OA11429A - Pharmaceutical compositions containing micronized bicyclic drugs. - Google Patents
Pharmaceutical compositions containing micronized bicyclic drugs. Download PDFInfo
- Publication number
- OA11429A OA11429A OA1200000176A OA1200000176A OA11429A OA 11429 A OA11429 A OA 11429A OA 1200000176 A OA1200000176 A OA 1200000176A OA 1200000176 A OA1200000176 A OA 1200000176A OA 11429 A OA11429 A OA 11429A
- Authority
- OA
- OAPI
- Prior art keywords
- alkyl
- hydrogen
- composition according
- disorders
- alkoxy
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
- 239000003814 drug Substances 0.000 title description 15
- 229940079593 drug Drugs 0.000 title description 12
- 125000002619 bicyclic group Chemical group 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 75
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- 239000002245 particle Substances 0.000 claims abstract description 35
- 238000009826 distribution Methods 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 62
- 239000001257 hydrogen Substances 0.000 claims description 37
- 229910052739 hydrogen Inorganic materials 0.000 claims description 37
- 239000011324 bead Substances 0.000 claims description 33
- 238000003801 milling Methods 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 31
- 239000000725 suspension Substances 0.000 claims description 31
- -1 aminosulphinyl Chemical group 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
- 208000035475 disorder Diseases 0.000 claims description 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 12
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
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- 230000000694 effects Effects 0.000 claims description 11
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- 125000003118 aryl group Chemical group 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000006185 dispersion Substances 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 238000011282 treatment Methods 0.000 claims description 10
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 9
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- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
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- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 6
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical class N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 6
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- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 6
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 5
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- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 4
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- 125000005843 halogen group Chemical group 0.000 claims description 4
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
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- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
- 125000004685 alkoxythiocarbonyl group Chemical group 0.000 claims description 3
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 3
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 239000005864 Sulphur Substances 0.000 claims description 2
- 125000003282 alkyl amino group Chemical group 0.000 claims description 2
- 125000003435 aroyl group Chemical group 0.000 claims description 2
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- 125000004429 atom Chemical group 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000001207 fluorophenyl group Chemical group 0.000 claims description 2
- 125000005204 heteroarylcarbonyloxy group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims description 2
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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- 238000004448 titration Methods 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
- B02C17/18—Details
- B02C17/20—Disintegrating members
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Food Science & Technology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726543.3A GB9726543D0 (en) | 1997-12-16 | 1997-12-16 | Novel compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11429A true OA11429A (en) | 2004-04-26 |
Family
ID=10823680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200000176A OA11429A (en) | 1997-12-16 | 2000-06-16 | Pharmaceutical compositions containing micronized bicyclic drugs. |
Country Status (32)
| Country | Link |
|---|---|
| EP (2) | EP1037612B1 (de) |
| JP (1) | JP2002508310A (de) |
| KR (1) | KR20010033149A (de) |
| CN (2) | CN1475206A (de) |
| AP (1) | AP2000001837A0 (de) |
| AR (1) | AR017212A1 (de) |
| AT (1) | ATE260094T1 (de) |
| AU (1) | AU743155B2 (de) |
| BG (1) | BG104596A (de) |
| BR (1) | BR9813602A (de) |
| CA (1) | CA2314968A1 (de) |
| DE (1) | DE69821978T2 (de) |
| DZ (1) | DZ2677A1 (de) |
