OA11306A - Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione - Google Patents

Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione Download PDF

Info

Publication number: OA11306A
Authority: OA; OAPI
Prior art keywords: compound; composition; pharmaceutically acceptable; acceptable form; composition according
Prior art date: 1997-06-05

Application number

OA9900267A

Other languages

English (en)

Inventor

Jai Patel

Hamish Ross

Jeffrey Roger Granett

Robin Price

Paul Nigel Wray

Original Assignee

Smithkline Beecham Corp Smithk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-05

Filing date

1999-12-02

Publication date

2003-10-22

1997-06-18 Priority claimed from GBGB9712851.6A external-priority patent/GB9712851D0/en

1999-12-02 Application filed by Smithkline Beecham Corp Smithk filed Critical Smithkline Beecham Corp Smithk

2003-10-22 Publication of OA11306A publication Critical patent/OA11306A/en

Links

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125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 76
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ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
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230000002411 adverse Effects 0.000 description 1
239000008168 almond oil Substances 0.000 description 1
239000004411 aluminium Substances 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
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235000019441 ethanol Nutrition 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
239000003925 fat Substances 0.000 description 1
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239000007937 lozenge Substances 0.000 description 1
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FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
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125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000007789 sealing Methods 0.000 description 1
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229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
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239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

OA9900267A 1997-06-05 1999-12-02 Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione OA11306A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9711683.4A GB9711683D0 (en)	1997-06-05	1997-06-05	Composition
GBGB9712851.6A GB9712851D0 (en)	1997-06-18	1997-06-18	Composition

Publications (1)

Publication Number	Publication Date
OA11306A true OA11306A (en)	2003-10-22

Family

ID=26311662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900267A OA11306A (en)	1997-06-05	1999-12-02	Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione

Country Status (29)

Country	Link
EP (1)	EP0998284A1 (fr)
JP (1)	JP2001521553A (fr)
KR (1)	KR20010013410A (fr)
CN (3)	CN1112926C (fr)
AP (1)	AP1214A (fr)
AR (2)	AR015120A1 (fr)
AU (1)	AU8215098A (fr)
BG (1)	BG104048A (fr)
BR (1)	BR9810405A (fr)
CA (2)	CA2333352A1 (fr)
CO (1)	CO4940400A1 (fr)
DZ (1)	DZ2510A1 (fr)
EA (1)	EA002384B1 (fr)
GB (1)	GB9711683D0 (fr)
HU (1)	HUP0004070A3 (fr)
ID (1)	ID24264A (fr)
IL (1)	IL133074A0 (fr)
MX (1)	MXPA99011322A (fr)
NO (2)	NO995938L (fr)
NZ (2)	NZ523725A (fr)
OA (1)	OA11306A (fr)
PE (1)	PE78899A1 (fr)
PL (1)	PL337201A1 (fr)
SK (1)	SK164899A3 (fr)
TR (2)	TR200002790T2 (fr)
TW (1)	TW570797B (fr)
UY (1)	UY25032A1 (fr)
WO (1)	WO1998055122A1 (fr)
ZA (2)	ZA984826B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
US20040248945A1 (en)	1999-04-23	2004-12-09	Smithkline Beecham P.L.C.	Thiazolidinedione derivative and its use as antidiabetic
EP1903043A1 (fr)	1999-04-23	2008-03-26	SmithKline Beecham P.L.C.	Nouveau composé pharmaceutique
UA67844C2 (uk) *	1999-04-23	2004-07-15	Смітклайн Бічам Плс	Поліморф 5-[4-[2-(n-метил-n-(2-піридил)аміно)етокси]бензил]тіазолідин-2,4-діону солі малеїнової кислоти
GB0021978D0 (en)	2000-09-07	2000-10-25	Smithkline Beecham Plc	Novel pharmaceutical
GB0127805D0 (en) *	2001-11-20	2002-01-09	Smithkline Beecham Plc	Pharmaceutical composition
GB0129876D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
GB0129871D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
WO2003050112A1 (fr) *	2001-12-13	2003-06-19	Smithkline Beecham Plc	Hydrates de toluenesulfonate d'un derive de thiazolidinedione
GB0130509D0 (en) *	2001-12-20	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
EP2270007A1 (fr) *	2006-05-09	2011-01-05	Teva Pharmaceutical Industries Ltd.	Acide 2-N-{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2-4-thiazolidinedione} butanedioique, procédés de préparation et compositions avec le maléate de rosiglitazone
US7435741B2 (en)	2006-05-09	2008-10-14	Teva Pharmaceutical Industries, Ltd.	2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
WO2015008234A1 (fr) *	2013-07-17	2015-01-22	Glenmark Pharmaceuticals S.A.	Composés hétécycliques bicycliques utilisés en tant que modulateurs des ror-gamma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0842925A1 (fr) *	1987-09-04	1998-05-20	Beecham Group Plc	Thiazolidinédiones substituées
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
CA2182986A1 (fr) *	1994-02-10	1995-08-17	Smithkline Beecham P.L.C.	Utilisation de sensibilisateurs a l'insuline dans le traitement de l'insuffisance renale
EA199800177A1 (ru) *	1995-08-10	1998-10-29	Варнер-Ламберт Компани	Способ снижения количества экзогенного инсулина, вводимого пациенту с инсулиннезависимым сахарным диабетом
WO1997018811A1 (fr) *	1995-11-17	1997-05-29	Warner-Lambert Company	Procede de traitement de dystrophie myotonique
IL120443A (en) *	1996-03-18	2000-07-16	Sankyo Co	Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
CA2260044A1 (fr) *	1996-07-12	1998-01-22	Stephen Alistair Smith	Nouveau traitement contre la resistance a la leptine

1997
- 1997-06-05 GB GBGB9711683.4A patent/GB9711683D0/en active Pending
1998
- 1998-06-02 TR TR2000/02790T patent/TR200002790T2/xx unknown
- 1998-06-02 EP EP98932144A patent/EP0998284A1/fr not_active Withdrawn
- 1998-06-02 CN CN98805686A patent/CN1112926C/zh not_active Expired - Lifetime
- 1998-06-02 JP JP50158799A patent/JP2001521553A/ja not_active Ceased
- 1998-06-02 NZ NZ523725A patent/NZ523725A/en unknown
- 1998-06-02 AU AU82150/98A patent/AU8215098A/en not_active Abandoned
- 1998-06-02 IL IL13307498A patent/IL133074A0/xx unknown
- 1998-06-02 CA CA002333352A patent/CA2333352A1/fr not_active Abandoned
- 1998-06-02 TR TR1999/02963T patent/TR199902963T2/xx unknown
- 1998-06-02 HU HU0004070A patent/HUP0004070A3/hu unknown
- 1998-06-02 EA EA199901116A patent/EA002384B1/ru not_active IP Right Cessation
- 1998-06-02 PL PL98337201A patent/PL337201A1/xx unknown
- 1998-06-02 CN CNA2003101199090A patent/CN1526391A/zh active Pending
- 1998-06-02 SK SK1648-99A patent/SK164899A3/sk unknown
- 1998-06-02 MX MXPA99011322A patent/MXPA99011322A/es unknown
- 1998-06-02 WO PCT/EP1998/003478 patent/WO1998055122A1/fr not_active Ceased
- 1998-06-02 KR KR19997011411A patent/KR20010013410A/fr not_active Ceased
- 1998-06-02 ID IDW991520A patent/ID24264A/id unknown
- 1998-06-02 CA CA002292629A patent/CA2292629C/fr not_active Expired - Fee Related
- 1998-06-02 AP APAP/P/1999/001696A patent/AP1214A/en active
- 1998-06-02 BR BR9810405-5A patent/BR9810405A/pt not_active IP Right Cessation
- 1998-06-03 DZ DZ980120A patent/DZ2510A1/fr active
- 1998-06-04 AR ARP980102650A patent/AR015120A1/es not_active Application Discontinuation
- 1998-06-04 UY UY25032A patent/UY25032A1/es not_active IP Right Cessation
- 1998-06-04 ZA ZA9804826A patent/ZA984826B/xx unknown
- 1998-06-04 ZA ZA9811572A patent/ZA9811572B/xx unknown
- 1998-06-04 CO CO98031614A patent/CO4940400A1/es unknown
- 1998-06-04 AR ARP980102649A patent/AR008198A1/es not_active Application Discontinuation
- 1998-06-05 PE PE1998000466A patent/PE78899A1/es not_active Application Discontinuation
- 1998-10-23 TW TW087117536A patent/TW570797B/zh not_active IP Right Cessation
1999
- 1999-12-02 OA OA9900267A patent/OA11306A/en unknown
- 1999-12-03 NO NO995938A patent/NO995938L/no not_active Application Discontinuation
- 1999-12-27 BG BG104048A patent/BG104048A/bg unknown
2001
- 2001-09-03 NZ NZ513922A patent/NZ513922A/xx unknown
2002
- 2002-11-05 CN CN02149972A patent/CN1430959A/zh active Pending
2004
- 2004-02-20 NO NO20040738A patent/NO20040738L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1998055122A1 (fr)	1998-12-10
AU8215098A (en)	1998-12-21
IL133074A0 (en)	2001-03-19
CA2333352A1 (fr)	1998-12-10
CA2292629A1 (fr)	1998-12-10
AP9901696A0 (en)	1999-12-31
ID24264A (id)	2000-07-13
NO20040738L (no)	2000-02-02
NO995938L (no)	2000-02-02
TW570797B (en)	2004-01-11
NZ513922A (en)	2001-09-28
DZ2510A1 (fr)	2003-01-25
ZA9811572B (en)	1999-07-22
JP2001521553A (ja)	2001-11-06
AR008198A1 (es)	1999-12-29
EA199901116A1 (ru)	2000-06-26
UY25032A1 (es)	1998-11-26
NO995938D0 (no)	1999-12-03
CO4940400A1 (es)	2000-07-24
CN1526391A (zh)	2004-09-08
EP0998284A1 (fr)	2000-05-10
CN1430959A (zh)	2003-07-23
BG104048A (bg)	2000-07-31
PL337201A1 (en)	2000-08-14
CN1259050A (zh)	2000-07-05
CN1112926C (zh)	2003-07-02
ZA984826B (en)	1999-08-03
BR9810405A (pt)	2000-08-29
AP1214A (en)	2003-10-08
EA002384B1 (ru)	2002-04-25
PE78899A1 (es)	1999-10-22
CA2292629C (fr)	2004-01-06
AR015120A1 (es)	2001-04-18
TR199902963T2 (xx)	2000-02-21
SK164899A3 (en)	2000-11-07
HUP0004070A2 (hu)	2002-02-28
MXPA99011322A (es)	2004-12-02
TR200002790T2 (tr)	2001-11-21
NZ523725A (en)	2004-09-24
KR20010013410A (fr)	2001-02-26
HUP0004070A3 (en)	2002-03-28
GB9711683D0 (en)	1997-08-06

