OA10952A - Erythromycins and process for their preparation - Google Patents

Erythromycins and process for their preparation Download PDF

Info

Publication number: OA10952A
Authority: OA; OAPI
Prior art keywords: plasmid; compound; alkyl; erythraea; group
Prior art date: 1996-07-05

Application number

OA9900002A

Other languages

English (en)

Inventor

Peter Francis Leadlay

James Staunton

Jesus Cortes

Michael Stephen Pacey

Original Assignee

Biotica Tech Ltd

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-05

Filing date

1999-01-04

Publication date

2002-02-25

1996-07-05 Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en

1997-05-28 Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en

1999-01-04 Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd

2002-02-25 Publication of OA10952A publication Critical patent/OA10952A/en

Links

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238000000034 method Methods 0.000 title claims description 36
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 40
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-1 trifiuoromethyl Chemical group 0.000 claims description 27
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
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Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Cardiology (AREA)
Plant Pathology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

OA9900002A 1996-07-05 1999-01-04 Erythromycins and process for their preparation OA10952A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9614189.0A GB9614189D0 (en)	1996-07-05	1996-07-05	Polyketides and their synthesis
US2418896P	1996-08-19	1996-08-19
GBGB9710962.3A GB9710962D0 (en)	1997-05-28	1997-05-28	Polyketides and their synthesis

Publications (1)

Publication Number	Publication Date
OA10952A true OA10952A (en)	2002-02-25

Family

ID=27268361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900002A OA10952A (en)	1996-07-05	1999-01-04	Erythromycins and process for their preparation

Country Status (28)

Country	Link
EP (3)	EP0910633B1 (de)
JP (2)	JP4173551B2 (de)
KR (1)	KR20000023579A (de)
CN (1)	CN1179046C (de)
AP (1)	AP1029A (de)
AT (2)	ATE296893T1 (de)
AU (2)	AU731654B2 (de)
BG (1)	BG103133A (de)
BR (1)	BR9710209A (de)
CA (2)	CA2259463A1 (de)
DE (2)	DE69739688D1 (de)
DK (2)	DK0909327T3 (de)
EA (1)	EA001744B1 (de)
EE (1)	EE03976B1 (de)
ES (2)	ES2244001T3 (de)
GB (1)	GB2331518B (de)
GE (1)	GEP20012348B (de)
IL (1)	IL127916A0 (de)
IS (1)	IS4940A (de)
NO (1)	NO990012L (de)
NZ (1)	NZ333861A (de)
OA (1)	OA10952A (de)
PL (1)	PL331285A1 (de)
PT (1)	PT909327E (de)
SI (1)	SI0910633T1 (de)
SK (1)	SK182498A3 (de)
TR (1)	TR199900006T2 (de)
WO (2)	WO1998001571A2 (de)

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US6060234A (en) *	1991-01-17	2000-05-09	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) *	1992-01-17	1993-07-22	Abbott Laboratories	Method of directing biosynthesis of specific polyketides
CA2171629A1 (en) *	1993-09-20	1995-03-30	Chaitan Khosla	Recombinant production of novel polyketides
US5712146A (en) *	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides

1997
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 EP EP97930631A patent/EP0910633B1/de not_active Expired - Lifetime
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 EE EEP199900014A patent/EE03976B1/xx not_active IP Right Cessation
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 EP EP97930626A patent/EP0909327B1/de not_active Expired - Lifetime
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 EP EP09178121A patent/EP2182067A3/de not_active Withdrawn
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Ceased
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en not_active Ceased
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
1999
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Ceased
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown

Also Published As

Publication number	Publication date
BR9710209A (pt)	2000-01-11
GB2331518A (en)	1999-05-26
GB2331518B (en)	2001-03-14
JP2000511063A (ja)	2000-08-29
CA2259463A1 (en)	1998-01-15
AU3451497A (en)	1998-02-02
JP2000516450A (ja)	2000-12-12
IS4940A (is)	1999-01-04
SK182498A3 (en)	2000-05-16
EP0909327A2 (de)	1999-04-21
EA199900087A1 (ru)	1999-08-26
AP9901444A0 (en)	1999-03-31
EP0909327B1 (de)	2005-06-01
ATE451455T1 (de)	2009-12-15
WO1998001546A3 (en)	1998-04-09
AU731301B2 (en)	2001-03-29
CN1229438A (zh)	1999-09-22
WO1998001546A2 (en)	1998-01-15
CN1179046C (zh)	2004-12-08
BG103133A (en)	2000-04-28
EA001744B1 (ru)	2001-08-27
NO990012D0 (no)	1999-01-04
GEP20012348B (en)	2001-01-25
ATE296893T1 (de)	2005-06-15
AP1029A (en)	2001-12-11
EE03976B1 (et)	2003-02-17
EP2182067A3 (de)	2010-07-14
DK0910633T3 (da)	2010-03-29
NO990012L (no)	1999-02-23
EP0910633B1 (de)	2009-12-09
KR20000023579A (ko)	2000-04-25
IL127916A0 (en)	1999-11-30
WO1998001571A2 (en)	1998-01-15
NZ333861A (en)	2000-08-25
TR199900006T2 (xx)	1999-04-21
DE69733416T2 (de)	2006-04-27
SI0910633T1 (sl)	2010-04-30
GB9900156D0 (en)	1999-02-24
EE9900014A (et)	1999-08-16
ES2244001T3 (es)	2005-12-01
AU731654B2 (en)	2001-04-05
DE69733416D1 (de)	2005-07-07
PL331285A1 (en)	1999-07-05
DK0909327T3 (da)	2005-09-26
DE69739688D1 (de)	2010-01-21
PT909327E (pt)	2005-10-31
ES2337424T3 (es)	2010-04-23
EP2182067A2 (de)	2010-05-05
WO1998001571A3 (en)	1998-02-19
AU3450997A (en)	1998-02-02
CA2259420A1 (en)	1998-01-15
CA2259420C (en)	2007-09-18
JP4173551B2 (ja)	2008-10-29
EP0910633A2 (de)	1999-04-28

Publication	Publication Date	Title
EP0909327B1 (de)	2005-06-01	Erythromycine und verfahren zu ihrer herstellung
US6271255B1 (en)	2001-08-07	Erythromycins and process for their preparation
US6472371B1 (en)	2002-10-29	Macrolides
US6825171B2 (en)	2004-11-30	Erythromycin derivatives
AU2003217591B2 (en)	2009-02-26	Novel spinosyn-producing polyketide synthases
KR20010071684A (ko)	2001-07-31	폴리케타이드 및 그들의 합성방법
US7807418B2 (en)	2010-10-05	Method for producing hybrid polyketide synthases
EP1602727A2 (de)	2005-12-07	Neue Erythromycine und deren Herstellungsprozesse
WO2003106638A2 (en)	2003-12-24	Methods and cells for improved production of polyketides
CZ437598A3 (cs)	2000-01-12	Erythromyciny, způsoby jejich výroby, farmaceutická kompozice na jejich bázi, způsob léčení a použití
HRP20000474A2 (en)	2000-12-31	Polyketides and their synthesis
JP2009213479A (ja)	2009-09-24	ポリケチド類及びそれらの合成
MXPA00006604A (en)	2001-06-26	Novel macrolides
MXPA01010817A (en)	2002-06-05	13-methyl-erythromycin derivatives