| EA (1) | EA003732B1 (de) |
| ES (1) | ES2216350T3 (de) |
| GB (1) | GB9726543D0 (de) |
| HU (1) | HUP0100384A3 (de) |
| ID (1) | ID24930A (de) |
| IL (1) | IL136664A0 (de) |
| MA (1) | MA24721A1 (de) |
| MY (1) | MY132978A (de) |
| NO (1) | NO20003073L (de) |
| NZ (1) | NZ504991A (de) |
| OA (1) | OA11429A (de) |
| PE (1) | PE20000114A1 (de) |
| PL (1) | PL341339A1 (de) |
| SK (1) | SK9132000A3 (de) |
| TR (1) | TR200001792T2 (de) |
| TW (1) | TW200305442A (de) |
| UY (1) | UY25307A1 (de) |
| WO (1) | WO1999030687A1 (de) |
| ZA (1) | ZA9811502B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4484247B2 (ja) | 1995-02-24 | 2010-06-16 | エラン ファーマ インターナショナル，リミティド | ナノ粒子分散体を含有するエアロゾル |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| KR100786927B1 (ko) * | 2000-06-28 | 2007-12-17 | 스미스클라인비이참피이엘시이 | 습식 분쇄방법 |
| GB0112497D0 (en) * | 2001-05-22 | 2001-07-11 | Smithkline Beecham Plc | Formulation |
| GB0127805D0 (en) | 2001-11-20 | 2002-01-09 | Smithkline Beecham Plc | Pharmaceutical composition |
| KR20080066977A (ko) | 2005-11-10 | 2008-07-17 | 더루우브리졸코오포레이션 | 분산체의 제조방법 |
| US20130281524A1 (en) * | 2008-06-05 | 2013-10-24 | Peter Blower | Novel treatments |
| MX2010013312A (es) * | 2008-06-05 | 2011-05-30 | Minster Res Ltd | Tratamientos novedoos. |
| US20130018091A1 (en) * | 2009-12-03 | 2013-01-17 | Peter Blower | Treatment of allodynia and hyperalgesia |
| EP2506847A1 (de) * | 2009-12-03 | 2012-10-10 | Proximagen Limited | Behandlung von infektionserkrankungen |
| EP2471513B1 (de) * | 2010-12-28 | 2015-06-10 | LEK Pharmaceuticals d.d. | Verfahren zur Herstellung einer Zubereitung mit aktivem pharmazeutischem Inhaltsstoff in Form von Kügelchen |
| WO2016157061A1 (en) * | 2015-03-31 | 2016-10-06 | Wockhardt Limited | Aseptic wet milling process for paliperidone palmitate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5065946A (en) * | 1988-07-21 | 1991-11-19 | Matsushita Electric Industrial Co., Ltd. | Media agitating mill and method for milling ceramic powder |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| AU660852B2 (en) * | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
| EP0673374B1 (de) * | 1992-12-11 | 2000-03-01 | Smithkline Beecham Plc | Pharmazeutische zusammenstellung enthaltende bizyklisch typ verbindungen |
| CN1174975C (zh) * | 1994-06-10 | 2004-11-10 | 史密丝克莱恩比彻姆有限公司 | 苯并吡喃类化合物和它们作为治疗剂的用途 |
| US5518738A (en) * | 1995-02-09 | 1996-05-21 | Nanosystem L.L.C. | Nanoparticulate nsaid compositions |
| US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| DE19614295A1 (de) * | 1995-04-21 | 1996-10-24 | Friedrich Dr Ing Vock | Verfahren und Vorrichtung zum Nassmahlen und Dispergieren von Feststoffpartikeln in Flüssigkeiten |
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1997
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1998
- 1998-11-22 TW TW092109280A patent/TW200305442A/zh unknown
- 1998-12-14 DE DE69821978T patent/DE69821978T2/de not_active Expired - Fee Related
- 1998-12-14 BR BR9813602-0A patent/BR9813602A/pt not_active IP Right Cessation
- 1998-12-14 TR TR2000/01792T patent/TR200001792T2/xx unknown
- 1998-12-14 CN CNA031787088A patent/CN1475206A/zh active Pending
- 1998-12-14 EP EP98966322A patent/EP1037612B1/de not_active Expired - Lifetime
- 1998-12-14 EP EP03076016A patent/EP1338274A1/de not_active Withdrawn
- 1998-12-14 MA MA25390A patent/MA24721A1/fr unknown
- 1998-12-14 SK SK913-2000A patent/SK9132000A3/sk unknown
- 1998-12-14 JP JP2000538670A patent/JP2002508310A/ja active Pending
- 1998-12-14 ES ES98966322T patent/ES2216350T3/es not_active Expired - Lifetime
- 1998-12-14 WO PCT/EP1998/008156 patent/WO1999030687A1/en not_active Ceased
- 1998-12-14 CN CN98813568A patent/CN1284865A/zh active Pending
- 1998-12-14 AP APAP/P/2000/001837A patent/AP2000001837A0/en unknown
- 1998-12-14 KR KR1020007006525A patent/KR20010033149A/ko not_active Ceased
- 1998-12-14 IL IL13666498A patent/IL136664A0/xx unknown
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- 1998-12-14 AT AT98966322T patent/ATE260094T1/de not_active IP Right Cessation
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- 1998-12-14 EA EA200000664A patent/EA003732B1/ru not_active IP Right Cessation
- 1998-12-15 MY MYPI98005667A patent/MY132978A/en unknown
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- 1998-12-15 ZA ZA9811502A patent/ZA9811502B/xx unknown
- 1998-12-15 AR ARP980106367A patent/AR017212A1/es not_active Application Discontinuation
- 1998-12-15 DZ DZ980287A patent/DZ2677A1/xx active
- 1998-12-16 PE PE1998001230A patent/PE20000114A1/es not_active Application Discontinuation
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2000
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- 2000-06-16 OA OA1200000176A patent/OA11429A/en unknown
- 2000-07-11 BG BG104596A patent/BG104596A/xx unknown
Also Published As
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