OA12173A - Dual inhibitors of cholesterol ester and wax estersynthesis for sebaceous gland disorders. - Google Patents

Dual inhibitors of cholesterol ester and wax estersynthesis for sebaceous gland disorders. Download PDF

Info

Publication number: OA12173A
Authority: OA; OAPI
Prior art keywords: phenyl; acné; diisopropyl; acetyl; use according
Prior art date: 2000-02-02

Application number

OA1200200234A

Other languages

English (en)

Inventor

Reynold Homan

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-02

Filing date

2001-01-23

Publication date

2006-05-08

2001-01-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-05-08 Publication of OA12173A publication Critical patent/OA12173A/en

Links

208000015390 Sebaceous gland disease Diseases 0.000 title claims abstract description 22
239000003112 inhibitor Substances 0.000 title description 15
230000009977 dual effect Effects 0.000 title description 3
150000001840 cholesterol esters Chemical class 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 50
238000011282 treatment Methods 0.000 claims abstract description 32
PTQXTEKSNBVPQJ-UHFFFAOYSA-N Avasimibe Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1CC(=O)NS(=O)(=O)OC1=C(C(C)C)C=CC=C1C(C)C PTQXTEKSNBVPQJ-UHFFFAOYSA-N 0.000 claims abstract description 31
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208000008742 seborrheic dermatitis Diseases 0.000 claims abstract description 4
208000009675 Perioral Dermatitis Diseases 0.000 claims abstract description 3
-1 2,4,6-triisopropyl-phenyl Chemical group 0.000 claims description 40
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229960002023 chloroprocaine Drugs 0.000 description 1
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239000002270 dispersing agent Substances 0.000 description 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
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238000002955 isolation Methods 0.000 description 1
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
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229910052757 nitrogen Inorganic materials 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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JJVNINGBHGBWJH-UHFFFAOYSA-N ortho-vanillin Chemical compound COC1=CC=CC(C=O)=C1O JJVNINGBHGBWJH-UHFFFAOYSA-N 0.000 description 1
238000012261 overproduction Methods 0.000 description 1
239000001814 pectin Substances 0.000 description 1
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235000010987 pectin Nutrition 0.000 description 1
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239000007967 peppermint flavor Substances 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
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229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
239000000047 product Substances 0.000 description 1
ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
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239000000523 sample Substances 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229940080236 sodium cetyl sulfate Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
229940031439 squalene Drugs 0.000 description 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000010972 statistical evaluation Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
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239000011550 stock solution Substances 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
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239000002562 thickening agent Substances 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
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239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
125000001680 trimethoxyphenyl group Chemical group 0.000 description 1
FLTJDUOFAQWHDF-UHFFFAOYSA-N trimethyl pentane Natural products CCCCC(C)(C)C FLTJDUOFAQWHDF-UHFFFAOYSA-N 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

OA1200200234A 2000-02-02 2001-01-23 Dual inhibitors of cholesterol ester and wax estersynthesis for sebaceous gland disorders. OA12173A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17977800P	2000-02-02	2000-02-02

Publications (1)

Publication Number	Publication Date
OA12173A true OA12173A (en)	2006-05-08

Family

ID=22657957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200234A OA12173A (en)	2000-02-02	2001-01-23	Dual inhibitors of cholesterol ester and wax estersynthesis for sebaceous gland disorders.

Country Status (34)

Country	Link
US (2)	US6730703B2 (fr)
EP (1)	EP1263421B1 (fr)
JP (1)	JP2003531113A (fr)
KR (1)	KR20020073574A (fr)
CN (1)	CN1398182A (fr)
AP (1)	AP2002002612A0 (fr)
AT (1)	ATE295724T1 (fr)
AU (1)	AU781563B2 (fr)
BG (1)	BG107042A (fr)
BR (1)	BR0107954A (fr)
CA (1)	CA2398219A1 (fr)
CR (1)	CR6712A (fr)
DE (1)	DE60110897T2 (fr)
DZ (1)	DZ3288A1 (fr)
EA (1)	EA004255B1 (fr)
EE (1)	EE200200429A (fr)
ES (1)	ES2239145T3 (fr)
GE (1)	GEP20043286B (fr)
HR (1)	HRP20020717A2 (fr)
HU (1)	HUP0301010A3 (fr)
IL (1)	IL150865A0 (fr)
IS (1)	IS6478A (fr)
MA (1)	MA26872A1 (fr)
MX (1)	MXPA02007309A (fr)
NO (1)	NO20023659L (fr)
NZ (1)	NZ520330A (fr)
OA (1)	OA12173A (fr)
PL (1)	PL357041A1 (fr)
PT (1)	PT1263421E (fr)
SK (1)	SK10972002A3 (fr)
UA (1)	UA75345C2 (fr)
WO (1)	WO2001056556A2 (fr)
YU (1)	YU57502A (fr)
ZA (1)	ZA200206075B (fr)

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US20050031699A1 (en)	2003-06-26	2005-02-10	L'oreal	Porous particles loaded with cosmetically or pharmaceutically active compounds
ES2313065T3 (es)	2003-10-09	2009-03-01	Warner-Lambert Company Llc	Composiciones farmaceuticas que comprenden derivados de malonamida para disminuir la produccion de sebo.
KR100906288B1 (ko)	2005-02-24	2009-07-06	워너-램버트 캄파니 엘엘씨	결정질 ａｃａｔ 억제제
FR2904002A1 (fr) *	2006-07-19	2008-01-25	Galderma Res & Dev S N C Snc	Modulateurs de la lanosterol synthetase dans le traitement de l'acne ou de l'hyperseborrhee
FR2903999B1 (fr) *	2006-07-19	2008-09-05	Galderma Res & Dev S N C Snc	Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee
FR2938342A1 (fr) *	2008-11-13	2010-05-14	Galderma Res & Dev	Ciblage de modulateurs de ces1 et/ou ces3 dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee
CA2750233A1 (fr)	2009-01-28	2010-08-05	Nanobio Corporation	Composition pour le traitement et la prevention de l'acne, procedes de fabrication des compositions, et procedes d'utilisation associes
JP2021527634A (ja) *	2018-06-21	2021-10-14	デルマバントサイエンシズゲーエムベーハー	Ｄｇａｔ１阻害剤の局所製剤およびそれらの使用の方法

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2001
- 2001-01-23 EE EEP200200429A patent/EE200200429A/xx unknown
- 2001-01-23 MX MXPA02007309A patent/MXPA02007309A/es active IP Right Grant
- 2001-01-23 BR BR0107954-9A patent/BR0107954A/pt not_active Application Discontinuation
- 2001-01-23 NZ NZ520330A patent/NZ520330A/en unknown
- 2001-01-23 OA OA1200200234A patent/OA12173A/en unknown
- 2001-01-23 EP EP01948936A patent/EP1263421B1/fr not_active Expired - Lifetime
- 2001-01-23 AU AU29718/01A patent/AU781563B2/en not_active Ceased
- 2001-01-23 DZ DZ013288A patent/DZ3288A1/fr active
- 2001-01-23 WO PCT/US2001/002190 patent/WO2001056556A2/fr not_active Ceased
- 2001-01-23 AT AT01948936T patent/ATE295724T1/de not_active IP Right Cessation
- 2001-01-23 GE GEAP20016597A patent/GEP20043286B/en unknown
- 2001-01-23 PT PT01948936T patent/PT1263421E/pt unknown
- 2001-01-23 US US10/182,847 patent/US6730703B2/en not_active Expired - Fee Related
- 2001-01-23 ES ES01948936T patent/ES2239145T3/es not_active Expired - Lifetime
- 2001-01-23 EA EA200200764A patent/EA004255B1/ru not_active IP Right Cessation
- 2001-01-23 PL PL01357041A patent/PL357041A1/xx not_active Application Discontinuation
- 2001-01-23 JP JP2001556248A patent/JP2003531113A/ja active Pending
- 2001-01-23 HU HU0301010A patent/HUP0301010A3/hu unknown
- 2001-01-23 CN CN01804520A patent/CN1398182A/zh active Pending
- 2001-01-23 AP APAP/P/2002/002612A patent/AP2002002612A0/en unknown
- 2001-01-23 IL IL15086501A patent/IL150865A0/xx unknown
- 2001-01-23 SK SK1097-2002A patent/SK10972002A3/sk not_active Application Discontinuation
- 2001-01-23 CA CA002398219A patent/CA2398219A1/fr not_active Abandoned
- 2001-01-23 KR KR1020027009943A patent/KR20020073574A/ko not_active Ceased
- 2001-01-23 HR HR20020717A patent/HRP20020717A2/hr not_active Application Discontinuation
- 2001-01-23 YU YU57502A patent/YU57502A/sh unknown
- 2001-01-23 DE DE60110897T patent/DE60110897T2/de not_active Expired - Fee Related
- 2001-01-23 UA UA2002076160A patent/UA75345C2/uk unknown
2002
- 2002-07-19 IS IS6478A patent/IS6478A/is unknown
- 2002-07-24 CR CR6712A patent/CR6712A/es not_active Application Discontinuation
- 2002-07-30 ZA ZA200206075A patent/ZA200206075B/en unknown
- 2002-08-01 NO NO20023659A patent/NO20023659L/no not_active Application Discontinuation
- 2002-08-01 MA MA26756A patent/MA26872A1/fr unknown
- 2002-08-29 BG BG107042A patent/BG107042A/bg unknown
2004
- 2004-02-06 US US10/773,354 patent/US20040161393A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EA004255B1 (ru)	2004-02-26
EE200200429A (et)	2003-12-15
WO2001056556A3 (fr)	2002-03-07
MXPA02007309A (es)	2002-11-29
GEP20043286B (en)	2004-07-26
PL357041A1 (en)	2004-07-12
CR6712A (es)	2004-01-14
MA26872A1 (fr)	2004-12-20
IL150865A0 (en)	2003-02-12
HUP0301010A2 (hu)	2003-08-28
EA200200764A1 (ru)	2002-12-26
BG107042A (bg)	2003-04-30
SK10972002A3 (sk)	2003-07-01
IS6478A (is)	2002-07-19
BR0107954A (pt)	2002-10-22
CN1398182A (zh)	2003-02-19
PT1263421E (pt)	2005-08-31
CA2398219A1 (fr)	2001-08-09
US20040161393A1 (en)	2004-08-19
DE60110897D1 (de)	2005-06-23
US6730703B2 (en)	2004-05-04
KR20020073574A (ko)	2002-09-27
AP2002002612A0 (en)	2002-09-30
ES2239145T3 (es)	2005-09-16
ZA200206075B (en)	2003-10-30
NO20023659D0 (no)	2002-08-01
NO20023659L (no)	2002-09-25
YU57502A (sh)	2006-01-16
AU2971801A (en)	2001-08-14
NZ520330A (en)	2004-02-27
EP1263421B1 (fr)	2005-05-18
AU781563B2 (en)	2005-06-02
ATE295724T1 (de)	2005-06-15
EP1263421A2 (fr)	2002-12-11
JP2003531113A (ja)	2003-10-21
DE60110897T2 (de)	2006-03-23
DZ3288A1 (en)	2001-08-09
WO2001056556A2 (fr)	2001-08-09
UA75345C2 (en)	2006-04-17
HUP0301010A3 (en)	2005-03-29
HRP20020717A2 (en)	2003-12-31
US20030060507A1 (en)	2003-03-27

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CN115554184A (zh)	2023-01-03	一种延缓薁磺酸钠氧化的方法
HK1051813A (en)	2003-08-22	Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders