent/HUT74672A/hu unknown
- 1995-12-22 OA OA60759A patent/OA10204A/en unknown
- 1995-12-22 TR TR95/01644A patent/TR199501644A2/xx unknown
- 1995-12-22 NO NO955288A patent/NO955288L/no unknown
- 1995-12-22 SI SI9500393A patent/SI9500393A/sl unknown
- 1995-12-22 KR KR1019950054933A patent/KR960022510A/ko not_active Ceased
- 1995-12-22 CN CN95120143A patent/CN1133287A/zh active Pending
- 1995-12-22 CZ CZ953447A patent/CZ344795A3/cs unknown
- 1995-12-22 AU AU40677/95A patent/AU4067795A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE60096A1 (es) | 1996-12-28 |
| BG100248A (bg) | 1996-07-31 |
| PL311997A1 (en) | 1996-06-24 |
| OA10204A (en) | 1996-12-18 |
| CZ344795A3 (en) | 1996-09-11 |
| HU9503783D0 (en) | 1996-04-29 |
| CN1133287A (zh) | 1996-10-16 |
| SI9500393A (en) | 1997-04-30 |
| SK158795A3 (en) | 1997-01-08 |
| IL116399A0 (en) | 1996-03-31 |
| HUT74672A (en) | 1997-01-28 |
| NO955288L (no) | 1996-06-24 |
| TR199501644A2 (tr) | 1996-11-21 |
| FI972696A0 (fi) | 1997-06-23 |
| FI972696A7 (fi) | 1997-06-23 |
| BR9505995A (pt) | 1997-12-23 |
| MX9704683A (es) | 1997-09-30 |
| JPH10500702A (ja) | 1998-01-20 |
| KR960022510A (ko) | 1996-07-18 |
| WO1996020184A1 (fr) | 1996-07-04 |
| GT199500058A (es) | 1997-06-05 |
| MA23746A1 (fr) | 1996-07-01 |
| IS4312A (is) | 1996-06-24 |
| US5770594A (en) | 1998-06-23 |
| AU4067795A (en) | 1996-07-04 |
| FI972696L (fi) | 1997-06-23 |
| CA2207772A1 (fr) | 1996-07-04 |
| TNSN95133A1 (fr) | 1996-02-06 |
| NO955288D0 (no) | 1995-12-22 |
| LV11325A (lv) | 1996-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7829597B2 (en) | Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease | |
| US5965553A (en) | Squalene synthetase inhibitors | |
| JP5203361B2 (ja) | プロリルヒドロキシラーゼ阻害剤 | |
| US6166005A (en) | Heterocyclic metalloprotease inhibitors | |
| ES2384309T3 (es) | Derivados de ácido carboxílico sustituidos de manera oxo-heterocíclica y su uso | |
| JP6325449B2 (ja) | シクロプロパンアミン化合物およびその用途 | |
| JP4944286B1 (ja) | シクロプロパン化合物 | |
| IL284640B1 (en) | Pcsk9 inhibitors and methods of use thereof | |
| BRPI0806566A2 (pt) | Derivados de glicina n-substituída: inibidores de hidroxilase | |
| OA11663A (en) | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors recptors (antipsychotic agents). | |
| CA2450475A1 (fr) | Inhibiteurs de dipeptidyl peptidase utilises dans le traitement du diabete | |
| JP2009543790A (ja) | ２−置換プロリンビス−アミドオレキシン受容体アンタゴニスト | |
| TW201040166A (en) | Isoxazol-3(2H)-one analogs as therapeutic agents | |
| TW202003466A (zh) | 人類整合素α４β７拮抗劑 | |
| JP2012506378A (ja) | ２，３−二置換フェニルカルボキサミド・オレキシン受容体アンタゴニスト | |
| US5770594A (en) | Naphthyl-benzoxazepines or -benzothiazepines as squalene synthetase inhibitors | |
| JP2011506466A (ja) | カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用 | |
| EA008928B1 (ru) | Активаторы рецепторов, активируемых пролифератором пероксисом (ppar ) | |
| EA036137B1 (ru) | Производные тетрагидроизохинолина | |
| JPH09506371A (ja) | 神経伝達物質放出増強薬としての新規な非環式および環式アミド類 | |
| EA015813B1 (ru) | Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
| US7820674B2 (en) | Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease | |
| EP3423467B1 (fr) | Nouveaux dérivés de diflurokétamide comme inhibiteurs de la htra1 | |
| Suh et al. | Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)-and [(acylthio) alkanoyl] glycine derivatives | |
| JPH11152275A (ja) | 含窒素縮合環化合物、その製造法および剤 |