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SK286029B6 (sk)	2008-01-07	Farmaceutický prostriedok a jeho použitie
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AP1287A (en)	2004-06-26	Treatment of diabetes with rosiglitazone and insulin.
US20030187030A1 (en)	2003-10-02	Composition comprising 5-[4-[2-(N-methyl-N-2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
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AU743269B2 (en)	2002-01-24	Treatment of diabetes with thiazolidinedione and sulphonylurea
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AU778947B2 (en)	2004-12-23	Treatment of diabetes with thiazolidinedione and metformin
AU9513401A (en)	2002-01-17	Composition comprising 5-(4-(2-(N-methyl-N-2-pyridyl) amino)ethoxy)benzyl)thiazolidine-2,4-dione
AU783539B2 (en)	2005-11-10	Treatment of diabetes with thiazolidinedione and sulphonylurea
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AU1552102A (en)	2002-03-28	Treatment of diabetes with rosiglitazone and insulin
MXPA99012065A (en)	2000-08-01	Treatment of diabetes with rosiglitazone and insulin
HK1028200B (en)	2007-10-05	Treatment of diabetes with thiazolidinedione and sulphonylurea
NZ520542A (en)	2004-05-28	Treatment of diabetes with thiazolidinedione and metformin
MXPA99012098A (en)	2000-08-01	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor