OA12513A - Novel composition and use. - Google Patents

Novel composition and use. Download PDF

Info

Publication number: OA12513A
Authority: OA; OAPI
Prior art keywords: composition according; thiazolidinedione; carrier; compound; composition
Prior art date: 1999-11-16

Application number

OA1200200145A

Other languages

English (en)

Inventor

Karen Lewis

Nicola Jayne Lilliott

Donald Colin Mackenzie

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-16

Filing date

2000-11-16

Publication date

2006-05-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12513(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-11-16 Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en

1999-11-16 Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en

2000-05-31 Priority claimed from GB0013236A external-priority patent/GB0013236D0/en

2000-05-31 Priority claimed from GB0013240A external-priority patent/GB0013240D0/en

2000-11-16 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2006-05-29 Publication of OA12513A publication Critical patent/OA12513A/en

Links

239000000203 mixture Substances 0.000 title claims description 128
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ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims abstract description 39
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NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
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229960001855 mannitol Drugs 0.000 description 1
239000000463 material Substances 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
201000009925 nephrosclerosis Diseases 0.000 description 1
201000001119 neuropathy Diseases 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
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235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229960002668 sodium chloride Drugs 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
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GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
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HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

OA1200200145A 1999-11-16 2000-11-16 Novel composition and use. OA12513A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9927119.9A GB9927119D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GBGB9927120.7A GB9927120D0 (en)	1999-11-16	1999-11-16	Novel composition and use
GB0013236A GB0013236D0 (en)	2000-05-31	2000-05-31	Novel composition and use
GB0013240A GB0013240D0 (en)	2000-05-31	2000-05-31	Novel composition and use

Publications (1)

Publication Number	Publication Date
OA12513A true OA12513A (en)	2006-05-29

Family

ID=27447849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200145A OA12513A (en)	1999-11-16	2000-11-16	Novel composition and use.

Country Status (40)

Country	Link
US (1)	US8236345B2 (fr)
EP (3)	EP1913945A3 (fr)
JP (2)	JP4865975B2 (fr)
KR (1)	KR100760063B1 (fr)
CN (1)	CN1222290C (fr)
AP (1)	AP1389A (fr)
AR (2)	AR030920A1 (fr)
AT (1)	ATE292466T1 (fr)
AU (3)	AU775654B2 (fr)
BG (1)	BG65616B1 (fr)
BR (1)	BR0015605A (fr)
CA (1)	CA2388846A1 (fr)
CO (1)	CO5300392A1 (fr)
CZ (1)	CZ302500B6 (fr)
DE (1)	DE60019329T2 (fr)
DK (1)	DK1231918T3 (fr)
DZ (1)	DZ3251A1 (fr)
EA (1)	EA004878B1 (fr)
ES (1)	ES2240199T3 (fr)
HK (1)	HK1049788B (fr)
HR (1)	HRP20020416B1 (fr)
HU (1)	HU229960B1 (fr)
IL (3)	IL149618A0 (fr)
MA (1)	MA25567A1 (fr)
ME (1)	ME00318B (fr)
MX (1)	MXPA02005005A (fr)
MY (1)	MY125516A (fr)
NO (1)	NO329926B1 (fr)
NZ (1)	NZ518946A (fr)
OA (1)	OA12513A (fr)
PE (1)	PE20011011A1 (fr)
PL (1)	PL200943B1 (fr)
PT (1)	PT1231918E (fr)
RS (1)	RS51343B (fr)
SI (1)	SI1231918T1 (fr)
SK (1)	SK286985B6 (fr)
TW (1)	TWI240626B (fr)
UA (1)	UA73150C2 (fr)
UY (1)	UY26439A1 (fr)
WO (1)	WO2001035941A2 (fr)

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GB9824893D0 (en)	1998-11-12	1999-01-06	Smithkline Beckman Corp	Novel method of treatment
US20040102486A1 (en)	1998-11-12	2004-05-27	Smithkline Beecham Corporation	Novel method of treatment
AR023700A1 (es)	1998-11-12	2002-09-04	Smithkline Beecham Plc	Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
EA007610B1 (ru)	1998-11-12	2006-12-29	Смитклайн Бичам Плс	Таблетка с энтеропокрытием, обеспечивающая отсроченное высвобождение
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US6296874B1 (en)	2000-05-01	2001-10-02	Aeropharm Technology Incorporated	Core formulation comprising troglitazone and abiguanide
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US6451342B2 (en)	2000-05-01	2002-09-17	Aeropharm Technology Incorporated	Core formulation comprised of troglitazone and a biguanide
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US6403121B1 (en)	2000-05-01	2002-06-11	Aeropharm Technology Incorporated	Core formulation
GB0318824D0 (en)	2003-08-11	2003-09-10	Glaxo Group Ltd	Novel composition

2000
- 2000-11-15 MY MYPI20005360A patent/MY125516A/en unknown
- 2000-11-15 AR ARP000106019A patent/AR030920A1/es active IP Right Grant
- 2000-11-16 UA UA2002064826A patent/UA73150C2/uk unknown
- 2000-11-16 BR BR0015605-1A patent/BR0015605A/pt not_active Application Discontinuation
- 2000-11-16 AU AU14040/01A patent/AU775654B2/en not_active Expired
- 2000-11-16 DE DE60019329T patent/DE60019329T2/de not_active Expired - Lifetime
- 2000-11-16 WO PCT/GB2000/004368 patent/WO2001035941A2/fr not_active Ceased
- 2000-11-16 AT AT00976156T patent/ATE292466T1/de active
- 2000-11-16 OA OA1200200145A patent/OA12513A/en unknown
- 2000-11-16 CA CA002388846A patent/CA2388846A1/fr not_active Abandoned
- 2000-11-16 DK DK00976156T patent/DK1231918T3/da active
- 2000-11-16 KR KR1020027006271A patent/KR100760063B1/ko not_active Expired - Lifetime
- 2000-11-16 CZ CZ20021679A patent/CZ302500B6/cs not_active IP Right Cessation
- 2000-11-16 MX MXPA02005005A patent/MXPA02005005A/es active IP Right Grant
- 2000-11-16 PT PT00976156T patent/PT1231918E/pt unknown
- 2000-11-16 UY UY26439A patent/UY26439A1/es not_active IP Right Cessation
- 2000-11-16 DZ DZ003251A patent/DZ3251A1/fr active
- 2000-11-16 EP EP07120386A patent/EP1913945A3/fr not_active Withdrawn
- 2000-11-16 PL PL355331A patent/PL200943B1/pl unknown
- 2000-11-16 CN CNB008178224A patent/CN1222290C/zh not_active Expired - Lifetime
- 2000-11-16 NZ NZ518946A patent/NZ518946A/en not_active IP Right Cessation
- 2000-11-16 HK HK03100745.5A patent/HK1049788B/en not_active IP Right Cessation
- 2000-11-16 AP APAP/P/2002/002505A patent/AP1389A/en active
- 2000-11-16 JP JP2001537934A patent/JP4865975B2/ja not_active Expired - Lifetime
- 2000-11-16 HU HU0204122A patent/HU229960B1/hu unknown
- 2000-11-16 EP EP00976156A patent/EP1231918B1/fr not_active Expired - Lifetime
- 2000-11-16 SI SI200030697T patent/SI1231918T1/xx unknown
- 2000-11-16 ES ES00976156T patent/ES2240199T3/es not_active Expired - Lifetime
- 2000-11-16 EA EA200200571A patent/EA004878B1/ru not_active IP Right Cessation
- 2000-11-16 HR HR20020416A patent/HRP20020416B1/xx not_active IP Right Cessation
- 2000-11-16 ME MEP-2008-340A patent/ME00318B/fr unknown
- 2000-11-16 SK SK679-2002A patent/SK286985B6/sk not_active IP Right Cessation
- 2000-11-16 PE PE2000001226A patent/PE20011011A1/es not_active Application Discontinuation
- 2000-11-16 IL IL14961800A patent/IL149618A0/xx unknown
- 2000-11-16 EP EP04078538A patent/EP1520581A1/fr not_active Withdrawn
- 2000-11-16 RS YUP-388/02A patent/RS51343B/sr unknown
- 2000-11-20 CO CO00088045A patent/CO5300392A1/es not_active Application Discontinuation
- 2000-12-04 TW TW089125730A patent/TWI240626B/zh not_active IP Right Cessation
2002
- 2002-05-13 IL IL149618A patent/IL149618A/en unknown
- 2002-05-15 MA MA26640A patent/MA25567A1/fr unknown
- 2002-05-15 NO NO20022334A patent/NO329926B1/no not_active IP Right Cessation
- 2002-05-29 BG BG106747A patent/BG65616B1/bg unknown
2004
- 2004-11-04 AU AU2004226955A patent/AU2004226955B2/en not_active Expired
2006
- 2006-12-05 AR ARP060105370A patent/AR057970A2/es active IP Right Grant
2007
- 2007-07-18 US US11/779,546 patent/US8236345B2/en not_active Expired - Fee Related
2008
- 2008-03-17 IL IL190220A patent/IL190220A0/en unknown
- 2008-08-18 AU AU2008207375A patent/AU2008207375A1/en not_active Abandoned
