OA10546A - pharmaceutical composition comprising a proteinaseinhibitor and a monoglyceride - Google Patents

pharmaceutical composition comprising a proteinaseinhibitor and a monoglyceride Download PDF

Info

Publication number: OA10546A
Authority: OA; OAPI
Prior art keywords: hydroxy; phenyl; amino; acid; tert
Prior art date: 1995-06-06

Application number

OA70151A

Other languages

English (en)

Inventor

Carole Anne Bailey

Josephine Christine Ferdinando

Navnit Shah

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1997-12-05

Publication date

2002-05-29

1996-05-07 Priority claimed from US08/616,233 external-priority patent/US6008228A/en

1997-12-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-05-29 Publication of OA10546A publication Critical patent/OA10546A/en

Links

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125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
GSYSFVSGPABNNL-UHFFFAOYSA-N methyl 2-dimethoxyphosphoryl-2-(phenylmethoxycarbonylamino)acetate Chemical group COC(=O)C(P(=O)(OC)OC)NC(=O)OCC1=CC=CC=C1 GSYSFVSGPABNNL-UHFFFAOYSA-N 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
OUQVKRKGTAUJQA-UHFFFAOYSA-N n-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine Chemical compound C1=CC=CC2=C(O)C(C(=O)NCC(=O)O)=NC(Cl)=C21 OUQVKRKGTAUJQA-UHFFFAOYSA-N 0.000 description 1
125000005185 naphthylcarbonyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
235000015205 orange juice Nutrition 0.000 description 1
239000008012 organic excipient Substances 0.000 description 1
230000008520 organization Effects 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
125000003232 p-nitrobenzoyl group Chemical group [N+](=O)([O-])C1=CC=C(C(=O)*)C=C1 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
150000002993 phenylalanine derivatives Chemical class 0.000 description 1
125000000405 phenylalanyl group Chemical group 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
229940068886 polyethylene glycol 300 Drugs 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
230000006337 proteolytic cleavage Effects 0.000 description 1
239000008213 purified water Substances 0.000 description 1
125000003072 pyrazolidinyl group Chemical group 0.000 description 1
125000002755 pyrazolinyl group Chemical group 0.000 description 1
125000005400 pyridylcarbonyl group Chemical group N1=C(C=CC=C1)C(=O)* 0.000 description 1
125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
238000011002 quantification Methods 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
125000005372 silanol group Chemical group 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
235000014347 soups Nutrition 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000006633 tert-butoxycarbonylamino group Chemical group 0.000 description 1
NAJDZKGRZBLNON-RKGCBODKSA-N tert-butyl n-[(2s,3s,5r)-5-benzyl-3-hydroxy-6-[[(2s)-3-methyl-1-[[(2s)-1-morpholin-4-yl-1-oxo-3-phenylpropan-2-yl]amino]-1-oxobutan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]carbamate Chemical compound C([C@@H]([C@@H](O)C[C@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1CCOCC1)CC=1C=CC=CC=1)NC(=O)OC(C)(C)C)C1=CC=CC=C1 NAJDZKGRZBLNON-RKGCBODKSA-N 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
108010020532 tyrosyl-proline Proteins 0.000 description 1
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
210000002845 virion Anatomy 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
235000008939 whole milk Nutrition 0.000 description 1
ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Indole Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)

OA70151A 1995-06-06 1997-12-05 pharmaceutical composition comprising a proteinaseinhibitor and a monoglyceride OA10546A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US46849395A	1995-06-06	1995-06-06
US08/616,233 US6008228A (en)	1995-06-06	1996-05-07	Pharmaceutical compositions containing proteinase inhibitors

Publications (1)

Publication Number	Publication Date
OA10546A true OA10546A (en)	2002-05-29

Family

ID=27042422

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA70151A OA10546A (en)	1995-06-06	1997-12-05	pharmaceutical composition comprising a proteinaseinhibitor and a monoglyceride

Country Status (26)

Country	Link
EP (1)	EP0831826B1 (ja)
JP (1)	JP3238412B2 (ja)
CN (1)	CN1092960C (ja)
AT (1)	ATE226075T1 (ja)
AU (1)	AU709796B2 (ja)
BG (1)	BG63711B1 (ja)
BR (1)	BR9610842A (ja)
CA (1)	CA2224125C (ja)
CY (1)	CY2373B1 (ja)
CZ (1)	CZ292192B6 (ja)
DE (1)	DE69624354T2 (ja)
DK (1)	DK0831826T3 (ja)
EA (1)	EA001413B1 (ja)
ES (1)	ES2182996T3 (ja)
HU (1)	HU223899B1 (ja)
IL (1)	IL122353A0 (ja)
IS (1)	IS2661B (ja)
MX (1)	MX9709193A (ja)
NO (1)	NO324531B1 (ja)
NZ (1)	NZ311646A (ja)
OA (1)	OA10546A (ja)
PL (1)	PL184820B1 (ja)
PT (1)	PT831826E (ja)
SK (1)	SK282121B6 (ja)
TR (1)	TR199701541T1 (ja)
WO (1)	WO1996039142A1 (ja)

