OA12100A - Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents. - Google Patents

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents. Download PDF

Info

Publication number: OA12100A
Authority: OA; OAPI
Prior art keywords: alkyl; crce; alkoxy; amino; membered
Prior art date: 1999-12-03

Application number

OA1200200159A

Other languages

English (en)

Inventor

Hengmiao Cheng

Jin Li

Kristin Marie Lundy

Martha Lou Minichi

Subas Man Sakya

Chikara Uchida

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-03

Filing date

2000-11-24

Publication date

2006-05-04

2000-11-24 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-05-04 Publication of OA12100A publication Critical patent/OA12100A/en

Links

230000003110 anti-inflammatory effect Effects 0.000 title description 6
239000002260 anti-inflammatory agent Substances 0.000 title description 3
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
-1 formamidyl Chemical group 0.000 claims description 310
125000000217 alkyl group Chemical group 0.000 claims description 291
229910052684 Cerium Inorganic materials 0.000 claims description 257
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 149
229920006395 saturated elastomer Polymers 0.000 claims description 145
125000003118 aryl group Chemical group 0.000 claims description 127
125000005843 halogen group Chemical group 0.000 claims description 108
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JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 98
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 93
229910052739 hydrogen Inorganic materials 0.000 claims description 87
125000001424 substituent group Chemical group 0.000 claims description 83
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239000001257 hydrogen Substances 0.000 claims description 78
125000003368 amide group Chemical group 0.000 claims description 75
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239000000203 mixture Substances 0.000 claims description 51
125000000623 heterocyclic group Chemical group 0.000 claims description 50
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238000000034 method Methods 0.000 claims description 36
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 33
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GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 2
SCVTWTWDHRDTKP-UHFFFAOYSA-N 5-methylsulfonyl-2-[5-phenyl-3-(trifluoromethyl)pyrazol-1-yl]pyridine Chemical compound N1=CC(S(=O)(=O)C)=CC=C1N1C(C=2C=CC=CC=2)=CC(C(F)(F)F)=N1 SCVTWTWDHRDTKP-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P15/06—Antiabortive agents; Labour repressants
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
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OA1200200159A 1999-12-03 2000-11-24 Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents. OA12100A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16870199P	1999-12-03	1999-12-03

Publications (1)

Publication Number	Publication Date
OA12100A true OA12100A (en)	2006-05-04

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ID=22612589

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OA1200200159A OA12100A (en)	1999-12-03	2000-11-24	Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents.

Country Status (34)

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US (2)	US6531492B1 (fr)
EP (1)	EP1233959B1 (fr)
JP (1)	JP2003517475A (fr)
KR (1)	KR20020058074A (fr)
CN (1)	CN1423646A (fr)
AP (1)	AP2002002532A0 (fr)
AR (1)	AR026711A1 (fr)
AT (1)	ATE291019T1 (fr)
AU (1)	AU783359B2 (fr)
BG (1)	BG106694A (fr)
BR (1)	BR0016031A (fr)
CA (1)	CA2392931A1 (fr)
CO (1)	CO5261496A1 (fr)
DE (1)	DE60018792T2 (fr)
DZ (1)	DZ3246A1 (fr)
EA (1)	EA200200520A1 (fr)
ES (1)	ES2238324T3 (fr)
GT (1)	GT200000204A (fr)
HK (1)	HK1052701A1 (fr)
HU (1)	HUP0300157A3 (fr)
IL (1)	IL149581A0 (fr)
IS (1)	IS6376A (fr)
MA (1)	MA26848A1 (fr)
MX (1)	MXPA02005539A (fr)
NO (1)	NO20022624L (fr)
OA (1)	OA12100A (fr)
PA (1)	PA8508201A1 (fr)
PE (1)	PE20010962A1 (fr)
PL (1)	PL356669A1 (fr)
SK (1)	SK7412002A3 (fr)
TN (1)	TNSN00235A1 (fr)
WO (1)	WO2001040216A1 (fr)
YU (1)	YU35102A (fr)
ZA (1)	ZA200204285B (fr)

