HRP20020717A2 - Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders - Google Patents

Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders Download PDF

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Publication number
HRP20020717A2
HRP20020717A2 HR20020717A HRP20020717A HRP20020717A2 HR P20020717 A2 HRP20020717 A2 HR P20020717A2 HR 20020717 A HR20020717 A HR 20020717A HR P20020717 A HRP20020717 A HR P20020717A HR P20020717 A2 HRP20020717 A2 HR P20020717A2
Authority
HR
Croatia
Prior art keywords
acne
phenyl
disorder
treatment
triisopropyl
Prior art date
Application number
HR20020717A
Other languages
English (en)
Croatian (hr)
Inventor
Reynold Homan
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HRP20020717A2 publication Critical patent/HRP20020717A2/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20020717A 2000-02-02 2001-01-23 Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders HRP20020717A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17977800P 2000-02-02 2000-02-02

Publications (1)

Publication Number Publication Date
HRP20020717A2 true HRP20020717A2 (en) 2003-12-31

Family

ID=22657957

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020717A HRP20020717A2 (en) 2000-02-02 2001-01-23 Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders

Country Status (34)

Country Link
US (2) US6730703B2 (fr)
EP (1) EP1263421B1 (fr)
JP (1) JP2003531113A (fr)
KR (1) KR20020073574A (fr)
CN (1) CN1398182A (fr)
AP (1) AP2002002612A0 (fr)
AT (1) ATE295724T1 (fr)
AU (1) AU781563B2 (fr)
BG (1) BG107042A (fr)
BR (1) BR0107954A (fr)
CA (1) CA2398219A1 (fr)
CR (1) CR6712A (fr)
DE (1) DE60110897T2 (fr)
DZ (1) DZ3288A1 (fr)
EA (1) EA004255B1 (fr)
EE (1) EE200200429A (fr)
ES (1) ES2239145T3 (fr)
GE (1) GEP20043286B (fr)
HR (1) HRP20020717A2 (fr)
HU (1) HUP0301010A3 (fr)
IL (1) IL150865A0 (fr)
IS (1) IS6478A (fr)
MA (1) MA26872A1 (fr)
MX (1) MXPA02007309A (fr)
NO (1) NO20023659L (fr)
NZ (1) NZ520330A (fr)
OA (1) OA12173A (fr)
PL (1) PL357041A1 (fr)
PT (1) PT1263421E (fr)
SK (1) SK10972002A3 (fr)
UA (1) UA75345C2 (fr)
WO (1) WO2001056556A2 (fr)
YU (1) YU57502A (fr)
ZA (1) ZA200206075B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1281399A3 (fr) * 2001-08-01 2004-02-11 Warner-Lambert Company Inhibiteurs doubles de la synthèse des des esters de cires et des esters du cholestérol pour inhiber la production de sébum
US20050031699A1 (en) 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
AU2004280134B2 (en) 2003-10-09 2007-10-11 Medicis Pharmaceutical Corporation Pharmaceutical compositions comprising malonamide derivatives for decreasing sebum production
EP1856029A1 (fr) 2005-02-24 2007-11-21 Warner-Lambert Company LLC Inhibiteur cristallin de la acat
FR2903999B1 (fr) * 2006-07-19 2008-09-05 Galderma Res & Dev S N C Snc Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee
FR2904002A1 (fr) * 2006-07-19 2008-01-25 Galderma Res & Dev S N C Snc Modulateurs de la lanosterol synthetase dans le traitement de l'acne ou de l'hyperseborrhee
FR2938342A1 (fr) * 2008-11-13 2010-05-14 Galderma Res & Dev Ciblage de modulateurs de ces1 et/ou ces3 dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee
US20100226983A1 (en) 2009-01-28 2010-09-09 Nanobio Corporation Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof
AU2019290231A1 (en) * 2018-06-21 2020-12-17 Dermavant Sciences GmbH Topical formulations of DGAT1 inhibitors and their methods of use

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4545977A (en) * 1985-01-11 1985-10-08 G. D. Searle & Co. Compositions and methods for treating severe acne with isotretinoin
US4751026A (en) 1986-03-24 1988-06-14 Warner-Lambert Company Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase
US4722927A (en) 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
JPS6323848A (ja) 1986-07-11 1988-02-01 ワ−ナ−−ランバ−ト・コンパニ− Ω−（置換フエニルオキシ）−アルカン酸のアリ−ル−およびアラルキルアミド
US4716175A (en) 1987-02-24 1987-12-29 Warner-Lambert Company Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
US5015644A (en) 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
IE61716B1 (en) 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds
JPH0193569A (ja) 1987-07-02 1989-04-12 Warner Lambert Co アシル‐ＣｏＡ：コレステロールアシルトランスフエラーゼのＮ‐〔（２，６‐ジ置換）フエニル〕尿素およびカルバメート阻害剤
US4948806A (en) 1988-03-30 1990-08-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5030653A (en) 1988-03-30 1991-07-09 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4999373A (en) 1988-03-30 1991-03-12 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5116848A (en) 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US5155127A (en) 1989-02-09 1992-10-13 Warner-Lambert Company N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US4923896A (en) 1989-02-09 1990-05-08 Warner-Lambert Company N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US4994465A (en) 1989-02-17 1991-02-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
AU632809B2 (en) 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
AU629376B2 (en) 1989-08-04 1992-10-01 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives
WO1991004027A1 (fr) 1989-09-15 1991-04-04 Pfizer Inc. Nouveaux derives de n-aryle de n-heteroarylamide et d'uree en tant qu'inhibiteurs d'acyl coenzyme a: cholesterol acyl transferase
TW205037B (fr) 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
JPH05310678A (ja) 1990-01-22 1993-11-22 Mitsubishi Kasei Corp １−フェニルアルキル−３−フェニル尿素誘導体
US5362878A (en) 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
JP2668163B2 (ja) 1992-01-23 1997-10-27 ファイザー インク． コレステロール血症および抗アテローム動脈硬化症薬としての４−アリール−３−（ヘテロアリールウレイド）−１，２−ジヒドロ−２−オキソ−キノリン誘導体
WO1993024458A1 (fr) 1992-05-28 1993-12-09 Pfizer Inc. Nouveau derives n-aryle et de n-heteroaryluree en tant qu'inhibiteurs de l'acylcoenzime a: cholesterol acyltransferase (acat)
US5565472A (en) 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
US5491172A (en) 1993-05-14 1996-02-13 Warner-Lambert Company N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
US5596001A (en) 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
US5494172A (en) * 1994-05-12 1996-02-27 Miller Compressing Company Magnetic pulley assembly
US6133326A (en) * 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
ATE248845T1 (de) * 1998-06-25 2003-09-15 Tularik Inc Arylsulfonanilid-phosphate
AU2001292874B2 (en) * 2000-09-27 2006-06-15 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders

Also Published As

Publication number Publication date
EA200200764A1 (ru) 2002-12-26
CR6712A (es) 2004-01-14
PL357041A1 (en) 2004-07-12
AU781563B2 (en) 2005-06-02
PT1263421E (pt) 2005-08-31
OA12173A (en) 2006-05-08
MA26872A1 (fr) 2004-12-20
BR0107954A (pt) 2002-10-22
ZA200206075B (en) 2003-10-30
NO20023659D0 (no) 2002-08-01
IL150865A0 (en) 2003-02-12
KR20020073574A (ko) 2002-09-27
ES2239145T3 (es) 2005-09-16
GEP20043286B (en) 2004-07-26
CN1398182A (zh) 2003-02-19
CA2398219A1 (fr) 2001-08-09
ATE295724T1 (de) 2005-06-15
SK10972002A3 (sk) 2003-07-01
DE60110897D1 (de) 2005-06-23
HUP0301010A2 (hu) 2003-08-28
MXPA02007309A (es) 2002-11-29
AP2002002612A0 (en) 2002-09-30
AU2971801A (en) 2001-08-14
EA004255B1 (ru) 2004-02-26
EP1263421B1 (fr) 2005-05-18
WO2001056556A3 (fr) 2002-03-07
US20030060507A1 (en) 2003-03-27
JP2003531113A (ja) 2003-10-21
EP1263421A2 (fr) 2002-12-11
WO2001056556A2 (fr) 2001-08-09
NO20023659L (no) 2002-09-25
US6730703B2 (en) 2004-05-04
IS6478A (is) 2002-07-19
DE60110897T2 (de) 2006-03-23
DZ3288A1 (en) 2001-08-09
EE200200429A (et) 2003-12-15
US20040161393A1 (en) 2004-08-19
UA75345C2 (en) 2006-04-17
BG107042A (bg) 2003-04-30
YU57502A (sh) 2006-01-16
NZ520330A (en) 2004-02-27
HUP0301010A3 (en) 2005-03-29

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ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
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