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PL192080B1 (pl) *	1997-07-29	2006-08-31	Upjohn Co	Kompozycja farmaceutyczna zawierająca związek piranonowy
HU228923B1 (en)	1997-07-29	2013-06-28	Upjohn Co	Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation
CA2361424C (en) *	1999-02-08	2009-04-28	Intarcia Therapeutics, Inc.	Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en)	1999-02-08	2007-08-21	Alza Corporation	Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en)	1999-02-08	2011-04-05	Intarcia Therapeutics, Inc.	Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US6956048B2 (en)	1999-03-31	2005-10-18	Pharmacia & Upjohn Company	Pharmaceutical emulsions for retroviral protease inhibitors
US6309663B1 (en) *	1999-08-17	2001-10-30	Lipocine Inc.	Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
BR0202252A (pt)	2002-06-12	2004-06-29	Cristalia Prod Quimicos Farm	Composição farmacêutica solúvel estável para administração de inibidores da hiv protease e processo de obtenção de composições farmacêuticas concentradas para a administração de inibidores da hiv protease
US7731947B2 (en)	2003-11-17	2010-06-08	Intarcia Therapeutics, Inc.	Composition and dosage form comprising an interferon particle formulation and suspending vehicle
WO2006083761A2 (en)	2005-02-03	2006-08-10	Alza Corporation	Solvent/polymer solutions as suspension vehicles
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
KR101106510B1 (ko)	2006-05-30	2012-01-20	인타르시아 세라퓨틱스 인코포레이티드	투피스, 내부채널 삼투압 전달 시스템 유동 조절기
WO2008133908A2 (en)	2007-04-23	2008-11-06	Intarcia Therapeutics, Inc.	Suspension formulations of insulinotropic peptides and uses thereof
CA2726861C (en)	2008-02-13	2014-05-27	Intarcia Therapeutics, Inc.	Devices, formulations, and methods for delivery of multiple beneficial agents
EP2108705A1 (en)	2008-04-08	2009-10-14	Universität Duisburg-Essen	Method for analysing the epigenetic status of the HtrA 1 gene in a biological sample
RU2547990C2 (ru)	2009-09-28	2015-04-10	Интарсия Терапьютикс, Инк.	Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
RU2730996C2 (ru)	2015-06-03	2020-08-26	Интарсия Терапьютикс, Инк.	Системы установки и извлечения имплантата
KR102574993B1 (ko)	2016-05-16	2023-09-06	인타르시아 세라퓨틱스 인코포레이티드	글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
JP7286542B2 (ja)	2017-01-03	2023-06-05	インターシアセラピューティクス，インコーポレイティド	Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8927913D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Amino acid derivatives
IL110752A (en) *	1993-09-13	2000-07-26	Abbott Lab	Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor

1996
- 1996-06-04 ES ES96921929T patent/ES2182996T3/es not_active Expired - Lifetime
- 1996-06-04 PL PL96323860A patent/PL184820B1/pl unknown
- 1996-06-04 HU HU9801905A patent/HU223899B1/hu active IP Right Grant
- 1996-06-04 DK DK96921929T patent/DK0831826T3/da active
- 1996-06-04 AT AT96921929T patent/ATE226075T1/de active
- 1996-06-04 DE DE69624354T patent/DE69624354T2/de not_active Expired - Lifetime
- 1996-06-04 EP EP96921929A patent/EP0831826B1/en not_active Expired - Lifetime
- 1996-06-04 CA CA002224125A patent/CA2224125C/en not_active Expired - Lifetime
- 1996-06-04 EA EA199800023A patent/EA001413B1/ru not_active IP Right Cessation
- 1996-06-04 CZ CZ19973803A patent/CZ292192B6/cs not_active IP Right Cessation
- 1996-06-04 BR BR9610842A patent/BR9610842A/pt not_active IP Right Cessation
- 1996-06-04 SK SK1627-97A patent/SK282121B6/sk not_active IP Right Cessation
- 1996-06-04 NZ NZ311646A patent/NZ311646A/en not_active IP Right Cessation
- 1996-06-04 IL IL12235396A patent/IL122353A0/xx not_active IP Right Cessation
- 1996-06-04 PT PT96921929T patent/PT831826E/pt unknown
- 1996-06-04 AU AU63004/96A patent/AU709796B2/en not_active Expired
- 1996-06-04 JP JP50014397A patent/JP3238412B2/ja not_active Expired - Lifetime
- 1996-06-04 CN CN96194327A patent/CN1092960C/zh not_active Expired - Lifetime
- 1996-06-04 WO PCT/EP1996/002431 patent/WO1996039142A1/en not_active Ceased
- 1996-06-04 MX MX9709193A patent/MX9709193A/es unknown
- 1996-06-04 TR TR97/01541T patent/TR199701541T1/xx unknown
1997
- 1997-12-04 IS IS4627A patent/IS2661B/is unknown
- 1997-12-05 OA OA70151A patent/OA10546A/en unknown
- 1997-12-05 BG BG102106A patent/BG63711B1/bg unknown
- 1997-12-05 NO NO19975665A patent/NO324531B1/no not_active IP Right Cessation
2003
- 2003-08-22 CY CY0300057A patent/CY2373B1/xx unknown

