OA12801A - Process for preparing acid salts of gemifloxacin. - Google Patents

Process for preparing acid salts of gemifloxacin. Download PDF

Info

Publication number: OA12801A
Authority: OA; OAPI
Prior art keywords: acid; formula; compound; reaction; température
Prior art date: 2002-04-08

Application number

OA1200400271A

Other languages

English (en)

Inventor

Hoon Choi

Sang-Chul Choi

Bo-Seung Choi

Do-Hyun Nam

Original Assignee

Lg Life Sciences Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-08

Filing date

2003-04-04

Publication date

2006-07-11

2003-04-04 Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd

2006-07-11 Publication of OA12801A publication Critical patent/OA12801A/en

Links

239000002253 acid Substances 0.000 title claims abstract description 31
ZRCVYEYHRGVLOC-HYARGMPZSA-N gemifloxacin Chemical class C1C(CN)C(=N/OC)/CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 ZRCVYEYHRGVLOC-HYARGMPZSA-N 0.000 title claims abstract description 15
238000004519 manufacturing process Methods 0.000 title claims abstract description 11
229960003170 gemifloxacin Drugs 0.000 title claims abstract description 10
150000003839 salts Chemical class 0.000 title claims abstract description 8
238000000034 method Methods 0.000 claims abstract description 42
150000001875 compounds Chemical class 0.000 claims description 46
238000006243 chemical reaction Methods 0.000 claims description 35
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 33
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 27
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 14
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 12
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims description 11
239000012046 mixed solvent Substances 0.000 claims description 10
238000005755 formation reaction Methods 0.000 claims description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
229940098779 methanesulfonic acid Drugs 0.000 claims description 7
150000007530 organic bases Chemical class 0.000 claims description 7
239000003960 organic solvent Substances 0.000 claims description 7
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 6
SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 claims description 6
QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims description 5
YZBFISOEIGOFAF-UHFFFAOYSA-N (4-methoxyiminopyrrolidin-3-yl)methanamine Chemical compound CON=C1CNCC1CN YZBFISOEIGOFAF-UHFFFAOYSA-N 0.000 claims description 4
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 4
125000000217 alkyl group Chemical group 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
150000007522 mineralic acids Chemical class 0.000 claims description 4
150000007524 organic acids Chemical class 0.000 claims description 4
ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 claims description 4
229920006395 saturated elastomer Polymers 0.000 claims description 4
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 4
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 3
229910052794 bromium Inorganic materials 0.000 claims description 3
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
229910052801 chlorine Inorganic materials 0.000 claims description 3
238000010511 deprotection reaction Methods 0.000 claims description 3
229910052731 fluorine Inorganic materials 0.000 claims description 3
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 3
229940071870 hydroiodic acid Drugs 0.000 claims description 3
229910052740 iodine Inorganic materials 0.000 claims description 3
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
SNLMOXFUCILIPL-UHFFFAOYSA-N 1,8-naphthyridine-2-carboxylic acid Chemical compound C1=CC=NC2=NC(C(=O)O)=CC=C21 SNLMOXFUCILIPL-UHFFFAOYSA-N 0.000 claims description 2
FPYUJUBAXZAQNL-UHFFFAOYSA-N 2-chlorobenzaldehyde Chemical compound ClC1=CC=CC=C1C=O FPYUJUBAXZAQNL-UHFFFAOYSA-N 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000003118 aryl group Chemical group 0.000 claims description 2
125000004093 cyano group Chemical group *C#N 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
BTFQKIATRPGRBS-UHFFFAOYSA-N o-tolualdehyde Chemical compound CC1=CC=CC=C1C=O BTFQKIATRPGRBS-UHFFFAOYSA-N 0.000 claims 2
239000001431 2-methylbenzaldehyde Substances 0.000 claims 1
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 claims 1
230000000845 anti-microbial effect Effects 0.000 abstract description 3
230000003389 potentiating effect Effects 0.000 abstract description 2
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract description 2
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 description 12
239000011541 reaction mixture Substances 0.000 description 12
239000000203 mixture Substances 0.000 description 7
238000003756 stirring Methods 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
238000005859 coupling reaction Methods 0.000 description 6
238000003786 synthesis reaction Methods 0.000 description 6
238000001953 recrystallisation Methods 0.000 description 5
GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 4
CQVKMVQRSNNAGO-UHFFFAOYSA-N 2-[4-formyl-3-methyl-n-(2-methylsulfonyloxyethyl)anilino]ethyl methanesulfonate Chemical compound CC1=CC(N(CCOS(C)(=O)=O)CCOS(C)(=O)=O)=CC=C1C=O CQVKMVQRSNNAGO-UHFFFAOYSA-N 0.000 description 4
101150041968 CDC13 gene Proteins 0.000 description 4
HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 4
239000012535 impurity Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
-1 and éthanol Substances 0.000 description 3
239000007810 chemical reaction solvent Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
230000001976 improved effect Effects 0.000 description 3
IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000000463 material Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
SQAINHDHICKHLX-UHFFFAOYSA-N 1-naphthaldehyde Chemical compound C1=CC=C2C(C=O)=CC=CC2=C1 SQAINHDHICKHLX-UHFFFAOYSA-N 0.000 description 1
229940044613 1-propanol Drugs 0.000 description 1
MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 description 1
XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N n-propyl alcohol Natural products CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000007086 side reaction Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

