OA11446A - Sustained release compositions, method of its production and use thereof. - Google Patents
Sustained release compositions, method of its production and use thereof. Download PDFInfo
- Publication number
- OA11446A OA11446A OA1200000208A OA1200000208A OA11446A OA 11446 A OA11446 A OA 11446A OA 1200000208 A OA1200000208 A OA 1200000208A OA 1200000208 A OA1200000208 A OA 1200000208A OA 11446 A OA11446 A OA 11446A
- Authority
- OA
- OAPI
- Prior art keywords
- acid
- sustained
- sait
- release composition
- composition according
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 125
- 238000000034 method Methods 0.000 title claims abstract description 95
- 238000013268 sustained release Methods 0.000 title claims abstract description 83
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 83
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 82
- 239000000126 substance Substances 0.000 claims description 79
- 239000000243 solution Substances 0.000 claims description 73
- 230000000975 bioactive effect Effects 0.000 claims description 68
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 67
- 239000003960 organic solvent Substances 0.000 claims description 60
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 58
- 239000002253 acid Substances 0.000 claims description 57
- ALKYHXVLJMQRLQ-UHFFFAOYSA-N 3-Hydroxy-2-naphthoate Chemical compound C1=CC=C2C=C(O)C(C(=O)O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-N 0.000 claims description 47
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- ALKYHXVLJMQRLQ-UHFFFAOYSA-M 3-carboxynaphthalen-2-olate Chemical compound C1=CC=C2C=C(C([O-])=O)C(O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-M 0.000 claims description 5
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- Bioinformatics & Cheminformatics (AREA)
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- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| JP641298 | 1998-01-16 |
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| AU (1) | AU758596B2 (no) |
| BR (1) | BR9906903A (no) |
| CA (1) | CA2316273A1 (no) |
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| SK (1) | SK10272000A3 (no) |
| TR (1) | TR200002059T2 (no) |
| WO (1) | WO1999036099A1 (no) |
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-
1999
- 1999-01-13 TR TR2000/02059T patent/TR200002059T2/xx unknown
- 1999-01-13 KR KR1020007007533A patent/KR100577877B1/ko not_active Expired - Fee Related
- 1999-01-13 CN CNB998021148A patent/CN1199686C/zh not_active Expired - Fee Related
- 1999-01-13 BR BR9906903-2A patent/BR9906903A/pt not_active IP Right Cessation
- 1999-01-13 WO PCT/JP1999/000086 patent/WO1999036099A1/ja not_active Ceased
- 1999-01-13 CA CA002316273A patent/CA2316273A1/en not_active Abandoned
- 1999-01-13 HR HR20000471A patent/HRP20000471A2/hr not_active Application Discontinuation
- 1999-01-13 US US09/582,926 patent/US6740634B1/en not_active Expired - Fee Related
- 1999-01-13 PL PL99341733A patent/PL341733A1/xx unknown
- 1999-01-13 EP EP99900300A patent/EP1048301A4/en not_active Withdrawn
- 1999-01-13 SK SK1027-2000A patent/SK10272000A3/sk unknown
- 1999-01-13 IL IL13695199A patent/IL136951A0/xx not_active IP Right Cessation
- 1999-01-13 RU RU2000121545/15A patent/RU2230550C2/ru not_active IP Right Cessation
- 1999-01-13 AU AU18897/99A patent/AU758596B2/en not_active Ceased
- 1999-01-13 NZ NZ505651A patent/NZ505651A/en unknown
- 1999-01-13 HU HU0100221A patent/HUP0100221A3/hu unknown
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2000
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- 2000-07-11 IS IS5560A patent/IS5560A/is unknown
- 2000-07-14 OA OA1200000208A patent/OA11446A/en unknown
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2004
- 2004-03-12 US US10/799,320 patent/US7388032B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050025826A1 (en) | 2005-02-03 |
| SK10272000A3 (sk) | 2001-01-18 |
| EP1048301A4 (en) | 2005-03-09 |
| CN1199686C (zh) | 2005-05-04 |
| AU1889799A (en) | 1999-08-02 |
| KR100577877B1 (ko) | 2006-05-09 |
| IS5560A (is) | 2000-07-11 |
| HRP20000471A2 (en) | 2000-12-31 |
| US7388032B2 (en) | 2008-06-17 |
| CA2316273A1 (en) | 1999-07-22 |
| US6740634B1 (en) | 2004-05-25 |
| TR200002059T2 (tr) | 2001-01-22 |
| NO20003530D0 (no) | 2000-07-07 |
| WO1999036099A1 (fr) | 1999-07-22 |
| AU758596B2 (en) | 2003-03-27 |
| HUP0100221A3 (en) | 2002-11-28 |
| RU2230550C2 (ru) | 2004-06-20 |
| CN1288387A (zh) | 2001-03-21 |
| PL341733A1 (en) | 2001-05-07 |
| EP1048301A1 (en) | 2000-11-02 |
| IL136951A0 (en) | 2001-06-14 |
| NO20003530L (no) | 2000-09-14 |
| BR9906903A (pt) | 2000-12-12 |
| HUP0100221A2 (hu) | 2001-06-28 |
| WO1999036099A8 (fr) | 1999-11-18 |
| NZ505651A (en) | 2003-08-29 |
| KR20010033949A (ko) | 2001-04-25 |
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