Also Published As

Publication number	Publication date
JP3238412B2 (ja)	2001-12-17
WO1996039142A1 (en)	1996-12-12
BG63711B1 (bg)	2002-10-31
DK0831826T3 (da)	2003-02-03
NO975665D0 (no)	1997-12-05
JPH10507202A (ja)	1998-07-14
CA2224125C (en)	2004-09-28
BR9610842A (pt)	1999-07-13
CY2373B1 (en)	2004-06-04
ES2182996T3 (es)	2003-03-16
EA199800023A1 (ru)	1998-08-27
DE69624354D1 (de)	2002-11-21
TR199701541T1 (xx)	1998-03-21
PT831826E (pt)	2003-02-28
MX9709193A (es)	1998-03-31
IL122353A0 (en)	1998-04-05
EP0831826A1 (en)	1998-04-01
ATE226075T1 (de)	2002-11-15
EA001413B1 (ru)	2001-02-26
CN1092960C (zh)	2002-10-23
SK282121B6 (sk)	2001-11-06
HK1010136A1 (en)	1999-06-17
AU709796B2 (en)	1999-09-09
PL323860A1 (en)	1998-04-27
PL184820B1 (pl)	2002-12-31
HUP9801905A3 (en)	2001-04-28
IS4627A (is)	1997-12-04
HUP9801905A2 (hu)	1999-05-28
HU223899B1 (hu)	2005-03-29
IS2661B (is)	2010-08-15
BG102106A (en)	1998-08-31
NO324531B1 (no)	2007-11-12
CN1186434A (zh)	1998-07-01
CA2224125A1 (en)	1996-12-12
CZ380397A3 (cs)	1998-03-18
DE69624354T2 (de)	2003-06-05
EP0831826B1 (en)	2002-10-16
NO975665L (no)	1998-02-05
CZ292192B6 (cs)	2003-08-13
AU6300496A (en)	1996-12-24
NZ311646A (en)	2000-02-28
SK162797A3 (en)	1998-05-06

Publication	Publication Date	Title
CA2224125C (en)	2004-09-28	Pharmaceutical composition comprising a proteinase inhibitor and a monoglyceride
US6008228A (en)	1999-12-28	Pharmaceutical compositions containing proteinase inhibitors
US6037157A (en)	2000-03-14	Method for improving pharmacokinetics
KR102461176B1 (ko)	2022-11-01	빈혈 치료용 조성물 및 치료방법
RU2139052C1 (ru)	1999-10-10	Комбинация ингибитора вич-протеазы с другими антивирусными соединениями, фармацевтическая композиция на их основе и способ получения фармацевтической композиции
PL190185B1 (pl)	2005-11-30	Kompozycja farmaceutyczna
Bhattacherjee	1975	Release of prostaglandin-like substances by Shigella endotoxin and its inhibition by non-steroidal anti-inflammatory compounds
JP2002537258A5 (ja)	2011-08-25
US6201009B1 (en)	2001-03-13	Absorption-enhancing composition for pantothenic acid derivative
US5939450A (en)	1999-08-17	N,N-dimethyl-8,8-dipropyl-2-azaspiro 4.5!decane-2-propanamine dimaleate
AU759386B2 (en)	2003-04-10	Use of Ritonavir (ABT-538) for improving the pharmacokinetics of drugs metabolized by cytochrome P450 in a method of treating AIDS
JPH03157385A (ja)	1991-07-05	細胞防護剤
JP2002241311A (ja)	2002-08-28	界面活性剤を含む医薬組成物
HK1010136B (en)	2003-07-25	Pharmaceutical composition comprising a proteinase inhibitor and a monoglyceride
Morton	1999	244 quingestanol
PL203441B1 (pl)	2009-10-30	Kompozycja farmaceutyczna zawieraj aca rozpuszczony zwi azek hamuj acy proteaz e HIV
CZ20001752A3 (cs)	2000-10-11	Farmaceutické prostředky obsahující kombinaci pro léčbu AIDS
MXPA97010403A (en)	1998-11-09	Use of ritonavir (abt-538) to improve the pharmacokinetics of metabolised drugs through cytochrome p450 in a method for the treatment of the