2011
- 2011-08-11 JP JP2011175883A patent/JP5282130B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
MEP34008A (en)	2011-02-10
MXPA02005005A (es)	2003-10-14
WO2001035941A3 (fr)	2002-05-23
EP1231918A2 (fr)	2002-08-21
EP1520581A1 (fr)	2005-04-06
NO20022334L (no)	2002-07-09
HU229960B1 (hu)	2015-03-30
PT1231918E (pt)	2005-08-31
CO5300392A1 (es)	2003-07-31
JP2003514012A (ja)	2003-04-15
DZ3251A1 (fr)	2001-05-25
BR0015605A (pt)	2002-07-09
PL355331A1 (en)	2004-04-19
CN1414852A (zh)	2003-04-30
RS51343B (sr)	2011-02-28
NZ518946A (en)	2003-10-31
IL149618A (en)	2008-07-08
AR057970A2 (es)	2007-12-26
US8236345B2 (en)	2012-08-07
NO20022334D0 (no)	2002-05-15
JP4865975B2 (ja)	2012-02-01
IL149618A0 (en)	2002-12-01
CA2388846A1 (fr)	2001-05-25
AU2008207375A1 (en)	2008-09-11
MY125516A (en)	2006-08-30
BG65616B1 (bg)	2009-03-31
AU2004226955B2 (en)	2008-08-28
ES2240199T3 (es)	2005-10-16
IL190220A0 (en)	2008-11-03
HUP0204122A3 (en)	2006-01-30
MA25567A1 (fr)	2002-10-01
UA73150C2 (uk)	2005-06-15
PE20011011A1 (es)	2001-10-28
AP2002002505A0 (en)	2002-06-30
HRP20020416A2 (en)	2004-08-31
EA200200571A1 (ru)	2002-12-26
DE60019329D1 (de)	2005-05-12
CZ302500B6 (cs)	2011-06-22
BG106747A (en)	2003-01-31
AU1404001A (en)	2001-05-30
UY26439A1 (es)	2001-07-31
ATE292466T1 (de)	2005-04-15
KR20030019300A (ko)	2003-03-06
CN1222290C (zh)	2005-10-12
ME00318B (fr)	2011-05-10
AU775654B2 (en)	2004-08-12
WO2001035941A8 (fr)	2002-08-29
YU38802A (sh)	2005-03-15
AR030920A1 (es)	2003-09-03
HRP20020416B1 (hr)	2011-04-30
HK1049788A1 (en)	2003-05-30
EP1231918B1 (fr)	2005-04-06
EP1913945A2 (fr)	2008-04-23
AU2004226955A1 (en)	2004-12-02
SI1231918T1 (en)	2005-08-31
AP1389A (en)	2005-04-14
JP2011252007A (ja)	2011-12-15
WO2001035941A2 (fr)	2001-05-25
NO329926B1 (no)	2011-01-24
US20070275054A1 (en)	2007-11-29
PL200943B1 (pl)	2009-02-27
KR100760063B1 (ko)	2007-09-18
SK286985B6 (sk)	2009-08-06
TWI240626B (en)	2005-10-01
EA004878B1 (ru)	2004-08-26
DE60019329T2 (de)	2006-03-09
HK1049788B (en)	2005-11-04
JP5282130B2 (ja)	2013-09-04
HUP0204122A2 (hu)	2003-03-28
DK1231918T3 (da)	2005-08-01
SK6792002A3 (en)	2002-09-10
EP1913945A3 (fr)	2008-04-30

Publication	Publication Date	Title
OA12513A (en)	2006-05-29	Novel composition and use.
AU768994B2 (en)	2004-01-15	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
US20040081697A1 (en)	2004-04-29	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
KR100732599B1 (ko)	2007-06-27	조절 방출형 인슐린 감작제용 제약 조성물
EP1231917A2 (fr)	2002-08-21	Composition pharmaceutique a base d'hydrochloride de thiazolidinedione-metformine
ZA200203865B (en)	2002-11-22	Novel composition and use.
HK1076045A (en)	2006-01-06	Composition based on a thiazolidinedione and metformin and its use
HK1116681A (en)	2009-01-02	Composition based on a thiazolidinedione and metformin and its use
AU2757202A (en)	2002-05-16	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
ZA200103843B (en)	2002-05-14	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent.
AU2005200704A1 (en)	2005-03-17	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
AU2008203540A1 (en)	2008-08-28	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
HK1106135A (en)	2008-03-07	Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
HK1127277A (en)	2009-09-25	Novel modified release composition and use