OA1200400271A 2002-04-08 2003-04-04 Process for preparing acid salts of gemifloxacin. OA12801A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
KR10-2002-0018847A KR100517638B1 (ko)	2002-04-08	2002-04-08	게미플록사신 산염의 새로운 제조방법

Publications (1)

Publication Number	Publication Date
OA12801A true OA12801A (en)	2006-07-11

Family

ID=36241771

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400271A OA12801A (en)	2002-04-08	2003-04-04	Process for preparing acid salts of gemifloxacin.

Country Status (31)

Country	Link
US (1)	US7361762B2 (fr)
EP (1)	EP1497290B1 (fr)
JP (1)	JP4315815B2 (fr)
KR (1)	KR100517638B1 (fr)
CN (1)	CN1291987C (fr)
AP (1)	AP1786A (fr)
AT (1)	ATE404559T1 (fr)
AU (1)	AU2003219581B2 (fr)
BR (1)	BRPI0309037B8 (fr)
CA (1)	CA2481217C (fr)
CO (1)	CO5611198A2 (fr)
CY (1)	CY1108469T1 (fr)
DE (1)	DE60322872D1 (fr)
DK (1)	DK1497290T3 (fr)
EA (1)	EA007222B1 (fr)
ES (1)	ES2311694T3 (fr)
GE (1)	GEP20074025B (fr)
HR (1)	HRP20040929B1 (fr)
IL (1)	IL164328A (fr)
IS (1)	IS2731B (fr)
MA (1)	MA26408A1 (fr)
MX (1)	MXPA04009777A (fr)
NO (1)	NO330042B1 (fr)
NZ (1)	NZ536174A (fr)
OA (1)	OA12801A (fr)
PL (1)	PL372815A1 (fr)
PT (1)	PT1497290E (fr)
SI (1)	SI1497290T1 (fr)
UA (1)	UA77070C2 (fr)
WO (1)	WO2003087100A1 (fr)
ZA (1)	ZA200408088B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1412078E (pt) *	2001-08-02	2009-01-08	Lg Life Sciences Ltd	Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
WO2006134431A1 (fr) *	2005-05-03	2006-12-21	Ranbaxy Laboratories Limited	Sel de formiate de la gemifloxacine
EP1891037A1 (fr) *	2005-06-15	2008-02-27	Hetero Drugs Limited	Procede de preparation de la gemifloxacine et polymorphes
NZ570865A (en) *	2006-03-07	2010-11-26	Wockhardt Ltd	Alanine and valine prodrugs of nadifloxacin, S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
WO2008053324A1 (fr) *	2006-10-31	2008-05-08	Orchid Chemicals & Pharmaceuticals Limited	Procédé perfectionné pour la préparation de mésylate de gémifloxacine

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57134482A (en)	1981-02-13	1982-08-19	Dainippon Pharmaceut Co Ltd	1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (fr)	1984-11-13	1988-07-09	Kyorin Seiyaku Kk
NZ222047A (en)	1986-10-08	1991-01-29	Bristol Myers Co	Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja)	1987-10-13	1989-04-18	Shionogi & Co Ltd	オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en)	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents
JPH0356479A (ja)	1989-07-24	1991-03-12	Takeshi Yokota	水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
RU2049777C1 (ru)	1989-08-16	1995-12-10	Пфайзер Инк.	Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
US5137892A (en)	1990-12-12	1992-08-11	Abbott Laboratories	Quinoline, naphthyridine and pyridobenzoxazine derivatives
EP0541086A1 (fr)	1991-11-08	1993-05-12	Kaken Pharmaceutical Co., Ltd.	Fluoro-6-chinolones antibactériennes ayant un groupe oxime sur le substituant en position 7
JPH0673056A (ja)	1992-08-26	1994-03-15	Kaken Pharmaceut Co Ltd	キノリンカルボン酸誘導体およびその塩
US5776944A (en)	1994-06-16	1998-07-07	Lg Chemical Ltd.	7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
EP0688772B1 (fr)	1994-06-16	1999-05-06	LG Chemical Limited	Dérivés de l'acide quinolinecarboxylique ayant des substituants 7-(4-amino-méthyl-3-oxime)-pyrrolidine et procédé pour leur préparation
JP3449658B2 (ja)	1994-12-21	2003-09-22	杏林製薬株式会社	安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
JP3145715B2 (ja)	1995-06-06	2001-03-12	ファイザー・インコーポレーテッド	無水７−（［１α，５α，６α］−６−アミノ−３−アザビシクロ［３．１．０］ヘキサ−３−イル）−６−フルオロ−１−（２，４−ジフルオロフェニル）−１，４−ジヒドロ−４−オキソ−１，８−ナフチリディン−３−カルボン酸メタンスルホン酸塩の新規な結晶形態
ATE215072T1 (de)	1995-08-11	2002-04-15	Pfizer	(1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4- phenylpiperidin-1-yl)-1-propanol-methansulfonat trihydrat
AR006439A1 (es)	1996-03-29	1999-08-25	Smithkline Beecham Corp	Dihidrato de eprosartano y un procedimiento para su produccion y formulacion
MA24500A1 (fr) *	1997-03-21	1998-10-01	Lg Life Sciences Ltd	Derive du sel d'acide carboxylique de naphthyridine .
KR100286874B1 (ko)	1998-03-04	2001-04-16	성재갑	보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
PT1082300E (pt)	1998-05-29	2004-02-27	Upjohn Co	Monometanossulfonato de 3-¬(1'-n-metilamino)etil-n-benzil\|pirrolidina
GB9820405D0 (en)	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
PT1223935E (pt)	1999-06-29	2008-04-03	Lg Life Sciences Ltd	Utilização de compostos de gemifloxacina contra bactérias
AU6947900A (en)	1999-09-01	2001-03-26	Smithkline Beecham Corporation	Methods of use of fluoroquinolone compounds against bacteria
GB9920919D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
GB9920917D0 (en) *	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
EP1242079A4 (fr)	1999-09-22	2003-01-22	Smithkline Beecham	Méthodes d'utilisation anti-bactérienne de composés fluoroquinoloniques
KR20010091379A (ko)	2000-03-15	2001-10-23	성재갑	7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko)	2000-09-01	2002-03-08	성재갑	3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

2002
- 2002-04-08 KR KR10-2002-0018847A patent/KR100517638B1/ko not_active Expired - Lifetime
2003
- 2003-04-04 JP JP2003584056A patent/JP4315815B2/ja not_active Expired - Fee Related
- 2003-04-04 EP EP03715805A patent/EP1497290B1/fr not_active Expired - Lifetime
- 2003-04-04 BR BRPI0309037A patent/BRPI0309037B8/pt not_active IP Right Cessation
- 2003-04-04 NZ NZ536174A patent/NZ536174A/en not_active IP Right Cessation
- 2003-04-04 GE GEAP8436A patent/GEP20074025B/en unknown
- 2003-04-04 AT AT03715805T patent/ATE404559T1/de active
- 2003-04-04 ES ES03715805T patent/ES2311694T3/es not_active Expired - Lifetime
- 2003-04-04 DE DE60322872T patent/DE60322872D1/de not_active Expired - Lifetime
- 2003-04-04 UA UA20041008144A patent/UA77070C2/uk unknown
- 2003-04-04 CA CA2481217A patent/CA2481217C/fr not_active Expired - Lifetime
- 2003-04-04 WO PCT/KR2003/000683 patent/WO2003087100A1/fr not_active Ceased
- 2003-04-04 AU AU2003219581A patent/AU2003219581B2/en not_active Ceased
- 2003-04-04 MX MXPA04009777A patent/MXPA04009777A/es active IP Right Grant
- 2003-04-04 AP APAP/P/2004/003148A patent/AP1786A/en active
- 2003-04-04 SI SI200331341T patent/SI1497290T1/sl unknown
- 2003-04-04 DK DK03715805T patent/DK1497290T3/da active
- 2003-04-04 PL PL03372815A patent/PL372815A1/xx not_active Application Discontinuation
- 2003-04-04 US US10/510,514 patent/US7361762B2/en not_active Expired - Lifetime
- 2003-04-04 PT PT03715805T patent/PT1497290E/pt unknown
- 2003-04-04 OA OA1200400271A patent/OA12801A/en unknown
- 2003-04-04 EA EA200401328A patent/EA007222B1/ru not_active IP Right Cessation
- 2003-04-04 HR HRP20040929AA patent/HRP20040929B1/hr not_active IP Right Cessation
- 2003-04-04 CN CNB038095483A patent/CN1291987C/zh not_active Expired - Lifetime
2004
- 2004-09-30 IS IS7477A patent/IS2731B/is unknown
- 2004-10-05 CO CO04099283A patent/CO5611198A2/es active IP Right Grant
- 2004-10-07 ZA ZA200408088A patent/ZA200408088B/xx unknown
- 2004-10-07 MA MA27894A patent/MA26408A1/fr unknown
- 2004-10-21 IL IL164328A patent/IL164328A/en unknown
- 2004-10-27 NO NO20044629A patent/NO330042B1/no not_active IP Right Cessation
2008
- 2008-10-31 CY CY20081101234T patent/CY1108469T1/el unknown

Also Published As

Publication number	Publication date
WO2003087100A1 (fr)	2003-10-23
AP1786A (en)	2007-10-04
AU2003219581A1 (en)	2003-10-27
EA007222B1 (ru)	2006-08-25
BR0309037A (pt)	2005-02-01
IL164328A0 (en)	2005-12-18
EP1497290A4 (fr)	2006-05-10
SI1497290T1 (sl)	2008-12-31
MXPA04009777A (es)	2004-12-13
KR20030080292A (ko)	2003-10-17
NO20044629L (no)	2004-10-27
ATE404559T1 (de)	2008-08-15
CO5611198A2 (es)	2006-02-28
KR100517638B1 (ko)	2005-09-28
HRP20040929B1 (hr)	2013-12-06
HK1074440A1 (en)	2005-11-11
MA26408A1 (fr)	2004-12-01
US20050148622A1 (en)	2005-07-07
BRPI0309037B1 (pt)	2018-07-31
NO330042B1 (no)	2011-02-07
US7361762B2 (en)	2008-04-22
PT1497290E (pt)	2008-11-14
UA77070C2 (uk)	2006-10-16
BRPI0309037B8 (pt)	2021-05-25
JP2005529112A (ja)	2005-09-29
IS7477A (is)	2004-09-30
DE60322872D1 (de)	2008-09-25
EP1497290A1 (fr)	2005-01-19
AU2003219581B2 (en)	2006-08-24
PL372815A1 (en)	2005-08-08
IL164328A (en)	2009-08-03
CY1108469T1 (el)	2014-04-09
CA2481217C (fr)	2010-06-01
CN1649868A (zh)	2005-08-03
CN1291987C (zh)	2006-12-27
JP4315815B2 (ja)	2009-08-19
CA2481217A1 (fr)	2003-10-23
ES2311694T3 (es)	2009-02-16
EP1497290B1 (fr)	2008-08-13
DK1497290T3 (da)	2008-12-15
GEP20074025B (en)	2007-01-25
EA200401328A1 (ru)	2005-06-30
ZA200408088B (en)	2006-05-31
AP2004003148A0 (en)	2004-12-31
HRP20040929A2 (en)	2005-02-28
IS2731B (is)	2011-04-15
NZ536174A (en)	2006-09-29

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