OA12711A - 3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. - Google Patents

3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. Download PDF

Info

Publication number: OA12711A
Authority: OA; OAPI
Prior art keywords: alkyl; aza; crc4 alkyl; crc4; hex
Prior art date: 2001-10-22

Application number

OA1200400109A

Other languages

English (en)

Inventor

Steven Donald Heck

Stanton Furst Mchardy

Spiros Liras

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-22

Filing date

2002-09-09

Publication date

2006-06-27

2002-09-09 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-06-27 Publication of OA12711A publication Critical patent/OA12711A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Psychology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

OA1200400109A 2001-10-22 2002-09-09 3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. OA12711A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33851101P	2001-10-22	2001-10-22

Publications (1)

Publication Number	Publication Date
OA12711A true OA12711A (en)	2006-06-27

Family

ID=23325099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400109A OA12711A (en)	2001-10-22	2002-09-09	3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists.

Country Status (42)

Country	Link
US (3)	US7049335B2 (is)
EP (1)	EP1440059B1 (is)
JP (2)	JP4155522B2 (is)
KR (1)	KR100621292B1 (is)
CN (1)	CN100368398C (is)
AP (1)	AP1816A (is)
AR (1)	AR036905A1 (is)
AT (1)	ATE392415T1 (is)
AU (1)	AU2002329557B2 (is)
BR (1)	BR0213464A (is)
CA (1)	CA2463264C (is)
CR (1)	CR7317A (is)
DE (1)	DE60226161T2 (is)
DK (1)	DK1440059T3 (is)
EA (1)	EA006708B1 (is)
EC (1)	ECSP045077A (is)
ES (1)	ES2302839T3 (is)
GE (1)	GEP20084300B (is)
GT (1)	GT200200216A (is)
HN (1)	HN2002000299A (is)
HR (1)	HRP20040288A2 (is)
HU (1)	HUP0401884A2 (is)
IL (2)	IL161157A0 (is)
IS (1)	IS7187A (is)
MA (1)	MA27141A1 (is)
MX (1)	MXPA04003730A (is)
MY (1)	MY136580A (is)
NO (1)	NO329092B1 (is)
NZ (1)	NZ531807A (is)
OA (1)	OA12711A (is)
PA (1)	PA8556701A1 (is)
PE (1)	PE20030610A1 (is)
PL (1)	PL368919A1 (is)
PT (1)	PT1440059E (is)
PY (1)	PY0225353A (is)
RS (1)	RS25104A (is)
SI (1)	SI1440059T1 (is)
SV (1)	SV2004001363A (is)
TN (1)	TNSN04071A1 (is)
UA (1)	UA75714C2 (is)
WO (1)	WO2003035622A1 (is)
ZA (1)	ZA200402172B (is)

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BR0209129A (pt)	2001-04-18	2005-12-20	Euro Celtique Sa	Compostos, composições farmacêuticas, métodos para tratamento de dores, métodos para modulação de uma resposta farmacológica e usos de compostos
DE60226161T2 (de) *	2001-10-22	2009-07-02	Pfizer Products Inc., Groton	3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren
MXPA05011070A (es) *	2003-04-14	2005-12-12	Pfizer Prod Inc	Derivados de 3-azabiciclo [3.2.1] octano.
US20050043327A1 (en) *	2003-08-21	2005-02-24	Pfizer Inc	Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) *	2003-10-06	2006-12-26	Pfizer Inc.	Purification process for an azabicyclo[3.1.0]hexane compound
ES2634841T3 (es) *	2003-10-14	2017-09-29	Pfizer Products Inc.	Derivados bicíclicos [3.1.0] como inhibidores del transportador de glicina
EP1675829A1 (en) *	2003-10-16	2006-07-05	Pfizer Products Inc.	Preparation of 3-azabicyclo [3.1.0] hexane derivatives
ATE451364T1 (de)	2004-02-23	2009-12-15	Glaxo Group Ltd	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
AU2005219785B2 (en) *	2004-03-05	2010-05-27	Msd K.K.	Cycloalkanopyridine derivative
EP1837022A4 (en) *	2004-12-14	2009-12-16	Toray Industries	INDOLOMORPHINANE DERIVATIVE WITH CARBOXY IN 6 'POSITION
GB0512099D0 (en) *	2005-06-14	2005-07-20	Glaxo Group Ltd	Compounds
GB0517191D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
MY145633A (en)	2006-03-01	2012-03-15	Theravance Inc	8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2008075162A2 (en) *	2006-12-15	2008-06-26	Pfizer Limited	Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
TWI409067B (zh) *	2007-02-28	2013-09-21	Theravance Inc	８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
ES2390195T3 (es) *	2007-08-27	2012-11-07	Theravance, Inc.	Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
US7947710B2 (en) *	2007-08-27	2011-05-24	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029253A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
CA2927527C (en) *	2013-11-20	2021-06-01	Sanwa Kagaku Kenkyusho Co., Ltd.	Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof as u-opioid receptor antagonist
HK1246778A1 (zh) *	2015-05-20	2018-09-14	株式会社三和化学研究所	一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
EP3590511A4 (en)	2017-03-02	2020-09-02	Sanwa Kagaku Kenkyusho Co., Ltd	THERAPEUTIC AGENT FOR DISORDERS RELATED TO THE CONSUMPTION OF ALCOHOL

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GB9912415D0 (en) *	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
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US20020025948A1 (en) *	2000-06-23	2002-02-28	Banks Bernard Joseph	3-azabicyclo[3.1.0]hexane derivatives useful in therapy
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DE60226161T2 (de)	2001-10-22	2009-07-02	Pfizer Products Inc., Groton	3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren
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US20040204453A1 (en) *	2003-04-14	2004-10-14	Pfizer Inc	4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
US20050043327A1 (en) *	2003-08-21	2005-02-24	Pfizer Inc	Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) *	2003-10-06	2006-12-26	Pfizer Inc.	Purification process for an azabicyclo[3.1.0]hexane compound

2002
- 2002-09-09 DE DE60226161T patent/DE60226161T2/de not_active Expired - Lifetime
- 2002-09-09 ES ES02765197T patent/ES2302839T3/es not_active Expired - Lifetime
- 2002-09-09 NZ NZ531807A patent/NZ531807A/xx unknown
- 2002-09-09 KR KR1020047006011A patent/KR100621292B1/ko not_active Expired - Fee Related
- 2002-09-09 WO PCT/IB2002/003668 patent/WO2003035622A1/en not_active Ceased
- 2002-09-09 GE GEAP20028173A patent/GEP20084300B/en unknown
- 2002-09-09 HU HU0401884A patent/HUP0401884A2/hu unknown
- 2002-09-09 JP JP2003538138A patent/JP4155522B2/ja not_active Expired - Fee Related
- 2002-09-09 OA OA1200400109A patent/OA12711A/en unknown
- 2002-09-09 DK DK02765197T patent/DK1440059T3/da active
- 2002-09-09 SI SI200230688T patent/SI1440059T1/sl unknown
- 2002-09-09 AP APAP/P/2004/003007A patent/AP1816A/en active
- 2002-09-09 PT PT02765197T patent/PT1440059E/pt unknown
- 2002-09-09 EA EA200400467A patent/EA006708B1/ru not_active IP Right Cessation
- 2002-09-09 MX MXPA04003730A patent/MXPA04003730A/es active IP Right Grant
- 2002-09-09 EP EP02765197A patent/EP1440059B1/en not_active Expired - Lifetime
- 2002-09-09 AU AU2002329557A patent/AU2002329557B2/en not_active Ceased
- 2002-09-09 RS YUP-251/04A patent/RS25104A/sr unknown
- 2002-09-09 CA CA002463264A patent/CA2463264C/en not_active Expired - Fee Related
- 2002-09-09 UA UA20040402979A patent/UA75714C2/uk unknown
- 2002-09-09 HR HRP20040288 patent/HRP20040288A2/hr not_active Application Discontinuation
- 2002-09-09 IL IL16115702A patent/IL161157A0/xx unknown
- 2002-09-09 BR BR0213464-0A patent/BR0213464A/pt not_active IP Right Cessation
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 PL PL02368919A patent/PL368919A1/xx not_active Application Discontinuation
- 2002-09-09 CN CNB028208854A patent/CN100368398C/zh not_active Expired - Fee Related
- 2002-10-16 PY PY200200225353A patent/PY0225353A/es unknown
- 2002-10-17 MY MYPI20023878A patent/MY136580A/en unknown
- 2002-10-17 PA PA20028556701A patent/PA8556701A1/es unknown
- 2002-10-18 PE PE2002001032A patent/PE20030610A1/es not_active Application Discontinuation
- 2002-10-18 HN HN2002000299A patent/HN2002000299A/es unknown
- 2002-10-21 SV SV2002001363A patent/SV2004001363A/es not_active Application Discontinuation
- 2002-10-21 AR ARP020103960A patent/AR036905A1/es unknown
- 2002-10-22 US US10/278,142 patent/US7049335B2/en not_active Expired - Fee Related
- 2002-10-22 GT GT200200216A patent/GT200200216A/es unknown
2004
- 2004-03-18 IS IS7187A patent/IS7187A/is unknown
- 2004-03-18 ZA ZA200402172A patent/ZA200402172B/en unknown
- 2004-03-29 IL IL161157A patent/IL161157A/en not_active IP Right Cessation
- 2004-04-15 MA MA27630A patent/MA27141A1/fr unknown
- 2004-04-20 CR CR7317A patent/CR7317A/es unknown
- 2004-04-21 NO NO20041626A patent/NO329092B1/no not_active IP Right Cessation
- 2004-04-21 TN TNP2004000071A patent/TNSN04071A1/fr unknown
- 2004-04-22 EC EC2004005077A patent/ECSP045077A/es unknown
2005
- 2005-02-24 US US11/066,095 patent/US20050171178A1/en not_active Abandoned
2006
- 2006-03-01 US US11/366,903 patent/US20070054950A1/en not_active Abandoned
2007
- 2007-10-19 JP JP2007272602A patent/JP2008069169A/ja active Pending

Also Published As

Publication number	Publication date
CR7317A (es)	2006-08-09
AU2002329557B2 (en)	2008-07-31
US20070054950A1 (en)	2007-03-08
EP1440059A1 (en)	2004-07-28
MA27141A1 (fr)	2005-01-03
MY136580A (en)	2008-10-31
GT200200216A (es)	2003-05-23
BR0213464A (pt)	2004-11-09
PE20030610A1 (es)	2003-07-12
EA006708B1 (ru)	2006-02-24
SI1440059T1 (sl)	2008-08-31
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Publication	Publication Date	Title
AU2002329557B2 (en)	2008-07-31	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
AU2002329557A1 (en)	2003-07-03	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
EP1615893B1 (en)	2009-11-18	2-azabicyclo¬3.3.1 nonane derivatives as opioid receptor antagonists
ES2345437T3 (es)	2010-09-23	Antagonistas de nk1.
JP2006522792A (ja)	2006-10-05	４−フェニル−ピペリジン化合物およびそのオピオイド受容体のモジュレーターとしての使用
WO2004089908A2 (en)	2004-10-21	3-azabicyclo[3.2.1]octane derivatives
HK1072052B (en)	2008-07-11	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
HK1066787B (en)	2010-10-29	Nk1 antagonists