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AP2002002532A0 (en) *	1999-12-03	2002-06-30	Pfizer Prod Inc	Heterocyclo-alkylsulfonyl pyrazole derivatives as ant-inflammatory/analgesic agents.
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GT200200183A (es)	2001-09-28	2003-05-23		Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
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KR100686537B1 (ko) *	2001-12-28	2007-02-27	씨제이 주식회사	사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
TW200403072A (en) *	2002-01-23	2004-03-01	Upjohn Co	Combination therapy for the treatment of bacterial infections
KR100470076B1 (ko) *	2002-11-27	2005-02-05	씨제이 주식회사	1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
US7247628B2 (en) *	2002-12-12	2007-07-24	Pfizer, Inc.	Cannabinoid receptor ligands and uses thereof
DE602004028800D1 (en)	2003-02-07	2010-10-07	Daiichi Sankyo Co Ltd	Pyrazolderivat
BRPI0409888A (pt)	2003-04-18	2006-05-23	Memory Pharm Corp	derivados de pirazol como inibidores de fosfodiesterase 4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento
US20050107350A1 (en) *	2003-08-22	2005-05-19	Pharmacia Corporation	Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
JP2008516964A (ja) *	2004-10-15	2008-05-22	メモリーファーマシューティカルスコーポレーション	ホスホジエステラーゼ４阻害剤としてのピラゾール誘導体
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RU2139281C1 (ru)	1993-11-30	1999-10-10	Джи Ди Сирл энд Компани	Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания
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GB9520584D0 (en)	1995-10-09	1995-12-13	Fujisawa Pharmaceutical Co	Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
UA57002C2 (uk)	1995-10-13	2003-06-16	Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі.	Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
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AP2002002532A0 (en) *	1999-12-03	2002-06-30	Pfizer Prod Inc	Heterocyclo-alkylsulfonyl pyrazole derivatives as ant-inflammatory/analgesic agents.

2000
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- 2000-11-24 AU AU12953/01A patent/AU783359B2/en not_active Ceased
- 2000-11-24 DZ DZ003246A patent/DZ3246A1/fr active
- 2000-11-28 US US09/724,446 patent/US6531492B1/en not_active Expired - Fee Related
- 2000-12-01 PE PE2000001289A patent/PE20010962A1/es not_active Application Discontinuation
- 2000-12-01 TN TNTNSN00235A patent/TNSN00235A1/fr unknown
- 2000-12-04 GT GT200000204A patent/GT200000204A/es unknown
- 2000-12-04 AR ARP000106402A patent/AR026711A1/es unknown
- 2000-12-04 PA PA20008508201A patent/PA8508201A1/es unknown
- 2000-12-04 CO CO00092095A patent/CO5261496A1/es not_active Application Discontinuation
2002
- 2002-05-10 IS IS6376A patent/IS6376A/is unknown
- 2002-05-13 BG BG106694A patent/BG106694A/xx unknown
- 2002-05-29 ZA ZA200204285A patent/ZA200204285B/en unknown
- 2002-05-31 MA MA26662A patent/MA26848A1/fr unknown
- 2002-06-03 NO NO20022624A patent/NO20022624L/no unknown
2003
- 2003-01-14 US US10/342,666 patent/US20030236258A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60018792T2 (de)	2006-01-26
IS6376A (is)	2002-05-10
KR20020058074A (ko)	2002-07-12
EP1233959A1 (fr)	2002-08-28
JP2003517475A (ja)	2003-05-27
AU783359B2 (en)	2005-10-20
PE20010962A1 (es)	2001-09-22
EA200200520A1 (ru)	2002-10-31
HK1052701A1 (zh)	2003-09-26
BR0016031A (pt)	2002-07-23
SK7412002A3 (en)	2003-08-05
MXPA02005539A (es)	2002-09-02
CO5261496A1 (es)	2003-03-31
MA26848A1 (fr)	2004-12-20
US20030236258A1 (en)	2003-12-25
TNSN00235A1 (fr)	2002-05-30
GT200000204A (es)	2002-05-28
ES2238324T3 (es)	2005-09-01
CA2392931A1 (fr)	2001-06-07
HUP0300157A2 (hu)	2003-06-28
DE60018792D1 (de)	2005-04-21
AR026711A1 (es)	2003-02-26
BG106694A (en)	2003-03-31
PL356669A1 (en)	2004-06-28
EP1233959B1 (fr)	2005-03-16
ZA200204285B (en)	2003-05-29
US6531492B1 (en)	2003-03-11
YU35102A (sh)	2005-03-15
HUP0300157A3 (en)	2006-01-30
WO2001040216A1 (fr)	2001-06-07
CN1423646A (zh)	2003-06-11
ATE291019T1 (de)	2005-04-15
PA8508201A1 (es)	2005-08-04
IL149581A0 (en)	2002-11-10
NO20022624L (no)	2002-07-30
DZ3246A1 (fr)	2001-06-07
AP2002002532A0 (en)	2002-06-30
AU1295301A (en)	2001-06-12
NO20022624D0 (no)	2002-06-03

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CA2411009A1 (fr)	2003-05-02	Heterocyclylalkylsulfonylpyrazoles
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